AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JANUARY 19, 1999
                                                           Registration No. 333-
================================================================================
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                           --------------------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                           --------------------------

                                 CONSYGEN, INC.
             (Exact Name of Registrant as Specified in its Charter)

           TEXAS                                                76-0260145
(State or Other Jurisdiction of                              (I.R.S. Employer
Incorporation or Organization)                            Identification Number)


               125 S. 52ND STREET, TEMPE, AZ, 85281 (602) 394-9100
          (Address, Including Zip Code, and Telephone Number, Including
             Area Code, of Registrant's Principal Executive Offices)
                           --------------------------

CONSYGEN, INC. SECOND AMENDED AND RESTATED 1997 NON-QUALIFIED STOCK OPTION PLAN
                              (Full title of Plans)
                           --------------------------

                                THOMAS S. DREAPER
                      PRESIDENT AND CHIEF EXECUTIVE OFFICER
               125 SOUTH 52ND STREET TEMPE, AZ 85281(602) 394-9100
                      (Name, Address and Telephone Number,
                   Including Area Code, of Agent for Service)

                                 WITH A COPY TO:

                             STEPHEN T. MEADOW, ESQ.
                           CRUSE, FIRETAG & BOCK, P.C.
                        5611 NORTH 16TH STREET, SUITE 300
                             PHOENIX, ARIZONA 85016
                                 (602) 279-9411
                           --------------------------


                         CALCULATION OF REGISTRATION FEE
================================================================================
Title of Each                     Proposed           Proposed
  Class of          Amount         Maximum           Maximum          Amount of
Securities to       to Be       Offering Price       Aggregate      Registration
Be Registered     Registered      Per Share(1)    Offering Price(1)      Fee
- --------------------------------------------------------------------------------
Common Stock,       1,500,000
 $.003 par value    Shares(2)       $1.09           $1,635,000         $454.53
================================================================================
(1)  Estimated  solely for purposes of calculating the registration fee pursuant
     to Rule  457(c)  under  the  Securities  Act of 1933,  on the  basis of the
     average of the high and low reported  price of the Common Stock of $1.09 on
     the Nasdaq Stock Market's SmallCap Market on January 14, 1999.
(2)  The Shares being registered  hereunder include 1,500,000 shares that may be
     issued  pursuant to the  ConSyGen,  Inc.  1997 Second  Amended and Restated
     Non-Qualified  Stock Option Plan. Such presently  indeterminable  number of
     additional  shares of Common Stock are also registered  hereunder as may be
     issued   in  the  event  of  a   merger,   consolidation,   reorganization,
     recapitalization,  stock  dividend,  stock split or other similar change in
     Common Stock.
================================================================================

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.

         The following  documents are hereby incorporated by reference into this
Registration Statement:

          (a)  The  Registrant's  Annual Report on Form 10-K for the fiscal year
               ended May 31, 1998 filed  pursuant  to Section  13(a) or 15(d) of
               the  Securities  Exchange Act of 1934, as amended (the  "Exchange
               Act");

          (b)  The Registrant's  quarterly reports on Form 10-Q for the quarters
               ended  August 31, 1998 and  November  30, 1998 filed  pursuant to
               Section 13(a) or 15(d) of the Exchange Act; and

          (c)  The  Registrant's  current  report on Form 8-K dated December 30,
               1998.

          (d)  The description of the Registrant's Common Stock contained in the
               Registrant's  Registration  Statement  on Form 8-A, as amended by
               Amendment No. 1 thereto  (Registration No. 0-17598),  filed under
               the Exchange Act with the Securities and Exchange Commission.

         All  documents  filed by the  Registrant  pursuant to  Sections  13(a),
13(c),  14 and 15(d) of the Exchange Act subsequent to the date hereof and prior
to the filing of a post-effective  amendment which indicates that all securities
offered have been sold or which deregisters all securities then remaining unsold
shall be deemed to be incorporated by reference in this  Registration  Statement
and to be a part hereof from the date of filing of such documents.

ITEM 4. DESCRIPTION OF SECURITIES.

         Not Applicable.

ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL.

         Not Applicable.

ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         The Registrant's  Articles of  Incorporation,  as amended (the "Amended
Articles"),  eliminate, subject to certain exceptions, the personal liability of
directors  to the  Registrant  or its  stockholders  for  monetary  damages  for
breaches of fiduciary  duties as directors to the extent permitted by state law.
The Amended  Articles do not provide for the  elimination  of, or any limitation
on, the personal liability of a director (i) for a breach of the director's duty
of loyalty,  (ii)  engaged in a  transaction  from which he receives an improper

benefit,  (iii) for  intentional  misconduct  or knowing  violation of law, (iv)
found not to have  acted in good  faith,  (v)  engaged  in an act  related to an
unlawful  stock  repurchase  or payment of dividend or (vi) where  liability  is
prescribed  by law.  These  provisions  of the  Amended  Articles  may limit the
remedies  available to a stockholder  in the event of breaches of any director's
duties to such stockholder or the Registrant.

         The  Registrant's  Amended and Restated  Bylaws (the "Amended  Bylaws")
include  provisions for mandatory  indemnification of its officers and directors
to the  maximum  extent  provided  under  the  Texas  Business  Corporation  Act
("TBCA").  To the extent  permitted  under the TBCA,  the Amended Bylaws provide
that no officer or director  shall be liable to the Company for any action taken
or  omitted  to be taken by him as a  director  or  officer  if such  person (i)
exercised  the same  degree  of care and skill as a prudent  person  would  have
exercised  under  similar  circumstances  or (ii) took or  omitted  to take such
action in reliance  upon  advice of counsel  for the Company or upon  statements
made or information furnished by directors,  officers,  employees,  or agents of
the Company, which he had no reasonable grounds to disbelieve.  In addition, the
Amended  Bylaws provide that directors and officers shall be paid or reimbursed,
to the fullest extent provided under the TBCA, for reasonable  expenses incurred
by such director or officer in connection with certain  proceedings,  in advance
of the final disposition of such proceeding.

         Article 2.02-1 of the TBCA generally permits a corporation to indemnify
a person who was, is, or is threatened to be a named  defendant or respondent in
a  proceeding  because  the  person  was or is a  director  or  officer if it is
determined that such person (1) conducted  himself in good faith; (2) reasonably
believed  (a) in the case of conduct in his  official  capacity as a director or
officer of the  corporation,  that his  conduct  was in the  corporation's  best
interests, or (b) in the case of other situations, that his conduct was at least
not  opposed to the  corporation's  best  interests;  and (3) in the case of any
criminal  proceeding,  had no  reasonable  cause  to  believe  his  conduct  was
unlawful.  In addition,  the TBCA requires a corporation to indemnify a director
or officer for any action that such director or officer successfully defended on
the merits.

         The Registrant has entered into indemnification agreements with each of
its directors  and officers.  The  indemnification  agreements  provide that the
Registrant  will pay  certain  amounts  incurred  by a  director  or  officer in
connection  with any civil or criminal  action or  proceeding  and  specifically
including actions by or in the name of the Registrant  (derivative  suits) where
the  individual's  involvement  is by  reason  of the  fact  that he is or was a
director or officer.  Such amounts  include,  to the maximum extent permitted by
law, attorney's fees, judgments, civil or criminal fines, settlement amounts and
other expenses customarily included in connection with legal proceedings.  Under
the  indemnification   agreements,  a  director  or  officer  will  not  receive
indemnification if he is found not to have acted in good faith in the reasonable
belief that his action was in the best interests of the Registrant.

         The  Registrant  has  also  purchased  and  maintains   director's  and
officer's liability insurance for each of its officers and directors.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933,  as amended (the  "Securities  Act") may be permitted to directors,
officers or controlling  persons of the Registrant  pursuant to the Registrant's
By-Laws,  or otherwise,  the Registrant has been informed that in the opinion of
the Commission such indemnification is against public policy as expressed in the
Securities Act and is therefore unenforceable.

ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.

         Not Applicable.

ITEM 8. EXHIBITS.

Number                              Description
- ------                              -----------
4.1*   Specimen  Common  Stock   Certificate   (Filed  as  Exhibit  4.B  to  the
       Registrant's Registration Statement on Form S-8 (File No. 33-22900-FW)).

4.2*   Articles of Incorporation of the Registrant, as amended (Filed as Exhibit
       3.1 to the  Registrant's  Quarterly  Report on Form 10-Q for the  quarter
       ended August 31, 1997).

4.3*   Amended and Restated  By-Laws of the Registrant  (Filed as Exhibit 3.2 to
       the  Registrant's  Quarterly  Report on Form 10-Q for the  quarter  ended
       March 31, 1998).

4.4*   Subscription  Agreement  used in  connection  with  the  Rule 506 sale of
       Convertible  Debentures in the aggregate  principal  amount of $3,500,000
       (including form of Convertible  Debenture,  form of warrant,  and form of
       Registration   Rights   Agreement,   attached  as  Exhibits  A,B  and  D,
       respectively,  to the Subscription  Agreement).  (Filed as Exhibit 4.3 to
       the  Registrant's  Annual  Report on Form 10-K for the year ended May 31,
       1998).

