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                                                                    Exhibit 24.1

                                POWER OF ATTORNEY

The undersigned who is a director or officer of Neoprobe Corporation, a Delaware
     corporation (the "Company");

Does hereby constitute and appoint David C. Bupp, Brent L. Larson and Patricia
     A. Coburn to be his agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full power
     of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission a Registration
     Statement on Form S-3 for the resale of certain shares of common stock, par
     value $.001, of the Company, and any amendments or supplements to such Form
     S-3; and

To execute and deliver any instruments, certificates or other documents which
     they shall deem necessary or proper in connection with the filing of such
     Form S-3, and generally to act for and in the name of the undersigned with
     respect to such filings as fully as could the undersigned if then
     personally present and acting.

Each agent named above is hereby empowered to determine in his discretion the
     times when, the purposes for, and the names in which, any power conferred
     upon him herein shall be exercised and the terms and conditions of any
     instrument, certificate or document which may be executed by him pursuant
     to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be governed
     by those laws of the State of Ohio that apply to instruments negotiated,
     executed, delivered and performed solely within the State of Ohio.

This Power of Attorney may be executed in any number of counterparts, each of
     which shall have the same effect as if it were the original instrument and
     all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 30th day of
     March, 1999.


                                                     /s/ Melvin D. Booth
                                                 ----------------------------
                                                       Melvin D. Booth
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                                POWER OF ATTORNEY

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "Company");

Does hereby constitute and appoint Brent L. Larson and Patricia A. Coburn
     to be his agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full
     power of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission a Registration
     Statement on Form S-3 for the resale of certain shares of common stock, par
     value $.001, of the Company, and any amendments or supplements to such Form
     S-3; and

To execute and deliver any instruments, certificates or other documents
     which they shall deem necessary or proper in connection with the filing of
     such Form S-3, and generally to act for and in the name of the undersigned
     with respect to such filings as fully as could the undersigned if then
     personally present and acting.

Each agent named above is hereby empowered to determine in his discretion
     the times when, the purposes for, and the names in which, any power
     conferred upon him herein shall be exercised and the terms and conditions
     of any instrument, certificate or document which may be executed by him
     pursuant to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be
     governed by those laws of the State of Ohio that apply to instruments
     negotiated, executed, delivered and performed solely within the State of
     Ohio.

This Power of Attorney may be executed in any number of counterparts, each
     of which shall have the same effect as if it were the original instrument
     and all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 8th day of
     March, 1999.

                                                  /s/ David C. Bupp
                                                  ----------------------------
                                                      David C. Bupp


   3



                                POWER OF ATTORNEY

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "Company");

Does hereby constitute and appoint David C. Bupp, Brent L. Larson and
     Patricia A. Coburn to be his agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full
     power of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission a Registration
     Statement on Form S-3 for the resale of certain shares of common stock, par
     value $.001, of the Company, and any amendments or supplements to such Form
     S-3; and

To execute and deliver any instruments, certificates or other documents
     which they shall deem necessary or proper in connection with the filing of
     such Form S-3, and generally to act for and in the name of the undersigned
     with respect to such filings as fully as could the undersigned if then
     personally present and acting.

Each agent named above is hereby empowered to determine in his discretion
     the times when, the purposes for, and the names in which, any power
     conferred upon him herein shall be exercised and the terms and conditions
     of any instrument, certificate or document which may be executed by him
     pursuant to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be
     governed by those laws of the State of Ohio that apply to instruments
     negotiated, executed, delivered and performed solely within the State of
     Ohio.

This Power of Attorney may be executed in any number of counterparts, each
     of which shall have the same effect as if it were the original instrument
     and all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 4th day of
     March, 1999.

                                                       /s/ John S. Christie
                                                       ------------------------
                                                           John S. Christie


   4



                                POWER OF ATTORNEY

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "Company");

Does hereby constitute and appoint David C. Bupp, Brent L. Larson and
     Patricia A. Coburn to be his agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full
     power of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission a Registration
     Statement on Form S-3 for the resale of certain shares of common stock, par
     value $.001, of the Company, and any amendments or supplements to such Form
     S-3; and

To execute and deliver any instruments, certificates or other documents
     which they shall deem necessary or proper in connection with the filing of
     such Form S-3, and generally to act for and in the name of the undersigned
     with respect to such filings as fully as could the undersigned if then
     personally present and acting.

Each agent named above is hereby empowered to determine in his discretion
     the times when, the purposes for, and the names in which, any power
     conferred upon him herein shall be exercised and the terms and conditions
     of any instrument, certificate or document which may be executed by him
     pursuant to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be
     governed by those laws of the State of Ohio that apply to instruments
     negotiated, executed, delivered and performed solely within the State of
     Ohio.

This Power of Attorney may be executed in any number of counterparts, each
     of which shall have the same effect as if it were the original instrument
     and all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 8th day of
     March, 1999.

