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                                                                     EXHIBIT 3.1

                    RESTATED CERTIFICATE OF INCORPORATION OF
                                CYTRX CORPORATION
             AS APPROVED BY THE BOARD OF DIRECTORS ON JUNE 26, 1997

         CytRx Corporation, a corporation organized and existing under the laws
of the State of Delaware, hereby certifies as follows:

1. The name of the corporation is CytRx Corporation. CytRx Corporation was
originally incorporated under the name SynthRx, Inc., and the original
certificate of incorporation of the corporation was filed with the Secretary of
State of Delaware on February 28, 1985.

2. This Restated Certificate of Incorporation was duly adopted in accordance
with Section 245 of the Delaware General Corporation Law.

3. This Restated Certificate of Incorporation merely restates and integrates but
does not further amend the provisions of the corporation's certificate of
incorporation as theretofore amended or supplemented, and there is no
discrepancy between those provisions and the provisions of this Restated
Certificate of Incorporation.

         FIRST: The name of the corporation (hereinafter called the
"corporation") is CytRx Corporation.

         SECOND: The address, including street, number, city, and county, of the
registered office of the corporation in the State of Delaware is 1013 Centre
Road, City of Wilmington, County of New Castle; and the name of the registered
agent of the corporation in the State of Delaware at such address is The
Prentice-Hall Corporation System, Inc.

         THIRD: The nature of the business and of the purposes to be conducted
and promoted by the corporation are as follows:

                  To manufacture, prepare, compound, refine, distill, produce,
         invent, discover, devise, develop, conduct scientific researches in
         respect of and exploit the findings therefrom, acquire, assign, and
         transfer formulae, concentrates, compounds, and processes for, apply,
         buy, sell, import and export, and generally deal in and with at
         wholesale and retail and as principal, agent, broker, distributor,
         sales, financial, and special representative, licensor, licensee, and
         in any other lawful capacity, pharmaceuticals, drugs and nutritional
         aspects for animals and humans.

                  To engage in any lawful act or activity for which corporations
         may be organized under the General Corporation Law of the State of
         Delaware.
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         FOURTH: The total number of shares of all classes of stock that the
corporation shall have the authority to issue is Eighteen Million Seven Hundred
Fifty-One Thousand (18,751,000), of which Eighteen Million Seven Hundred Fifty
Thousand (18,750,000) shall be common stock, par value $.001 per share (the
"Common Stock") and One Thousand (1,000) shall be preferred stock, par value
$.01 per share (the "Preferred Stock").

         The Board of Directors is hereby authorized, subject to any limitations
prescribed by law, to provide for the issuance of the Shares of Preferred Stock
in series, and by filing a Certificate pursuant to the applicable law of the
State of Delaware (hereinafter referred to as a "Preferred Stock Designation"),
to establish from time to time the number of shares to be included in each such
series, and to fix the designations, powers, preferences, and rights of the
shares of each such series, and any qualifications, limitations or restrictions
thereof.

         FIFTH: The name and the mailing address of the incorporator are as
follows:




       NAME                            MAILING ADDRESS
       ----                            ---------------

                        
R. G. Dickerson            229 South State Street, Dover, Delaware




         SIXTH: The corporation is to have perpetual existence.

         SEVENTH: Whenever a compromise or arrangement is proposed between this
corporation and its creditors or any class of them and/or between this
corporation and its stockholders or any class of them, any court of equitable
jurisdiction within the State of Delaware may, on the application in a summary
way of this corporation or of any creditor or stockholder thereof or on the
application of any receiver or receivers appointed for this corporation under
the provisions of section 291 of Title 8 of the Delaware Code or on the
application of trustees in dissolution or of any receiver or receivers appointed
for this corporation under the provisions of section 279 of Title 8 of the
Delaware Code order a meeting of the creditors or class of creditors, and/or of
the stockholders or class of stockholders of this corporation, as the case may
be, to be summoned in such manner as the said court directs. If a majority in
number representing three-fourths in value of the creditors or class of
creditors, and/or of the stockholders or class of stockholders of this
corporation, as the case may be, agree to any compromise or arrangement and to
any reorganization of this corporation as consequence of such compromise or
arrangement, the said compromise or arrangement and the said reorganization
shall, if sanctioned by the court to which the said application has been made,
be binding on all the creditors or class of creditors, and/or on all the
stockholders or class of stockholders, of this corporation, as the case may be,
and also on this corporation.



