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                                                                     EXHIBIT 2.2
                    PRIVATE SECURITIES SUBSCRIPTION AGREEMENT
                                CYTRX CORPORATION
                                (REGULATION "D")


         THIS PRIVATE SECURITIES SUBSCRIPTION AGREEMENT (hereinafter the
"Agreement") has been executed by the undersigned in connection with the
purchase in a private placement pursuant to Section 4(2) of the Securities Act
of 1933, as amended (the "Securities Act"), of certain debentures (hereinafter
the "Debentures"), convertible into shares of common stock (hereinafter the
"Shares"), and certain share purchase warrants (hereinafter the "Warrants") from
CytRx Corporation ("CYTR") 154 Technology Parkway, Technology Parkway, Atlanta,
Georgia, 30092, USA, a corporation organized under the laws of Delaware
(hereinafter the "COMPANY" or "SELLER") by Name: Excalibur Limited Partnership,
c/o H&H Securities Limited located at: 205 Vesta Drive; City: Toronto;
Province/State: Ontario; Zip/Postal Code: M5P 3A1; Country: Canada a limited
partnership organized under the laws of Ontario and Canada (hereinafter
"Buyer"). SELLER and BUYER (hereinafter collectively the "parties") each hereby
represents, warrants and agrees as follows:


         1.       AGREEMENT TO SUBSCRIBE; PURCHASE PRICE:

                  (i)   SELLER and BUYER are executing and delivering this
         Agreement in reliance upon the exemption from securities registration
         afforded by Rule 506 under Regulation D ("Regulation D") as promulgated
         by the United States Securities and Exchange Commission (the
         "Commission") under the Securities Act; and

                  (ii)  BUYER hereby subscribes for Four Hundred Thousand 
         Dollars (USD $400,000) U.S. principal amount of Debentures,
         substantially in the form attached as Exhibit A to and forming an
         integral part of this Agreement.

                  (iii) BUYER will receive 8,000 Warrants substantially in the
         form attached as Exhibit B to and forming an integral part of this
         Agreement. Each Warrant will entitle BUYER to purchase one treasury
         Common Share at the price of $5.68. The Warrants will expire two (2)
         years after the Closing; and

                  (iv)  BUYER shall on or before the Closing execute a copy of
         the Registration Rights Agreement (the "Registration Rights Agreement")
         substantially in the form attached as Exhibit "A" to and forming an
         integral part of this Agreement.

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         2.       BUYER'S REPRESENTATIONS

                  BUYER represents and warrants follows:

                  (i)    Authorization: Such BUYER has full power and authority 
         to enter into this Agreement, the Debenture, the Warrant and the
         Registration Rights Agreement (collectively, the "Transaction
         Documents") and that the Transaction Documents, when executed and
         delivered will constitute a valid and legally binding obligation of
         BUYER in accordance with their terms, subject to (A) bankruptcy,
         insolvency, fraudulent conveyance, reorganization, moratorium and
         similar laws now or hereafter in effect relating to creditors' rights
         and (B) that the remedy of specific performance and injunctive and
         other forms of equitable relief may be subject to equitable defenses
         and to the discretion of the court before which any proceedings
         therefor may be brought and (C) to the extent that the indemnification
         provisions contained in the Registration Rights Agreement may be
         limited by applicable laws.

                  (ii)   Purchase Entirely for Own Account. This Agreement is 
         made with BUYER in reliance upon BUYER'S representation to the Company,
         which by such BUYER'S execution of this Agreement BUYER hereby
         confirms, that the Debentures and Warrants to be purchased by BUYER and
         the Common Stock issuable upon conversion thereof (collectively, the
         "Securities") will be acquired for investment for BUYERS own account,
         not a nominee as agent, and not with a view to the resale or
         distribution of any part thereof. By execution of this Agreement, Buyer
         further represents that Buyer does not have any contract, undertaking,
         agreement or arrangement with any person, to sell, transfer or grant
         participation to such person or to any third person, with respect to
         any of the Securities.

