As executed
- -----------

                               Dated 2 July, 1999



                             ELAN CORPORATION, PLC.

                                       AND

                          EMISPHERE TECHNOLOGIES, INC.

                                       AND

                                EBBISHAM LIMITED


                              TERMINATION AGREEMENT

(terminating the

i.       the Joint Venture Agreement dated 26 September 1996 between Ebbisham
         Limited and Elan Corporation, plc. and Emisphere Technologies, Inc.;
         and

ii.      the License Agreement dated 26 September 1996 between Ebbisham Limited
         and Elan Corporation, plc.)

[* * *] = This provision is subject to a request for confidential treatment.


                                Table of Contents
                                -----------------

                                                                          Page #

1.       Interpretation........................................................3

2.       Termination of the JV Agreement and the Elan License Agreement........5

3.       Payment of monies:....................................................8

4.       Property Ownership Rights.............................................8

5.       Non-competition and agreement not to sue.............................11

6.       Sale of Shares and Completion........................................12

7.       Warranties and Indemnities...........................................13

8.       Secrecy/No announcements.............................................16

9.       Waiver of accrued rights/covenant not to sue.........................18

10.      Governing law and jurisdiction.......................................20

11.      General..............................................................21

                                        i


THIS TERMINATION AGREEMENT is made on 2 July, 1999.

AMONG:

(1)      ELAN CORPORATION, PLC, a company incorporated in Ireland of Lincoln
         House, Lincoln Place, Dublin 2, Ireland (including its Affiliates and
         successors) ("Elan"); and

(2)      EMISPHERE TECHNOLOGIES, INC., a corporation incorporated under the laws
         of the State of Delaware, USA, having its executive offices at 765 Old
         Saw Mill River Road, Tarrytown, NY 10591, USA (including its Affiliates
         and successors) ("Emisphere"); and

(3)      EBBISHAM LIMITED, a company incorporated in Ireland of Monksland,
         Athlone, Co. Westmeath, Ireland (including its Affiliates and
         successors) ("Ebbisham").

RECITALS:

A.       Elan, Emisphere and Ebbisham entered into various agreements on 26
         September 1996 whereby, inter alia, Elan and Emisphere established the
         joint venture company, Ebbisham, and Elan and Emisphere each licensed
         certain patents and know-how to Ebbisham for a specified field of use.
         Specifically:

         (i)      Elan, Emisphere and Ebbisham entered into a Joint Venture
                  Agreement dated 26 September 1996 (the "JV Agreement");

         (ii)     Elan and Ebbisham entered into a (non-exclusive) License
                  Agreement dated 26 September 1996 (the "Elan License
                  Agreement");

         (iii)    Emisphere and Ebbisham entered into an (exclusive) License
                  Agreement dated 26 September 1996 (the "Emisphere License
                  Agreement");

         (iv)     Elan, Emisphere and Ebbisham entered into various other
                  transaction documents dated 26 September 1996 (the
                  "Transaction Documents").

B.       Elan, Emisphere and Ebbisham wish to terminate in full the JV Agreement
         and the Elan License Agreement pursuant to this Termination Agreement
         and to set forth their agreement in relation to other matters
         including, inter alia, the transfer by Elan to Emisphere of the A
         Shares.

C.       As of the Effective Date, Elan (or certain Affiliates of Elan, as the
         case may be) and Emisphere and/or Ebbisham, as the case may be, are
         entering into various financing documents including, inter alia, the
         Note Purchase Agreement, the Subscription

                                        2


         Agreement, the Registration Rights Agreement and the Ebbisham Loan
         Agreement ("the Current Transaction Financing Documents") pursuant to
         which Emisphere, among other things, will issue a zero coupon note in
         the initial principal amount of $20,000,000.

D.       As of the Effective Date, Elan and Emisphere have entered into a
         license agreement ("the New License Agreement") whereby Elan has
         licensed to Emisphere certain rights relating to [* * *] filed by Elan
         on [* * *] and [* * *] filed by Elan on [* * *].

E.       As of the Effective Date, Elan has caused the [* * *] Patent
         Application to be assigned to Ebbisham pursuant to a written assignment
         agreement ("the Assignment Agreement").

         NOW IT IS HEREBY AGREED AS FOLLOWS IN CONSIDERATION OF THE PAYMENT OF
         $10 AND OTHER GOOD AND VALUABLE CONSIDERATION, THE RECEIPT AND ADEQUACY
         OF WHICH IS HEREBY ACKNOWLEDGED:

1.       Interpretation:

         "Affiliate" means any corporation or other entity other than Ebbisham
         controlling, controlled or under the common control of Emisphere or
         Elan, as the case may be. For the purpose of this definition, "control"
         shall mean direct or indirect ownership of fifty percent (50%) or more
         of the stock or shares entitled to vote for the election of directors
         or if not meeting the preceding criteria, the power to direct or cause
         the direction of management and strategic decisions of that corporation
         or other entity.

         "Agreements" mean collectively the Elan License Agreement, the
         Emisphere License Agreement, the JV Agreement and the Transaction
         Documents.

