EXHIBIT 16.1 Crowe Chizek and Company LLC 105 Continental Place, Suite 200 Brentwood, TN 37027 May 16, 2005 Securities and Exchange Commission Mail Stop 9-5 450 5th Street, N.W. Washington, D.C. 20549 Ladies and Gentlemen: We have read the comments made regarding us in Item 4 of Form 8-K of First Community Corporation, dated May 16, 2005 and filed May 16, 2005, as contained in the third, fourth, sixth, and eighth paragraphs, insofar as they pertain to us, of Item 4, and are in agreement with those statements. /s/ Crowe Chizek and Company LLC Crowe Chizek and Company LLC Brentwood, Tennessee cc: Mr. William Krickbaum Audit Committee Chairman First Community Corporation