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    As filed with the Securities and Exchange Commission on September 7, 2000

                                                           FILE NO. 333-________

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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  ------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                                  ------------

                   INTERNATIONAL REMOTE IMAGING SYSTEMS, INC.
             (Exact Name of Registrant as Specified in Its Charter)


            DELAWARE                                    94-2579751
  (State or Other Jurisdiction             (I.R.S. Employer Identification No.)
 of Incorporation or Organization)


                 9162 ETON AVENUE, CHATSWORTH, CALIFORNIA 91311
               (Address of Principal Executive Offices) (Zip Code)

                                  ------------

                         EMPLOYEE STOCK PURCHASE PROGRAM
                       1998 STOCK OPTION PLAN, AS AMENDED
                            (Full Title of the Plan)

                                  ------------


                                 With a Copy to:

        DR. JOHN A. O'MALLEY                      DANIEL G. CHRISTOPHER, ESQ.
INTERNATIONAL REMOTE IMAGING SYSTEMS, INC.     GUTH ROTHMAN & CHRISTOPHER LLP
         9162 ETON AVENUE                   10866 WILSHIRE BOULEVARD, SUITE 1250
     CHATSWORTH, CALIFORNIA 91311               LOS ANGELES, CALIFORNIA 90024

                     (Name and Address of Agent For Service)

           (818)709-1244                                (310) 234-6922

                     (Telephone Number, Including Area Code,
                              of Agent For Service)

                         CALCULATION OF REGISTRATION FEE


===========================================================================================================================
                                                                    PROPOSED               PROPOSED
              TITLE OF                                               MAXIMUM               MAXIMUM
             SECURITIES                       AMOUNT                OFFERING              AGGREGATE           AMOUNT OF
               TO BE                          TO BE                 PRICE PER              OFFERING         REGISTRATION
             REGISTERED                   REGISTERED(1)             SHARE(2)                PRICE                FEE
- ---------------------------------------------------------------------------------------------------------------------------
                                                                                                
Common Stock, $.01 par value                1,400,000                 $2.03125             $2,843,750          $750.75
===========================================================================================================================


(1)  Plus such additional number of shares as may be required pursuant to the
     terms of the Employee Stock Purchase Program or the 1998 Stock Option Plan,
     as amended, in the event of a stock dividend, stock split, recapitalization
     or other similar change in the Common Stock. Of the 1,400,000 shares of
     Common Stock to be registered, 800,000 shares relates to the Employee Stock
     Purchase Plan and 600,000 shares relates to an increase in the number of
     shares covered by the 1998 Stock Option Plan, as amended.

(2)  The offering price is to be computed pursuant to Rule 457(h) and Rule
     457(c). As such, the offering price is the average of the high and low
     price as of September 5, 2000.





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                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS

ITEM 1. PLAN INFORMATION.*

ITEM 2. REGISTRANT INFORMATION AND EMPLOYEE PLAN ANNUAL INFORMATION.*


* Information required by Part I to be contained in the Section 10(a) prospectus
is omitted from this registration statement in accordance with Rule 428 under
the Securities Act and the Note to Part I of Form S-8.


                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT


ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.

     The following documents, which have been filed by us with the SEC are
incorporated herein by reference:

     (a)  Our annual report on Form 10-K for the fiscal year ended December 31,
          1999, which is our latest annual report filed pursuant to Section
          13(a) of the Securities Act, that contains audited financial
          statements for our latest fiscal year for which such statements have
          been filed;

     (b)  Our quarterly reports on Form 10-Q for the quarters ended March 31,
          2000 and June 30, 2000;

     (c)  Our Current Reports on Form 8-K filed January 26, 2000, February 4,
          2000, March 27, 2000 and May 23, 2000; and

     (d)  The description of our Common Stock set forth in our Registration
          Statement on Form 8-A filed with the SEC on June 22, 1993.

     In addition, all documents subsequently filed by us pursuant to Section
13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended,
prior to the filing of a post-effective amendment that indicates that all
securities offered have been sold or that deregisters all securities then
remaining unsold, shall be deemed to be incorporated by reference in this
registration statement and to be part hereof from the date of filing of such
documents.

     Any statement contained in a document deemed to be incorporated herein by
reference shall be deemed to be modified or superseded for purposes of this
registration statement to the extent that a statement contained herein or in any
other subsequently filed document that also is or is deemed to be incorporated
by reference herein modifies or supersedes such statement. Any such statement so
modified or superseded shall not be deemed, except as so modified or superseded,
to constitute a part of this registration statement.

ITEM 4. DESCRIPTION OF SECURITIES.

     Not Applicable.

ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL.

     Not Applicable.

ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.


