Exhibit 3.13

                            ARTICLES OF INCORPORATION
                                       OF
                           PHARMABIO DEVELOPMENT INC.

         The undersigned does hereby submit these Articles of Incorporation for
the purpose of forming a business corporation under and by virtue of the laws of
the State of North Carolina:

         1.       The name of the corporation is PharmaBio Development Inc.

         2.       The corporation shall have authority to issue One Hundred
Thousand (100,000) shares of common stock with a par value of One Dollar ($1.00)
per share.

         3.       The address of the initial registered office of the
corporation in the State of North Carolina is 4709 Creekstone Drive, Riverbirch
Building, Suite 300, Durham, Durham County, North Carolina 27703, and the name
of its initial registered agent at such address is Gregory D. Porter.

         4.       The name and address of the incorporator is Christopher B.
Capel, 2500 First Union Capitol Center, Raleigh, Wake County, North Carolina
27601.

         5.       The number of directors constituting the initial board of
directors shall be two (2), and the names and addresses of the persons who are
to serve as directors until the first meeting of shareholders, or until their
successors are elected and qualified, are:



         NAME                                        ADDRESS
         ----                                        -------
                                          
Dennis B. Gillings                           4709 Creekstone Drive
                                             Riverbirch Building, Suite 300
                                             Durham, North Carolina 27703

Gregory D. Porter                            4709 Creekstone Drive
                                             Riverbirch Building, Suite 300
                                             Durham, North Carolina 27703


         6.       A director of the corporation shall not be personally liable
to the corporation or otherwise for monetary damages for breach of any duty as a
director, except for liability with respect to (i) acts or omissions that the
director at the time of such breach knew or believed were clearly in



conflict with the best interests of the corporation; (ii) any liability under
N.C. Gen. Stat. Section 55-8-33; or (iii) any transaction from which the
director derived an improper personal benefit. If the North Carolina Business
Corporation Act is amended to authorize corporate action for further eliminating
or limiting personal liability of directors, then the liability of a director of
the corporation shall be eliminated or limited to the fullest extent permitted
by the North Carolina Business Corporation Act, as so amended.

                  Any repeal or modification of the foregoing paragraph shall
not adversely affect any right or protection of a director of the corporation
existing at the time of such repeal or modification.

         7.       The provisions of Article 9 and Article 9A of the North
Carolina Business Corporation Act, entitled "The North Carolina Shareholder
Protection Act" and "The North Carolina Control Share Acquisition Act,"
respectively, shall not be applicable to the corporation.

         IN WITNESS WHEREOF, I have hereunto set my hand this 20th day of
August, 1996.

                                             /s/ Christopher B. Capel
                                    --------------------------------------------
                                    Christopher B. Capel, Incorporator

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