ASSIGNMENT


         WHEREAS, we, Mary Martin, residing at 10 Brookfield Green, KCR Dublin
12, Ireland and Kenneth Iain Cumming, residing at 46 Old Cabra Road, Phibsboro,
Dublin 7, Ireland, have invented new and useful improvements in a "Solid Oral
Dosage Form Containing Heparin or a Heparinoid in Combination with a Carrier"
for which a provisional application for United States Letters Patent was filed
on February 22, 1999, Serial No. 60/121,065; and

         WHEREAS, Ebbisham Limited, an Irish company located in 26 Lower Hatch
Street, Dublin 2, Ireland, is desirous of acquiring the entire interest in the
same;

         NOW, THEREFORE, in consideration of the sum of Ten Dollars ($10.00),
the receipt of which is hereby acknowledged, and for other good and valuable
consideration, we, Mary Martin and Kenneth Iain Cumming, hereby do sell, assign
and transfer unto said Ebbisham Limited, the entire right, title and interest in
and to said invention and application throughout the world, including, without
limitation, any U.S. application claiming a right of priority from this
provisional application and any Letters Patent which may issue thereon, and any
reissue, reexamination, division, extension or continuation thereof and all
rights of priority under the International Convention arising from said
application; the same for its legal representatives and assigns, as fully and
entirely as the same would have been held by us had this assignment and sale not
been made;

         AND, we hereby bind ourselves, our heirs, legal representatives,
administrators and assigns properly to execute without further consideration any
and all applications, petitions, oaths and assignments or other papers and
instruments which may be necessary in order to carry into full force and effect,
the sale, assignment, transfer and conveyance hereby made or intended to be made
and to aid its legal representatives and assigns to obtain and enforce proper
protection for said invention in all countries throughout the world.

                                        1


         IN TESTIMONY WHEREOF, we hereunto set our hands and seals the day and
year set opposite our respective signatures.


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Date _________________, 1999                /s/ Mary Martin (L.S.)
                                ------------------------------------------------
                                                Mary Martin

Date _________________, 1999    _______________________________________________
                                                Witnessed by

Date _________________, 1999    ________________________________________________
                                                Witnessed by

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Date _________________, 1999                /s/ Kenneth Iain Cumming (L.S.)
                                ------------------------------------------------
                                                Kenneth Iain Cumming

Date _________________, 1999    _______________________________________________
                                                Witnessed by

Date _________________, 1999    ________________________________________________
                                                Witnessed by

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