. . . Exhibit 12.01 Quintiles Transnational Corporation Computation of Ratio of Earnings to Fixed Charges September January 26 - 1- December September 2003 31, 2003 25, 2003 Combined 2002 2001 2000 1999 ----------------------------------------------------------------------- SELECTED HISTORICAL DATA: Earnings were calculated as follows: Income (loss) before income taxes $ 3,395 $ 65,341 $ 68,736 $ 123,660 $(262,496) $ (51,005) $ 115,910 Add: Fixed charges (from below) $ 27,299 $ 20,154 $ 47,454 $ 25,279 $ 28,861 $ 31,351 $ 25,168 ----------------------------------------------------------------------- Earnings $ 30,694 $ 85,495 $ 116,190 $ 148,939 $(233,635) $ (19,654) $ 141,078 Fixed Charges were calculated as follows: Interest costs - expensed $ 20,652 $ 1,737 $ 22,389 $ 2,551 $ 3,172 $ 4,842 $ 11,233 Such portion of rental expense as can be demonstrated to be representative of the interest factor $ 6,647 $ 18,417 $ 25,065 $ 22,728 $ 25,689 $ 26,509 $ 13,935 ----------------------------------------------------------------------- Fixed charges $ 27,299 $ 20,154 $ 47,454 $ 25,279 $ 28,861 $ 31,351 $ 25,168 Ratio of Earnings to Fixed Charges 1.12 4.24 2.45 5.89 -- -- 5.61 -----------------------------------------------------------------------