                                                      /s/ Julius R. Krevans
                                                   ----------------------------
                                                        Julius R. Krevans


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                                POWER OF ATTORNEY

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "Company");

Does hereby constitute and appoint David C. Bupp and Patricia A. Coburn to
     be his agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full
     power of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission a Registration
     Statement on Form S-3 for the resale of certain shares of common stock, par
     value $.001, of the Company, and any amendments or supplements to such Form
     S-3; and

To execute and deliver any instruments, certificates or other documents
     which they shall deem necessary or proper in connection with the filing of
     such Form S-3, and generally to act for and in the name of the undersigned
     with respect to such filings as fully as could the undersigned if then
     personally present and acting.

Each agent named above is hereby empowered to determine in his discretion
     the times when, the purposes for, and the names in which, any power
     conferred upon him herein shall be exercised and the terms and conditions
     of any instrument, certificate or document which may be executed by him
     pursuant to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be
     governed by those laws of the State of Ohio that apply to instruments
     negotiated, executed, delivered and performed solely within the State of
     Ohio.

This Power of Attorney may be executed in any number of counterparts, each
     of which shall have the same effect as if it were the original instrument
     and all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 4th day of
     March, 1999.

                                                     /s/ Brent L. Larson
                                                  ---------------------------
                                                           Brent L. Larson


   6



                                                               POWER OF ATTORNEY

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "Company");

Does hereby constitute and appoint David C. Bupp, Brent L. Larson and
     Patricia A. Coburn to be his agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full
     power of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission a Registration
     Statement on Form S-3 for the resale of certain shares of common stock, par
     value $.001, of the Company, and any amendments or supplements to such Form
     S-3; and

To execute and deliver any instruments, certificates or other documents
     which they shall deem necessary or proper in connection with the filing of
     such Form S-3, and generally to act for and in the name of the undersigned
     with respect to such filings as fully as could the undersigned if then
     personally present and acting.

Each agent named above is hereby empowered to determine in his discretion
     the times when, the purposes for, and the names in which, any power
     conferred upon him herein shall be exercised and the terms and conditions
     of any instrument, certificate or document which may be executed by him
     pursuant to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be
     governed by those laws of the State of Ohio that apply to instruments
     negotiated, executed, delivered and performed solely within the State of
     Ohio.

This Power of Attorney may be executed in any number of counterparts, each
     of which shall have the same effect as if it were the original instrument
     and all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 10th day of
     March, 1999.

                                                 /s/ Michael P. Moore
                                               ---------------------------------
                                                                Michael P. Moore


   7



                                                               POWER OF ATTORNEY

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "Company");

Does hereby constitute and appoint David C. Bupp, Brent L. Larson and
     Patricia A. Coburn to be his agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full
     power of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission a Registration
     Statement on Form S-3 for the resale of certain shares of common stock, par
     value $.001, of the Company, and any amendments or supplements to such Form
     S-3; and

To execute and deliver any instruments, certificates or other documents
     which they shall deem necessary or proper in connection with the filing of
     such Form S-3, and generally to act for and in the name of the undersigned
     with respect to such filings as fully as could the undersigned if then
     personally present and acting.

Each agent named above is hereby empowered to determine in his discretion
     the times when, the purposes for, and the names in which, any power
     conferred upon him herein shall be exercised and the terms and conditions
     of any instrument, certificate or document which may be executed by him
     pursuant to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be
     governed by those laws of the State of Ohio that apply to instruments
     negotiated, executed, delivered and performed solely within the State of
     Ohio.

This Power of Attorney may be executed in any number of counterparts, each
     of which shall have the same effect as if it were the original instrument
     and all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 3rd day of
     March, 1999.

                                            /s/ J. Frank Whitley, Jr.
                                            -----------------------------------
                                                           J. Frank Whitley, Jr.


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                                POWER OF ATTORNEY

The undersigned who is a director or officer of Neoprobe Corporation, a
     Delaware corporation (the "Company");

Does hereby constitute and appoint David C. Bupp, Brent L. Larson and
     Patricia A. Coburn to be his agents and attorneys-in-fact;

Each with the power to act fully hereunder without the other and with full
     power of substitution to act in the name and on behalf of the undersigned;

To sign and file with the Securities and Exchange Commission a Registration
     Statement on Form S-3 for the resale of certain shares of common stock, par
     value $.001, of the Company, and any amendments or supplements to such Form
     S-3; and

To execute and deliver any instruments, certificates or other documents
     which they shall deem necessary or proper in connection with the filing of
     such Form S-3, and generally to act for and in the name of the undersigned
     with respect to such filings as fully as could the undersigned if then
     personally present and acting.

Each agent named above is hereby empowered to determine in his discretion
     the times when, the purposes for, and the names in which, any power
     conferred upon him herein shall be exercised and the terms and conditions
     of any instrument, certificate or document which may be executed by him
     pursuant to this instrument.

This Power of Attorney shall not be affected by the disability of the
     undersigned or the lapse of time.

The validity, terms and enforcement of this Power of Attorney shall be
     governed by those laws of the State of Ohio that apply to instruments
     negotiated, executed, delivered and performed solely within the State of
     Ohio.

This Power of Attorney may be executed in any number of counterparts, each
     of which shall have the same effect as if it were the original instrument
     and all of which shall constitute one and the same instrument.

IN WITNESS WHEREOF, I have executed this Power of Attorney this 5th day of
     March, 1999.

                                                    /s/ James F. Zid
                                                  ------------------------------
                                                                  James F. Zid