EXHIBIT 99.04

                          QUINTILES TRANSNATIONAL CORP.

                          EXCHANGE OFFER IN RESPECT OF

                     10% SENIOR SUBORDINATED NOTES DUE 2013,
          WHICH HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933,
                           FOR ANY AND ALL OUTSTANDING
                     10% SENIOR SUBORDINATED NOTES DUE 2013,
         WHICH HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933


To Registered Holders:

         We are enclosing herewith the material listed below relating to the
offer (the "Exchange Offer") by Quintiles Transnational Corp. ("Quintiles") to
exchange $450,000,000 aggregate principal amount of 10% Senior Subordinated
Notes due 2013 which have been registered under the Securities Act of 1933, as
amended (the "Securities Act") (the "exchange notes"), for the outstanding
unregistered $450,000,000 aggregate principal amount of 10% Senior Subordinated
Notes due 2013 (the "private notes") issued on September 25, 2003, upon the
terms and subject to the conditions set forth in the Prospectus dated          ,
2004 (the "Prospectus") and the related Letter of Transmittal.

         Enclosed herewith are copies of the following documents:

                           1.       Prospectus dated           , 2004;

                           2.       Letter of Transmittal, including Guidelines
                  for Certification of Taxpayer Identification;

                           3.       Instruction to Registered Holder from
                  Beneficial Owner;

                           4.       Notice of Guaranteed Delivery; and

                           5.       Letter to Clients which may be sent to your
                  clients for whose account you hold private notes in your name
                  or in the name of your nominee, which shall accompany the
                  Instruction to Registered Holder from Beneficial Owner for
                  obtaining such client's instruction with regard to the
                  Exchange Offer.

         WE URGE YOU TO CONTACT YOUR CLIENTS PROMPTLY. PLEASE NOTE THAT THE
EXCHANGE OFFER WILL EXPIRE AT 5:00 P.M., NEW YORK CITY TIME, ON    , 2004 UNLESS
EXTENDED BY QUINTILES IN ITS SOLE DISCRETION.

         The Exchange Offer is not conditioned upon any minimum number of
private notes being tendered.

        Pursuant to the Letter of Transmittal, each holder of private notes (a
"Holder") will represent to Quintiles that:

         -        the exchange notes acquired pursuant to the Exchange Offer are
                  being acquired in the ordinary course of business of the
                  person receiving the exchange notes, whether or not the person
                  is the Holder;

         -        neither the Holder nor any other recipient of the exchange
                  notes (if different than the Holder) is engaged in, intends to
                  engage in, or has any arrangement or understanding with any
                  person to participate in, the distribution of the private
                  notes or exchange notes;

         -        neither the Holder nor any other recipient is an "affiliate"
                  of Quintiles within the meaning of Rule 405 promulgated under
                  the Securities Act or, if the Holder or such recipient is an
                  affiliate, that the Holder or



                  such recipient will comply with the registration and
                  prospectus delivery requirements of the Securities Act to the
                  extent applicable;

         -        if the signatory is a broker-dealer, it has not entered into
                  any arrangement or understanding with Quintiles or any
                  "affiliate" of Quintiles within the meaning of Rule 405
                  promulgated under the Securities Act to distribute the
                  exchange notes;

         -        if the signatory is a broker-dealer, the signatory further
                  represents and warrants that if it will receive exchange notes
                  for its own account in exchange for private notes that were
                  acquired as a result of market-making activities or other
                  trading activities, the signatory will deliver a prospectus
                  meeting the requirements of the Securities Act (for which
                  purposes, the delivery of the Prospectus, as the same may be
                  hereafter supplemented or amended, shall be sufficient) in
                  connection with any resale of exchange notes received in the
                  Exchange Offer; and

         -        the Holder is not acting on behalf of any person or entity
                  that could not truthfully make these representations.

         By acknowledging that you will deliver and by delivering a prospectus
meeting the requirements of the Securities Act in connection with any resale of
such exchange notes, you will not be deemed to admit that you are an
"underwriter" within the meaning of the Securities Act.

         The enclosed Instruction to Registered Holders from Beneficial Owner
contains an authorization by the beneficial owners of the private notes for you
to make the foregoing representations.

         Quintiles will not pay any fee or commission to any broker or dealer or
to any other person other than the exchange agents for the Exchange Offer.
Quintiles will pay all transfer taxes, if any, applicable to the exchange of
private notes pursuant to the Exchange Offer, except as otherwise provided in
the Prospectus under the caption "The Exchange Offer--Fees and Expenses."

         Any inquiries you may have with respect to the Exchange Offer may be
addressed to, and additional copies of the enclosed materials may be obtained
from, the Exchange Agent, Wells Fargo Bank , National Association, in the manner
set forth below.

                                 EXCHANGE AGENT:


                                                                         
By Registered and Certified Mail     By Overnight Courier or Regular Mail:              By Hand Delivery
      Wells Fargo Bank , N.A.                Wells Fargo Bank, N.A.                   Wells Fargo Bank, N.A.
    Corporate Trust Operations             Corporate Trust Operations                Corporate Trust Services
           MAC N9303-121                          MAC N9303-121                        608 2nd Avenue South
           P.O. Box 1517                     6th & Marquette Avenue            Northstar East Building - 12th Floor
       Minneapolis, MN 55480                  Minneapolis, MN 55479                    Minneapolis, MN 55402
         Attention: Reorg.                      Attention: Reorg                         Attention: Reorg



                                       or
                            Facsimile: (612) 667-4927


                                                 Very truly yours,

                                                 QUINTILES TRANSNATIONAL CORP.

NOTHING CONTAINED HEREIN OR IN THE ENCLOSED DOCUMENTS SHALL CONSTITUTE YOU OR
ANY OTHER PERSON AS AN AGENT OF QUINTILES OR THE EXCHANGE AGENT, OR


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AUTHORIZE YOU OR ANY OTHER PERSON TO USE ANY DOCUMENT OR MAKE ANY STATEMENT ON
BEHALF OF QUINTILES OR THE EXCHANGE AGENT IN CONNECTION WITH THE EXCHANGE OFFER
OTHER THAN THE DOCUMENTS ENCLOSED HEREWITH AND THE STATEMENTS CONTAINED HEREIN.



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