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     As filed with the Securities and Exchange Commission on March 19, 1997


                                                 Registration No. 333-21631-01

===============================================================================


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                 ---------------
                            POST-EFFECTIVE AMENDMENT
                                      NO. 1
                                       ON
                                    FORM S-8
                                       TO
                                    FORM S-4
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933*
                              ---------------------
                              Cardinal Health, Inc.
                              ---------------------
             (Exact name of registrant as specified in its charter)

                Ohio                                    31-0958666
                ----                                    ----------
     (State or other jurisdiction           (I.R.S. Employer Identification No.)
    of incorporation or organization)

    5555 Glendon Court, Dublin, Ohio                       43016
    --------------------------------                       -----
 (Address of Principal Executive Offices)                (Zip Code)
                               -------------------
                  OWEN HEALTHCARE, INC. 1987 STOCK OPTION PLAN
                  OWEN HEALTHCARE, INC. 1992 STOCK OPTION PLAN
       OWEN HEALTHCARE, INC. 1992 NONEMPLOYEE DIRECTORS' STOCK OPTION PLAN
                  OWEN HEALTHCARE, INC. 1996 STOCK OPTION PLAN
                               -------------------
                            (Full title of the plans)

                             George H. Bennett, Jr.,
             Executive Vice President, Secretary and General Counsel
                              Cardinal Health, Inc.
                               5555 Glendon Court
                               Dublin, Ohio 43016
                     ---------------------------------------
                     (Name and address of agent for service)

                                 (614) 717-5000
                               -------------------
          (Telephone number, including area code, of agent for service)

                         CALCULATION OF REGISTRATION FEE


==================================================================================================
Title of                Amount           Proposed               Proposed              Amount of
securities to           to be            maximum offering       maximum aggregate     registration
be registered           registered(1)    price per share(1)     offering price        fee
- --------------------------------------------------------------------------------------------------
                                                                         
Common Shares,
without par value       748,029          (2)                    (2)                   (2)
==================================================================================================
<FN>
(1)    Also includes an indeterminable number of additional shares that may
       become issuable pursuant to the anti-dilution provisions of the Plans.

(2)    Not applicable. All filing fees payable in connection with the
       registration of the issuance of these securities were paid in
       connection with the filing of (a) preliminary proxy materials on
       Schedule 14A of Owen Healthcare, Inc. on December 24, 1996, and (b) the
       Registrant's Form S-4 Registration Statement (333-21631) on February
       12, 1997.

*      Filed as a Post-Effective Amendment on Form S-8 to such Form S-4
       Registration Statement pursuant to the procedure described in Part II
       under "Introductory Statement."



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                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

                             INTRODUCTORY STATEMENT

     Cardinal Health, Inc. (the "Company" or the "Registrant") hereby amends its
Registration Statement on Form S-4 (No. 333-21631) (the "Form S-4") by filing
this Post-Effective Amendment No. 1 on Form S-8 ("Amendment No. 1") with respect
to up to 748,029 of the Registrant's Common Shares, without par value ("Common
Shares"), issuable in connection with the following plans (collectively, the
"Plans") of Owen Healthcare, Inc. ("Owen"): 1987 Stock Option Plan, 1992 Stock
Option Plan, 1992 Nonemployee Directors' Stock Option Plan and 1996 Stock Option
Plan. All such Common Shares were previously included in the Form S-4.

     On March 18 1997, Owl Merger Corp., a Texas corporation and a wholly
owned subsidiary of the Registrant ("OMC"), was merged with and into Owen (the
"Merger") pursuant to an Agreement and Plan of Merger dated November 27, 1996,
among the Registrant, OMC and Owen (the "Merger Agreement"). As a result of the
Merger, each outstanding share of Owen Common Stock (with certain specified     
exceptions) was converted into .45 of a Common Share of the Registrant pursuant
to the exchange ratio (the "Exchange Ratio") set forth in the Merger Agreement.
Also as a result of the Merger, shares of Owen Common Stock are no longer
issuable upon the exercise of options to purchase Owen Common Stock ("Owen
Options") pursuant to the Plans. Instead, participants in the Plans will
receive in lieu of Owen Common Stock that number of Common Shares of the
Registrant equal to the number of shares of Owen Common Stock issuable
immediately prior to the effective time of the Merger upon exercise of an Owen
Option multiplied by the Exchange Ratio, with an exercise price for such option
equal to the exercise price which existed under the corresponding Owen Option
divided by the Exchange Ratio.

