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                                                                    EXHIBIT 4.31

          THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON THE
         EXERCISE OF THIS WARRANT (COLLECTIVELY, THE "SECURITIES") HAVE
              NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,
                AS AMENDED (THE "SECURITIES ACT"), AND MAY NOT BE
                 OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE
               REGISTRATION STATEMENT, OR PURSUANT TO AN AVAILABLE
                  EXEMPTION FROM THE REGISTRATION REQUIREMENTS
                            UNDER THE SECURITIES ACT.

                               WARRANT TO PURCHASE

                    COMMON STOCK, PAR VALUE $.00001 PER SHARE

                                       OF

                          ADVANCED VIRAL RESEARCH CORP.

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         This certifies that, for value received, [NAME OF PURCHASER], or
registered assigns ("Warrantholder"), is entitled to purchase from ADVANCED
VIRAL RESEARCH CORP. (the "Company"), subject to the provisions of this Warrant,
at any time and from time to time until 5:00 p.m. Eastern Standard Time on
November 8, 2005, _______ shares of the Company's Common Stock, par value
$.00001 per share ("Warrant Shares"). The purchase price payable upon the
exercise of this Warrant shall be $0.56 per Warrant Share. The Warrant Price and
the number of Warrant Shares which the Warrantholder is entitled to purchase is
subject to adjustment upon the occurrence of the contingencies set forth in
Section 3 of this Warrant, and as adjusted from time to time, such purchase
price is hereinafter referred to as the "Warrant Price."

         This Warrant is subject to the following terms and conditions:

         I.       EXERCISE OF WARRANT.

                  (a) This Warrant may be exercised in whole or in part but not
for a fractional share. Upon delivery of this Warrant at the offices of the
Company or at such other address as the Company may designate by notice in
writing to the registered holder hereof with the Subscription Form annexed
hereto duly executed, accompanied by payment of the Warrant Price for the number
of Warrant Shares purchased (in cash, by certified, cashier's or other check
acceptable to the Company, or any combination of the foregoing), the registered


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holder of this Warrant shall be entitled to receive a certificate or
certificates for the Warrant Shares so purchased. Such certificate or
certificates shall be promptly delivered to the Warrantholder. Upon any partial
exercise of this Warrant, the Company shall execute and deliver a new Warrant of
like tenor for the balance of the Warrant Shares purchasable hereunder.

                  (b) The Warrant Shares deliverable hereunder shall, upon
issuance, be fully paid and non-assessable and the Company agrees that at all
times during the term of this Warrant it shall cause to be reserved for issuance
such number of shares of its Common Stock as shall be required for issuance and
delivery upon exercise of this Warrant.

         II.      TRANSFER OR ASSIGNMENT OF WARRANT.

                  (a) Any assignment or transfer of this Warrant shall be made
by surrender of this Warrant at the offices of the Company or at such other
address as the Company may designate in writing to the registered holder hereof
with the Assignment Form annexed hereto duly executed and accompanied by payment
of any requisite transfer taxes, and the Company shall, without charge, execute
and deliver a new Warrant of like tenor in the name of the assignee for the
portion so assigned in case of only a partial assignment, with a new Warrant of
like tenor to the assignor for the balance of the Warrant Shares purchasable.

                  (b) Prior to any assignment or transfer of this Warrant, the
holder thereof shall, if reasonably requested by the Company, deliver an opinion
of counsel to the Company to the effect that the proposed transfer may be
effected without registration under the Act.

         III.     ADJUSTMENT OF WARRANT PRICE AND WARRANT SHARES --
                  ANTI-DILUTION PROVISIONS.

                           A. (1) Except as hereinafter provided, in case the
                  Company shall at any time after the date hereof issue any
                  shares of Common Stock (including shares held in the Company's
                  treasury) without consideration, then, and thereafter
                  successively upon each issuance, the Warrant Price in effect
                  immediately prior to each such issuance shall forthwith be
                  reduced to a price determined by multiplying the Warrant Price
                  in effect immediately prior to such issuance by a fraction:

                           (a)      the numerator of which shall be the total
                                    number of shares of Common Stock outstanding
                                    immediately prior to such issuance, and

                           (b)      the denominator of which shall be the total
                                    number of shares of Common Stock outstanding
                                    immediately after such issuance.