                  (iii)  Reliance Upon BUYER'S Representations. BUYER 
         understands that the Debentures and the Warrants are not, and any
         Common Stock acquired on conversion thereof at the time of issuance may
         not be, registered under the Securities Act on the ground that the sale
         provided for in this Agreement and the issuance of securities hereunder
         is exempt from registration under the Securities Act pursuant to
         Section 4(2) thereof and that the Company's reliance on such exemption
         is predicated on the BUYERS' representations set forth herein. Buyer
         also understands that no prospectus or offering memorandum has been
         received by Buyer or filed by the Seller with any Canadian securities
         commission or similar authority in connection with the sale of the
         Debentures and Warrants, and that no prospectus or offering memorandum
         shall be received by the Seller or so filed by Buyer in connection with
         any sale of Shares issued on the conversion of the Debentures or
         Warrants, and that as a result the Buyer will be unable to rely upon
         civil or contractual remedies that might otherwise be available to it
         if the Debentures, Warrants and/or Shares had been issued by the Seller
         by way of a prospectus or offering memorandum, respectively, and the
         prospectus or offering 

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          memorandum, as the case may be, contained a misrepresentation as that
          term is defined in the Securities Act (Ontario).

                  (iv)   Buyer is not a corporation, syndicate, partnership or
          other form of unincorporated entity or corporation created solely to
          permit the purchase of the Securities by a group of individuals who
          individual share in the aggregate acquisition cost of the Securities
          is less than $150,000 and Buyer is not purchasing the Securities as
          the result of an advertisement of the Securities, including an
          advertisement in printed media of general and regular paid
          circulation, radio or television.

                  (v)    BUYER believes BUYER has received all the information
          BUYER considers necessary or appropriate for deciding whether to
          purchase any of the Securities. BUYER further represents that BUYER
          has had an opportunity to ask questions and receive answers from the
          Company regarding the terms and conditions of the offering any of the
          Securities and the business, properties, prospects, and financial
          condition of the Company and to obtain additional information (to the
          extent the Company possessed such information or could acquire it
          without reasonable effort or expense) necessary to verify the accuracy
          of any information furnished to BUYER or to which BUYER had access.

                  (vi)   BUYER represents that BUYER is experienced in 
         evaluating and investing in private placement transactions of
         securities of companies in a similar stage of development and
         acknowledges that BUYER is able to fend for himself, herself or itself,
         can bear the economic risk of BUYER'S investment, and has such
         knowledge and experience in financial and business matters that BUYER
         is capable of evaluating the merits and risks of the investment in the
         Debentures and Warrants. If other than an individual, BUYER also
         represents BUYER has not been organized for the purpose of acquiring
         the Debentures and Warrants.

                  (vii)  The BUYER represents that BUYER is an Accredited
         Investor.

                  The term "Accredited Investor" as used herein refers to:

                  (1)      A person or entity who is a direct or executive 
                           officer of the Company;

                  (2)      Any bank as defined in Section 3(a)(2) of the
                           Securities Act, or any savings and loan association
                           or other institution as defined in section 3(a)(5)(A)
                           of the Securities Act whether acting in its
                           individual or fiduciary capacity; any broker or
                           dealer registered pursuant to Section 15 of the
                           Securities Exchange Act of 1934; any insurance
                           company as defined in Section 2(13) of the Securities
                           Act; any investment company registered under the
                           Investment Company Act of 1940 or a business
                           development company as 

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                    defined in Section 2(a(48) of that Act; any Small Business
                    Investment Company licensed by the U.S. Small Business
                    Administration under Section 301 (c) or (d) of the Small
                    Business Investment Act of 1958; any plan established and
                    maintained by a state, its political subdivisions, or any
                    agency or instrumentality of a state or its political
                    subdivisions, for the benefit of its employees, if such plan
                    has total assets in excess of $5,000,000; any employee
                    benefit plan within the meaning of Title I of the Employee
                    Retirement Income Security Act of 1974, if the investment
                    decision is made by a plan fiduciary, as defined in Section
                    3(21)of such Act, which is either a bank, savings and loan
                    association, insurance company or registered investment
                    adviser, or if the employee benefit plan has total assets in
                    excess of $5,000,000 or, if a self-directed plan, with
                    investment decisions made solely by the persons that are
                    Accredited Investors.

