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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                    FORM 10-K/A

(Mark One)
[X]      ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES
         EXCHANGE ACT OF 1934. For the fiscal year ended December 31, 1998.

                                       or

[ ]      TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES
         EXCHANGE ACT OF 1934. 
         For the transition period from ____________ to ____________.

                         Commission File Number: 0-22179

                                  SPECTRX, INC.
             (Exact name of registrant as specified in its charter)

                     Delaware                             58-2029543
         (State or other jurisdiction of               (I.R.S. employer
         incorporation or organization)                identification no.)

         6025A Unity Drive, Norcross, GA                     30071
         (Address of principal executive offices)          (Zip code)

       Registrant's telephone number, including area code: (770) 242-8723
        Securities registered pursuant to Section 12(b) of the Act: None
           Securities registered pursuant to Section 12(g) of the Act:
                         Common Stock, $0.001 par value
                                (Title of class)

         Indicate by check mark whether the Registrant: (1) has filed all
reports required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period that the
Registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days. Yes X No

         Indicate by check mark if disclosures of delinquent filers pursuant to
Item 405 of Regulation S-K is not contained herein, and will not be contained,
to the best of Registrant's knowledge, in definitive proxy or information
statements incorporated by reference in part III of this Form 10-K or any
amendment to this Form 10-K. [X]

         The aggregate market value of the voting stock held by non-affiliates
of the Registrant was approximately $41.1 million as of February 28, 1999, based
upon the average of the high and low prices of the Registrant's Common Stock
reported for such date by the Nasdaq National Market. Shares of Common Stock
held by each executive officer and director and by each person who owns 5% or
more of the outstanding Common Stock have been excluded in that such persons may
be deemed to be affiliates. The determination of affiliate status is not
necessarily a conclusive determination for other purposes.

         As of February 28, 1999, the Registrant had outstanding 8,014,080
shares of Common Stock.

                      DOCUMENTS INCORPORATED BY REFERENCE.

         Parts of the following documents are incorporated by reference in Part
III of this Form 10-K Report: Proxy Statement for Registrant's 1999 Annual
Meeting of Shareholders -- Items 10, 11, 12 and 13.


                           DESCRIPTION OF AMENDMENT.

         This Annual Report on Form 10-K/A is filed solely for the purpose of 
filing Exhibits 10.19B and 10.24, for which certain pages were unintentionally
omitted from the Annual Report on Form 10-K filed on March 31, 1999. 
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                                  EXHIBIT INDEX




       EXHIBIT
          NO.                              DESCRIPTION
       ---------    -------------------------------------------------------------
                 
          3.1(2)    Certificate of Incorporation of the Company, as amended, as
                    currently in effect.

          3.2(1)    Bylaws of the Company.

          4.1(1)    Specimen Common Stock Certificate.

         10.1(1)    1997 Employee Stock Purchase Plan and form of agreement
                    thereunder.

         10.2(1)    1995 Stock Plan, as amended, and form of Stock Option
                    Agreement thereunder.

         10.3(1)    Stock Purchase Agreement, dated June 30, 1994, between Mark A.
                    Samuels and the Company.

         10.4(1)    Stock Purchase Agreement, dated June 30, 1994, between Keith
                    D. Ignotz and the Company.

         10.5(1)    Assignment and Bill of Sale, dated February 29, 1996, between
                    Laser Atlanta Optics, Inc. and the Company.

         10.6(1)    Security Agreement, dated October 31, 1996, between Mark A.
                    Samuels and the Company.

         10.7(1)    Security Agreement, dated October 31, 1996, between Keith D.
                    Ignotz and the Company.

       10.11A(1)*   License Agreement, dated May 7, 1991, between Georgia Tech
                    Research Corporation and Laser Atlanta Optics, Inc.

       10.11B(1)    Agreement for Purchase and Sale of Technology, Sale, dated
                    January 16, 1993, between Laser Atlanta Optics, Inc. and the
                    Company.

       10.11C(1)    First Amendment to License Agreement, dated October 19, 1993,
                    between Georgia Tech Research Corporation and the Company.

        10.12(1)    Clinical Research Study Agreement, dated July 22, 1993,
                    between Emory University and the Company.

       10.13A(1)*   Development and License Agreement, dated December 2, 1994,
                    between Boehringer Mannheim Corporation and the Company.

       10.13B(1)*   Supply Agreement, dated January 5, 1996, between Boehringer
                    Mannheim and the Company.

        10.14(1)    Sponsored Research Agreement, No. SR95-006, dated May 3, 1995,
                    between University of Texas, M.D. Anderson Cancer Center and
                    the Company.

        10.15(1)    Sole Commercial Patent License Agreement, dated May 4, 1995,
                    between Martin Marietta Energy Systems, Inc. and the Company.

       10.16A(1)    License Agreement, dated November 22, 1995, between Joseph R.
                    Lakowicz, Ph.D. and the Company.

       10.16B(1)    Amendment of License Agreement, dated November 28, 1995,
                    between Joseph R. Lakowicz, Ph.D. and the Company.

       10.16C(1)    Second Amendment to License Agreement, dated March 26, 1997,
                    between Joseph R. Lakowicz, Ph.D. and the Company.