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                  For the purposes of any computation to be made in accordance
with the provisions of this clause (1), the following provisions shall be
applicable:

                           (i)      Shares of Common Stock issuable by way of
                                    dividend or other distribution on any stock
                                    of the Company shall be deemed to have been
                                    issued and to be outstanding at the close of
                                    business on the record date fixed for the
                                    determination of stockholders entitled to
                                    receive such dividend or other distribution
                                    and shall be deemed to have been issued
                                    without consideration. Shares of Common
                                    Stock issued otherwise than as a dividend,
                                    shall be deemed to have been issued and to
                                    be outstanding at the close of business on
                                    the date of issue.

                           (ii)     The number of shares of Common Stock at any
                                    time outstanding shall not include any
                                    shares then owned or held by or for the
                                    account of the Company.

                           (2) In case the Company shall at any time subdivide
                  or combine the outstanding shares of Common Stock, the Warrant
                  Price shall forthwith be proportionately decreased in the case
                  of the subdivision or proportionately increased in the case of
                  combination to the nearest one cent. Any such adjustment shall
                  become effective at the close of business on the date that
                  such subdivision or combination shall become effective.

                  B. In the event that the number of outstanding shares of
         Common Stock is increased by a stock dividend payable in shares of
         Common Stock or by a subdivision of the outstanding shares of Common
         Stock, which may include a stock split, then from and after the time at
         which the adjusted Warrant Price becomes effective pursuant to the
         foregoing Subsection A of this Section by reason of such dividend or
         subdivision, the number of shares issuable upon the exercise of this
         Warrant shall be increased in proportion to such increase in
         outstanding shares. In the event that the number of outstanding shares
         of Common Stock is decreased by a combination of the outstanding shares
         of Common Stock, then, from and after the time at which the adjusted
         Warrant Price becomes effective pursuant to such Subsection A of this
         Section by reason of such combination, the number of shares issuable
         upon the exercise of this Warrant shall be decreased in proportion to
         such decrease in outstanding shares.


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                  C. In the event of an adjustment of the Warrant Price, the
         number of shares of Common Stock (or reclassified stock) issuable upon
         exercise of this Warrant after such adjustment shall be equal to the
         number determined by dividing:

                           (1)      an amount equal to the product of (i) the
                                    number of shares of Common Stock issuable
                                    upon exercise of this Warrant immediately
                                    prior to such adjustment, and (ii) the
                                    Warrant Price immediately prior to such
                                    adjustment, by

                           (2)      the Warrant Price immediately after such
                                    adjustment.

                  D. In the case of any reorganization or reclassification of
         the outstanding shares of Common Stock (other than a change in par
         value, or from par value to no par value, or from no par value to par
         value, or as a result of a subdivision or combination) or in the case
         of any consolidation of the Company with, or merger of the Company
         with, another corporation, or in the case of any sale, lease or
         conveyance of all, or substantially all, of the property, assets,
         business and goodwill of the Company as an entity, the holder of this
         Warrant shall thereafter have the right upon exercise to purchase the
         kind and amount of shares of stock and other securities and property
         receivable upon such reorganization, reclassification, consolidation,
         merger or sale by a holder of the number of shares of Common Stock
         which the holder of this Warrant would have received had all Warrant
         Shares issuable upon exercise of this Warrant been issued immediately
         prior to such reorganization, reclassification, consolidation, merger
         or sale, at a price equal to the Warrant Price then in effect
         pertaining to this Warrant (the kind, amount and price of such stock
         and other securities to be subject to adjustment as herein provided).