           (3)      Any private business development company as defined in
                    section 202(a)(22) of the Investment Advisers Act of 1940;

           (4)      Any organization described in Section 501(c)(3) of the
                    Internal Revenue Code, corporation, Massachusetts or similar
                    business trust, or partnership, not formed for the specific
                    purpose of acquiring the securities offered, with total
                    assets in excess of $5,000,000;

           (5)      Any natural person whose individual net worth, or joint net
                    worth with that person's spouse, at the time of the purchase
                    exceeds $1,000,000;

           (6)      Any natural person who had an individual income in excess of
                    $200,000 in each of the two most recent years or joint
                    income with that person's spouse in excess of $300,000 in
                    each of those years and has a reasonable expectation of
                    reaching the same income level in the current year;

           (7)      Any trust, with total assets in excess of $5,000,000, not
                    formed for the specific purpose of acquiring the securities
                    offered, whose purchase is directed by a person who has such
                    knowledge and experience in financial and business matters
                    that he or she is capable of evaluating the merits and risks
                    of the prospective investment; or

           (8)      Any entity in which all of the equity owners are Accredited
                    Investors.

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         As used in this Paragraph 3.(vii) the term "net worth" means the
         excesses of total assets over total liabilities. For the purpose of
         determining a person's net worth, the principal residence owned by an
         individual should be valued at fair market value, including the cost of
         improvements, net of current encumbrances. As used in this paragraph
         "income" means actual economic income, which may differ from adjusted
         gross income for income tax purposes. Accordingly, Buyer should
         consider whether Buyer should add any or all of the following items to
         Buyer's adjusted gross income for income tax purposes in order to
         reflect more accurately Buyer's actual economic income; any amounts
         attributable to tax-exempt income received, losses claimed as a limited
         partner in any limited partnership, deductions claimed for depletion,
         contributions an IRA or keogh retirement plan, and alimony payments.

                  (viii) BUYER understands that the Securities may not be sold,
         transferred or otherwise disposed of in the United States without
         registration under the Securities Act or an exemption therefrom, and
         that in the absence of an effective registration statement covering any
         of the Securities or an available exemption from registration under the
         Securities Act, the Securities must be held indefinitely. In
         particular, BUYER is aware that the Securities may not be sold pursuant
         to Rule 144 promulgated under the Securities Act unless all of the
         condition of that Rule are met. BUYER also understands that any resale
         of the Securities must be conducted in accordance with the applicable
         requirements of the Securities Act (Ontario).

                  (ix)   Buyer acknowledges that no person has made to Buyer any
         written or oral representations:

                  (i)    that any person will resell or repurchase the 
         Securities;

                  (ii)   that any person will refund the purchase price of the 
         Securities; and

                  (iii)  as to the future price or value of the Securities.


         3.       SELLER'S REPRESENTATIONS

                  SELLER represents and warrants as follows:

                  (i)    SELLER has not conducted any general solicitation or 
         general advertising (as defined in Regulation D) with respect to any 
         of the Securities offered hereby;

                  (ii)   The Debentures, when issued and delivered pursuant to 
         the terms of this Agreement, will have been duly authorized, executed,
         issued and delivered and will constitute valid and legally binding
         obligations of the Company in 

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          accordance with their terms, subject to (A) bankruptcy, insolvency,
          fraudulent conveyance, reorganization, moratorium and similar laws now
          or hereafter in effect relating to creditors' rights and (B) that the
          remedy of specific performance and injunctive and other forms of
          equitable relief may be subject to equitable defenses and to the
          discretion of the court before which any proceedings therefor may be
          brought and (C) to the extent that the indemnification provisions
          contained in the Registration Rights Agreement may be limited by
          applicable laws.

