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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549




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                                    FORM 8-K


                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934





      Date of report (Date of earliest event reported): September 20, 2001

                   INTERNATIONAL REMOTE IMAGING SYSTEMS, INC.
               (Exact Name of Registrant as Specified in Charter)


          DELAWARE                      1-9767                    94-2579751
(State or Other Jurisdiction         (Commission                (IRS Employer
     of Incorporation)               File Number)            Identification No.)


9162 ETON AVENUE, CHATSWORTH, CALIFORNIA                            91311
(Address of Principal Executive Offices)                          (Zip Code)


       Registrant's telephone number, including area code: (818) 709-1244





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ITEM 4.  CHANGES IN REGISTRANT'S CERTIFYING ACCOUNTANT.

        (a)    Previous independent accountants

        (i) On September 20, 2001, International Remote Imaging Systems, Inc.
("IRIS") dismissed PricewaterhouseCoopers LLP as its independent accountants.
IRIS's Board of Directors participated in and approved the decision to change
independent accountants.

        (ii) The reports of PricewaterhouseCoopers LLP on the financial
statements for the past two fiscal years contained no adverse opinion or
disclaimer of opinion and were not qualified or modified as to uncertainty,
audit scope or accounting principle.

        (iii) In connection with its audits for the two most recent fiscal years
and through September 20, 2001, there have been no disagreements with
PricewaterhouseCoopers LLP on any matter of accounting principles or practices,
financial statement disclosure, or auditing scope or procedure, which
disagreements if not resolved to the satisfaction of PricewaterhouseCoopers LLP
would have caused them to make reference thereto in their report on the
financial statements for such years.

        (iv) During the two most recent fiscal years and through September 20,
2001, there have been no reportable events (as defined in Regulation S-K, Item
304(a)(1)(v)).

        (v) IRIS has requested that PricewaterhouseCoopers LLP furnish it with a
letter addressed to the SEC stating whether or not it agrees with the above
statements. A copy of such letter, dated September 26, 2001 is filed as Exhibit
16 to this Form 8-K.

        (b)    New independent accountants

        IRIS engaged BDO Seidman, LLP as its new independent accountants as
of September 27, 2001. During the two most recent fiscal years and through
September 27, 2001, IRIS has not consulted with BDO Seidman, LLP regarding
either (i) the application of accounting principles to a specified transaction,
either completed or proposed; or the type of audit opinion that might be
rendered on IRIS's financial statements, and either a written report was
provided to IRIS or oral advice was provided that BDO Seidman, LLP concluded was
an important factor considered by IRIS in reaching a decision as to the
accounting, auditing or financial reporting issue, or (ii) any matter that was
either the subject of a disagreement, as that term is defined in Item
304(a)(1)(iv) of Regulation S-K and the related instructions to Item 304 of
Regulation S-K, or a reportable event, as that term is defined in Item
304(a)(1(v) of Regulation S-K.




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ITEM 7.  FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

        Listed below are the financial statements, pro forma financial
information and exhibits, if any, filed as a part of this report:

        None.

        (c)    EXHIBITS

               Exhibit 16       Letter from PricewaterhouseCoopers LLP




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                                   SIGNATURES


        Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                        INTERNATIONAL REMOTE IMAGING
                                           SYSTEMS, INC.



Dated:  September 27, 2001              By:    /s/ John Caloz
                                           -------------------------------------
                                               John Caloz
                                               Corporate Vice President, Finance
                                               and Chief Financial Officer





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                                  Exhibit Index



No.                Document
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16                 Letter from PricewaterhouseCoopers LLP