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                                                                EXHIBIT 10.72(b)
                FIRST AMENDMENT TO CREDIT AND SECURITY AGREEMENT

         THIS FIRST AMENDMENT TO CREDIT AND SECURITY AGREEMENT (the "Amendment")
is made as of the 29th day of May, 1996 by and between MEDICIS PHARMACEUTICAL
CORPORATION, a Delaware corporation ("Borrower"), and NORWEST BANK ARIZONA,
NATIONAL ASSOCIATION, a national banking association, as successor-in-interest
to NORWEST BUSINESS CREDIT, INC., a Minnesota corporation ("Lender").

                                R E C I T A L S:

         WHEREAS, Borrower and Norwest Business Credit, Inc. ("NBCI") are
parties to that certain Credit and Security Agreement dated as of August 3,
1995, as modified by letter agreements dated March 6, 1996 and April 11, 1996
(collectively, the "Credit Agreement"), pursuant to which NBCI agreed to make
available to Borrower, on a revolving basis, a sum not to exceed $2,000,000 (the
"Revolving Loan"), which Revolving Loan is evidenced by that certain Promissory
Note dated August 3, 1995 from Borrower to NBCI in an amount not to exceed
$2,000,000 (the "Revolving Note");

         WHEREAS, NBCI has assigned, and Lender has assumed, all of NBCI's
right, title, interest, privileges, obligations and liabilities under the Credit
Agreement, as amended, and any documents, agreements or instruments evidencing,
securing or in any way related to Borrower's obligations under the Credit
Agreement, as amended (the "Loan Documents"), subject to and on the terms and
conditions contained herein; and

         WHEREAS, Borrower has requested that Lender commit to advance an
additional $3,000,000 to finance capital expenditures, product development
costs, brand purchase contracts, licensing agreements and other financial needs
mutually agreed upon in writing by Borrower and Lender in their sole and
absolute discretion, and Lender has agreed thereto on the terms and conditions
set forth herein;

         NOW, THEREFORE, in consideration of the premises and the mutual
covenants contained herein and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, Borrower and Lender,
intending to be legally bound, agree as follows:

         1. INTERPRETATION. Except as otherwise defined herein, all capitalized
terms used herein shall have the meanings ascribed thereto in the Credit
Agreement.

         2. RECITALS. The recitals set forth above are true and accurate in
every respect.

         3. OUTSTANDING INDEBTEDNESS. As of May 29, 1996: the outstanding
principal balance of the Revolving Loan is $0.00; the accrued and unpaid
interest on the Revolving Loan is $0.00; the prorated Minimum Interest Charge
(including the unused 

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fee described in Section 2.11(b) of the Credit Agreement) payable to NBCI is
$24,843.36; and the collateral examination fee previously incurred by, and
payable to, NBCI is $2,300.

         4. NO OFFSETS. Borrower acknowledges with respect to the amounts owing
to Lender that, as of the date of execution of this Amendment, Borrower has no
offset, defense or counterclaim with respect thereto, no claim or defense in the
abatement or reduction thereof, or any other claim against Lender or NBCI or
with respect to any document forming part of the transaction in respect of which
the Revolving Loan was made or forming part of any other transaction under which
Borrower is indebted to Lender or NBCI. Borrower acknowledges that all interest
imposed under the Revolving Note through the date of execution hereof, and all
fees and other charges that have been collected from or known by Borrower to
have been imposed upon Borrower with respect to the Revolving Loan evidenced by
the Revolving Note were and are agreed to, and were properly computed and
collected, and that NBCI has fully performed all obligations that it may have
had or now has to Borrower, and neither NBCI nor Lender has any obligation to
make any additional loan or extension of credit to or for the benefit of
Borrower, except as provided in the Credit Agreement, as amended by this
Amendment.

         5. REPRESENTATIONS AND WARRANTIES OF BORROWER. To induce Lender to
enter into this Amendment and the arrangement contemplated by this Amendment,
Borrower represents and warrants to Lender as follows:

                  (a) This Amendment and all other instruments executed and
delivered to Lender concurrently herewith, were executed in accordance with the
requirements of law and in accordance with any requirements of Borrower's
certificate of incorporation and bylaws and any amendments thereto.