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     Article SEVENTH of our Certificate of Incorporation contains certain
provisions permitted under the Delaware General Corporation Law ("DGCL")
relating to the liability of directors. The provisions eliminate a director's
liability for monetary damages for a breach of fiduciary duty, except in certain
circumstances involving wrongful acts, such as the breach of a director's duty
of loyalty or acts or omissions that involve intentional misconduct or knowing
violation of law. Our Certificate of Incorporation also contains provisions
requiring us to indemnify our directors and officers to the fullest extent
permitted by the DGCL.

     Section 145 of the DGCL provides, in part, that a corporation shall have
the power to indemnify any person who was or is a party or is threatened to be
made a party to any suit or proceedings because such person is or was a
director, officer, employee or agent of the corporation or was serving at the
request of the corporation, as a director, officer, employee or agent of another
corporation, against all costs actually and reasonably incurred by such person
in connection with such suit or proceedings if he or she acted in good faith and
in a manner he reasonably believed to be in or not opposed to the best interests
of the corporation. Similar indemnity is permitted to be provided to such
persons in connection with an action or suit by or in the right of the
corporation, provided such person acted in good faith and in a manner he or she
believed to be in or not opposed to the best interests of the corporation, and
provided further (unless a court of competent jurisdiction otherwise determines)
that such person shall not have been adjudged liable to the corporation.

     We also maintain insurance policies under which our directors and officers
are insured, within the limits and subject to the limitations of the policies,
against expenses in connection with the defense of actions, suits or
proceedings, and certain liabilities that might be imposed as a result of such
actions, suits or proceedings, to which they are parties by reason of being or
having served as one of our directors or officers.

ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.

     Not Applicable.

ITEM 8. EXHIBITS.




- ---------------------------------------------------------------------------------------------------------------------
        EXHIBIT NO.                                                DESCRIPTION
- ---------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------
                         
          4.1(a)             Specimen of Common Stock Certificate (1)
- ---------------------------------------------------------------------------------------------------------------------

          4.1(b)             Legend re Transfer Restrictions and Repurchase Option (2)
- ---------------------------------------------------------------------------------------------------------------------

            4.2              Employee Stock Purchase Program (as amended and restated on February 20, 1999) (3)
- ---------------------------------------------------------------------------------------------------------------------

            4.3              1998 Stock Option Plan, as amended
- ---------------------------------------------------------------------------------------------------------------------

            5.1              Legal Opinion of Guth Rothman & Christopher LLP
- ---------------------------------------------------------------------------------------------------------------------

           23.1              Consent of Guth Rothman & Christopher LLP (included in Exhibit 5.1)
- ---------------------------------------------------------------------------------------------------------------------

           23.2              Consent of PricewaterhouseCoopers LLP
- ---------------------------------------------------------------------------------------------------------------------


- ----------------------

(1)  Incorporated by reference to from our Registration Statement on Form S-3,
     as filed with the SEC on March 27, 1996 (File No. 333-02001).

(2)  Incorporated by reference from our Registration Statement on Form S-8, as
     filed with the SEC on October 9, 1998 (File No. 333-65547).

(3)  Incorporated by reference from our Annual Report on Form 10-K for the year
     ended December 31, 1999.




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ITEM 9. UNDERTAKINGS.

     (a)  Rule 415 Offering. The undersigned registrant hereby undertakes:

          (1)  To file, during any period in which offers or sales are being
               made, a post-effective amendment to this Registration Statement:

               (i)  to include any prospectus required by Section 10(a)(3) of
                    the Securities Act;

               (ii) to reflect in the prospectus any facts or events arising
                    after the effective date of the Registration Statement (or
                    the most recent post-effective amendment thereof) which,
                    individually or in the aggregate, represent a fundamental
                    change in the information set forth in the Registration
                    Statement;

               (iii) to include any material information with respect to the
                    plan of distribution not previously disclosed in the
                    registration statement or any material change to such
                    information in the Registration Statement; provided,
                    however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
                    apply if the information required to be included in a
                    post-effective amendment by those paragraphs is contained in
                    periodic reports filed by the Registrant pursuant to Section
                    13 or Section 15(d) of the Exchange Act that are
                    incorporated by reference in this Registration Statement.

          (2)  That, for the purpose of determining any liability under the
               Securities Act of 1933, each such post-effective amendment shall
               be deemed to be a new registration statement relating to the
               securities offered therein, and the offering of such securities
               at that time shall be deemed to be the initial bona fide offering
               thereof.

          (3)  To remove from registration by means of a post-effective
               amendment any of the securities being registered which remain
               unsold at the termination of the offering.