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         EIGHTH: For the management of the business and for the conduct of the
affairs of the corporation, and in further definition, limitation and regulation
of the powers of the corporation and of its directors and of its stockholders or
any class thereof, as the case may be, it is further provided:

         1. The management of the business and the conduct of the affairs of the
corporation shall be vested in its Board of Directors. The number of directors
which shall constitute the whole Board of Directors shall be fixed by, or in the
manner provided in, the By-Laws. The phrase "whole Board" and the phrase "total
number of directors" shall be deemed to have the same meaning, to wit, the total
number of directors which the corporation would have if there were no vacancies.
No election of directors need be by written ballot.

         2. After the original or other By-Laws of the corporation have been
adopted, amended, or repealed, as the case may be, in accordance with the
provisions of Section 109 of the General Corporation Law of the State of
Delaware, and, after the corporation has received any payment for any of its
stock, the power to adopt, amend, or repeal the By-Laws of the corporation may
be exercised by the Board of Directors of the corporation; provided, however,
that any provision for the classification of directors of the corporation for
staggered terms pursuant to the provisions of subsection (d) of Section 141 of
the General Corporation Law of the State of Delaware shall be set forth in an
initial By-Law or in a By-Law adopted by the stockholders entitled to vote of
the corporation unless provisions for such classification shall be set forth in
this certificate of incorporation.

         3. Whenever the corporation shall be authorized to issue only one class
of stock, each outstanding share shall entitle the holder thereof to notice of,
and the right to vote at, any meeting of stockholders. Whenever the corporation
shall be authorized to issue more than one class of stock, no outstanding share
of any class of stock which is denied voting power under the provisions of the
certificate of incorporation shall entitle the holder thereof to the right to
vote at any meeting of stockholders except as the provisions of paragraph (b)
(2) of section 242 of the General Corporation Law of the State of Delaware shall
otherwise require; provided, that no share of any such class which is otherwise
denied voting power shall entitle the holder thereof to vote upon the increase
or decrease in the number of authorized shares of said class.

         NINTH: The corporation shall, to the fullest extent permitted by
Section 145 of the General Corporation Law of the State of Delaware, as the same
may be amended and supplemented, indemnify any and all persons whom it shall
have power to indemnify under said section from and against any and all of the
expenses, liabilities or other matters referred to in or covered by said
section, and the indemnification provided for herein shall not be deemed
exclusive of any other rights to which those indemnified may be entitled under
any By-Law, agreement, vote of stockholders or disinterested directors or
otherwise, both as to action in his official capacity and as to action in
another capacity while holding such office, and shall continue as to a person
who has ceased to be a 



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director, officer, employee or agent and shall inure to the benefit of the
heirs, executors and administrators of such a person.

         TENTH: From time to time any of the provisions of this certificate of
incorporation may be amended, altered or repealed, and other provisions
authorized by the laws of the State of Delaware at the time in force may be
added or inserted in the manner and at the time prescribed by said laws, and all
rights at any time conferred upon the stockholders of the corporation by this
certificate of incorporation are granted subject to the provisions of this
Article TENTH.

         ELEVENTH: A director of the corporation shall not be personally liable
to the corporation or its stockholders for monetary damages for breach of
fiduciary duty as a director, except for liability (i) for any breach of the
director's duty of loyalty to the corporation or its stockholders, (ii) for acts
or omissions not in good faith or which involve intentional misconduct or a
knowing violation of law, (iii) under Section 174 of the Delaware General
Corporation Law, or (iv) for any transaction from which the director derived any
improper personal benefit. If the Delaware General Corporation Law is amended
after approval by the stockholders of this Article to authorize corporate action
further eliminating or limiting the personal liability of directors, then the
liability of a director of the corporation shall be eliminated or limited to the
fullest extent permitted by the Delaware General Corporation Law as so amended.

         Any repeal or modification of the foregoing paragraph by the
stockholders of the corporation shall not adversely affect any right or
protection of a director of the corporation existing at the time of such repeal
or modification.

         IN WITNESS WHEREOF, this Restated Certificate of Incorporation has been
signed by Jack J. Luchese, its authorized officer this 26 day of September,
1997.