                  (b) The execution and delivery of this Amendment and any other
instruments executed and delivered to Lender concurrently herewith, and the full
and complete performance of the provisions hereof will not result in any breach
of, or constitute a default under, or result in the creation of any lien, charge
or encumbrance upon any property or assets of Borrower under any indenture,
mortgage, deed of trust, bank loan or credit agreement or other instrument to
which Borrower is a party or by which Borrower is bound.

                  (c) The Loan Documents executed by Borrower and this Amendment
are the legal, valid and binding obligations of Borrower enforceable against
Borrower in accordance with their terms.

                  (d) There is no pending or overtly threatened litigation
involving Borrower.

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                  (e) Borrower has not derived ten percent (10%) or more of
Borrower's Net Sales in any Fiscal Year from any Applicable License as described
in Section 6.14 of the Credit Agreement.

                  (f) The patent applications described in Exhibit F to this
First Amendment are the only patent applications Borrower has pending before the
PTO Office and none of the pending patent applications has yet been approved by
the PTO Office.

                  (g) The Beecham Loan (as defined in the Credit Agreement) has
been paid in full and any collateral securing the Beecham Loan has been duly
released of record.

                  (h) There are no oral agreements, understandings or course of
conduct that would modify, amend, rearrange, vary, diminish or impair the Loan
Documents or the obligation of Borrower to pay the indebtedness evidenced
thereby or to perform fully the obligations of Borrower in strict accordance
with the Loan Documents, or which would permit Borrower to void or avoid its
obligations in whole or in part.

                  (i) The indebtedness relating to the financing statement from
Borrower, as debtor, to Victor T. Weber, as Collateral Agent, as secured party,
filed on August 10, 1993 in File No. 32228383, Financing Records of the Maryland
State Department of Assessments and Taxation, has been paid in full and the
secured party has no further obligation to advance monies to Borrower.

                  (j) All of the respective representations and warranties made
by Borrower in the Loan Documents remain true, complete and correct as of the
date hereof, including, without limitation, the representations and warranties
in Section 5 of the Credit Agreement.

No representation or warranty made by Borrower and contained herein or in the
other Loan Documents, and no certificate, information or report furnished or to
be furnished by Borrower in connection with any of the Loan Documents or any of
the transactions contemplated hereby or thereby, contains or will contain a
misstatement of material fact, or omits or will omit to state a material fact
required to be stated in order to make the statements contained herein or
therein not misleading in the light of the circumstances under which such
statements were made.

         6. CONTINUED ENFORCEABILITY OF LOAN DOCUMENTS. Except as modified
herein, all of the terms and provisions of the Loan Documents remain in full
force and effect. In the event of any conflict between the terms and provisions
of this Amendment and the terms and provisions of the Loan Documents, the terms
and provisions of this Amendment shall govern and prevail. Borrower
acknowledges, confirms and ratifies the enforceability of the Credit Agreement,
the Revolving Note and the Loan Documents, as modified pursuant to this
Amendment, and the continuing validity,

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enforceability and priority of the liens and security interests granted in the
Loan Documents.

         7.       RELEASE OF CLAIMS.

                  (a) Borrower hereby releases Lender and NBCI, their officers,
employees and agents from all claims and demands (known and unknown) it may have
on the date hereof arising out of or in any way relating to the extension or
denial of credit by NBCI or the Lender to Borrower or other matters relating to
the indebtedness, any collateral securing payment and performance of such
indebtedness, or any matter preliminary to the execution and delivery by
Borrower and Lender of this Amendment. The release set forth above shall not
extend to any claim arising after the date hereof to the extent based on acts or
omissions of Lender occurring after such date, except that such release is
specifically intended by the parties to include the transactions leading up to
the execution of this Amendment. This Amendment and the release provisions
contained in this Section 7 are contractual, and not a mere recital.

                  (b) Borrower acknowledges and agrees that Lender is not, and
shall not be, obligated in any way to continue or undertake any loan, financing
or other credit arrangement with Borrower, including, without limitation, any
renewal of the indebtedness evidenced by the Loan Documents, except on the terms
and subject to the conditions set forth in the Loan Documents as hereby amended
and modified.