                  (iii) The Shares, when issued and delivered upon conversion
          of the Debentures in accordance with their terms, will be duly and
          validly authorized and issued, fully-paid and non assessable and will
          not subject the holders thereof to personal liability by reason of
          being such holders. There are no preemptive rights of any shareholder
          of SELLER with respect to the Shares contained in SELLER'S Certificate
          of Incorporation or any agreement to which SELLER is a party;

                  (iv)  This Agreement has been duly authorized, validly 
          executed and delivered on behalf of SELLER and is a valid and binding
          agreement of SELLER in accordance with its terms, subject to (A)
          bankruptcy, insolvency, fraudulent conveyance, reorganization,
          moratorium and similar laws now or hereafter in effect relating to
          creditors' rights and (B) that the remedy of specific performance and
          injunctive and other forms of equitable relief may be subject to
          equitable defenses and to the discretion of the court before which any
          proceedings therefor may be brought and (C) to the extent that the
          indemnification provisions contained in the Registration Rights
          Agreement may be limited by applicable laws.

                  (v)   The execution and delivery of this Agreement and the
          consummation of the transactions contemplated by this Agreement do not
          and will not conflict with or result in a breach by SELLER of any of
          the terms or provisions of, or constitute a default under, the
          certificate of incorporation (or charter) or by-laws of SELLER, or any
          indenture, mortgage, deed of trust or other material agreement or
          instrument to which SELLER is a party or by which it or any of its
          properties or assets are bound, or any existing applicable decree,
          judgment or order of any court, federal or state regulatory body,
          administrative agency or other governmental body having jurisdiction
          over SELLER or any of its properties or assets;

                  (vi)  No authorization, approval or consent of or filing with
          any federal, state or local governmental body of the United States is
          legally required for the issuance and sale of the Debentures and
          (provided no commission or other remuneration is paid or given
          directly or indirectly by SELLER for soliciting such conversion) the
          issuance of the Shares upon conversion of the Debentures in accordance
          with their terms, as contemplated by this Agreement, except the filing
          of a Form D with the Commission;

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                  (vii)  To the best of the Company's knowledge after reasonable
          investigation, the information contained in the Company's Annual
          Report on Form 10K for the year ended December 31, 1996, Proxy
          statement relating to the Annual Meeting of Shareholders held on June
          26, 1997 or Quarterly Report on Form 10-Q for the quarter ended June
          30, 1997, as filed with the Commission does not contain any untrue
          statement of a material fact or omit to state any material fact
          necessary in order to make the statements therein, in the light of the
          circumstance under which they are made, not misleading. Since
          September 30, 1997, there has been no material adverse development in
          the business, properties, operations, financial condition or results
          of operations of SELLER.

                  (viii) SELLER will issue one or more certificates representing
          the Debentures in the name of BUYER in such denominations (in
          multiples of $25,000) to be specified by BUYER prior to closing and
          will issue one or more certificates representing the Shares in such
          denominations to be specified by Buyer upon conversion of the
          Debentures. SELLER further warrants that the Debentures and the Shares
          shall be transferable on the books and records of SELLER as and to the
          extent provided in the Transaction Documents, subject to compliance
          with Federal and State securities laws. Nothing in this Section shall
          affect in any way BUYER'S obligations and agreement to comply with all
          applicable securities laws upon resale of the Securities.


          4.      CLOSING. Debentures and Warrants shall be delivered to BUYER 
          and the funds therefor shall be delivered to SELLER on the 22nd day of
          October, 1997 (the "Closing") or at such time to be mutually agreed in
          accordance with the following procedures.

                  SELLER shall execute the appropriate copies of the     
          Transaction Documents (the "Seller's Closing Documents") and
          deliver the executed documents to Gowling, Strathy & Henderson,
          counsel for BUYER, with instructions to hold the documents in trust
          and not to release the documents to BUYER until advised to do so by
          SELLER. BUYER shall execute the appropriate copies of the Transaction
          Documents (the "BUYER'S Closing Documents") and deliver the executed
          documents to Alston & Bird, counsel for SELLER, with instructions to
          hold the documents in trust and not to release the documents to
          SELLER until advised to do so by BUYER.