     (b)  Filings Incorporating Subsequent Exchange Act Documents by Reference.
          The undersigned Registrant hereby undertakes that, for purposes of
          determining any liability under the Securities Act of 1933, each
          filing of the Registrant's annual report pursuant to Section 13(a) or
          Section 15(d) of the Exchange Act that is incorporated by reference in
          this Registration Statement shall be deemed to be a new registration
          statement relating to the securities offered therein, and the offering
          of such securities at that time shall be deemed to be the initial bona
          fide offering thereof.

     (c)  Request for Acceleration of Effective Date or Filing of Registration
          Statement on Form S-8. Insofar as indemnification for liabilities
          arising under the Securities Act may be permitted to directors,
          officers and controlling persons of the Registrant pursuant to the
          foregoing provisions or otherwise, the Registrant has been advised
          that in the opinion of the Securities and Exchange Commission, such
          indemnification is against public policy as expressed in the
          Securities Act and is, therefore, unenforceable. In the event that a
          claim for indemnification against such liabilities (other than the
          payment by the Registrant of expenses incurred or paid by a director,
          officer or controlling person of the Registrant in the successful
          defense of any action, suit or proceeding) is asserted by such
          director, officer or controlling person in connection with the
          securities being registered, the Registrant will, unless in the
          opinion of its counsel the matter has been settled by controlling
          precedent, submit to a court of appropriate jurisdiction the question
          of whether such indemnification by it is against public policy as
          expressed in the Securities Act and will be governed by the final
          adjudication of such issue.



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                                   SIGNATURES


     Pursuant to the requirements of the Securities Act of 1933, the registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Los Angeles, State of California, on the 7th day of
September, 2000.


                                   INTERNATIONAL REMOTE IMAGING SYSTEMS, INC.



                                   By: /s/ JOHN A. O'MALLEY
                                      ----------------------------------------
                                      John A. O'Malley
                                      Chairman of the Board, President
                                      and Chief Executive Officer


     KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints John A. O'Malley, as attorney-in-fact,
with power of substitution, for such person in any and all capacities, to sign
any and all amendments and post-effective amendments to this registration
statement, and to file the same, with all exhibits thereto and other documents
in connection therewith, with the SEC, hereby ratifying and confirming all that
said attorney-in-fact, or his or her substitute, may do or cause to be done by
virtue thereof.

     Pursuant to the requirements of the Securities Act of 1933, this amendment
has been signed below by the following persons in the capacities and on the
dates indicated.




SIGNATURE                                   TITLE                                                              DATE
- ---------                                   -----                                                              -----
                                                                                                   

/s/ JOHN A. O'MALLEY                        Chairman of the Board, President                              September 7, 2000
- -----------------------------------         and Chief Executive Officer
John A. O'Malley

/s/ DONALD E. HORACEK                       Secretary, Controller, and                                    September 7, 2000
- -----------------------------------         Principal Accounting Officer
Donald E. Horacek


/s/ STEVEN M. BESBECK                       Director                                                      September 7, 2000
- -----------------------------------
Steven M. Besbeck


/s/ THOMAS F. KELLEY                        Director                                                      September 7, 2000
- -----------------------------------
Thomas F. Kelley


/s/ RICHARD G. NADEAU                       Director                                                      September 7, 2000
- -----------------------------------
Richard G. Nadeau







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                                  EXHIBIT INDEX




- ---------------------------------------------------------------------------------------------------------------------
        EXHIBIT NO.                                                DESCRIPTION
- ---------------------------------------------------------------------------------------------------------------------

- ---------------------------------------------------------------------------------------------------------------------
                         
          4.1(a)             Specimen of Common Stock Certificate (1)
- ---------------------------------------------------------------------------------------------------------------------

          4.1(b)             Legend re Transfer Restrictions and Repurchase Option (2)
- ---------------------------------------------------------------------------------------------------------------------

            4.2              Employee Stock Purchase Program (as amended and restated on February 20, 1999) (3)
- ---------------------------------------------------------------------------------------------------------------------

            4.3              1998 Stock Option Plan, as amended
- ---------------------------------------------------------------------------------------------------------------------

            5.1              Legal Opinion of Guth Rothman & Christopher LLP
- ---------------------------------------------------------------------------------------------------------------------

           23.1              Consent of Guth Rothman & Christopher LLP (included in Exhibit 5.1)
- ---------------------------------------------------------------------------------------------------------------------

           23.2              Consent of PricewaterhouseCoopers LLP
- ---------------------------------------------------------------------------------------------------------------------

- ----------------------

(1)  Incorporated by reference from our Registration Statement on Form S-3, as
     filed with the SEC on March 27, 1996 (File No. 333-02001).

(2)  Incorporated by reference from our Registration Statement on Form S-8, as
     filed with the SEC on October 9, 1998 (File No. 333-65547).

(3)  Incorporated by reference from our Annual Report on Form 10-K for the year
     ended December 31, 1999.