Exhibit 21.1 Subsidiaries of Registrant 1. NewQuest, Inc. - Delaware 2. NewQuest, LLC - Texas 3. GulfQuest, L.P. - Texas 4. HealthSpring Employer Services, Inc. - Tennessee 5. HealthSpring of Tennessee, Inc. - Tennessee 6. HealthSpring Management, Inc. - Tennesee 7. HealthSpring of Alabama, Inc. - Alabama 8. HealthSpring of Illinois I, Inc. - Illinois 9. HealthSpring USA, LLC - Tennessee 10. HouQuest, L.L.C. - Delaware 11. NewQuest Management of Alabama, LLC - Alabama 12. NewQuest Management of Illinois, LLC - Illinois 13. Signature Health Alliance, Inc. - Tennessee 14. Texas HealthSpring, LLC - Texas 15. TexQuest, L.L.C. - Delaware