       10.16D(4)    Third Amendment to License Agreement, dated November 20, 1998, 
                    between Joseph R. Lokawicz, Ph.D. and the Company.

     10.16E**(4)    Fourth Amendment to License Agreement, dated November 20, 
                    1998, between Joseph R. Lakowicz, Ph.D. and the Company. 


        10.17(1)    License and Joint Development Agreement, dated March 1, 1996,
                    between NonInvasive-Monitoring Company, Inc., Altea
                    Technologies, Inc. and the Company.

        10.18(1)*   Patent License Agreement, dated March 12, 1996, between the
                    Board of Regents of the University of Texas System, M.D.
                    Anderson and the Company.

       10.19A(1)*   Purchasing and Licensing Agreement, dated June 19, 1996,
                    between Respironics and the Company.

     10.19B**(+)    Amendment to Purchasing and Licensing Agreement, dated 
                    October 21, 1998 between Respironics and the Company.

        10.20(1)    Research Services Agreement, dated September 3, 1996, between
                    Sisters of Providence in Oregon doing business as the Oregon
                    Medical Laser Center, Providence St. Vincent Medical Center
                    and the Company.

       10.21A(1)*   Research and Development and License Agreement, dated October
                    10, 1996, between Abbott Laboratories and the Company.

       10.21B(3)*   Letter Agreement, dated December 22, 1997, between Abbott
                    Laboratories and the Company.

       10.22A(1)    Lease, dated September 21, 1993, between National Life
                    Insurance Company d/b/a Plaza 85 Business Park and the
                    Company, together with amendments 1, 2 and 3 thereto and
                    Tenant Estoppel Certificate, dated September 20, 1994.

      10.24**(+)    Development and Commercialization Agreement, dated December 
                    31, 1998, between Welch Allyn, Inc. and the Company

         11.1(4)    Calculation of earnings per share.

         21.1(4)    Subsidiaries of the Registrant.



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           23.1(4)  Consent of independent accountants.

           24.1     Power of Attorney (included at signature page.)
 
           27.1(4)  Financial Data Schedule. (for SEC use only)



- ------------
*     Confidential treatment granted for portions of these agreements.
**    Confidential treatment requested for portions of these agreements.
(1)   Incorporated by reference to the exhibit filed with the Registrant's
      Registration Statement on Form S-1 (No. 333-22429) filed February 27,
      1997, and amended on April 24, 1997, June 11, 1997, and June 30, 1997,
      which Registration Statement became effective June 30, 1997.
(2)   Incorporated by reference to the exhibit filed with the Registrant's
      Quarterly Report on Form 10-Q for the quarter ended June 30, 1997 filed
      August 12, 1997.
(3)   Incorporated by reference to the exhibit filed with the Registrant's
      Annual Report on Form 10-K for the year ended December 31, 1997 filed
      March 26, 1998.
(4)   Incorporated by reference to the exhibit filed with the Registrant's
      Annual Report on Form 10-K for the year ended December 31, 1998 filed
      March 31, 1998.
(+)   To be filed herewithin.
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                                   SIGNATURES

         Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, the Registrant has duly caused this report to be signed on
its behalf by the undersigned, thereunto duly authorized, in the City of
Norcross, State of Georgia, on the 8th day of April 1999.

                                             SPECTRX, INC.


                                             By:  /s/ MARK A. SAMUELS
                                                  -----------------------------
                                                  Mark A. Samuels
                                                  Chairman and Chief Executive 
                                                  Officer

         KNOW ALL MEN AND WOMEN BY THESE PRESENTS, that each person whose
signature appears below constitutes and appoints Mark A. Samuels and Thomas H.
Muller, Jr., jointly and severally, his or her attorneys-in-fact, and each with
the power of substitution, for him or her in any and all capacities, to sign any
amendments to this Annual Report on Form 10-K, and to file the same, with
exhibits thereto and other documents in connection therewith, with the
Securities and Exchange Commission, hereby ratifying and confirming all that
each of said attorneys-in-fact, or his or her substitute or substitutes, may do
or cause to be done by virtue thereof.

         Pursuant to the requirements of the Securities Exchange Act of 1934,
this Report has been signed below by the following persons on behalf of the
Registrant and in the capacities and on the dates indicated.





                SIGNATURE                                         TITLE                                  DATE
- ------------------------------------------ ---------------------------------------------------- -----------------------
                                                                                          

           /s/ MARK A. SAMUELS             Chairman,  Chief Executive Officer and Director          April 8, 1999
- ---------------------------------------    (Principal Executive Officer)
             Mark A. Samuels

        /s/ THOMAS H. MULLER, JR.          Executive Vice President and Chief Financial             April 8, 1999
- ---------------------------------------    Officer (Principal Financial and Accounting
          Thomas H. Muller, Jr.            Officer)

           /s/ KEITH D. IGNOTZ             President, Chief Operating Officer and Director          April 8, 1999
- ---------------------------------------
             Keith D. Ignotz

          /s/ CHARLES G. HADLEY            Director                                                 April 8, 1999
- ---------------------------------------
            Charles G. Hadley

           /s/ EARL R. LEWIS               Director                                                 April 8, 1999
- ---------------------------------------
             Earl R. Lewis