         "A Shares" means the [* * *] Shares in the capital of Ebbisham which
         were allotted to Elan under the JV Agreement.

         "Balance Sheet Date" means 30 April 1999.

         "Completion" means the completion of the transactions that occur on the
         Effective Date.

         "Compounds" (as previously defined in the Agreements) means Heparin
         and/or Heparinoids.

         "Current Transaction Documents" means the Current Transaction Financing
         Documents, this Termination Agreement, the New License Agreement and
         the Assignment Agreement.

         "Effective Date" means the date of signing of this Termination
         Agreement by the parties.

                                        3


         "Ebbisham Loan Agreement" means the Loan Agreement of even date
         herewith between Elan and Ebbisham in the amount of [* * *].

         "Ebbisham's 30 April Balance Sheet" means the balance sheet contained
         in Ebbisham's 30 April Management Accounts.

         "Ebbisham's 30 April Management Accounts" means the management accounts
         of Ebbisham for the period ended 30 April 1999, a copy of which is
         attached at Schedule 1.

         "Heparin" (as previously defined in the Agreements) means naturally
         occurring forms of Heparin, including Heparin USP, BP and EP as well as
         smaller molecular fractions thereof.

         "Heparinoids" (as previously defined in the Agreements) means various
         sulphated polysaccharides that have anti-coagulant activity resembling
         that of Heparin.

         "[* * *] Patent Application" means [* * *] Patent Application [* * *],
         filed on [* * *].

         "Note Purchase Agreement" means the Note Purchase Agreement of even
         date herewith between Emisphere and Elan International Services, Ltd.,
         a Bermudian company.

         "Registration Rights Agreement" means the Registration Rights Agreement
         of even date herewith between Emisphere and Elan International
         Management, Ltd., a Bermudian company.

         "Scheduled Company Programme Technology" means only the patents,
         know-how and other intellectual property, as the case may be, which is
         described in Schedule 2.

         "Scheduled Elan Programme Technology" means only the Elan Programme
         Technology which is described in Schedule 3.

         "Scheduled Emisphere Programme Technology" means only the Emisphere
         Programme Technology which is described in Schedule 4.

         "Scheduled Serendipity Inventions" means only the patents, know-how and
         other intellectual property, as the case may be, which is described in
         Schedule 5.

         "SNAC" means Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate, its free
         acid, esters thereof and other pharmaceutically accepted salt forms
         thereof.

                                        4


         "SNAD" means Sodium N-[10-(2-hydroxybenzoyl)amino] decanoate, its free
         acid, esters thereof and other pharmaceutically accepted salt forms
         thereof.

         "Subscription Agreement" means the Subscription Agreement of even date
         herewith between Emisphere and Elan International Management, Ltd., a
         Bermudian company.

         "1090 Patent Application" means the [* * *] patent application which
         was filed by Elan [* * *], a copy of which is attached at Schedule
         [* * *], entitled [* * *]; any equivalent [* * *]-provisionals,
         continuations, continuations-in-part, divisionals, and re-issues
         thereof and any foreign counterpart applications, and any patents
         granted on such applications.

         [* * *]

         Capitalised terms used in this Termination Agreement shall have the
         same meanings assigned to them in the Agreements, unless such terms are
         expressly defined to the contrary in this Termination Agreement.

2. Termination of the JV Agreement and the Elan License Agreement:

         2.1      Subject to the provisions of Clause 2.2, Elan and Ebbisham
                  hereby agree to terminate the JV Agreement and the Elan
                  License Agreement, in each case with effect from the Effective
                  Date.

         All the provisions of the JV Agreement and the Elan License Agreement
         shall terminate forthwith with effect from the Effective Date and be of
         no further legal force or effect.

         2.2      For the avoidance of doubt and without prejudice to the
                  generality of the foregoing Clause 2.1, Elan, Emisphere and
                  Ebbisham hereby acknowledge and agree as follows as of the
                  Effective Date:-

                  2.2.1     the Management Committee and the Research Committee
                            (as such terms were defined in the JV Agreement)
                            shall each be dissolved forthwith with effect from
                            the Effective Date and thereby cease to have any
                            function in relation to Ebbisham;

                                        5


                  2.2.2     the nominees on the Management Committee of the "A"
                            Directors and the "B" Directors respectively shall
                            be deemed to have been removed from the Management
                            Committee by the "A" Directors and the "B" Directors
                            respectively immediately prior to the dissolution of
                            the Management Committee;

                  2.2.3     the nominees on the Research Committee of the
                            nominees on the Management Committee of the "A"
                            Directors and the "B" Directors respectively, shall
                            be deemed to have been removed from the Research
                            Committee by the nominees on the Management
                            Committee of the "A" Directors and the "B" Directors
                            respectively, immediately prior to the dissolution
                            of the Management Committee pursuant to Clause
                            2.2.1;

                  2.2.4     the rights granted to Ebbisham pursuant to the Elan
                            License Agreement to use the Elan Patents, the Elan
                            Know-How, Improvements and the Elan Trademarks (as
                            such terms were defined in the Elan License
                            Agreement) shall terminate forthwith with effect
                            from the Effective Date;

