UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C.  20549



                                   FORM 10-Q


            (X) QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D) OF
                     THE SECURITIES EXCHANGE ACT OF 1934.
                 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 1995
                                      OR
         ( ) TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE
                       SECURITIES EXCHANGE ACT OF 1934.
                FOR THE TRANSITION PERIOD FROM ______ TO ______



                        Commission File Number 33-14582
                       PAINEWEBBER R&D PARTNERS II, L.P.
        (Exact name of registrant as specified in its charter)



                  DELAWARE                     13-3437420
       (State or other jurisdiction of      (I.R.S. Employer
       incorporation or organization)      Identification No.)



1285 AVENUE OF THE AMERICAS, NEW YORK, NEW YORK   10019
  (Address of principal executive offices)     (Zip code)


  Registrant's telephone number, including area code: (212) 713-2000
                      ---------------



   Indicate  by  check  mark  whether  the Registrant (1) has filed all reports
required to be filed by Section 13 or 15(d)  of  the Securities Exchange Act of
1934  during  the  preceding  12 months (or for such shorter  period  that  the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.  Yes  X    No
                      ---------------
 



                   PAINEWEBBER R&D PARTNERS II, L.P.
                   (A Delaware Limited Partnership)

                               FORM 10-Q
                            MARCH 31, 1995

                           TABLE OF CONTENTS



                                                            PAGE

PART I.      FINANCIAL INFORMATION

Item 1.      Financial Statements

             Statements of Financial Condition              2
             (unaudited) at March 31, 1995 and
             December 31, 1994

             Statements of Operations                       3
             (unaudited) for the three months
             ended March 31, 1995 and 1994

             Statement of Changes in Partners' Capital      4
             (unaudited) for the three months
             ended March 31, 1995

             Statements of Cash Flows                       5
             (unaudited) for the three months
             ended March 31, 1995 and 1994

             Notes to Financial Statements                  6-11
             (unaudited)

Item 2.      Management's Discussion and Analysis of        12-13
             Financial Condition and Results of Operations

PART II.     OTHER INFORMATION

Item 1.      Legal Proceedings                              14

Item 6.      Exhibits and Reports on Form 8-K               14

             Signatures                                     15



All  schedules are omitted either  because  they  are  not  applicable  or  the
information  required  to  be  submitted  has  been  included  in the financial
statements or notes thereto.


                             Page 2


PART I. FINANCIAL INFORMATION
                            
ITEM 1. FINANCIAL STATEMENTS
                                 
PAINEWEBBER R&D PARTNERS II, L.P.
(a Delaware Limited Partnership)
                                   
Statements of Financial Condition
(unaudited)                       
                                                       March       December  
                                                         31,            31,
                                                        1995          1994
- - ---------------------------------------------------------------------------
Assets:                                                           
                                                                     
              Cash                                $    5,487   $      6,703  
                                                                    
              Marketable                           1,281,998      2,308,631
              securities, at                             
              market value
                                                                 
              Investments                         11,857,043     10,327,102  
                                                        
                                                               
              Interest                                 4,244          7,673 
              receivable
                                                                        
              Investments in                         179,079        183,228
              product
              development
              projects
                                                                      
              Royalty income                          27,731         42,472
              receivable                        -------------  ------------
                                                                        
Total assets                                    $ 13,355,582   $ 12,875,809
                                                ============   ============
                                                        
                                                                   
                                       
Liabilities                                                
and partners'
capital
                                                                
              Accrued                             $  158,072   $    151,442  
              liabilities
                                                                   
              Partners'                           13,197,510     12,724,367 
              capital                                    
                                                ------------   ------------
Total liabilities and partners' capital         $ 13,355,582   $ 12,875,809
                                                ============   ============

- - ----------------------------------------------------------------------------
                                                            
See notes to financial statements.
                                             
                                                         
                                                       
                                                        
                             Page 3                    
                                                                           
                                                                           
                                                                              
PAINEWEBBER R&D PARTNERS II, L.P.
(a Delaware Limited Partnership)
                                                                             
Statements of Operations
(unaudited)                                                                  
                                                                                