     The designation of Amendment No. 1 as Registration No. 333-21631-01 denotes
that Amendment No. 1 relates only to the Common Shares issuable pursuant to the
Plans and that this is the first Post-Effective Amendment to the S-4 filed with
respect to such shares.

ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE.

     The documents listed below are incorporated by reference in the
registration statement. All documents filed by the Company pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended
(the "Exchange Act"), subsequent to the date of the filing of this registration
statement and prior to the filing of a post-effective amendment that indicates
that all securities registered hereunder have been sold, or that de-registers
all securities then remaining unsold, shall be deemed to be incorporated by
reference in the registration statement and to be a part hereof from the date of
the filing of such documents.

     (a) The Annual Report on Form 10-K of the Company for the fiscal year ended
June 30, 1996 filed with the Commission on August 26, 1996;

     (b) The information contained in the Company's Proxy Statement dated
September 27, 1996 for its Annual Meeting of Shareholders held on October 29,
1996 that was filed with the Commission on Schedule 14A on September 27, 1996,
other than the information contained therein under the captions "Report of the
Committee on Executive Compensation" and "Performance Graphs";

     (c) The Current Report on Form 8-K of the Company filed with the Commission
on October 18, 1996;

     (d) The Quarterly Report on Form 10-Q of the Company for the fiscal quarter
ended September 30, 1996 filed with the Commission on November 6, 1996;

     (e) The Quarterly Report on Form 10-Q of the Company for the fiscal quarter
ended December 31, 1996 filed with the Commission on February 6, 1997;

     (f) The Current Report on Form 8-K of the Company filed with the Commission
on March 4, 1997; and


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     (g) The description of the Company's Common Shares contained in the
Company's Registration Statement on Form 8-A dated August 19, 1994, pursuant to
Section 12 of the Exchange Act.


ITEM 5.  INTEREST OF NAMED EXPERTS AND COUNSEL.

     The legality of the Common Shares offered hereby has been passed upon for
the Company by Paul S. Williams, Assistant General Counsel of the Company. Mr.
Williams holds unvested options to purchase Common Shares of the Company.


ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

     Section 1701.13(E) of the Ohio Revised Code sets forth conditions and
limitations governing the indemnification of officers, directors, and other
persons.

     Article 6 of the Company's Restated Code of Regulations ("Code of
Regulations"), as amended, contains certain indemnification provisions adopted
pursuant to authority contained in Section 1701.13(E) of the Ohio Revised Code.
The Company's Code of Regulations provides for the indemnification of its
officers, directors, employees, and agents against all expenses with respect to
any judgments, fines, and amounts paid in settlement, or with respect to any
threatened, pending, or completed action, suit, or proceeding to which they were
or are parties or are threatened to be made parties by reason of acting in such
capacities, provided that it is determined, either by a majority vote of a
quorum of disinterested directors of the Company or the shareholders of the
Company or otherwise as provided in Section 1701.13(E) of the Ohio Revised Code,
that (a) they acted in good faith and in a manner they reasonably believed to be
in or not opposed to the best interest of the Company; (b) in any action, suit,
or proceeding by or in the right of the Company, they were not, and have not
been adjudicated to have been, negligent or guilty of misconduct in the
performance of their duties to the Company; and (c) with respect to any criminal
action or proceeding, that they had no reasonable cause to believe that their
conduct was unlawful. Section 1701.13(E) provides that to the extent a director,
officer, employee, or agent has been successful on the merits or otherwise in
defense of any such action, suit, or proceeding, he shall be indemnified against
expenses reasonably incurred in connection therewith. At present there are no
material claims, actions, suits, or proceedings pending where indemnification
would be required under these provisions, and the Company does not know of any
such threatened claims, actions, suits, or proceedings which may result in a
request for such indemnification.