                  Immediately after BUYER has confirmed that its counsel has
          received the SELLER'S Closing Documents executed by SELLER, then BUYER
          shall pay to SELLER the principal amount of the Debentures for which
          BUYER subscribed (the "Purchase Price"). BUYER shall pay the Purchase
          Price, less all appropriate legal fees and commissions by wire
          transfer of immediately available funds in accordance with the
          following instructions:

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                  Mellon Bank, Pittsburgh, P.A.
                  ABA# 0430-0026-1
                  Credit: Merrill Lynch
                  Acct# 101-1730
                  For further credit to CytRx Corporation
                  Acct# 701-96D69

                  On the banking day that SELLER has confirmed that its counsel
         has received the BUYER'S Closing Documents and is credited with having
         received the Purchase Price (the "Closing Date"), SELLER shall advise
         BUYER. Immediately thereafter, SELLER shall advise Gowling, Strathy &
         Henderson to release the SELLER'S Closing Documents to BUYER and BUYER
         shall advise Alston & Bird to release the BUYER'S Closing Documents to
         SELLER. The Transaction Documents shall not be deemed to have been
         delivered except in accordance with the procedure described in this
         Section 4.

                  If the Closing Date does not occur before October 23, 1997,
         then either party may terminate this Agreement immediately upon written
         notice to the other party and all Transaction Documents shall be deemed
         to be null and void.


         5.       CONDITIONS TO CLOSING

                  (i)  BUYER understands that SELLER'S obligation to sell the
         Debentures and the Warrants is conditioned upon the receipt in
         immediately available funds of the amount set forth in Paragraph 1
         hereof and an opinion of counsel substantially in the form attached as
         D to and forming an integral part of this Agreement, SELLER shall have
         the right to reject any given Agreement which is tendered to SELLER,
         for the reason that SELLER reasonably believes any representations and
         warranties of BUYER to be untrue and in such event SELLER shall provide
         BUYER written notice of such rejection and the reason therefore and
         shall provide reasonable opportunity for a response to such stated
         reason. Also, SELLER may decline to accept this Agreement for any other
         reason which in the sole discretion of SELLER may materially affect
         SELLER.

                  (ii) SELLER understands that BUYER'S obligation to purchase
         the Debentures is conditioned upon delivery of certificate(s)
         representing Debentures as described in Paragraph 1(ii) hereto and
         provision of an opinion of counsel attached as Exhibit E substantially
         in the form and forming an integral part of this Agreement.


         6.       SELLER'S OPTION ADDITIONAL $2,000,000 TO BUYER AND
                  OTHER CONCURRENT BUYERS CONVERSION AND
                  WARRANT PRICE

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         SELLER shall have the option (the "Option") to require BUYER to
         purchase Four Hundred Thousand Dollars (USD $400,000) of additional
         Debentures at any time between 90 and 270 days (the "Option Period")
         after the Shelf Registration (as defined in the Rights Registration
         Agreement) has been declared effective by the Commission subject to the
         following conditions:

                  (i)   The ten day Average Closing Bid Price of the Shares 
         shall not be below $3.50 per share on (a) the day SELLER gives BUYER 
         notice of SELLER'S election to exercise this Option and (b) the day 
         before the closing of the Option;

                  (ii)  SELLER shall not be in default under any material
         borrowings from any financial institution or other persons;

                  (iii) the class of common stock into which the Debentures are
         convertible shall continue to be listed by Nasdaq; or

                  (iv)  the Company shall not have been convicted of any fraud 
         in the sale of its securities.

         The closing of the purchase of the additional Debentures will take
         place 10 business days after the day of SELLER'S notice to BUYER.

         With the exception of any further option in favour of SELLER, and the
         Conversion Price and Warrant Price and the maturity dates which will
         have to be reset, the terms and conditions in connection with the
         funding and closing of the Option will be the same as those relating to
         the initial funding of October, 1997.

         Provided however if the Black-Out Period as defined in Section 1(ii) of
         the Debenture is invoked, then the actual number of days of the
         Black-Out Period shall be added to each of the 90 and 270 days
         comprising the Option Period.

         If the Option is completed:

         "Average Closing Bid Price" for the purposes of this Section 6 means
         the average of the daily last bid price for the shares of Common Stock
         for the five (5) or ten (10), as the case may be, consecutive trading
         days on which such shares are actually traded as over-the-counter
         securities and quoted on Nasdaq National Market (as reported by
         Bloomberg Business News, or, if not reported thereby, any other
         authoritative source selected by the Company ending at the close of the
         trading on the trading day immediately preceding the measurement date.