         8. CONDITIONS OF CLOSING. Lender's obligation to enter into this
Amendment and the other documents and instruments required hereunder shall be
subject to the satisfaction of all of the following conditions on or before May
29, 1996 (the "Closing" or the "Closing Date") in a manner, form and substance
satisfactory to Lender, which conditions may be waived by Lender in its sole and
absolute discretion:

                  (a) On the Closing Date the representations and warranties of
Borrower set forth in the Loan Documents shall be true and correct in all
material respects when made and at and as of the time of the Closing.

                  (b) The following shall have been delivered to Lender, each
duly authorized, executed and acknowledged, where applicable:

                           (i) An Assignment of the Loan Documents from NBCI to
                  Lender.

                           (ii) Assignments by NBCI to Lender of each of the
                  UCC-1 Financing Statement from Borrower to NBCI.

                           (iii) This Amendment.

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                           (iv) A Multiple Advance Note from Borrower payable to
                  Lender in the original principal amount not to exceed
                  $3,000,000.

                           (v) A UCC-1 Financing Statement from Borrower in
                  favor of Lender to be filed in the central filing agency of
                  the State of Maryland.

                           (vi) An Amendment to the Collateral Account
                  Agreement.

                           (vii) An Amendment to the Patent Collateral
                  Assignment and Security Agreement.

                           (viii) An Amendment to the Trademark, Tradename and
                  Service Mark Collateral Assignment and Security Agreement.

                           (ix) An Amendment to the Agreement as to Lockbox
                  Services.

                           (x) A Consent from CEDC in connection with the
                  Intercreditor Agreement between CEDC and NBCI.

                           (xi) A Consent from Londen Center L.L.C. in
                  connection with the Landlord's Subordination, Disclaimer and
                  Consent dated as of August 3, 1995 among NBCI, Borrower and
                  Londen Center L.L.C.

                           (xii) A Consent from USCO Distribution Services, Inc.
                  ("USCO") in connection with the Tri-Party Agreement among
                  NBCI, Borrower and USCO.

                  (c) Borrower shall have performed and complied in all material
respects with all agreements and conditions contained in the Loan Documents to
be performed by or complied with by Borrower prior to or at the Closing, and no
Event of Default or Default shall have occurred and be continuing or would occur
by Borrower entering into this Amendment and each condition precedent to the
effectiveness of each of the Loan Documents shall have been satisfied.

                  (d) Lender shall have received such documents as Lender shall
require to establish the proper organization and good standing of Borrower, the
authority of Borrower to execute this Amendment and any other documents or
instruments required hereunder, and evidence that all approvals and/or consents
of, or other action by, any shareholder, governmental agency or other Person
whose approval or consent is necessary or required to enable Borrower to (a)
enter into and perform its obligations under the Loan Documents and (b) grant to
Lender the Security Interests, have been obtained.

                  (e) All filings of Uniform Commercial Code financing
statements and other filings and actions necessary to perfect and maintain the
Security Interests as

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first, valid and perfected security interest in the Collateral shall have been
filed or taken (or such filings delivered for filing immediately following the
Closing, to Lender or a third party acceptable to Lender) and confirmation
thereof shall have been received by Lender.

                  (f) Lender shall have determined to its satisfaction that, as
of the Closing Date, there has been no material adverse change in the financial
condition of Borrower from the financial statements dated as of March 31, 1996
and other documents submitted by Borrower to Lender prior to the Closing Date.

                  (g) Borrower shall have paid to Lender an origination fee of
$50,000, which shall be fully earned and non-refundable upon Lender's execution
and delivery of this Amendment (Lender shall pay its attorneys' fees associated
with negotiating and preparing this Amendment and the related documents).

                  (h) Lender shall be satisfied that (a) Borrower has good and
indefeasible title to all of the Collateral and (b) Borrower at all times shall
be entitled to the use and quiet enjoyment of all assets necessary and desirable
for the continued ownership and operation of Borrower's business, including,
without limitation, the use of equipment, licenses, fixtures and warehouses.

                  (i) Borrower shall have paid all of Lender's out-of-pocket
costs and expenses incurred in connection with UCC lien, litigation and judgment
searches and verifications and filing and recording fees.