                                    CYTRX CORPORATION


                                    By:      /s/ Jack J. Luchese
                                       -------------------------------------
                                             Jack J. Luchese
                                             President and Chief
                                             Executive Officer






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                     CERTIFICATE OF DESIGNATION, PREFERENCES
                                AND RIGHTS OF THE
                  SERIES A JUNIOR PARTICIPATING PREFERRED STOCK
                                       OF
                                CYTRX CORPORATION

                         Pursuant to Section 151 of the
                        Delaware General Corporation Law

                  CytRx Corporation, a corporation organized under the laws of
the State of Delaware (the "Corporation"), hereby certifies that, pursuant to
the authority conferred upon the Board of Directors by the Certificate of
Incorporation, as amended, of the Corporation, the Board of Directors on April
16, 1997, adopted the following resolution creating a series of 1,000 shares of
Preferred Stock designated as Series A Junior Participating Preferred Stock:

         RESOLVED, that pursuant to the authority granted to and vested in the
Board of Directors of this Corporation (the "Board") in accordance with the
provisions of its Certificate of Incorporation, as amended, a series of
Preferred Stock of the Corporation be and it hereby is created, and that the
designation and amount thereof and the voting rights or powers, preferences and
relative, participating, optional and other special rights of the shares of such
series, and the qualifications, limitations or restrictions thereof are as
follows:


                  1. Series A Participating Preferred Stock. There is hereby
established a series of Preferred Stock, par value $0.01 per share, of the
Corporation, and the designation and certain terms, powers, preferences and
other rights of the shares of such series, and certain qualifications,
limitations and restrictions thereon, are hereby fixed as follows:

                           (i)      The distinctive serial designation of this
series shall be "Series A Junior Participating Preferred Stock" (hereinafter
called "this Series"). Each share of this Series shall be identical in all with
the other shares of this Series except as to the dates from and after which
dividends thereon shall be cumulative.

                           (ii)     The number of shares in this Series shall
initially be 1,000, which number may from time to time be increased or decreased
(but not below the number then outstanding) by the Board of Directors. Shares of
this Series purchased by the Corporation shall be canceled and shall revert to
authorized but unissued shares of Preferred Stock undesignated as to series.
Shares of this Series may be issued in fractional shares, which fractional
shares shall entitle the holder, in proportion to such holder's fractional
share, to all rights of a holder of a whole share of this Series.

                           (iii)    The holders of full or fractional shares of
this Series shall be entitled to receive, when and as declared by the Board of
Directors, but only out of funds legally available therefor, dividends, (A) on
each date that dividends or other distributions payable in Common Stock of the
Corporation are payable on or in respect of Common Stock comprising part of the
Reference Package (as defined below), in an amount per whole share of this
Series equal to the aggregate amount of dividends or other distributions (other
than dividends or distributions payable in Common Stock of the Corporation) that
would be payable on such date to a holder of



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the Reference Package and (B) on the last day of March, June, September and
December in each year, in an amount per whole share of this Series equal to the
excess (if any) of $1.00 over the aggregate dividends paid per whole share of
this Series during the three-month period ending on such last day. Each such
dividend shall be paid to the holders of record of shares of this Series on the
date, not exceeding sixty days preceding such dividend or distribution payment
date, fixed for that purpose by the Board of Directors in advance of payment of
each particular dividend or distribution. Dividends on each full and each
fractional share of this Series shall be cumulative from the date such full or
fractional share is originally issued; provided that any such full or fractional
share originally issued after a dividend record date and on or prior to the
dividend payment date to which such record date relates shall not be entitled to
receive the dividend payable on such dividend payment date or any amount in
respect of the period from such original issuance to such dividend payment date.

                  The term "Reference Package" shall initially mean 10,000
shares of Common Stock, par value $.001 per share ("Common Stock"), of the
Corporation. In the event the Corporation shall at any time (A) declare or pay a
dividend on any Common Stock payable in Common Stock, (B) subdivide any Common
Stock or (C) combine any Common Stock into a smaller number of shares, then and
in each such case the Reference Package after such event shall be the Common
Stock that a holder of the Reference Package immediately prior to such event
would hold thereafter as a result thereof.

                  Holders of shares of this Series shall not be entitled to any
dividends, whether payable in cash, property or stock, in excess of full
cumulative dividends, as herein provided on this Series.