For the three                                                    
months ended
March 31,                                               1995          1994
- - --------------------------------------------------------------------------
Revenues:                                                                       
   Interest income                                $   28,323    $   29,180      
   Income from                                        27,731        50,935     
   product           
   development           
   projects           

   Unrealized                                                               
   appreciation of           
   investments           
   and marketable                                   1,531,958          -  
   securities                                      

   Realized gain on                                         -      166,841
   distribution of           
   investment                                       ----------   ---------
                                                    1,588,012      246,956
                                                    ----------   ---------

Expenses: 
Expenditures                                                                    
under product          
development           
  projects                                            4,149       413,548   
  
Management fee                                      125,582       157,613 

General and                                          67,694        31,210 
administrative         
costs                                               -------       -------
                                                    197,425       602,371
                                                    -------       -------

Net income (loss) before cumulative effect of
    change in accounting method                    1,390,587      (355,415)

                                                                     
   Cumulative effect of change in
   accounting method                                       -       366,334
                                                   ---------     ---------
                                                                           
Net income                                       $ 1,390,587    $   10,919
                                                   =========     =========

                                                                      
Net income (loss) per partnership
   unit before cumulative effect of
   change in accounting
   method:

   Limited partners                               $   166.73     $  (42.61) 
   (based on 8,257           
   units)           
   General partner                               $ 13,905.87   $ (3,554.15)   
                                                        
                                                                       
Cumulative effect of change in
   accounting method per partnership unit:

   Limited partners                              $        -     $    43.92
   (based on 8,257           
   units)           

   General partner                               $        -     $ 3,663.34
                     
                                                 
Net income per partnership unit:

   Limited partners                               $    166.73   $     1.31
   (based on 8,257           
   units)           
   General partner                                $ 13,905.87   $   109.19

- - ---------------------------------------------------------------------------
                                                                        
See notes to financial statements.
                                                                        
                                                                               

                             Page 4                         
                                                                     

PAINEWEBBER R&D PARTNERS II, L.P.
(a Delaware Limited Partnership)
                                                            
Statement of Changes in Partners' Capital 
(unaudited)                                                              
                            
For the three               
months ended
March 31,                    Limited             General 
1995                        Partners             Partner           Total
- - -----------------------------------------------------------------------------
                                                          
Balance at                $ 12,594,066         $  130,301     $ 12,724,367
December 31,                   
1994
                                      
Net income                   1,376,681             13,906        1,390,587
                                                     
Cash                          (908,270)            (9,174)        (917,444)
distribution   
to partners
                          ------------         ----------     ------------ 
Balance at                $ 13,062,477         $  135,033     $ 13,197,510
March 31,                 ============         ==========     ============    
1995

- - -----------------------------------------------------------------------------

See notes to financial statements.              


                             Page 5
                                                                     
                                                                              
                                                                              
                                                                             
PAINEWEBBER R&D PARTNERS II, L.P.
(a Delaware Limited Partnership)
                     
Statements of Cash Flows
(unaudited)                                                                    
                                                                               
For the three                                          
months ended
March 31,                                               1995         1994
- - -----------------------------------------------------------------------------
Cash flows from operating activities:

Net income                                        $ 1,390,587     $   10,919

Adjustments to reconcile net income to
 cash provided by operating activities:

Unrealized appreciation of investments
 and marketable securities                         (1,531,958)             -

Realized gain on distribution of investment                 -       (166,841)

Cumulative effect of change in accounting                   -       (366,334)
 method
                                                                      
Decrease in operating assets:

Marketable securities                               1,028,650      1,294,602

Investment                                                  -         22,701

Investments in product development projects             4,149        244,298

Interest receivable                                     3,429          3,758

Royalty income receivable                              14,741         49,476

Increase (decrease) in operating liabilities:

  Accrued liabilities                                   6,630          5,669
  
  Liabilities under product development projects            -     (1,083,866)

Distributions payable                                       -        417,020
                                                     --------      ---------
Cash provided by operating activities:                916,228        431,402
                                                     --------      ---------
Cash flows from financing activities:

Distribution to partners                             (917,444)      (417,020)
                                                     --------       --------
Cash used for financing activities                   (917,444)      (417,020)
                                                     --------       --------
(Decrease) increase in cash                            (1,216)        14,382

Cash at beginning of period                              6,703         6,369
                                                    ----------    ----------
Cash at end of period                               $    5,487    $   20,751
                                                    ==========    ==========


- - ----------------------------------------------------------------------------
                                                                         
Supplemental disclosure of cash flow information:

The Partnership paid no cash for interest during the three months ended March
31, 1995 and 1994.
                                                                        
Supplemental schedule of non-cash activities:
                                                                               
For the three
months ended
March 31,                                           1995             1994 
- - -----------------------------------------------------------------------------
                                                                
Distribution of investments
to partners:
   Alkermes, Inc. common stock               $        -         $ 1,334,728


- - ------------------------------------------------------------------------------
See notes to financial statements.
                                                                              
                                                                               
                                                                          

                                                     
                             Page 6


                     PAINEWEBBER R&D PARTNERS II, L.P.
                     (A Delaware Limited Partnership)

                      NOTES TO FINANCIAL STATEMENTS
                              (UNAUDITED)


                        MARCH 31, 1995 AND 1994

1.  ORGANIZATION AND BUSINESS

   The financial information as of and for the periods ended March 31, 1995 and
1994  is  unaudited.  However, in the opinion of management of PaineWebber  R&D
Partners  II,   L.P.   (the   "Partnership"),  such  information  includes  all
adjustments, consisting only of normal recurring accruals, necessary for a fair
presentation.  These financial  statements  should  be read in conjunction with
the  most recent annual report of the Partnership on Form  10-K  for  the  year
ended December 31, 1994.

   The  Partnership is a Delaware limited partnership that commenced operations
on September  30,  1987.   PWDC  Holding Company (the "Manager") is the general
partner of PaineWebber Technologies  II, L.P. (the "General Partner"), which is
the general partner of the Partnership.  PWDC Holding Company is a wholly owned
subsidiary of PaineWebber Development  Corporation ("PWDC"), an indirect wholly
owned subsidiary of Paine Webber Group Inc.  ("PWG").   The  Partnership  had a
total  of  $72.0  million  available  for  investment  from  all closings.  The
Partnership will terminate on December 31, 2012,  unless its term  is  extended
or reduced by the General Partner.

   The  principal  objective of the Partnership is to provide long-term capital
appreciation  to  investors   through   investing   in   the   development  and
commercialization   of   new   products  with  technology  companies  ("Sponsor
Companies"), which are expected  to  address  significant market opportunities.
Once the product development phase is completed, the Sponsor Companies have the
option to license and commercialize the products  resulting  from  the  product
development  project,  and  the  Partnership  has the right to receive payments
based upon the sale of such products.  In connection  with  product development
projects  (the  "Projects"),  the  Partnership  sought  to  obtain warrants  to
purchase the common stock of Sponsor Companies.  These warrants  will  have the
potential  to provide additional capital appreciation to the Partnership  which
is not directly  dependent upon the outcome of the Projects (see Note 5).  As a
result of restructuring  some  of  the  original projects, the Partnership also
obtained restricted common stock in some of the Sponsor Companies (see Note 3).
As  such,  the Partnership is engaged in diverse  Projects  through  contracts,
participation  in  other  partnerships  and  investments  in  securities of the
Sponsor Companies.