         "Conversion Price" shall mean the lessor of (A:) one hundred ten
         percent (110%) of the five day Average Closing Bid Price, calculated
         using the closing date as the measurement date, or (B) eighty five
         percent (85%) of the ten day Average 

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          Closing Bid Price calculated using the date of conversion as the
          measurement date, provided, however, but if the holder will have
          delivered a Forbearance Request to the Company in accordance with what
          is presently Section 5(ii) of the Debenture used in the October 1997
          Closing, within twenty-four (24) hours before it will have delivered a
          conversion notice of the Company in accordance with what is presently
          Section 4.3.1 of the Debenture, then the ten day Average Closing Bid
          Price for the portion of the debenture that the Holder will have
          identified in the Forbearance Request shall be calculated using either
          the date of conversion or the date the Company actually received such
          Forbearance Request as the measurement date, whichever results in a
          lower Conversion Price.

          "Exercise Price" for per share under each Warrant shall be one hundred
          ten percent (110%) of the five day Average Closing Bid Price
          calculated as of the Closing Date of the Option. The Exercise Price
          shall be paid in cash.

          "Right of First Refusal Period" shall mean the period that begins on
          the Closing Date and ends on the earlier of (a) the closing date of
          the Option, (b) the refusal of Buyer to purchase the Debentures
          covered by the Option because Seller failed to meet the conditions set
          forth in clauses (i) to (iv) above, or (c) the end of the Option
          Period.

          The "closing date" means the closing date of the Option.

          If, during the Right of First Refusal Period, but only ninety (90)
          days after the Closing Date the Company proposes to undertake an
          issuance of any securities pursuant to Regulations D or S promulgated
          under the Securities Act (the "New Securities"), then the Company
          shall give written notice of the Company's intention to BUYER,
          describing the type of the securities, and their price and the general
          terms upon which the Company proposes to issue the same. The Debenture
          is being issued in connection with debentures on similar terms to
          Charles N. Eckert, David Kosloff, Pine Street Asset Management and
          Gundyco in trust for R.R.S.P. 550-98866-19 (collectively, the "Other
          Buyers"). Each of the BUYER and the Other Buyer who remain Accredited
          Investors ("Qualified Buyer") shall have twenty (20) days after any
          such notice is mailed or delivered to agree to purchase all of such
          New Securities for the price and upon the terms specified in the
          notice by giving written notice to the Company and stating therein the
          quantity of New Securities to be purchased. Each of the Qualified
          Buyers shall be entitled to purchase New Securities in the proportion
          of its purchase of Debentures and if one or more buyers decline, or is
          not qualified, to so purchase, then the others, as the case may be,
          shall be entitled to purchase the New Securities not taken by the
          Qualified Buyer(s), as the case may be within the original twenty (20)
          day period.

          "New Securities" does not include (i) securities issued pursuant to
          the acquisition of another business entity or segment of any such
          entity by the Company by merger, asset purchase, stock purchase or
          otherwise, (ii) any borrowings, direct or

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          indirect, from financial institutions or other persons by the Company,
          whether or not presently authorized, including any type of loan or
          payment evidenced by any type of debt instrument, provided such
          borrowings do not have any equity features including warrants, options
          or other rights to purchase capital stock and are not convertible into
          capital stock of the Company, (iii) securities issued to employees,
          consultants, officers or directors of the Company pursuant to any
          stock option, stock purchase or stock bonus plan, agreement or
          arrangement, (iv) securities issued to vendors or customers or to
          other persons in similar commercial situations with the Company, (v)
          securities issued in connection with obtaining lease financing,
          whether issued to a lessor, guarantor or other person, (vi) securities
          issued in connection with any stock split, stock dividend or
          recapitalization of the Company, or (vi) securities issued in
          connection with corporate partnering transactions.