                  (j) Borrower shall have paid all of the fees and reimbursable
costs and expenses due to NBCI pursuant to Section 3 hereof.

         9. DEFINITIONS. (a) The definitions of "Beecham Loan" and "Minimum
Interest Charge" in Section 1.1 of the Credit Agreement is hereby deleted in its
entirety; (b) the definitions of "Base Rate", "Floating Rate", "Loan Documents"
and "Termination Date" in Section 1.1 of the Credit Agreement are hereby deleted
in their entirety and the following inserted therefor:

                           "Base Rate" means the rate of interest publicly
                  announced from time to time by Norwest Bank Arizona, National
                  Association, as its "base rate" or, if such bank ceases to
                  announce a rate so designated, any similar successor rate
                  designated by the Lender.

                           "Floating Rate" means an annual rate equal to the sum
                  of the Base Rate plus 125 basis points, which Floating Rate
                  shall change when and as the Base Rate changes.

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                           "Loan Documents" means this Agreement, the Notes, the
                  Financing Statements Form UCC-1, the Security Documents and
                  all other documents previously, concurrently or hereafter
                  executed or delivered in connection with the Revolving Credit
                  Facility or the Term Credit Facility.

                           "Termination Date" means July 31, 1997.

and (c) Section 1.1 of the Credit Agreement is hereby amended to add the
following definitions in proper alphabetical order:

                           "Borrowing Base Certificate" means a monthly
                  statement, in form approved by Lender, showing Accounts,
                  Eligible Accounts, Inventory and Eligible Inventory by
                  location, and the outstanding principal balance on the
                  Revolving Credit Facility at the last day of each month,
                  certified as correct by Borrower's President or Chief
                  Financial Officer.

                           "Current Assets" means cash, cash equivalents,
                  including Permitted Investments, trade receivables, tax
                  refunds and inventory.

                           "Current Ratio" means, as of any date of
                  determination, on a consolidated basis, the ratio of Current
                  Assets to current liabilities under GAAP.

                           "Maturity Date" means July 31, 2001.

                           "Maximum Amount" means $3,000,000.

                           "Net Worth" means the gross value of the Borrower's
                  Equity plus debt subordinated to the Lender in a manner
                  acceptable to the Lender (using the Lender's standard form).
                  "Equity" means Borrower's retained earnings plus the "book
                  value" of all issued and outstanding stock in Borrower
                  (including all common and preferred), plus paid-in capital
                  less treasury stock.

                           "Permitted Investments" means investments in direct
                  obligations of the United States of America or any agency or
                  instrumentality thereof whose obligations constitute full
                  faith and credit obligations of the United States of America
                  having a maturity of one year or less, commercial paper issued
                  by U.S. corporations rated "A-1" or "A-2" by Standard 

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                  & Poor's Corporation or "P-1" or "P-2" by Moody's Investors
                  Service or certificates of deposit or bankers' acceptances
                  having a maturity of one year or less issued by members of the
                  Federal Reserve System having deposits in excess of
                  $100,000,000 (which certificates of deposit or bankers'
                  acceptances are fully insured by the Federal Deposit Insurance
                  Corporation and "Money Market Funds" acquired through an FDIC
                  insured bank and/or a division or subsidiary thereof.

                           "Revolving Credit Facility" means the working capital
                  credit facility not to exceed the Commitment being made
                  available to Borrower by Lender pursuant to Article 2 hereof.

                           "Tangible Net Worth" means, as of any date of
                  determination, on a consolidated basis, Net Worth less the net
                  book value (after deducting reserves applicable thereto) of
                  all assets classified as intangible assets under GAAP,
                  including, without limitation, goodwill, trademarks, trade
                  names, service marks, copyrights, patents, licenses, permits,
                  covenants not to compete, and rights related thereto, less any
                  stock or other securities or evidences of indebtedness of any
                  other Person, any loans or advances to any other Person, or
                  any investment or interest whatsoever in any other Person,
                  including specifically, but without limitation, any
                  partnership or joint venture, except Permitted Investments.