   All  distributions  to  limited  partners  of the Partnership (the  "Limited
Partners")  and the General Partner (collectively,  the  "Partners")  from  the
Partnership will initially be made pro rata in accordance with their respective
net capital contributions.   The  following  table sets forth the proportion of
each distribution to be received by Limited Partners  and  the General Partner,
respectively:



                             Page 7

                     PAINEWEBBER R&D PARTNERS II, L.P.
                     (A Delaware Limited Partnership)

                     NOTES TO FINANCIAL STATEMENTS
                               (UNAUDITED)

(NOTE 1 CONTINUED)


                                                             Limited    General
                                                            Partners    Partner
                                                            --------    -------

I.  Until the value of the aggregate distributions for 
    each limited partnership unit ("Unit") equals $10,000
    plus simple interest on such amount accrued at 7% per 
    annum for each Unit sold at the Initial Closing (6% 
    per annum for each subsequent Unit sold up to the 
    5,000th Unit and 5% per annum for each Unit sold
    thereafter) ("Contribution Payout")                      99%        1%

II. After Contribution Payout and until the value of the
    aggregate distributions for each Unit equals 
    $50,000 ("Final Payout")                                 80%       20%

III.  After Final Payout                                     75%       25%



   At March 31, 1995 the Partnership has made cash and securities distributions
since inception of $1,565 and $5,750 per Unit, respectively.

2.  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

   The Partnership adopted the provisions of Statement of Financial  Accounting
Standards  No.  115,  "Accounting  for  Certain  Investments in Debt and Equity
Securities" ("Statement No. 115") for investments  held as of or acquired after
January 1, 1994.  In accordance with Statement No. 115,  prior period financial
statements have not been restated to reflect the change in  accounting  method.
The  cumulative effect of adopting Statement No. 115 as of January 1, 1994  was
to increase  net  income  for  the  quarter ended March 31, 1994 by $366,334 or
$43.92 per Unit.

   Marketable securities consist of a  money market fund and common stock which
are recorded at market value.  Marketable  securities  are  not considered cash
equivalents for the Statements of Cash Flows.

   Realized  and  unrealized  gains  or  losses  are determined on  a  specific
identification method and are reflected in the Statements  of Operations during
the period in which the change in value occurs.

   The Partnership invested in Projects, further described in  Note  5, through
one of the following two vehicles:



                             Page 8

                     PAINEWEBBER R&D PARTNERS II, L.P.
                     (A Delaware Limited Partnership)

                      NOTES TO FINANCIAL STATEMENTS
                                (UNAUDITED)

(NOTE 2 CONTINUED)

      -  Product Development Contracts
         The  Partnership  paid  amounts  to  Sponsor  Companies  under product
         development contracts.  Such amounts were expensed by the  Partnership
         when incurred by the Sponsor Companies.

      -  Product Development Limited Partnerships
         The   Partnership   participated  as  a  limited  partner  in  product
         development limited partnerships  formed to develop specific products.
         Such participations were accounted  for using the equity method.  Such
         partnerships expensed product development costs when incurred.

   The Partnership carries warrants at a zero  value in cases where the Sponsor
Company's  stock is not publicly traded or the exercise  period  has  not  been
attained.   To  the  extent  that  the  Partnership's  warrants  are  currently
exercisable and  the  Sponsor  Company's stock is publicly traded, the warrants
are carried at intrinsic value (the  excess  of market price per share over the
exercise price per share), which approximates  fair  value.  Prior to 1993, the
Partnership accounted for the distribution of warrants  at their carrying value
of zero.

3. MARKETABLE SECURITIES AND INVESTMENTS

   MARKETABLE SECURITIES:

    The money market fund consists of obligations with maturities  of  one year
or less that are subject to fluctuations in value.

   At March 31, 1995, the Partnership held the following marketable securities:



                                              MARKET         COST

     Money market fund                   $1,273,124      $1,273,124
     Alkermes, Inc. common stock 
     (3,227 shares)                           8,874          22,589
                                         ----------      ----------
                                         $1,281,998      $1,295,713
                                         ==========      ==========


   At  December  31,  1994,  the  Partnership  held  the  following  marketable
securities:



                                              MARKET         COST

     Money market fund                      $2,301,774   $2,301,774
     Alkermes, Inc. common stock 
     (3,227 shares)                              6,857       22,589
                                            ----------   ----------
                                            $2,308,631   $2,324,363
                                            ==========   ==========

     Alkermes, Inc. common stock had a market value of $2.75 and $2.125  per  
share  as  of  March  31,  1995 and December 31, 1994, respectively.



