Exhibit 8

December 26, 2000


Empyrean Bioscience, Inc.
23800 Commerce Park Road
Suite A
Cleveland, Ohio   44122


Ladies and Gentlemen:

     We  have  acted  as  counsel  to  Empyrean  Bioscience,   Inc.,  a  Wyoming
corporation  ("Empyrean  Wyoming")  and  Empyrean  Bioscience,  Inc., a Delaware
corporation ("Empyrean Delaware"),  in connection with the Agreement and Plan of
Merger dated as of December __, 2000,  (the  "Agreement")  by and among Empyrean
Delaware and Empyrean Wyoming. Pursuant to the Agreement,  Empyrean Wyoming will
merge with and into Empyrean  Delaware (the  "Merger"),  with Empyrean  Delaware
surviving the Merger.

     Except as otherwise provided, capitalized terms referred to herein have the
meanings set forth in the Agreement.  All section  references,  unless otherwise
indicated, are to the Internal Revenue Code of 1986, as amended (the "Code").

FACTUAL BASIS FOR OPINION

     For the purpose of rendering this opinion, we have examined and are relying
upon  (without  any  independent  investigation  or review  thereof)  the truth,
accuracy  and  completeness,  at all  relevant  times,  of  the  certifications,
representations,   statements,   and  warranties   contained  in  the  following
documents:

     1. The Agreement;

     2.  Certifications and  representations  made to us by Empyrean Wyoming and
Empyrean  Delaware  in a  certificate  reproduced  as Exhibit A hereto (the "Tax
Certificate"); and

     3.  Empyrean  Wyoming's  Form S-4  Registration  Statement  filed  with the
Securities  and  Exchange  Commission  in  connection  with the  Agreement  (the
"Registration Statement").

     The  foregoing   documents  shall   collectively  be  referred  to  as  the
"Documents" in this letter.

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ASSUMPTIONS

     In connection  with  rendering this opinion,  we have assumed  (without any
independent investigation) that:

     1. Original  documents  (including  signatures)  are  authentic,  documents
submitted to us as copies  conform to, and are true and complete  copies of, the
original  documents,  and there has been or will be by the Effective Time of the
Merger due  execution  and delivery of all  documents  where due  execution  and
delivery are prerequisites to the effectiveness thereof.

     2. Any  certification,  representation,  or statement made in the Documents
"to the knowledge of," "to the best of the  knowledge,"  or otherwise  similarly
qualified is correct  without such  qualification.  As to all matters in which a
person or entity  making a  certification,  representation,  or statement in the
Documents  has  certified,  represented,  or stated  that such  person or entity
either  is not a party  to,  does  not  have,  or is not  aware  of,  any  plan,
intention, understanding or agreement, there is in fact no such plan, intention,
understanding or agreement.  As to any matter in which a person or entity making
a  certification,  representation,  or statement in the Documents has certified,
represented, or stated that such certification,  representation, or statement is
true and accurate in all "material aspects," such certification, representation,
or  statement  is true and  accurate  in all  respects  insofar as it relates to
issues associated with the federal income tax consequences of the Merger.

     3. All certifications,  representations,  or statements contained in any of
the  Documents or otherwise  made to us are true and correct in all respects and
will  continue  to be  true  and  correct  in all  material  respects  as of the
Effective Time of the Merger and all other relevant  times,  and no actions have
been  or  will  be  taken  which  are  inconsistent  with  such  certifications,
representations, or statements.

     4. Each entity that is a party to the Documents has been duly  organized or
formed and is validly  existing and in good standing as a corporation or similar
organization under the laws of its jurisdiction of organization and is qualified
to do  business  and is in good  standing  as a  foreign  corporation  or  other
organization  in  each  jurisdiction  where  by  law  it  is  required  to be so
qualified.

     5. All of the Documents have been duly  authorized,  executed and delivered
by each party thereto, constitute a valid and binding obligation upon each party
thereto, and are enforceable against each party thereto in accordance with their
terms. Each party has the requisite corporate or other  organizational power and
authority to perform such party's obligations under the Documents, and each such
party  has  performed  and will  perform  such  party's  obligations  under  the
Documents.

     6. The Merger will be reported by Empyrean Wyoming and Empyrean Delaware on
the federal income tax return which will be filed for such companies in a manner
consistent with the opinion set forth below.

     7. The Merger will be  consummated  in accordance  with the Agreement  (and
without any waiver,  breach or amendment of any of the  provisions  thereof) and
will be effective under applicable state laws.

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     8. No transactions have occurred or will occur following the Effective Time
othe Merger that would cause the continuity of interest requirement as specified
in Treasury Regulations Section 1.368-1(e) to be violated.