4.5*   Agreement  dated as of July 17, 1998  between the  Registrant  and Tom S.
       Dreaper relating to employment and grant of options to purchase 1,000,000
       shares of common stock of the  Registrant.  (Filed as Exhibit 4.12 to the
       Registrant's Annual Report on Form 10-K for the year ended May 31, 1998).

4.6*   ConSyGen,  Inc.  Second  Amended and Restated  1997  Non-Qualified  Stock
       Option Plan. (Filed as Exhibit 10.8 to the Registrant's  Quarterly Report
       on Form 10-Q for the quarter ended August 31,  1998).

5      Legal Opinion of Cruse, Firetag & Bock, P.C.

23.1   Consent of Cruse,  Firetag & Bock, P.C. (contained in their opinion filed
       as Exhibit 5).

23.2   Consent of Wolinetz, Gottlieb & Lafazan, P.C.

24     Power of Attorney  (included on the Signature  Page of this  Registration
       Statement).
- ----------
*    Not filed herewith. In accordance with Rule 411 promulgated pursuant to the
     Securities Act,  reference is made to the documents  previously  filed with
     the Commission, which are incorporated by reference herein.

ITEM 9. UNDERTAKINGS.

(a)  The undersigned Registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this Registration Statement:

               (i) To include any prospectus required by Section 10(a)(3) of the
Securities Act;

               (ii) To reflect  in the  prospectus  any facts or events  arising
after the  effective  date of the  Registration  Statement  (or the most  recent
post-effective  amendment  thereof)  which,  individually  or in the  aggregate,
represent a fundamental  change in the information set forth in the Registration
Statement;

                (iii) To include any  material  information  with respect to the
plan of distribution not previously  disclosed in the Registration  Statement or
any material change to such information in this Registration Statement;

                Provided,  however,  that paragraphs (a)(1)(i) and (a)(1)(ii) do
not  apply  if the  information  required  to be  included  in a  post-effective
amendment by those  paragraphs  is contained  in periodic  reports  filed by the
Registrant  pursuant to Section 13 or Section 15(d) of the  Securities  Exchange
Act that are incorporated by reference in this Registration Statement.

         (2) That,  for the  purpose  of  determining  any  liability  under the
Securities  Act,  each  post-effective  amendment  shall be  deemed  to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities  at the time shall be deemed to be the initial bona
fide offering thereof.

         (3) To remove from registration by means of a post-effective  amendment
any of the securities being registered which remain unsold at the termination of
the offering.

(b)  The  undersigned   Registrant  hereby  undertakes  that,  for  purposes  of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
Registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Securities  Exchange Act that is incorporated  by reference in the  Registration
Statement  shall be deemed to be a new  registration  statement  relating to the
securities  offered  therein,  and the offering of such  securities at that time
shall be deemed to be the initial BONA FIDE offering thereof.

(c)  Insofar as indemnification for liabilities arising under the Securities Act
may  be  permitted  to  directors,  officers  and  controlling  persons  of  the
Registrant  pursuant to the  Registrant's  Amended  Articles  of  Incorporation,
Amended and Restated By-Laws, or otherwise, the Registrant has been advised that
in the opinion of the Securities and Exchange Commission such indemnification is
against  public  policy as expressed in the  Securities  Act and is,  therefore,
unenforceable.  In the  event  that a claim  for  indemnification  against  such
liabilities  (other than the payment by the  Registrant of expenses  incurred or
paid by a  director,  officer or  controlling  person of the  Registrant  in the
successful  defense of any  action,  suit or  proceeding)  is  asserted  by such
director,  officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as  expressed  in the  Securities  Act and will be  governed by the final
adjudication of such issue.

                                   SIGNATURES

        The  Registrant.  Pursuant to the  requirements of the Securities Act of
1933, as amended,  the Registrant  certifies  that it has reasonable  grounds to
believe  that it meets all of the  requirements  for  filing on Form S-8 and has
duly  caused  this  Registration  Statement  to be signed  on its  behalf by the
undersigned,  thereunto  duly  authorized,  in the City of  Tempe,  Arizona,  on
January 18, 1999.
                                 CONSYGEN, INC.