                             Page 9


                     PAINEWEBBER R&D PARTNERS II, L.P.
                     (A Delaware Limited Partnership)

                      NOTES TO FINANCIAL STATEMENTS
                              (UNAUDITED)

(NOTE 3 CONTINUED)

    INVESTMENT:

    At  March 31, 1995 and December 31, 1994, the Partnership's sole investment
was 1,529,941 shares of Cygnus Therapeutic Systems ("Cygnus") restricted common
stock that  is the subject of a registration statement under the Securities Act
of 1933, as amended.   The  Partnership's  carrying value of this investment at
March  31,  1995  and  December  31,  1994  was  $11,857,043  and  $10,327,102,
respectively.

    In  1994,  in  accordance  with  the  adoption of Statement  No.  115,  the
Partnership commenced recording investments  in  restricted common stock (where
the  restriction  period  expires in one year or less)  at  market  value  with
unrealized gains and losses  reflected  in  the Statements of Operations during
the period in which the change in value occurs.   Restricted common stock, with
a restriction period greater than one year, is carried  at the lower of cost or
fair value.  The cumulative effect at January 1, 1994 of adopting Statement No.
115  was  to  increase the carrying value of the Alkermes restricted  stock  by
$366,334.  Prior  to  the  adoption  of  Statement  No.  115,  the  Partnership
accounted  for  its investments in restricted common stock (regardless  of  the
restriction period) at the lower of cost or fair value.

    In  December  1994,  the  Partnership  and  Cygnus  entered  into  the  GMS
Technology Purchase Agreement whereby Cygnus purchased from the Partnership the
rights to glucose monitoring  system ("GMS") technology developed under product
development agreements between Cygnus and the Partnership.  In exchange for its
technology rights, the Partnership  received  1,529,941 shares of Cygnus common
stock valued at $8,988,403 which was based on the  market  price  per  share of
$5.875  on the date of receipt.   At March 31, 1995 and December 31, 1994,  the
Partnership  recorded  its  Cygnus  common stock at the closing market price of
$7.75  per  share  (totaling  $11,857,043)   and   $6.75  per  share  (totaling
$10,327,102), respectively.  Accordingly, the Partnership recognized unrealized
appreciation of $1,529,941 for the three months ended  March 31, 1995 which has
been reflected in the Statements of Operations.

    On  January  2, 1994, 170,084 shares of Alkermes restricted  common  stock,
with a carrying value  of $1,190,588 ($7.00 per share), became saleable without
volume limitation pursuant to Securities and Exchange Commission Rule 144.  The
Partnership distributed 166,841 shares of Alkermes common stock to its Partners
on January 5, 1994.  The  market value of the Alkermes common stock on the date
of distribution was $1,334,728 ($8.00 per share) compared to the carrying value
of $1,167,887 ($7.00 per share).   A  realized  gain of $166,841 was recognized
with respect to the distribution.

4.  RELATED PARTY TRANSACTIONS

    The  Manager  receives  an  annual  management  fee   for   management  and
administrative  services  provided to the Partnership.  The management  fee  is
equal  to 2% of the aggregate  gross  proceeds  received  by  the  Partnership,
reduced  by  the  Partnership's  capital commitments in Projects that have been
concluded, and the final proceeds  of  which  (if any) have been distributed to
the Partners of the Partnership.  The management  fee  is  payable quarterly in
advance  and is adjusted annually on the first day of each fiscal  year  in  an
amount proportionate  to  the  increase in the prior year in the Consumer Price
Index published by the United States  Department of Labor.  The management fees
paid by the Partnership to the Manager were $125,582 and $157,613 for the three
months ended March 31, 1995 and 1994, respectively.



                             Page 10

                     PAINEWEBBER R&D PARTNERS II, L.P.
                     (A Delaware Limited Partnership)

                      NOTES TO FINANCIAL STATEMENTS
                               (UNAUDITED)


(NOTE 4 CONTINUED)

    As  of  January 1, 1995, the Manager  had  eliminated  the  management  fee
charged for the following seven of the Partnership's Projects:



                   - Alkermes, Inc.
                   - Cadre Technologies, Inc.
                   - Centocor Partners, III, L.P.
                   - Compression Labs, Inc.
                   - Genentech Clinical Partners IV, L.P.
                   - Rogers Corporation
                   - Synergen Clinical Partners, L.P.

