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                                    EXHIBIT 5


                             BASS, BERRY & SIMS PLC
                    A PROFESSIONAL LIMITED LIABILITY COMPANY
                                ATTORNEYS AT LAW


                                                                      
           KNOXVILLE OFFICE                                                          DOWNTOWN OFFICE:
   900 SOUTH GAY STREET, SUITE 1700                REPLY TO:                          AMSOUTH CENTER
         KNOXVILLE, TN 37902               THE TOWER AT PEABODY PLACE        315 DEADERICK STREET, SUITE 2700
            (865) 521-6200                100 PEABODY PLACE, SUITE 950            NASHVILLE, TN 37238-3001
                                             MEMPHIS, TN 38103-2625                    (615) 742-6200
            MEMPHIS OFFICE                       (901) 543-5900
      THE TOWER AT PEABODY PLACE                                                     MUSIC ROW OFFICE:
     100 PEABODY PLACE, SUITE 950              WWW.BASSBERRY.COM                    29 MUSIC SQUARE EAST
        MEMPHIS, TN 38103-2625                                                    NASHVILLE, TN 37203-4322
            (901) 543-5900                                                             (615) 255-6161





                                September 9, 2004



The Board of Directors of GTx, Inc.
3 North Dunlap, 3rd Floor
Van Vleet Building
Memphis TN 38103


         RE:   REGISTRATION STATEMENT ON FORM S-8 RELATING TO THE DIRECTORS'
               DEFERRED COMPENSATION PLAN.


Ladies and Gentlemen:

         We have acted as counsel to GTx, Inc., a Delaware corporation (the
"Company"), in connection with the preparation and filing of a registration
statement on Form S-8 (the "Registration Statement") relating to certain shares
of common stock, par value $.001 per share, of the Company (the "Common Stock")
to be issued pursuant to the above referenced plan (the "Plan").

         In our capacity as such counsel, we have examined originals or copies,
certified or otherwise identified to our satisfaction, of such corporate records
of the Company, such agreements and instruments, such certificates of public
officials, officers of the Company and other persons, and such other documents
as we have deemed necessary or appropriate as a basis for the opinions
hereinafter expressed. In such examinations, we have assumed the genuineness of
all signatures, the legal capacity of all natural persons, the authenticity and
completeness of all documents submitted to us as originals, the conformity to
original documents of all documents submitted to us as certified, conformed,
photostatic or facsimile copies, and the authenticity of the originals of such
copies, and we have assumed all certificates of public officials to have been
properly given and to be accurate.

         As to factual matters relevant to this opinion letter, we have relied
upon the representations and warranties as to factual matters contained in
certificates and statements of officers of the Company and certain public
officials. Except to the extent expressly set forth herein, we have made no
independent investigations with regard thereto, and, accordingly, we do not
express any opinion as to matters that might have been disclosed by independent
verification.

         On the basis of the foregoing, and subject to the limitations set forth
herein, we are of the opinion that the shares of Common Stock issuable in
connection with the Plan have been duly authorized and, when issued, sold and
paid for in accordance with the terms of the Plan, will be validly issued, fully
paid and non-assessable.

         The opinions expressed herein are limited in all respects to the laws
of the State of Tennessee, the General Corporation Law of the State of Delaware
("Delaware General Corporation Law") and the federal laws of the United States
of America, and no opinion is expressed with respect to the laws of any other
jurisdiction or any effect which such laws may have on the opinions expressed
herein. We are not rendering any opinion or providing any assurance as to
compliance with any antifraud law, rule or regulation relating to securities, or
to the sale or issuance thereof. We are not licensed to practice law in the
State of Delaware, and our opinion as to the Delaware General Corporation Law
are based solely on our review of standard compilations of the official statutes
of Delaware and without reference to its conflicts of law rules.

         We consent to the filing of this opinion letter as an exhibit to the
Registration Statement and to any related registration statement subsequently
filed by the Company pursuant to Rule 462(b) promulgated under the Securities
Act of 1933, as amended (the "Act"), and to the use of our name under the
heading "Legal Opinions" in any prospectus constituting a part thereof. In
giving such consent, we do not thereby admit that we are within the category of
persons whose consent is required under Section 7 of the Act or the rules and
regulations of the Securities and Exchange Commission (the "Commission")
thereunder.




         This opinion letter is being furnished by us to the Company and the
Commission solely for the benefit of the Company and the Commission in
connection with the Registration Statement and is not to be used, circulated,
quoted or otherwise relied upon by any other person, or by the Company or the
Commission for any other purpose, without our express written consent. The only
opinion rendered by us consists of those matters set forth in the fourth
paragraph hereof, and no opinion may be implied or inferred beyond those
expressly stated. This opinion letter is rendered as of the date hereof, and we
have no obligation to update this opinion letter.




                                              Yours very truly,

                                              /s/ Bass, Berry & Sims PLC