                  E. In case the Company shall, at any time prior to the
         expiration of this Warrant and prior to the exercise thereof, dissolve,
         liquidate or wind up its affairs, the Warrantholder shall be entitled,
         upon the exercise hereof, to receive, in lieu of the Warrant Shares of
         the Company which it would have been entitled to receive, the same kind
         and amount of assets as would have been issued, distributed or paid to
         it upon such Warrant Shares of the Company, had it been the holder of
         record of shares of Common Stock receivable upon the exercise of this
         Warrant on the record date for the determination of those entitled to
         receive any such liquidating distribution. After any such dissolution,
         liquidation or winding up which shall result in any distribution in
         excess of the Warrant Price provided for by this Warrant, the
         Warrantholder may at its option exercise the same without making
         payment of the aggregate Warrant Price and in such case the Company
         shall upon the distribution to said Warrantholder consider that the
         aggregate Warrant Price has been paid in full to it and in making
         settlement to


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         said Warrantholder, shall deduct from the amount payable to such
         Warrantholder an amount equal to the aggregate Warrant Price.

                  F. In case the Company shall, at any time prior to the
         expiration of this Warrant and prior to the exercise thereof make a
         distribution of assets (other than cash) or securities of the Company
         to its stockholders (the "Distribution") the Warrantholder shall be
         entitled, upon the exercise thereof, to receive, in addition to the
         Warrant Shares it is entitled to receive, the same kind and amount of
         assets or securities as would have been distributed to it in the
         Distribution had it been the holder of record of shares of Common Stock
         receivable upon exercise of this Warrant on the record date for
         determination of those entitled to receive the Distribution.

                  G. Irrespective of any adjustments in the number of Warrant
         Shares and the Warrant Price or the number or kind of shares
         purchasable upon exercise of this Warrant, this Warrant may continue to
         express the same price and number and kind of shares as originally
         issued.

         IV. OFFICER'S CERTIFICATE. Whenever the number of Warrant Shares and
the Warrant Price shall be adjusted pursuant to the provisions hereof, the
Company shall forthwith file at its principal executive office a statement,
signed by the Chairman of the Board, President, or one of the Vice Presidents of
the Company and by its Chief Financial Officer or one of its Treasurers or
Assistant Treasurers, stating the adjusted number of Warrant Shares and the new
Warrant Price calculated to the nearest one hundredth of a cent and setting
forth in reasonable detail the method of calculation and the facts requiring
such adjustment and upon which such calculation is based. Each adjustment shall
remain in effect until a subsequent adjustment hereunder is required. A copy of
such statement shall be mailed to the Warrantholder.

         V. CHARGES, TAXES AND EXPENSES. The issuance of certificates for
Warrant Shares upon any exercise of this Warrant shall be made without charge to
the Warrantholder for any tax or other expense in respect to the issuance of
such certificates, all of which taxes and expenses shall be paid by the Company,
and such certificates shall be issued only in the name of the Warrantholder.

         VI. MISCELLANEOUS.

                  (a) The terms of this Warrant shall be binding upon and shall
inure to the benefit of any successors or assigns of the Company and of the
holder or holders hereof and of the shares of Common Stock issued or issuable
upon the exercise hereof.

                  (b) No holder of this Warrant, as such, shall be entitled to
vote or receive dividends or be deemed to be a stockholder of the Company for
any purpose, nor shall anything contained in this Warrant be construed to confer
upon the holder of this Warrant, as



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such, any rights of a stockholder of the Company or any right to vote, give or
withhold consent to any corporate action, receive notice of meetings, receive
dividends or subscription rights, or otherwise.

                  (c) Receipt of this Warrant by the holder hereof shall
constitute acceptance of an agreement to the foregoing terms and conditions.

                  (d) The Warrant and the performance of the parties hereunder
shall be construed and interpreted in accordance with the laws of the State of
New York and the parties hereunder consent and agree that the State and Federal
Courts which sit in the State of New York and the County of New York shall have
exclusive jurisdiction with respect to all controversies and disputes arising
hereunder.

                  IN WITNESS WHEREOF, the Company has caused this Warrant to be
signed by its duly authorized officer and its corporate seal to be affixed
hereto.

Dated: November ___, 2000

                                         ADVANCED VIRAL RESEARCH CORP.


                                         BY:
                                            ----------------------------------
                                              Shalom Hirschman, M.D.
                                              President



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