EXHIBIT 32.1

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002


        In connection with the Quarterly Report of ProxyMed, Inc. (the
"Company") on Form 10-Q for the period ending September 30, 2005 as filed with
the Securities and Exchange Commission on the date hereof (the "Report"), I,
John G. Lettko, Chief Executive Officer of the Company, certify, pursuant to 18
U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley
Act of 2002, that:

        (1)     The Report fully complies with the requirements of section 13(a)
or 15(d) of the Securities Exchange Act of 1934; and

        (2)     The information contained in the Report fairly presents, in all
material respects, the financial condition and result of operations of the
Company.



                                            /s/John G. Lettko
                                            -----------------------------
                                            John G. Lettko
                                            Chief Executive Officer
                                            November 9, 2005


A signed original of this written statement required by Section 906 has been
provided to ProxyMed, Inc. and will be retained by ProxyMed, Inc. and furnished
to the Securities and Exchange Commission or its staff upon request.



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