OPINION

     Based on our  examination of the Documents and subject to the  assumptions,
exceptions,  limitations,  and  qualifications  set forth herein,  we are of the
opinion that if the Merger is consummated in accordance  with the Agreement (and
without any waiver,  breach, or amendment of any of the provisions  thereof) and
if the  certifications,  representations  and  warranties  set  forth in the Tax
Certificate  and the  Registration  Statement  are true and correct,  then,  for
United States federal income tax purposes:

     1. The Merger  will  qualify as a  "reorganization"  within the  meaning of
S368(a) of the Code.

     2. No gain or loss will be recognized by holders of Empyrean Wyoming common
stock upon the surrender of their shares of Empyrean Wyoming common stock solely
in exchange for shares of Empyrean Delaware common stock.

     3. Each  shareholder's  aggregate tax basis in the Empyrean Delaware common
stock received in the Merger will equal such  shareholder's  aggregate tax basis
in the Empyrean Wyoming common stock surrendered in exchange therefor.

     4. The holding period of the Empyrean Delaware common stock received in the
Merger by each  shareholder of Empyrean  Wyoming will include the holding period
of the Empyrean Wyoming common stock surrendered in exchange therefor,  provided
that the Empyrean Wyoming common stock was held by such shareholder as a capital
asset at the Effective Time of the Merger.

     5. Empyrean  Wyoming  should not recognize  gain or loss for federal income
tax purposes as a result of the Merger and Empyrean  Delaware  should succeed to
the federal  income tax  attributes  of Empyrean  Wyoming  enumerated in Section
381(c).

EXCEPTIONS, LIMITATIONS AND QUALIFICATIONS

     In addition to the assumptions set forth above,  this opinion is subject to
the exceptions, limitations, and qualifications set forth below.

     1. This opinion  represents  and is based upon our best judgment  regarding
the application of current federal income tax laws (including the Code, existing
judicial  decisions,  administrative  regulations,  and  published  rulings  and
procedures). Our opinion is not binding upon the Internal Revenue Service or the
courts,  and there is no assurance  that the Internal  Revenue  Service will not
successfully assert a contrary position.  Furthermore, no assurance can be given
that  future  legislative,  judicial,  or  administrative  changes,  on either a
prospective or retroactive basis, would not adversely affect the accuracy of the

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conclusions  stated  herein.  Nevertheless,  we undertake no  responsibility  to
advise you of any new  developments in the application or the federal income tax
laws.

     2.  This  opinion  addresses  only the  classification  of the  Merger as a
reorganization  under  Section  368(a) of the Code and the  consequences  of the
Merger as described  above, and does not address any other federal or any state,
local, or foreign tax consequences  that may result from the Merger or any other
transaction  (including  any  transaction  undertaken  in  connection  with  the
Merger).

     3. Insofar as the opinion  relates to the federal  income tax  consequences
associated  with the  classification  of the  Merger as a  reorganization  under
Sections  368(a)  of the Code  (Items 2 through 4 of the  opinion  above),  such
consequences are those generally applicable to Empyrean Wyoming shareholders who
do not exercise their dissenters'  rights.  The opinion does not address the tax
consequences to specific  categories of shareholders  accorded special treatment
under the Code including,  without  limitation,  shareholders who acquired their
shares of Empyrean Wyoming common stock upon the exercise of stock options or in
other  compensatory  transfers,   foreign  persons,   tax-exempt  organizations,
insurance  companies,   financial   institutions,   and  dealers  in  stock  and
securities.

     4. No opinion is expressed as to any  transaction  other than the Merger as
described  in the  Agreement or to any  transaction  whatsoever,  including  the
Merger,  if all the transactions  described in the Agreement are not consummated
in  accordance  with the  terms  of the  Agreement  without  waiver,  breach  or
amendment  of  any  provision  thereof,   or  if  all  of  the   certifications,
representations, warranties, statements and assumptions upon which we relied are
not true  and  accurate  at all  relevant  times.  In the  event  any one of the
certifications,  representations,  warranties,  statements,  or assumptions upon
which we have relied to issue this  opinion is  incorrect  our opinion  might be
adversely affected and may not be relied upon.

     5.  This  opinion  is only for the  benefit  of  Empyrean  Wyoming  and the
shareholders of Empyrean Wyoming who do not exercise their dissenters' rights in
connection with the Merger, and may not be relied upon by any other person, firm
or entity for any purpose without our express written consent.

     We hereby  consent  to the  filing of this  opinion  as an  exhibit  to the
Registration  Statement  on  Form  S-4  (SEC  File  No.  333-84147),   including
amendments thereto, and to the use of our name in the prospectus included in the
Registration Statement under the caption "Legal Matters" and to the reference to
our opinion  elsewhere in the  Registration  Statement.  Other than as specified
above,  this letter may not be paraphrased,  quoted,  summarized,  duplicated or
reproduced in whole or in part.

                                      Yours very truly,


                                      /s/ BENESCH, FRIEDLANDER,
                                          COPLAN & ARONOFF LLP

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