                           "Term Credit Facility" means term credit facility not
                  to exceed the Maximum Amount being made available to Borrower
                  by Lender pursuant to Article 2 hereof.

                           "Term Note" means the multiple advance promissory
                  note from Borrower payable to Lender in the principal amount
                  not to exceed the Maximum Amount and any amendments,
                  modifications, supplements, consolidations, replacements or
                  consolidations thereto or thereof, including, without
                  limitation, any replacement note issued pursuant to Section
                  2.13 hereof.

                           "Treasury Bill Constant" means the sum of (x)(i) the
                  yield to maturity reported, as of 10:00 a.m. (New York City
                  time) on the third Business Day preceding the Termination
                  Date, on the display designated as "Page 678" on the 

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                  Telerate Service (or such other display as may replace Page
                  678 on the Telerate Service) for actively traded U.S. Treasury
                  securities having a maturity of forty-eight (48) months from
                  the Termination Date (as near as practicable) or (ii) if such
                  yields shall not be reported as of such time or the yields
                  reported as of such time shall not be ascertainable, the
                  Treasury Constant Maturity Series yields reported, for the
                  latest day for which such yields shall have been so reported
                  on or prior to the third Business Day preceding the
                  Termination Date, in Federal Reserve Statistical Release H.15
                  (519) (or any comparable successor publication) for actively
                  traded U.S. Treasury securities having a constant maturity of
                  forty-eight (48) months from the Termination Date (as near as
                  practicable) plus (y) three hundred (300) basis points.

         10. ADVANCES. (a) The preface to Section 2.1 of the Credit Agreement is
hereby deleted in its entirety and the following inserted therefor:

                           Section 2.1 Advances. The Lender agrees, on the terms
                  and subject to the conditions herein set forth, to make
                  Advances to the Borrower from time to time during the period
                  from the date hereof to and including the Termination Date, or
                  the earlier date of termination in whole of the Revolving
                  Credit Facility and Term Credit Facility pursuant to Sections
                  2.4(a) or 8.2 hereof, in an aggregate amount at any time
                  outstanding not to exceed the Borrowing Base, with respect to
                  the Revolving Credit Facility, and the Maximum Amount, with
                  respect to the Term Credit Facility, which Advances shall be
                  secured by the Collateral as provided in Article 3 hereof. The
                  Revolving Credit Facility shall be a revolving facility and it
                  is contemplated that the Borrower will request Advances, make
                  prepayments and request additional Advances thereunder and the
                  Term Credit Facility shall be a term facility and it is
                  contemplated that Borrower will request Advances for capital
                  expenditures, product development costs, brand purchase
                  contracts, licensing agreements and other purposes mutually
                  agreed upon in writing by Borrower and Lender in their sole
                  and absolute discretion, which Advances will be repaid in
                  accordance with the terms of this Agreement. The Borrower
                  agrees to comply with the following procedures in requesting
                  Advances under this Section 2.1:

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and (b) Section 2.1(b) of the Credit Agreement is hereby deleted in its entirety
and the following inserted therefor:

                           (b) Each request for an Advance under this Section
                  2.1 shall be made to the Lender prior to 11:00 a.m. (Phoenix
                  time) of the day of the requested Advance by the Borrower.
                  Each request for an advance may be made in writing or by
                  telephone, specifying the date of the requested Advance and
                  the amount thereof, and (i) shall specify whether it is an
                  Advance under the Revolving Credit Facility or the Term Credit
                  Facility and the purpose of the Advance, and (ii) shall be
                  made by (A) any officer of the Borrower; or (B) any person
                  designated as the Borrower's agent by any officer of the
                  Borrower in a writing delivered to the Lender; or (C) any
                  person reasonably believed by the Lender to be an officer of
                  the Borrower or such a designated agent.

         11. NOTE. Section 2.2 of the Credit Agreement is hereby deleted in its
entirety and the following inserted therefor:

                           Section 2.2 Notes. All Advances made by the Lender
                  under this Section 2.1 shall be evidenced by and repayable
                  with interest in accordance with the Note and the Term Note.
                  The principal of the Note shall be payable as provided herein
                  and on the earlier of the Termination Date or acceleration by
                  the Lender pursuant to Section 8.2 hereof, and shall bear
                  interest as provided herein. The principal of the Term Note
                  shall be payable as provided herein and shall bear interest as
                  provided herein, and, absent acceleration by the Lender
                  pursuant to Section 8.2 hereof, shall be amortized commencing
                  on the Termination Date as provided herein.