                  2.2.5     the rights granted to Elan pursuant to the Elan
                            License Agreement to use the Elan Programme
                            Technology, the Emisphere Programme Technology, the
                            Company Programme Technology and the Emisphere
                            Technology shall terminate forthwith with effect
                            from the Effective Date;

                  2.2.6     any sub-license of the Elan Technology (as such term
                            was defined in the Elan License Agreement) which may
                            have been granted by Ebbisham to Emisphere pursuant
                            to Clause 2.5 of the Elan License Agreement shall
                            terminate forthwith with effect from the Effective
                            Date;

                  2.2.7     any sub-license of the Emisphere Technology (as such
                            term was defined in the Emisphere License Agreement)
                            which may have been granted by Ebbisham to Elan
                            pursuant to Clause 2.5 of the Emisphere License
                            Agreement shall terminate forthwith with effect from
                            the Effective Date;

                  2.2.8     subject only to the provisions of the New License
                            Agreement, with effect from the Effective Date,
                            neither of Emisphere nor Ebbisham shall have any
                            right of any nature to use, disclose, license or
                            otherwise transfer the Elan Patents, the Elan
                            Know-How, Improvements and/or the Elan Trademarks
                            (as such terms were defined in the Elan License
                            Agreement) and/or any other patents, know-how or any
                            other intellectual property rights whatsoever of
                            Elan;

                  2.2.9     with effect from the Effective Date, Elan shall not
                            have any right of any nature to use, disclose,
                            license or otherwise transfer the Emisphere

                                        6


                            Patents, the Emisphere Know-How, Improvements and/or
                            the Emisphere Trademarks (as such terms were defined
                            in the Emisphere License Agreement) and/or any other
                            patents, know-how or any other intellectual property
                            rights whatsoever of Emisphere;

                  2.2.10    with effect from the Effective Date, Elan shall not
                            have any right of any nature to use, disclose,
                            license or otherwise transfer the Scheduled Company
                            Programme Technology, the Scheduled Elan Programme
                            Technology, the Scheduled Emisphere Programme
                            Technology or the Scheduled Serendipity Inventions;

                  2.2.11    subject only to the provisions of this Termination
                            Agreement, as and from the Effective Date, Elan
                            shall be free to license, sublicense, commercialize
                            in any way and otherwise use the Elan Patents, the
                            Elan Know-How, Improvements and the Elan Trademarks
                            (as such terms were defined in the Elan License
                            Agreement)) in relation to or in connection with all
                            and any applications and uses, including for the
                            avoidance of doubt, in relation to the Compounds, or
                            otherwise, whether alone or in conjunction with any
                            third party;

                  2.2.12    subject only to the provisions of this Termination
                            Agreement and any restrictions which may apply as
                            between Emisphere and Ebbisham, as and from the
                            Effective Date, Emisphere and Ebbisham shall be free
                            to license, sublicense, commercialize in any way and
                            otherwise use the Emisphere Patents, the Emisphere
                            Know-How, Improvements and the Emisphere Trademarks
                            (as such terms were defined in the Emisphere License
                            Agreement), the Scheduled Company Programme
                            Technology, the Scheduled Elan Programme Technology,
                            the Scheduled Emisphere Programme Technology and the
                            Scheduled Serendipity Inventions) in relation to or
                            in connection with all and any applications and
                            uses, including for the avoidance of doubt, in
                            relation to the Compounds, or otherwise, whether
                            alone or in conjunction with any third party;

                  2.2.13    all research and development work (if any) being
                            conducted by Elan under Clause 6 of the Elan License
                            Agreement and all research and development services
                            (if any) being conducted by Elan and/or Emisphere
                            under Clause 7.6 of the JV Agreement shall terminate
                            forthwith with effect from the Effective Date;

                  2.2.14    with effect from the Effective Date, Elan shall have
                            no obligation to provide working capital or other
                            funding or financing of any nature to Ebbisham;

                                        7


                  2.2.15    all equipment or other tangible assets (if any)
                            purchased by Emisphere and/or Elan which were funded
                            by Ebbisham pursuant to Clause 10.1 of the JV
                            Agreement shall be delivered to and become the
                            absolute property of Ebbisham within 10 days of the
                            Effective Date;

                  2.2.16    all technical services and assistance (if any) being
                            conducted by Elan and/or Emisphere under Clause 13
                            of the JV Agreement (Technical Services and
                            Assistance) shall terminate forthwith with effect
                            from the Effective Date.

         2.3      Ebbisham hereby warrants to Elan that it has not granted any
                  sub-licences or any other rights of any nature to any third
                  parties pursuant to the Elan License Agreement, save any
                  sub-license of the Elan Technology (as such term was defined
                  in the Elan License Agreement) which may have been granted by
                  Ebbisham to Emisphere pursuant to Clause 2.5 of the Elan
                  License Agreement.

3.       Payment of monies:

         3.1 Subject to Clause 3.3 and 3.4, none of the parties shall be liable
         to repay to any other party any amount of money which may have been
         paid by any party to another party under the JV Agreement.