    The Company has entered into indemnification contracts with certain of
its directors and executive officers. These contracts generally: (i) confirm
the existing indemnity provided to them under the Company's Code of Regulations
and assure that this indemnity will continue to be provided; (ii) provide that
if the Company does not maintain directors' and officers' liability insurance,
the Company will, in effect, become a self-insurer of the coverage; and (iii)
provide that, in addition, the directors and officers shall be indemnified to
the fullest extent permitted by law against all expenses (including legal
fees), judgments, fines, and settlement amounts paid or incurred by them in any
action or proceeding, including any action by or in the right of the Company,
on account of their service as a director, officer, employee, or agent of the
Company or at the request of the Company as a director, officer, employee, or
agent of another corporation or enterprise. Coverage under the contracts is
excluded: (A) on account of conduct which is finally adjudged to be knowingly
fraudulent, deliberately dishonest, or willful misconduct; or (B) if a final
court of adjudication shall determine that such indemnification is not lawful;
or (C) in respect of any suit in which judgment is rendered for violations of
Section 16(b) of the Securities and Exchange Act of 1934, as amended, or
similar provisions of any federal, state, or local statutory law; or (D) on
account of any remuneration paid which is finally adjudged to have been in
violation of law; or (E) as to officers who are not directors, with respect to
any act or omission which is finally adjudged to have been a violation, other
than in good faith, of the Company's Standards of Business Conduct of which the
officer then most recently has received written notice. The indemnification
agreements are applicable to claims asserted after their effective date,
whether arising from acts or omissions occurring before or after their
effective date, and associated legal expenses.


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ITEM 8. EXHIBITS.

Exhibit Number                 Description of Exhibit
- --------------                 ----------------------

5                Opinion of Paul S. Williams as to legality of the Common Shares
                 being registered

23(a)            Consent of Deloitte & Touche LLP

23(b)            Consent of Ernst & Young LLP

23(c)            Consent of Paul S. Williams (included in Opinion filed as
                 Exhibit 5 hereto)

24               Power of attorney (included on the Signature Page of this
                 Form S-8)

99(a)            Owen Healthcare, Inc. 1987 Stock Option Plan

99(b)            Owen Healthcare, Inc. 1992 Stock Option Plan

99(c)            Owen Healthcare, Inc. 1992 Nonemployee Directors' Stock Option
                 Plan

99(d)            Owen Healthcare, Inc. 1996 Stock Option Plan

ITEM 9. UNDERTAKINGS.

A. The undersigned Registrant hereby undertakes:

     (1) To file, during any period in which offers or sales are being made, a
post-effective amendment to this registration statement: (i) to include any
prospectus required by Section 10(a)(3) of the Securities Act of 1933, as
amended (the "Securities Act"); (ii) to reflect in the prospectus any facts or
events arising after the effective date of the registration statement (or the
most recent post-effective amendment thereof) which, individually or in the
aggregate, represent a fundamental change in the information set forth in the
registration statement; and (iii) to include any material information with
respect to the plans of distribution not previously disclosed in the
registration statement or any material change to such information in the
registration statement; provided, however, that clauses (i) and (ii) do not
apply if the information required to be included in a post-effective amendment
by those clauses is contained in periodic reports filed with or furnished to the
Securities and Exchange Commission by the Registrant pursuant to Section 13 or
Section 15(d) of the Exchange Act that are incorporated by reference in the
registration statement;

     (2) That, for the purpose of determining any liability under the Securities
Act, each such post-effective amendment shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial bona fide offering
thereof; and

     (3) To remove from registration by means of a post-effective amendment any
of the securities being registered which remain unsold at the termination of the
offering.

B. The undersigned Registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
Registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Exchange Act that is incorporated by reference in the registration statement
shall be deemed to be a new registration statement relating to the securities
offered therein, and the offering of such securities at that time shall be
deemed to be the initial bona fide offering thereof.

C. Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the provisions described under Item 6 above or otherwise,
the Registrant has been advised that in the opinion of the Securities and
Exchange Commission such


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indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of expenses
incurred or paid by a director, officer or controlling person of the Registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Securities Act and will be governed by the final
adjudication of such issue.




































                                      -4-

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                                   SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing this Post-Effective Amendment No.1 on Form S-8 to Form
S-4 Registration Statement and has duly caused this registration statement to be
signed on its behalf by the undersigned, thereunto duly authorized, in the City
of Dublin, State of Ohio, on the 19th day of March, 1997.


                                           CARDINAL HEALTH, INC.



                                           By: /s/ Robert D. Walter
                                               -------------------------
                                               Robert D. Walter, Chairman
                                               and Chief Executive Officer


     KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears
below constitutes and appoints Robert D. Walter, George H. Bennett, Jr., and
Paul S. Williams, and each of them, severally, as his/her attorney-in-fact and
agent, with full power of substitution and resubstitution, for him/her and in
his/her name, place, and stead, in any and all capacities, to sign any and all
pre- or post-effective amendments to this Registration Statement, and to file
the same with all exhibits hereto, and other documents with the Securities and
Exchange Commission, granting unto said attorney-in-fact and agent, and each of
them, full power and authority to do and perform each and every act and thing
requisite or necessary to be done in and about the premises, as fully to all
intents and purposes as he/she might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact and agents, or any of them, or their
or his substitutes, may lawfully do or cause to be done by virtue hereof.

     Pursuant to the requirements of the Securities Act of 1933, this
Post-Effective Amendment No.1 on Form S-8 to Form S-4 Registration Statement has
been signed by the following persons in the capacities indicated on the 19th
day of March, 1997.


Signature                           Title
- ---------                           -----

/s/ Robert D. Walter                Chairman and Chief Executive
- -------------------------           Officer (principal executive officer)
Robert D. Walter                    and Director


/s/ David Bearman                   Executive Vice President and Chief
- -------------------------           Financial Officer (principal financial
David Bearman                       officer)


/s/Richard J. Miller                Vice President, Controller and Principal
- -------------------------           Accounting Officer
Richard J. Miller


/s/ John F. Finn                    Director
- -------------------------
John F. Finn




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/s/ Robert L. Gerbig                Director
- -------------------------
Robert L. Gerbig


/s/ John F. Havens                  Director
- -------------------------
John F. Havens


/s/ Regina E. Herzlinger            Director
- -------------------------
Regina E. Herzlinger


/s/ John C. Kane                    Director
- -------------------------
John C. Kane


/s/ J. Michael Losh                 Director
- -------------------------
J. Michael Losh


/s/ George R. Manser                Director
- -------------------------
George R. Manser


/s/ John B. McCoy                   Director
- -------------------------
John B. McCoy


/s/ Jerry E. Robertson              Director
- -------------------------
Jerry E. Robertson


/s/ L. Jack Van Fossen              Director
- -------------------------
L. Jack Van Fossen


/s/ Melburn G. Whitmire             Director
- -------------------------
Melburn G. Whitmire


                                      -6-



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                                  EXHIBIT INDEX
                                  -------------


EXHIBIT
NUMBER                  EXHIBIT DESCRIPTION
- ------                  -------------------

5           Opinion of Paul S. Williams as to legality of the Common Shares
            being registered

23(a)       Consent of Deloitte & Touche LLP

23(b)       Consent of Ernst & Young LLP

23(c)       Consent of Paul S. Williams (included in Opinion filed as
            Exhibit 5 hereto)

24          Power of Attorney (included on the Signature Page of this Form S-8)

99(a)       Owen Healthcare, Inc. 1987 Stock Option Plan

99(b)       Owen Healthcare, Inc. 1992 Stock Option Plan

99(c)       Owen Healthcare, Inc. 1992 Nonemployee Directors' Stock Option Plan

99(d)       Owen Healthcare, Inc. 1996 Stock Option Plan








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