    The Partnership's  portfolio of  a money market fund is managed by Mitchell
Hutchins Institutional Investors ("MHII"), an affiliate of PWDC.  PWDC (not the
Partnership) pays MHII a fee with respect to such money management services.

    PWDC and PaineWebber  Incorporated  ("PWI"), and its affiliates, have acted
in an investment banking capacity for several  of  the  Sponsor  Companies.  In
addition, PWDC and its affiliates have direct limited partnership  interests in
the same Projects as the Partnership.

    The Partnership is involved in certain legal actions.  The General  Partner
believes these actions will be resolved without material adverse effect on  the
Partnership's financial statements, taken as a whole.

5.  COMMITMENTS UNDER PRODUCT DEVELOPMENT PROJECTS

    The   Partnership   entered   into  ten  Projects  (Alkermes,  Inc.;  Cadre
Technologies Inc.; Centocor Partners III, L.P.; Compression Labs, Incorporated;
Cygnus Therapeutic Systems; FOCUS Surgery  Inc.  (formerly  Focal Surgery, Inc.
(successor to Diasonics, Inc.)); Genentech Clinical Partners  IV, L.P.; Genzyme
Development Partners, L.P.; Rogers Corporation; and Synergen Clinical Partners,
L.P).  As of March 31, 1995, all of the Projects were fully funded.

    If  the  Projects  produce  any  product  for commercial sale, the  Sponsor
Companies have the option to enter into joint ventures  or  royalty  agreements
with  the  Partnership  to  manufacture and market the products developed.   In
addition, the Sponsor Companies  have  the option to purchase the Partnership's
interest in the technology.  In consideration  for  such  purchase options, the
Partnership  has received warrants to purchase shares of common  stock  of  the
Sponsor Companies.  These  warrants  are  carried at zero value as of March 31,
1995  and  December 31, 1994.  At March 31, 1995,  the  Partnership  owned  the
following warrants:



                             Page 11

                   PAINEWEBBER R&D PARTNERS II, L.P.
                    (A DELAWARE LIMITED PARTNERSHIP)

                NOTES TO FINANCIAL STATEMENTS(UNAUDITED)

(NOTE 5 CONTINUED)



                                                                               3/31/95
                       Number of Shares    Exercise Price   Exercise       Market Price
                  that can be Purchased         per Share   Period          Per Share *
                  ---------------------    --------------   --------       ------------
                                                                                        
Cadre Technologies Inc.         625,000           $ 5.00    Current to 6/97        (A)

Centocor, Inc.                    2,800           $13.33    Current to 2/96     $15.88

Cygnus Therapeutics Systems     300,000           $ 9.90    Current to 9/97      $7.75

OEC Medical Systems, Inc. (B)   200,000           $12.70    Current to 8/97      $5.88

Synergen, Inc.                   28,176           $15.69    Current to 2/96        (C)
                                                  $17.69    3/96 to 2/98



* The share  prices of these technology companies are generally highly volatile
and the shares are often thinly traded. The market prices indicated as of March
31, 1995 may not  be  indicative  of  the  ultimate values, if any, that may be
realized by the Partnership.

(A) At  March  31, 1995, the common stock of Cadre Technologies  Inc.  was not
 publicly traded.

(B) In October 1993, Diasonics,  Inc. completed a major corporate restructuring
under which Diasonics,Inc. was divided  into  three  separate  publicly  traded
companies:  Diasonics  UltraSound,  Inc., FOCUS Surgery  Inc.  and  OEC Medical
Systems, Inc. The Partnership's warrant is to purchase the stock of OEC Medical
Systems,  Inc.  FOCUS  Surgery,  Inc. will continue to develop the product  for
which the Partnership has the rights.