         3.2 Subject to Clause 3.3 and 3.4, each of the parties acknowledges and
         agrees with the other parties that no monies are owed by any of the
         parties to the others pursuant to the JV Agreement on the Effective
         Date.

         3.3 The parties acknowledge that certain loans were made by Elan to
         Ebbisham as described in the Recitals to the Note Purchase Agreement
         which are being repaid by Ebbisham/Emisphere on the Effective Date in
         the manner set forth in the Recitals to the Note Purchase Agreement.

                  3.3.1     The parties acknowledge that there are certain
                            monies owed to Emisphere by Ebbisham that will
                            remain outstanding following the Effective Date.

4.       Property Ownership Rights:

         4.1      Ownership:

                  4.1.1 On and following the Effective Date:

                            (1)     for the avoidance of doubt, the Elan
                                    Patents, the Elan Know-How, Improvements
                                    and/or the Elan Trademarks (as such terms
                                    were

                                        8


                                    defined in the Elan License Agreement) shall
                                    remain the sole and exclusive property of
                                    Elan;

                            (2)     for the avoidance of doubt, the Emisphere
                                    Patents, the Emisphere Know-How,
                                    Improvements and/or the Emisphere Trademarks
                                    (as such terms were defined in the Emisphere
                                    License Agreement) shall remain the sole and
                                    exclusive property of Emisphere;

                            (3)     all Scheduled Company Programme Technology
                                    shall remain the sole and exclusive property
                                    of Ebbisham.

                            (4)     all Scheduled Elan Programme Technology
                                    shall remain the sole and exclusive property
                                    of Ebbisham;

                            (5)     all Scheduled Emisphere Programme Technology
                                    shall remain the sole and exclusive property
                                    of Ebbisham;

                            (6)     all Scheduled Serendipity Inventions shall
                                    remain the sole and exclusive property of
                                    Ebbisham.

                  4.1.2     Except as described in Item 4 of Schedule 3, Elan
                            hereby warrants to Ebbisham and Emisphere that it
                            has not granted any license or sublicense or any
                            other rights to any third party in respect of the
                            Scheduled Elan Programme Technology, the Scheduled
                            Emisphere Programme Technology or the Scheduled
                            Company Programme Technology.

                  4.1.3     Each of Ebbisham and Emisphere hereby warrants to
                            Elan that it has not granted any license or
                            sublicense to any third party in respect of the
                            Scheduled Elan Programme Technology, the Scheduled
                            Emisphere Programme Technology or the Scheduled
                            Company Programme
                            Technology.

                  4.1.4     Elan hereby warrants that it has used all reasonable
                            efforts in carrying out the work required in listing
                            the Scheduled Elan Programme Technology.

                  4.1.5     Emisphere hereby warrants that it has used all
                            reasonable efforts in carrying out the work required
                            in listing the Scheduled Emisphere Programme
                            Technology.

                  4.1.6     Each of Emisphere and Elan hereby warrants that it
                            has used all reasonable efforts in carrying out the
                            work required in listing the Scheduled Company
                            Programme Technology and the Scheduled
                            Serendipity Inventions.

                                        9


         4.2      Acknowledgements and confirmations:

                  For the avoidance of doubt, each of the parties irrevocably
                  acknowledges and confirms to the other parties as follows:

                  4.2.1     no Company Programme Technology (as such term was
                            defined in Clause 8.5 of the JV Agreement) has
                            arisen or been created at any time pursuant to the
                            Agreements, save the Scheduled Company Programme
                            Technology;

                  4.2.2     [* * *], no Emisphere Programme Technology (as such
                            term was defined in the Emisphere License Agreement)
                            has arisen or been created at any time pursuant to
                            the Agreements, save the Scheduled Emisphere
                            Programme Technology;

                  4.2.3     [* * *], no Elan Programme Technology (as such term
                            was defined in the Elan License Agreement) has
                            arisen or been created at any time pursuant to the
                            Agreements, save the Scheduled Elan Programme
                            Technology;

                  4.2.4     no "serendipity invention" (as such term was defined
                            in Clause 8.6 of the JV Agreement) has arisen or
                            been created at any time by any of the parties
                            pursuant to the Agreements, save the Scheduled
                            Serendipity Inventions.

         4.3      [* * *] Patent Application:

                  On the Effective Date, Elan shall cause the [* * *] Patent
                  Application to be assigned to Ebbisham pursuant to the
                  Assignment Agreement.

         4.4      Prosecution and maintenance of the [* * *] Patent Application:

                  4.4.1     Ebbisham, at Ebbisham's expense, shall have the
                            right to file and prosecute a regular US application
                            and foreign applications corresponding to the
                            [* * *] Patent Application and claiming priority to
                            the [* * *] Patent Application; defend all such
                            applications against third party oppositions; and to
                            maintain in force any issued letters patent.

                            Ebbisham shall have the right in its reasonable
                            business discretion to control such filing,
                            prosecution, defence and mainenance, provided
                            however, that Elan, shall be provided with copies of
                            all documents relating to such filing, prosecution,
                            defence, and maintenance in sufficient time to
                            review such documents to comment and approve in
                            writing prior

                                       10


                            to filing, said approval not to be unreasonably
                            withheld by Elan and required prior to Ebbisham
                            filing any document.