                  So long as any shares of this Series are outstanding, no
dividend (other than a dividend in Common Stock or in any other stock ranking
junior to this Series as to dividends and upon liquidation) shall be declared or
paid or set aside for payment or other distribution declared or made upon the
Common Stock or upon any other stock ranking junior to this Series as to
dividends or upon liquidation, nor shall any Common Stock nor any other stock of
the Corporation ranking junior to or on a parity with this Series as to
dividends or upon liquidation be redeemed, purchased or otherwise acquired for
any consideration (or any moneys be paid to or made available for a sinking fund
for the redemption of any shares of any such stock) by the Corporation (except
by conversion into or exchange for stock of the Corporation ranking junior to
this series as to dividends and upon liquidation), unless, in each case, the
full cumulative dividends (including the dividend to be due upon payment of such
dividend, distribution, redemption, purchase or other acquisition) on all
outstanding shares of this Series shall have been, or shall contemporaneously
be, paid.

                  (iv)     In the event of any merger, consolidation,
reclassification or other transaction in which the shares of Common Stock are
exchanged for or changed into other stock or securities, cash and/or any other
property, then in any such case the shares of this Series shall at the same time
be similarly exchanged or changed in an amount per whole share equal to the
aggregate amount of stock, securities, cash and/or any other property (payable
in kind), as the case may be, that a holder of the Reference Package would be
entitled to receive as a result of such transaction.



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                  (v)      In the event of any liquidation, dissolution or
winding up of the affairs of the Corporation, whether voluntary or involuntary,
the holders of full and fractional shares of this Series shall be entitled,
before any distribution or payment is made on any date to the holders of the
Common Stock or any other stock of the Corporation ranking junior to this Series
upon liquidation, to be paid in full an amount per whole share of this Series
equal to-the greater of (A) $1.00 or (B) the aggregate amount distributed or to
be distributed prior to such date in connection with such liquidation,
dissolution or winding up to a holder of the Reference Package (such greater
amount being hereinafter referred to as the "Liquidation Preference"), together
with accrued dividends to such distribution or payment date, whether or not
earned or declared. If such payment shall have been made in full to all holders
of shares of this Series, the holders of shares of this Series as such shall
have no right or claim to any of the remaining assets of the Corporation.

                  In the event the assets of the Corporation available for
distribution to the holders of shares of this Series upon any liquidation,
dissolution or winding up of the Corporation, whether voluntary or involuntary,
shall be insufficient to pay in full all amounts to which such holders are
entitled pursuant to the first paragraph of this Section (v), no such
distribution shall be made on account of any shares of any other class or series
of Preferred Stock ranking on a parity with the shares of this Series upon such
liquidation, dissolution or winding up unless proportionate distributive amounts
shall be paid on account of the shares of this Series, ratably in proportion to
the full distributable, amounts for which holders of all such parity shares are
respectively entitled upon such liquidation, dissolution or winding up.

                  Upon the liquidation, dissolution or winding up of the
Corporation, the holders of shares of this Series then outstanding shall be
entitled to be paid out of assets of the Corporation available for distribution
to its stockholders all amounts to which such holders are entitled pursuant to
the first paragraph of this Section (v) before any payment shall be made to the
holders of Common Stock or any other stock of the Corporation ranking junior
upon liquidation to this Series.

                  For the purposes of this Section (v), the consolidation or
merger of, or binding share exchange by, the Corporation with any other
corporation shall not be deemed to constitute a liquidation, dissolution or
winding up of the corporation.

                  (vi)     The shares of this series shall not be redeemable.

                  (vii)    In addition to any other vote or consent of
stockholders required by law or by the Certificate of Incorporation, as amended,
of the Corporation, each whole share of this Series shall, on any matter, vote
as a class with any other capital stock comprising part of the Reference Package
and voting on such matter and shall have the number of votes thereon that a
holder of the Reference Package would have.





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         IN WITNESS WHEREOF, CytRx Corporation has caused this Certificate of
Designation to be executed as of May 5th, 1997.



                                    CYTRX CORPORATION



                                    By:  /s/ Jack J. Luchese
                                       -----------------------------------------
                                       Jack J. Luchese
                                       President and Chief Executive Officer










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