(C) In December 1994, Amgen, Inc.  acquired  Synergen,  Inc.  ("Synergen") in a
 cash  tender  offer  of $9.25 per share of outstanding Synergen common  stock.
 Concurrently, the Partnership's  warrant to purchase shares of Synergen common
 stock was exercisable for $9.25 per  share in cash, rather than common shares,
 which  was  $6.44  and  $8.44  a  share  below   the  exercise  price  of  the
 Partnership's warrant.  Accordingly, the warrant was  rendered  valueless  and
 the Partnership did not exercise the warrant.

6.  INCOME TAXES

       The  Partnership is not subject to federal, state or local income taxes.
Accordingly,  the individual partners are required to report their distributive
shares of realized income and loss on their individual federal and state income
tax returns.



                             Page 12

ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS.

LIQUIDITY AND CAPITAL RESOURCES

  Partners' capital  at  March  31,  1995  was  $13.2 million compared to $12.7
million at December 31, 1994, an increase of $0.5  million.   The  increase  in
partners'  capital  was  a result of net income from operations of $1.4 million
(as discussed in Results of  Operations below) offset by a cash distribution to
the Partners of $0.9 million.

  The Partnership's working capital  is invested in marketable securities and a
money market fund.  Liquid assets at March  31, 1995 were $1.3 million compared
to $2.3 million at December 31, 1994, a decrease of $1.0 million.  The decrease
in liquid assets is primarily due to cash distributions  to  Partners  of  $0.9
million  and  the  payment  of management fees approximating $0.1 million.  The
balance of liquid assets will  be  used  for the payment of management fees and
administrative costs related to managing the Partnership's investments.

RESULTS OF OPERATIONS

  THREE MONTHS ENDED MARCH 31, 1995 COMPARED  TO  THE  THREE MONTHS ENDED MARCH
31, 1994:

  Net  income for the year ended March 31, 1995 was $1.4  million  compared  to
$0.01 million  for  the  same  period  in  1994,  a  favorable variance of $1.4
million.  The variance of $1.4 million was due to an increase  in  revenues  of
$1.4 million  and  a  decline  in  expenses  of $0.4 million offset by the 1994
cumulative  effect  of  a change in accounting method  of  $0.4  million.   The
increase in revenues was  due  to  an  increase  in  unrealized appreciation of
investments and marketable securities of $1.6 million  offset  by a decrease in
realized  gain  on  distribution of investment of $0.2 million.  The  favorable
variance in expenses  was  primarily attributable to a decrease in expenditures
under product development projects of $0.4 million.

  The Partnership adopted the  provisions  of Statement No. 115 for investments
held  as  of  or  acquired after January 1, 1994.   The  cumulative  effect  of
adopting Statement No. 115 as of January 1, 1994 was to increase net income for
the three months ended  March  31,  1994  by $0.4 million due to the difference
between the carrying value and market value  of  a restricted security position
as of December 31, 1993.  In accordance with Statement  No.  115,  prior period
financial statements have not been restated to reflect the change in accounting
method.

  Revenues for the three months ended March 31, 1995 were $1.6 million compared
to  $0.2  million  for  the  same period in 1994, a favorable variance of  $1.4
million.   The  increase  was  primarily  due  to  an  increase  in  unrealized
appreciation of investments and marketable securities of $1.6 million offset by
a decrease in realized gain on distribution  of investment of $0.2 million.  In
December  1994,  the Partnership and Cygnus entered  into  the  GMS  Technology
Purchase Agreement  whereby Cygnus purchased from the Partnership the rights to
GMS technology developed  under  research  and  development  agreements between
Cygnus  and  the  Partnership.   In  exchange  for  the technology rights,  the
Partnership  received  Cygnus  common  stock  with  a  carrying  value  to  the
Partnership of $8.9 million.  At March 31, 1995, the Partnership  wrote-up  its
investment  in  Cygnus  to market value resulting in unrealized appreciation of
$1.6 million.  During the  three  months  ended March 31, 1994, the Partnership
distributed  166,841  shares  of Alkermes common  stock  to  its  Partners  and
realized a gain of $0.2 million.