         12. INTEREST. Section 2.3(b) of the Credit Agreement is hereby deleted
in its entirety and the following inserted therefor:

                           (b)      INTENTIONALLY DELETED

         13. VOLUNTARY PREPAYMENT; TERMINATION OF AGREEMENT BY THE BORROWER;
PERMANENT REDUCTION OF COMMITMENT. (a) Section 2.4(a) of the Credit Agreement is
hereby deleted in its entirety and the following inserted therefor:

                           (a) Borrower may, in its discretion, prepay the
                  Advances in whole at any time or from time to time in part.
                  The Borrower may terminate this Agreement at any time 

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                  and, subject to payment and performance of all the Borrower's
                  obligations to the Lender, the Lender shall promptly release
                  the Security Interest and the Borrower may obtain any release
                  or termination of the Security Interest to which the Borrower
                  is otherwise entitled by law by giving at least 30 days' prior
                  written notice to the Lender of the Borrower's intention to
                  terminate this Agreement.

and (b) Section 2.4(b) of the Credit Agreement is hereby deleted in its entirety
and the following inserted therefor:

                           (b)      INTENTIONALLY DELETED

         14. MANDATORY PREPAYMENT. Section 2.5 of the Credit Agreement is hereby
deleted in its entirety and the following inserted therefor:

                           Section 2.5 Mandatory Prepayment. Without notice or
                  demand, if the sum of the outstanding principal balance of the
                  Advances with respect to the Note shall at any time exceed the
                  Borrowing Base, the Borrower shall within forty-eight (48)
                  hours (excluding Saturdays, Sundays and Holidays) thereof
                  prepay the Advances to the extent necessary to reduce the sum
                  of the outstanding principal balance of the Advances with
                  respect to the Note to the Borrowing Base. Any payment
                  received by the Lender under this Section 2.5 or under Section
                  2.4 may be applied to the Advances under the Revolving Credit
                  Facility, including interest thereon and any fees,
                  commissions, costs and expenses due and unpaid hereunder and
                  under the Security Documents, in such order and in such
                  amounts as the Lender, in its discretion, may from time to
                  time determine, and, if a Default or Event of Default has
                  occurred and is continuing, to the Advances under the Term
                  Credit Facility, including interest thereon.

         15. USE OF PROCEEDS. Section 2.8 of the Credit Agreement is hereby
deleted in its entirety and the following inserted therefor:

                           Section 2.8 Use of Proceeds. The proceeds of Advances
                  with respect to the Revolving Credit Facility shall be used by
                  the Borrower for ordinary working capital purposes and the
                  proceeds of Advances with respect to the Term Credit Facility
                  shall be used by the Borrower for capital expenditures,
                  product development costs, brand purchase contracts, licensing
                  agreements and other purposes 

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                  mutually agreed upon in writing by Borrower and Lender in
                  their sole and absolute discretion.

         16. FEES. (a) Section 2.11(a) of the Credit Agreement is hereby deleted
in its entirety and the following inserted therefor:

                           (a) The Borrower hereby agrees to pay Lender a fully
                  earned and non-refundable origination fee of $50,000 upon the
                  execution of the First Amendment to Credit and Security
                  Agreement dated as of May 29, 1996 between Borrower and Lender
                  (the "First Amendment").