          If the Qualified Buyers fail to exercise fully the right of first
          refusal within the prescribed twenty (20) day period, then the Company
          shall have one hundred twenty (120) days thereafter to sell or enter
          into an agreement to sell the New Securities, at a price and on terms
          no more favourable to the purchasers thereof than specified in the
          notice to the Qualified Buyers. If the Company has not sold or entered
          into an agreement to sell the New Securities in accordance with the
          foregoing within the one hundred twenty (120) day period, then the
          Company shall not thereafter issue or sell any New Securities, without
          first again offering such securities to the Qualified Buyers in
          accordance with this Section 6.


          7.       GOVERNING LAW; INTERPRETATION AND DISPUTES.
          This Agreement shall be governed by and construed under the laws of
          the State of Delaware and the laws applicable therein without regard
          to its choice of law principles.


          8.       ARBITRATION
          All disputes arising under this Agreement (other than claims in
          equity) shall be resolved by arbitration in accordance with the
          Commercial Arbitration Rules of the American Arbitration Association.
          Arbitration shall be by a single arbitrator experienced in the matters
          at issue and selected by the SELLER and BUYER in accordance with the
          Commercial Arbitration Rules of the American Arbitration Association.
          The arbitration shall be held in such place in New York, New York, as
          may be specified by the arbitrator (or any place agreed to by SELLER,
          BUYER and the arbitrator). The decision of the arbitrator shall be
          final and binding as to any matters submitted under this Agreement,
          provided, however, if necessary, such decision and satisfaction
          procedure may be enforced by either SELLER or BUYER in any court of
          record having jurisdiction over the subject matter or over any of the
          parties to this Agreement. All costs and expenses incurred in
          connection with any such arbitration proceeding (including reasonable
          attorneys fees) shall be borne by 

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          the party against which the decision is rendered, or, if no decision
          is rendered, such costs and expenses shall be home equally by SELLER
          as one party and BUYER as the other party. If the arbitrator's
          decision is a compromise, the determination of which party or parties
          bears the costs and expenses incurred in connection with any such
          arbitration proceeding shall be made by the arbitrator on the basis of
          the arbitrator's assessment of the relative merits of the parties'
          positions.


          9.      CONFIDENTIALITY.
          The parties hereto agree to maintain the confidentiality of this
          Agreement and not to disclose to any person or entity information
          concerning the transaction contemplated hereby unless required by law
          to do so.


          10.     ENTIRE AGREEMENT.
          This Agreement constitutes the entire agreement among the parties
          hereof with respect to the subject matter hereof and supersedes any
          and all prior or contemporaneous representations, warranties,
          agreements and understandings in connection therewith. This Agreement
          may be amended only by a writing executed by all parties hereto. This
          Agreement may be executed in counterparts and the facsimile
          transmission of an executed counterpart to this Agreement shall be
          effective as an original.

          [Signatures begin on next page]


          11.     FULL NAME AND ADDRESS OF BUYER FOR REGISTRATION
                  PURPOSES:

          NAME:             Excalibur Limited Partnership

          ADDRESS:          c/o H&H Securities Limited

                            205 Vesta Drive

                            Toronto, Ontario M5P 3AI

          Tel. No.          (416) 964-9077

          Fax. No.          (416) 964-8868

          Contact Name:     William S. Hechter


          12.     DELIVERY INSTRUCTIONS: (IF DIFFERENT FROM REGISTRATION NAME):

                                      -12-

   13


         NAME:             
                                -----------------------------

         ADDRESS:          
                                -----------------------------

                                -----------------------------

                                -----------------------------

         Tel.  No.                  
                                -----------------------------
         Fax.  No.                 
                                -----------------------------
         Contact Name:    
                                -----------------------------
         Special Instructions:  
                                -----------------------------

                                -----------------------------

                                -----------------------------

                                      -13-

   14



         IN WITNESS WHEREOF, this Agreement was duly executed or the date first
         written below.


Dated this 21st day of the month of October, 1997.


Company Name:         Excalibur Limited Partnership.
                      by its General Partner,
                      Excalibur Capital Management Inc.


By:                      
                      -------------------------------
                      William S. Hechter

Title:                President

Country of Execution: Canada


                                CYTRX CORPORATION

                        By: 
                           ----------------------------------

     I have the full authority to bind CYTRX CORPORATION _________ (initial)

Name:    Jack J. Luchese

Title:   President