                             Page 13


(ITEM 2 CONTINUED)

  Expenses for the three months ended March 31, 1995 were $0.2 million compared
to $0.6 million for the same period  in  1994, a decrease of $0.4 million.  The
variance  is  attributable  to  a  decrease  in   expenditures   under  product
development  projects of $0.4 million.  During the first quarter of  1994,  the
Partnership accrued  $0.2  million  for  payments  to  Cygnus and expensed $0.2
million   for  research  and  development  expenditures  related   to   Genzyme
Development Partners, L.P.



                             Page 14


                         PART II.  OTHER INFORMATION

ITEM 1. LEGAL PROCEEDINGS.

      In November  1994,  a  series  of  purported class actions (the "New York
Limited Partnership Actions") were filed in  the  United  States District Court
for the Southern District of New York concerning PWI's sale  and sponsorship of
various  limited  partnership  investments,  including  those  offered  by  the
Partnership.   The  lawsuits  were  brought  against  PWI  and  PWG  (together,
"PaineWebber"),  among  others,  by  allegedly  dissatisfied investors in these
partnerships.   In March 1995, after the actions were  consolidated  under  the
title IN RE PAINEWEBBER  LIMITED PARTNERSHIP LITIGATION, the plaintiffs amended
their  complaint to assert  claims  against  a  variety  of  other  defendants,
including  PaineWebber  Technologies  II,  L.P.,  the  General  Partner  of the
Partnership  and  an affiliate of PaineWebber.  Other affiliates of the General
Partner were also named in the complaint.

      The amended complaint in the New York Limited Partnership Actions alleges
that, in connection  with the sale of interests in the Partnership, PaineWebber
and the General Partner  (1) failed to provide adequate disclosure of the risks
involved; (2) made false and misleading representations about the safety of the
investments and the Partnership's anticipated performance; and (3) marketed the
Partnership to investors for  whom  such  investments  were  not suitable.  The
plaintiffs,  who purport to be suing on behalf of all persons who  invested  in
the Partnership,  also  allege  that  following  the  sale  of  the Partnership
interests,   PaineWebber  and  the  General  Partner  misrepresented  financial
information  about  the  Partnership's  value  and  performance.   The  amended
complaint alleges  that  PaineWebber  and  the  General  Partner  violated  the
Racketeer  Influenced  and  Corrupt  Organizations Act ("RICO") and the federal
securities   laws.   The  plaintiffs  seek   unspecified   damages,   including
reimbursement  for  all  sums  invested by them in the limited partnerships, as
well as disgorgement of all fees  and  other income derived by PaineWebber from
the limited partnerships.  In addition, the plaintiffs also seek treble damages
under RICO.  The defendants' time to move  against  or answer the complaint has
not yet expired.

      Pursuant to provisions of the Partnership Agreement and other contractual
obligations, under certain circumstances the Partnership  may  be  required  to
indemnify  the  General Partner and its affiliates for costs and liabilities in
connection with this  litigation.   The  General  Partner intends to vigorously
contest the allegations of the action, and believes  that  the  action  will be
resolved  without  material  adverse  effect  on  the  Partnership's  financial
statements, taken as a whole.




ITEM 6.   EXHIBITS AND REPORTS ON FORM 8-K

           a) EXHIBITS:

              None

           b) REPORTS ON FORM 8-K:

              None


                             Page 15


                              SIGNATURES

Pursuant  to the requirements of Section 13 or 15(d) of the Securities Exchange
Act of 1934,  the  Registrant  has  duly caused this report to be signed on its
behalf by the undersigned, thereunto  duly  authorized, on this 12th day of May
1995.

       PAINEWEBBER R&D PARTNERS II, L.P.

       By: PaineWebber Technologies II, L.P.
           (General Partner)

       By: PWDC Holding Company
           (General partner of the General Partner)

       By: EUGENE M. MATALENE, JR./S/
           Eugene M. Matalene, Jr.
           President and Principal Executive Officer

       By: PIERCE R. SMITH/S/
           Pierce R. Smith
           Principal Financial and Accounting Officer








*  The capacities listed are with respect to PWDC Holding Company, the Manager,
as well as the general partner of the General Partner of the Registrant.