(b) Section 2.11(b) of the Credit Agreement is hereby deleted in its entirety
and the following inserted therefor:

                           (b)      INTENTIONALLY DELETED

and (c) Section 2.11(c) of the Credit Agreement is hereby deleted in its
entirety and the following inserted therefor:

                           (c) Provided that no Default or Event of Default has
                  occurred and is continuing, Lender shall not undertake more
                  than two (2) collateral audits or inspections of the
                  operations or business of the Borrower in any Fiscal Year and
                  Borrower shall not be required to pay any audit fees or
                  out-of-pocket costs and expenses incurred by Lender in
                  connection with any such audits or inspections by the Lender
                  of any collateral or the corresponding operations or business
                  of the Borrower after May 29, 1996. Upon the occurrence of a
                  Default or Event of Default and during the continuance
                  thereof, Lender may undertake such collateral audits and
                  inspections of the operations or business of the Borrower as
                  Lender deems necessary in its sole and absolute discretion and
                  the Borrower hereby agrees to pay the Lender, on demand, audit
                  fees of $50 per hour (or the then applicable rate charged by
                  Lender) per auditor in connection with any such audits or
                  inspections by the Lender of any collateral or the
                  corresponding operations or business of the Borrower, together
                  with all actual out-of-pocket costs and expenses incurred in
                  conducting any such audit or inspection.

         17. AMORTIZATION OF TERM CREDIT FACILITY. Article 2 of the Credit
Agreement is hereby amended to add the following:

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                           Section 2.13 Amortization of Term Credit Facility.
                  Provided that no Default or Event of Default has occurred and
                  is continuing, on the Termination Date, all of the accrued and
                  unpaid interest and other fees and charges shall be due and
                  payable and, at Borrower's election to be made in writing on
                  or prior to the Termination Date, (a) the then outstanding
                  principal balance of the Term Credit Facility shall be
                  amortized over a forty-eight month period and paid in equal
                  principal payments, plus interest at the Floating Rate, on the
                  last day of each month, commencing August 31, 1997 and
                  continuing on the last day of each month thereafter until the
                  Maturity Date, at which time the entire outstanding principal
                  balance of the Term Credit Facility, all accrued and unpaid
                  interest and all other fees and charges shall be due and
                  payable, or (b) the then outstanding principal balance of the
                  Term Credit Facility shall be amortized over a forty-eight
                  month period, with interest calculated at the Treasury Bill
                  Constant, and paid in level principal and interest payments on
                  the last day of each month, commencing August 31, 1997 and
                  continuing on the last day of each month thereafter until the
                  Maturity Date, at which time the entire outstanding principal
                  balance of the Term Credit Facility, all accrued and unpaid
                  interest and all other fees and charges shall be due and
                  payable. At the request of Lender, Borrower shall execute and
                  deliver a replacement promissory note for the Term Note. In
                  the event that Borrower fails to make an election on or prior
                  to the Termination Date, Borrower shall be deemed to have
                  elected clause (a) above.

         18. CONDITIONS PRECEDENT TO THE INITIAL ADVANCE. Section 4.1 of the
Credit Agreement is hereby amended to add the following:

                                    (u) A certificate of the Secretary or an
                  Assistant Secretary of the Borrower, certifying as to the
                  resolutions of the directors and, if required, the
                  shareholders of the Borrower, authorizing the execution,
                  delivery and performance of the First Amendment, the Term Note
                  and the other documents and all documents and instruments
                  incident thereto and to the transactions contemplated thereby,
                  satisfactory to Lender and its counsel.

                                    (v) An opinion of counsel to the Borrower,
                  addressed to Lender, with respect to the transactions

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                  contemplated by the First Amendment, in form and substance
                  satisfactory to Lender and its counsel.

         19. FINANCIAL CONDITION; NO ADVERSE CHANGE. Section 5.5 of the Credit
Agreement is hereby deleted in its entirety and the following inserted therefor:

                           Section 5.5 Financial Condition; No Adverse Change.
                  The Borrower has heretofore furnished to the Lender audited
                  financial statements of the Borrower for its Fiscal Year ended
                  June 30, 1995 and unaudited financial statements of the
                  Borrower for the months ended through March 31, 1996, and
                  those statements fairly present the financial condition of the
                  Borrower on the dates thereof and the results of its
                  operations and cash flows for the periods then ended and were
                  prepared in accordance with generally accepted accounting
                  principles. Since the date of the most recent financial
                  statements of the Borrower, there has been no material adverse
                  change in the business, properties or condition (financial or
                  otherwise) of the Borrower.