                            At any time, Ebbisham has the right to abandon the
                            [* * *] Patent Application or any corresponding
                            application or patent claiming priority from the
                            [* * *] Patent Application.

                  4.4.2     Elan, Emisphere and Ebbisham agree that at no time
                            will any independent claim of any application filed
                            according to Clause 4.4.1 [* * *]:

                            [* * *]

                  4.4.3     Elan, Emisphere and Ebbisham agree that at no time
                            will Emisphere and Ebbisham [* * *] without the
                            prior consent in writing of Elan.

                  4.4.4     Elan, Emisphere and Ebbisham agree that at no time
                            [* * *] (as specifically defined in [* * *] Patent
                            Application).

                  4.4.5     Elan, Emisphere and Ebbisham agree that at no time
                            will [* * *] is in the form of [* * *].

[* * *]
                                       11


[* * *]

6.       Sale of Shares and Completion:

         6.1 Subject to the terms of this Termination Agreement:

                  6.1.1     Elan shall sell as beneficial owner and Emisphere
                            shall purchase, free from all liens, charges and
                            encumbrances and together with all rights now or
                            hereafter attaching to them, the A Shares;

                                       12


                  6.1.2     the A Shares will be sold by Elan to Emisphere at a
                            price of $1 each, making an aggregate of $10,000 in
                            respect of the transfer of the A Shares by Elan to
                            Emisphere under Clause 5.1.1.

         6.2      Completion shall take place at Elan's offices at Lincoln
                  House, Lincoln Place, Dublin 1 on 25 June 1999 at 2pm (or such
                  later date as may be agreed by the parties) and such other
                  places, if any, as the parties may agree.

                  On Completion, Elan and Emisphere shall take or (to the extent
                  that the same is within its powers) cause to be taken the
                  following steps at directors and shareholders meetings of
                  Ebbisham, or such other meetings, as appropriate:

                  6.2.1     the resignation of all the A Directors and the
                            Secretary of Ebbisham holding office prior to the
                            execution of this Termination Agreement;

                  6.2.2     the delivery by Elan to Emisphere of a transfer in
                            respect of the A Shares duly executed by Elan in
                            favour of Emisphere or as it may direct together
                            with the relative share certificates;

                  6.2.3     the payment by Emisphere to Elan of the
                            consideration for the A Shares as provided by Clause
                            6.1.2;

                  6.2.4     the transfer to Emisphere (or as it may direct) of
                            the share register, and all books and records of
                            Ebbisham in the possession of Elan (including minute
                            books and the company seal(s));

                  6.2.5     the change of the registered office of Ebbisham to
                            26 Lower Hatch Street, Dublin 2;

                  6.2.6     subject to the satisfaction of any pre-conditions to
                            the Ebbisham Loan Agreement, the funding by Elan of
                            [* * *] pursuant to the Ebbisham Loan Agreement; and

                  6.2.7     any other steps required by the Current Transaction
                            Documents.

         6.3      Emisphere shall, following Completion, promptly deliver to the
                  Irish Revenue Commissioners the stock transfer form referred
                  to in Clause 6.2.2 for assessment of stamp duty, and shall
                  promptly pay the duty thus assessed.

7.       Warranties and Indemnities:

         7.1      WITH REFERENCE TO THE TRANSFER BY ELAN TO EMISPHERE OF
                  THE A SHARES AS PROVIDED BY CLAUSE 6 AT COMPLETION (BUT

                                       13


                  WITHOUT PREJUDICE TO ELAN'S OBLIGATION UNDER CLAUSE 6.1.1
                  HEREOF TO TRANSFER THE A SHARES TO EMISPHERE FREE FROM ALL
                  LIENS, CHARGES AND ENCUMBRANCES), AND SAVE AS PROVIDED IN
                  CLAUSE 7.4.2, THE PARTIES ACKNOWLEDGE AND AGREE THAT ELAN
                  MAKES NO REPRESENTATION OR WARRANTY OF ANY NATURE TO EMISPHERE
                  OR ANY OTHER PERSON IN RELATION TO EBBISHAM OR ANY OF ITS
                  AFFAIRS PAST, PRESENT OR FUTURE.

                  Emisphere acknowledges that it is entering into this
                  Termination Agreement in reliance exclusively on its own
                  business judgement, the information which has been available
                  to it as a shareholder of Ebbisham and otherwise and on the
                  due diligence it has carried out in relation to Ebbisham.

         7.2      EXCEPT AS EXPRESSLY PROVIDED IN THIS TERMINATION AGREEMENT,
                  ALL OTHER WARRANTIES, CONDITIONS AND REPRESENTATIONS, EXPRESS
                  OR IMPLIED, STATUTORY OR OTHERWISE HEREUNDER ARE HEREBY
                  EXPRESSLY EXCLUDED BY THE PARTIES.

