EXHIBIT 32.1

                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report on Form 10-Q of CNB Corporation (the
"Company") for the quarterly period ended September 30, 2008 as filed with the
Securities and Exchange Commission on the date hereof (the "Report"), I Susan A.
Eno, President and Chief Executive Officer, certify, pursuant to section 906 of
the Sarbanes-Oxley Act of 2002, 18 U.S.C. Section 1350, that:

     (1)  the Report fully complies with requirements of Section 13(a) or 15(d)
          of the Securities Exchange Act of 1934; and

     (2)  the information contained in the Report fairly presents, in all
          material respects, the financial condition and results of operations
          of the Company.

Dated: November 14, 2008


                                       By: /s/ Susan A. Eno
                                           -------------------------------------
                                           Susan A. Eno
                                           President and Chief Executive Officer

A signed original of this written statement required by Section 906 has been
provided to the Company and will be retained by the Company and furnished to the
Securities and Exchange Commission or its staff upon request.


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