                                          By: /s/ Thomas S. Dreaper
                                             ----------------------------
                                                 THOMAS S. DREAPER
                                                 PRESIDENT

                                POWER OF ATTORNEY

        KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears
below  constitutes and appoints Thomas S. Dreaper and Rajesh K. Kapur,  and each
of them  (with  full  power to each of them to act  alone),  his true and lawful
attorneys-in-fact   and   agents,   with   full   power  of   substitution   and
resubstitution,  for  him  and in his  name,  place  and  stead,  in any and all
capacities, to sign any or all amendments (including post-effective  amendments)
to this Registration Statement,  and to file the same, with all exhibits thereto
and other  documents in connection  therewith,  with the Securities and Exchange
Commission,  granting unto said  attorneys-in-fact and agents, and each of them,
full  power  and  authority  to do and  perform  each and  every  act and  thing
requisite and  necessary to be done in and about the  premises,  as fully to all
intents and  purposes as he might or could do in person,  hereby  ratifying  and
confirming all that said  attorneys-in-fact and agents, or any of them, or their
substitutes, may lawfully do or cause to be done by virtue hereof.

      Pursuant to the  requirements  of the  Securities Act of 1933, as amended,
this  Registration  Statement  has been signed by the  following  persons in the
capacities and on the dates indicated.

       SIGNATURE                      TITLE                          DATE
       ---------                      -----                          ----

/s/ Robert L. Stewart          Chairman of the Board            January 18, 1999
- -----------------------------
    ROBERT L. STEWART

/s/ Thomas S. Dreaper          President, Chief Executive       January 18, 1999
- -----------------------------  Officer and Director
    THOMAS S. DREAPER          (Principal Executive Officer)


/s/ Rajesh K. Kapur            Vice President and Chief         January 18, 1999
- -----------------------------  Financial Officer
    RAJESH K. KAPUR            (Principal Financial Officer)

/s/ Andrew Lee                 Director                         January 18, 1999
- -----------------------------
    ANDREW LEE

/s/ Alvin Lewis Burridge       Director                         January 18, 1999
- -----------------------------
    ALVIN LEWIS BURRIDGE

/s/ Jeffrey L. Weiss           Director                         January 18, 1999
- -----------------------------
    JEFFREY L. WEISS

                                  EXHIBIT INDEX
Exhibit                                                              Sequential
Number                                                                Page No.
- ------                                                                --------

4.1    Specimen Common Stock Certificate (Filed as Exhibit 4.B to
       the Registrant's  Registration Statement on Form S-8 (File
       No. 33-22900-FW)).                                                 *

4.2    Articles of  Incorporation  of the Registrant,  as amended
       (Filed as Exhibit 3.1 to the Registrant's Quarterly Report
       on Form 10-Q for the quarter ended August 31, 1997).               *

4.3    Amended and Restated  By-Laws of the Registrant  (Filed as
       Exhibit 3.2 to the  Registrant's  Quarterly Report on Form
       10-Q for the quarter ended March 31, 1998).                        *

4.4    Subscription  Agreement  used in connection  with the Rule
       506  sale  of  Convertible  Debentures  in  the  aggregate
       principal   amount  of  $3,500,000   (including   form  of
       Convertible  Debenture,  form   of  warrant,  and  form of
       Registration  Rights Agreement,  attached as Exhibits A, B
       and D, respectively, to the Subscription Agreement). Filed
       as Exhibit 4.3 to the  Registrant's  Annual Report on Form
       10-K for the year ended May 31, 1998).                             *

4.5    Agreement dated as of July 17, 1998 between the Registrant
       and Tom S.  Dreaper  relating to  employment  and grant of
       options to purchase  1,000,000  shares of common  stock of
       the Registrant. (Filed as Exhibit 4.12 to the Registrant's
       Annual  Report  on Form  10-K for the year  ended May 31,
       1998).                                                             *

4.6    ConSyGen,   Inc.   Second   Amended  and   Restated   1997
       Non-Qualified Stock Option Plan. (Filed as Exhibit 10.8 to
       the  Registrant's  Quarterly  Report  on Form 10-Q for the
       quarter ended August 31, 1998).                                    *

5      Legal Opinion of Cruse, Firetag & Bock, P.C.

23.1   Consent of Cruse, Firetag & Bock, P.C.                            **

23.2   Consent of Wolinetz, Gottlieb & Lafazan, P.C.

24     Power of Attorney.                                               ***

- --------
*    Not filed herewith. In accordance with Rule 411 promulgated pursuant to the
     Securities Act of 1933, reference is made to the documents previously filed
     with the Commission, which are incorporated by reference herein.
**   Contained in Exhibit 5.
***  Included on the Signature Page of this Registration Statement.