                  NOTWITHSTANDING ANYTHING TO THE CONTRARY IN THIS TERMINATION
                  AGREEMENT, NONE OF THE PARTIES SHALL BE LIABLE TO ANY OF THE
                  OTHER PARTIES BY REASON OF ANY REPRESENTATION OR WARRANTY,
                  CONDITION OR OTHER TERM OR ANY DUTY OF COMMON LAW, OR UNDER
                  THE EXPRESS TERMS OF THIS TERMINATION AGREEMENT, FOR ANY
                  CONSEQUENTIAL OR INCIDENTAL OR PUNITIVE LOSS OR DAMAGE
                  (WHETHER FOR LOSS OF PROFITS OR OTHERWISE) AND WHETHER
                  OCCASIONED BY THE NEGLIGENCE OF THE RESPECTIVE PARTIES, THEIR
                  EMPLOYEES OR AGENTS OR OTHERWISE.

         7.3      Without prejudice to the generality of Clauses 7.1 and 7.2,
                  for the avoidance of doubt, each of Elan and Emisphere hereby
                  acknowledges as follows:

                  7.3.1     with reference to Ebbisham's 30 April Balance Sheet
                            and save in respect of Ebbisham's taxation
                            liabilities for which provision has been made in
                            Ebbisham's 30 April Management Accounts, the only
                            creditors of Ebbisham on 30 April 1999 were Elan and
                            Emisphere;

                  7.3.2     save in respect of Ebbisham's taxation liabilities
                            for which provision has been made in Ebbisham's 30
                            April Management Accounts, the only creditors of
                            Ebbisham immediately prior to Completion were Elan
                            and Emisphere;

                                       14


                  7.3.3     to the knowledge of Emisphere and Elan, the
                            financial position of Ebbisham as stated in
                            Ebbisham's 30 April Management Accounts is accurate
                            and since the Balance Sheet Date, there has been no
                            material adverse change in the financial position or
                            prospects of Ebisham provided that neither Emisphere
                            nor Elan will be liable to compensate the other in
                            the event that the acknowledgement in this Clause
                            7.3.3 is incorrect in any way.

         7.4      For the avoidance of doubt:

                  7.4.1     Subject only to the provisions of Clause 7.4.2,
                            Emisphere hereby indemnifies Elan, the A Directors
                            and the Secretary of Ebbisham holding office prior
                            to the execution of this Termination Agreement,
                            against any claims, costs liabilities or expenses of
                            any nature arising in relation to any claim or
                            proceedings which may be initiated against Ebbisham,
                            Elan, the A Directors or the Secretary of Ebbisham
                            holding office prior to the execution of this
                            Termination Agreement, following the Effective Date
                            which relate in any way to the activities of
                            Ebbisham, past, present or future, provided that the
                            indemnified party under this Clause 7.4.1 shall have
                            no right to indemnification hereunder to the extent
                            arising out of its own gross negligence or fraud.

                  7.4.2     To their respective knowledge, each of Emisphere and
                            Elan acknowledge and confirm that full provision or
                            reserve was made in Ebbisham's 30 April Balance
                            Sheet for all taxation that is or may be payable by,
                            or assessed against, Ebbisham for any taxable period
                            ending on or prior to 30 April 1999.

                            If following the Effective Date, Ebbisham's taxation
                            for any taxable period ending on or prior to 30
                            April 1999 is finally determined to be in excess of
                            the afore-mentioned provision or reserve for
                            taxation in Ebbisham's 30 April Balance Sheet, Elan
                            and Emisphere shall each contribute to Ebbisham 50%
                            of the amount of the excess.

                            Emisphere and Ebbisham agree to provide to Elan
                            copies of all correspondence and notices from the
                            relevant taxation authorities relating to the
                            taxation matters described in this Clause 7.4.2
                            together with all such additional materials and
                            assistance as may reasonably be requested by Elan,
                            and the parties agree to use all reasonable
                            commercial efforts to minimise any taxation
                            liability of Ebbisham described in this Clause 7.4.2
                            prior to discharge of same by Ebbisham.

                                       15


8.       Secrecy/No announcements:

         8.1      On or within 10 working days of the Effective Date:

                  8.1.1     Elan shall return to Ebbisham and Emisphere all
                            confidential information of Ebbisham and Emisphere
                            in its possession on the Effective Date, including,
                            without limitation, the information, product and
                            materials listed in Schedule 6; and

                  8.1.2     Ebbisham and Emisphere shall return to Elan all
                            confidential information of Elan in its possession
                            on the Effective Date.

         8.2      Emisphere and Ebbisham agree to maintain in confidence and,
                  save as otherwise provided in this Clause 8, shall not
                  disclose this Termination Agreement or any information of Elan
                  in the form of documentation or oral presentations of a
                  proprietary or confidential nature ("Confidential
                  Information") which may be disclosed by Elan to Emisphere or
                  Ebbisham pursuant to this Termination Agreement.

         8.3      Elan agrees to maintain in confidence and, save as otherwise
                  provided in this Clause 8, shall not disclose this Termination
                  Agreement or any information of Emisphere or Ebbisham in the
                  form of documentation or oral presentations of a proprietary
                  or confidential nature ("Confidential Information") which may
                  be disclosed by Emisphere or Ebbisham to Elan pursuant to this
                  Termination Agreement.

