1
     As filed with the Securities and Exchange Commission on June 27, 1996.

                                                       Registration No. 333-2146

- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                            -------------------------


                         POST EFFECTIVE AMENDMENT NO. 1
                                       TO
                                    FORM S-3


                             REGISTRATION STATEMENT
                                    UNDER THE
                             SECURITIES ACT OF 1933

                              ---------------------

                              NEOPROBE CORPORATION
                 (Name of Small Business Issuer in Its Charter)



                                                                            
           DELAWARE                                                31-1080091
   (State or Jurisdiction of                                    (I.R.S. Employer
Incorporation or Other Organization)                         Identification Number)


                              425 Metro Place North
                             Dublin, Ohio 43017-1367
                                 (614) 793-7500
          (Address and Telephone Number of Principal Executive Offices)



                                                                 with copies to:

                                                        
 Robert S. Schwartz, Esq.       David C. Bupp, President        Steven M. Spurlock, Esq.
Schwartz, Warren & Ramirez        Neoprobe Corporation          Gunderson Dettmer Stough
A Limited Liability Company      425 Metro Place North            Villeneuve Franklin &
   41 South High Street         Dublin, Ohio 43017-1367              Hachigian, LLP
   Columbus, Ohio 43215              (614) 793-7500           600 Hansen Way, Second Floor
      (614) 222-3000                                           Palo Alto, California 94304
                                                                         (415) 843-0500


(Name, Address and Telephone Number of Agent for Service)
   2
     The Company sold 1,750,000 shares of Common Stock hereunder and hereby
removes from registration 262,500 shares subject to an over-allotment option
which remained unsold at the termination of the offering.
   3

                                   SIGNATURES

     In accordance with the requirements of the Securities Act of 1933, the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and authorized this post-effective
amendment to the registration statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of Columbus, State of Ohio,
on June 24, 1996.

                                                  NEOPROBE CORPORATION



                                                  By   /s/David C. Bupp
                                                     ---------------------------
                                                          David C. Bupp
                                                          President

     In accordance with the requirements of the Securities Act of 1933, this
post-effective amendment to the registration statement has been signed on June
24, 1996, by the following persons in the capacities stated.



         SIGNATURES                          CAPACITY
         ----------                          --------

                                          
/s/ John L. Ridihalgh*                       Director, Chairman of the
- -------------------------------------        Board, Chief Executive Officer
    John L. Ridihalgh                        (principal executive officer)

                                               

/s/ David C. Bupp                            Director, President, Chief
- -------------------------------------        Operating Officer
    David C. Bupp                         


/s/ John Schroepfer*                         Vice President, Finance and
- -------------------------------------        Administration (principal financial  
    John Schroepfer                          and accounting officer)
                                              

/s/ Zwi Vromen*                              Director
- -------------------------------------
    Zwi Vromen

/s/ Jerry K. Mueller, Jr.*                   Director
- -------------------------------------
    Jerry K. Mueller, Jr.


/s/ James Zid*                               Director
- -------------------------------------
    James Zid


/s/ Julius R. Krevans*                       Director
- -------------------------------------
    Julius R. Krevans

/s/ Michael P. Moore*                        Director
- -------------------------------------
    Michael P. Moore


/s/ J. Frank Whitley, Jr.*                   Director
- -------------------------------------
     J. Frank Whitley, Jr.


/s/ C. Michael Hazard*                       Director
- -------------------------------------
    C. Michael Hazard


*By    /s/David C. Bupp
- -------------------------------------
         David C. Bupp
         Attorney-in-Fact