1 As filed with the Securities and Exchange Commission on December 10, 1996. Registration No. 33-51446 ================================================================================ SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ---------------------- POST-EFFECTIVE AMENDMENT NO. 4 TO FORM S-1 ON FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ---------------------- NEOPROBE CORPORATION (Name of Small Business Issuer in Its Charter) DELAWARE 3841 31-1080091 (State or Jurisdiction of (Primary Standard Industrial (I.R.S. Employer Incorporation or Other Organization) Classification Code Number) Identification Number) 425 Metro Place North Dublin, Ohio 43017-1367 (614) 793-7500 (Address and Telephone Number of Principal Executive Offices) Mr. David C. Bupp Neoprobe Corporation 425 Metro Place North Dublin, Ohio 43017-1367 (614) 793-7500 (Name, Address and Telephone Number of Agent for Service) ---------- with a copy to: Robert S. Schwartz, Esq. Schwartz, Warren & Ramirez A Limited Liability Company 41 South High Street Columbus, Ohio 43218-2338 (614) 222-3050 ================================================================================ 2 The Company hereby removes from registration 12,750 shares of Common Stock included in this registration statement or in registration number 33-72658 for issuance upon exercise of Class E Common Stock Purchase Warrants of the Company, which Warrants to purchase shares were not exercised prior to their expiration on November 12, 1996. 3 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this post-effective amendment to registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Columbus, State of Ohio, on December 5, 1996. NEOPROBE CORPORATION By /s/ DAVID C. BUPP ---------------------------------------- David C. Bupp President and Chief Operating Officer In accordance with the requirements of the Securities Act of 1933, this registration statement has been signed on December 5, 1996, by the following persons in the capacities stated. SIGNATURES CAPACITY ---------- -------- John L. Ridihalgh* - --------------------------------- Director, Chairman of the John L. Ridihalgh Board, Chief Executive Officer (principal executive officer) /s/ DAVID C. BUPP - --------------------------------- Director, President, Chief David C. Bupp Operating Officer John Schroepfer* - --------------------------------- Vice President, Finance and John Schroepfer Administration (principal financial and accounting officer) Zwi Vromen* - --------------------------------- Director Zwi Vromen Jerry K. Mueller, Jr.* - --------------------------------- Director Jerry K. Mueller, Jr. James Zid* - --------------------------------- Director James Zid Julius R. Krevans* - --------------------------------- Director Julius R. Krevans Michael P. Moore* - --------------------------------- Director Michael P. Moore J. Frank Whitley, Jr.* - --------------------------------- Director J. Frank Whitley, Jr. - --------------------------------- Director C. Michael Hazard *By: /s/ DAVID C. BUPP ---------------------------- David C. Bupp Attorney-in-Fact