         8.4      Each party agrees to treat Confidential Information disclosed
                  to it by the other hereunder with the same degree of care as
                  it does in protecting its own confidential information,
                  provided that:

                  8.4.1     Confidential Information may be disclosed to each
                            party's Representatives on a needtoknow basis;

                  8.4.2     Confidential Information shall be disclosed within
                            the recipient company only on a needtoknow basis;
                            and

                  [* * *]

                  For this purpose, each party shall ensure that any such
                  officers, directors, financial advisors, independent auditors,
                  legal counsel or employees (its "Representatives")

                                       16


                  and potential strategic partners are bound by confidentiality
                  undertakings no less strict than those set out herein.

         8.5      The restrictions and obligations of nondisclosure and nonuse
                  shall not apply to information which:

                  8.5.1     is in the public domain;

                  8.5.2     is in the possession of the recipient at the time of
                            disclosure;

                  8.5.3     becomes available to the recipient on a
                            non-confidential basis, from a third party who is
                            under no confidentiality obligations to the party
                            disclosing Confidential Information; or

                  8.5.4     is independently developed by the recipient.

         8.6      If any party or any of its Representatives or Affiliates
                  becomes legally compelled (by deposition, interrogatory,
                  request for documents, subpoena, civil investigative demand or
                  similar process) to disclose any of the other party's
                  Confidential Information, such party shall provide the other
                  party with prompt prior written notice and may disclose that
                  portion of the other party's Confidential Information that is
                  legally required and shall [* * *] to obtain (and shall
                  cooperate with the other party's efforts to obtain) assurance
                  that confidential treatment will be accorded the other party's
                  Confidential Information.

                  If any party is required by law to make any public disclosure,
                  including any public filings required to be made under the
                  rules or regulations of the U.S. Securities and Exchange
                  Commission, the Nasdaq Stock Market or other national
                  securities exchange, otherwise prohibited by this Termination
                  Agreement, such party shall provide the other party with
                  prompt prior written notice and may disclose that portion of
                  the other party's Confidential Information that is legally
                  required and shall [* * *] to obtain (and shall cooperate with
                  the other party's efforts to obtain) assurance that
                  confidential treatment will be accorded the other party's
                  Confidential Information.

         8.7      Each of the parties agree that money damages may not be a
                  sufficient remedy for any breach of this Section 8 and that
                  Elan or Emisphere or Ebbisham, as the case may be, shall be
                  entitled to seek injunctive or other equitable relief as a
                  remedy for any such breach.

         8.8      For the avoidance of doubt, in the event of any conflict
                  between the provisions of this Clause 8 and any of the
                  provisions of Clauses 2.2.4, 2.2.5, 2.2.6, 2.2.7, 2.2.8,

                                       17


                  2.2.9, 2,2.10, 2.2.11, 2.2.12 and 4 of this Termination
                  Agreement ("the Prevailing Provisions"), the Prevailing
                  Provisions shall prevail.

         8.9      Subject only to the specific exceptions set forth in this
                  Clause 8, none of the parties shall disclose the existence of
                  this Termination Agreement or the other agreements entered
                  into by the parties on the Effective Date, the subject matter
                  hereof nor originate any publicity, new release or other
                  public announcement, written or oral without the prior written
                  consent of the other parties.

9. Waiver of accrued rights/covenant not to sue:

         9.1      With reference to Clause 22.1 of the Elan License Agreement
                  and Clause 30.12 of the JV Agreement respectively and [* * *],
                  with effect from the Effective Date, each of the parties
                  waives any accrued rights which it may have under the Elan
                  License Agreement and the JV Agreement respectively.

         9.2      Without prejudice to the waiver of accrued rights set forth in
                  Clause 9.1 and [* * *].

                  9.2.1     Elan covenants to Emisphere and Ebbisham not to take
                            any legal proceedings or pursue any remedy in any
                            court or other forum against Emisphere or Ebbisham
                            or licensee or sub-licensee of Emisphere or Ebbisham
                            in respect of any accrued rights which Elan may have
                            under the Elan License Agreement or JV Agreement on
                            the Effective Date;

                  9.2.2     Each of Emisphere and Ebbisham covenant to Elan not
                            to take any legal proceedings or pursue any remedy
                            in any court or other forum against Elan or any
                            licensee or sub-licensee of Elan in respect of any
                            accrued rights which either of such parties may have
                            under Elan License Agreement or the JV Agreement on
                            the Effective Date.

         9.3      For the avoidance of doubt:

                  9.3.1     the provisions of this Clause 9 shall not in any way
                            act as a waiver by any of the parties in respect of
                            any of the provisions set forth in this Termination
                            Agreement or in respect of any claim of fraud;

                  9.3.2     the provisions of this Clause 9 shall not in any way
                            restrict any of the parties' respective rights to
                            take any legal proceedings or pursue any remedy in a
                            court in respect of any of the provisions set forth
                            in this Termination Agreement pursuant to Clause
                            10.2 of this Termination Agreement.

                                       18


         9.4      For the avoidance of doubt, each of the parties acknowledges
                  to the other parties that Elan was not a party to the
                  Emisphere License Agreement and accordingly, was not at any
                  time subject to any obligations to any party thereunder.

[* * *]
                                       19


[* * *]

10.      Governing law and jurisdiction:

         10.1     This Termination Agreement shall be governed by and construed
                  in accordance with the laws of Ireland.

                                       20


         10.2     The parties hereby submit to the jurisdiction of the state and
                  Federal courts located in the State of New York, USA and the
                  courts of Ireland and the parties hereby waive any and all
                  defences of improper venue or that the Forum is inconvenient.

11.      General:

         11.1     Good Faith

                  Each of the parties hereto undertakes with the others to do
                  all things reasonably within its power which are necessary or
                  desirable to give effect to the spirit and intent of this
                  Termination Agreement.

         11.2     Further Assurance

                  Each of the parties hereto shall, and shall use their
                  respective commercially reasonable endeavours to procure that
                  any necessary third party shall, do execute and perform all
                  such further deeds, documents, assurances, acts and things as
                  any of the parties hereto may reasonably require by notice in
                  writing to the others to carry the provisions of this
                  Termination Agreement into full force and effect.

         11.3     No Representation

                  Each of the parties hereby acknowledges that in entering into
                  this Termination Agreement it has not relied on any
                  representation or warranty save as expressly set out in this
                  Termination Agreement or in any other Current Transaction
                  Document.

         11.4     Counterparts

                  This Termination Agreement may be executed in any number of
                  counterparts, each of which when so executed shall be deemed
                  to be an original and all of which when taken together shall
                  constitute this Termination Agreement.

         11.5     Notices

                  Any notice to be given under this Termination Agreement shall
                  be sent in writing by registered or recorded delivery post or
                  telecopied to:

                                       21


         -        Elan at

                  Elan Corporation PLC
                  Lincoln House, Lincoln Place, Dublin 2, Ireland

                  Attention:        Vice President & General Counsel, Elan
                                    Pharmaceutical Technologies
                  Telephone:        353 1 7094301
                  Telefax:          353 1 7094124

         -        Emisphere at

                  Emisphere Technologies, Inc.
                  765 Old Saw Mill River Road, Tarrytown, NY 10591, USA

                  Attention:        Chief Financial Officer
                  Telephone:        001 914 785 4763
                  Telefax:          001 914 593 8292

         -        Ebbisham at

                  Ebbisham Limited
                  26 Lower Hatch Street, Dublin 2, Ireland

                  Attention:        James Cawley
                  Telephone:        353 1 6762599
                  Telefax:          353 1 6762688

         or to that other address(es) as may from time to time be notified by
         any Party to the others hereunder.

         Any notice sent by mail shall be deemed to have been delivered within
         seven (7) working days after dispatch and any notice sent by telecopy
         shall be deemed to have been delivered within twenty-four (24) hours of
         the time of the dispatch. Notices of change of address shall be
         effective upon receipt.

         11.6     Severability

                  If any provision in this Termination Agreement is agreed by
                  the parties to be, deemed to be or becomes invalid, illegal,
                  void or unenforceable under any applicable law, (i) the
                  provision will be deemed amended to conform to applicable laws
                  so as to be valid and enforceable or, if it cannot be so
                  amended without materially altering the intention of the
                  parties, it will be deleted, with effect from

                                       22


                  the date of such agreement or such earlier date as the parties
                  may agree, and (ii) the validity, legality and enforceability
                  of the remaining provisions of this Termination Agreement
                  shall not be impaired or affected in any way.

         11.7     Amendments

                  No amendment, modification or addition to this Termination
                  Agreement shall be effective or binding on any party unless
                  set forth in writing and executed by a duly authorised
                  representative of all parties.

         11.8     Waiver

                  No waiver of any right under this Termination Agreement shall
                  be deemed effective unless contained in a written document
                  signed by the party charged with such waiver, and no waiver of
                  any breach or failure to perform shall be deemed to be a
                  waiver of any future breach or failure to perform or of any
                  other right arising under this Termination Agreement.

         11.9     Successors

                  This Termination Agreement shall be binding upon and enure to
                  the benefit of the parties hereto and their successors.

                                       23


         IN WITNESS of which the parties have executed this Termination
Agreement.

                                       24


                                   SCHEDULE 1

        Management Accounts of Ebbisham for the year ended 30 April 1999

                                   (Attached)

                                       25


                                   SCHEDULE 2

                                     [* * *]

                                       26


                                   SCHEDULE 3

                                     [* * *]

                                       35


                                   SCHEDULE 4

                                     [* * *]

                                       36


                                   SCHEDULE 5

                                     [* * *]

                                       37


                                   SCHEDULE 6

                                     [* * *]

                                       38


                                   SCHEDULE 7

                                     [* * *]

                                       39


Executed by ELAN CORPORATION, PLC

/s/ Seamus Mulligan
- -------------------
Name: Seamus Mulligan
Title: Exec. V.P. - Corporate Development


Executed by EMISPHERE TECHNOLOGIES, INC.

/s/ Charles Abdalian
- --------------------
Name: Charles Abdalian
Title: Chief Financial Officer

                                       40