         20. REPORTING REQUIREMENTS. (a) Section 6.1(l) of the Credit Agreement
is hereby deleted in its entirety and the following inserted therefor:

                           (c) within 15 days after the end of each month,
                  agings of the Borrower's accounts receivable and its accounts
                  payable and a Borrowing Base Certificate as at the end of such
                  month;

Section 6.1(l) of the Credit Agreement is hereby deleted in its entirety and the
following inserted therefor:

                           (l) promptly after the sending or filing thereof,
                  copies of all regular and periodic financial reports and
                  special reports which the Borrower shall file with the
                  Securities and Exchange Commission or any national securities
                  exchange, including, without limitation, reports on Form 10-Q,
                  Form 10-K and Form 8-K.

         21. INCOME TAX RETURNS. Section 6.1 of the Credit Agreement is hereby
amended to add the following:

                           (o) as soon as available and in any event within
                  thirty (30) days following the filing of Borrower's federal
                  income tax return, a copy of such federal income tax return
                  and, if such federal income tax return is not filed on or

                                      -14-
   15
                  before October 15, then on or before November 15, a copy of
                  the completed request for extension delivered to the Internal
                  Revenue Service followed by the federal income tax return when
                  filed.

         22. LOCKBOX; COLLATERAL ACCOUNT. Section 6.10 of the Credit Agreement
is hereby deleted in its entirety and the following inserted therefor:

                           Section 6.10  Lockbox; Collateral Account.

                           (a) The Borrower will irrevocably direct all present
                  and future Account debtors and other Persons obligated to make
                  payments constituting Collateral to make such payments
                  directly to the Lockbox. All of the Borrower's invoices,
                  account statements and other written or oral communications
                  directing, instructing, demanding or requesting payment of any
                  Account or any other amount constituting Collateral shall
                  conspicuously direct that all payments be made to the Lockbox
                  and shall include the Lockbox address. Upon confirmation of
                  good, collected funds, all payments made to the Lockbox shall
                  be processed to Borrower's operating account no. 6438801379
                  maintained with Lender. In Lender's sole and absolute
                  discretion, all payments received in the Lockbox may be
                  processed to the Collateral Account.

                           (b) Upon the written request of Lender, the Borrower
                  agrees to deposit in the Collateral Account or, at the
                  Lender's option, to deliver to the Lender all collections on
                  Accounts, contract rights, chattel paper and other rights to
                  payment constituting Collateral, and all other cash proceeds
                  of Collateral, which the Borrower may receive directly
                  notwithstanding its direction to Account debtors and other
                  obligors to make payments to the Lockbox, immediately upon
                  receipt thereof, in the form received, except for the
                  Borrower's endorsement when deemed necessary. Until delivered
                  to the Lender or deposited in the Collateral Account, all
                  proceeds or collections of Collateral shall be held in trust
                  by the Borrower for and as the property of the Lender and
                  shall not be commingled with any funds or property of the
                  Borrower. Amounts deposited in the Collateral Account shall
                  not bear interest and shall not be subject to withdrawal by
                  the Borrower, except after full payment and discharge of all
                  Obligations. All such collections shall constitute proceeds of
                  Collateral and shall 

                                      -15-
   16
                  not constitute payment of any Obligation. Collected funds from
                  the Collateral Account shall be transferred to the Lender's
                  general account, and the Lender may deposit in its general
                  account or in the Collateral Account any and all collections
                  received by it directly from the Borrower. The Lender may
                  commingle such funds with other property of the Lender or any
                  other person. The Lender from time to time at its discretion
                  shall, after allowing two (2) Banking Days after deposit in
                  the Collateral Account, apply such funds to the payment of any
                  or all Obligations, in any order or manner of application
                  satisfactory to the Lender. All items delivered to the Lender
                  or deposited in the Collateral Account shall be subject to
                  final payment. If any such item is returned uncollected, the
                  Borrower will immediately pay the Lender, the amount of that
                  item, or Lender at its discretion may charge any uncollected
                  item to the Borrower's operating account or other account. The
                  Borrower shall be liable as an endorser on all items deposited
                  in the Collateral Account, whether or not in fact endorsed by
                  the Borrower.

         23. MINIMUM NET INCOME. Section 6.12 of the Credit Agreement is hereby
deleted in its entirety and the following inserted therefor:

                           Section 6.12 Tangible Net Worth. Borrower shall
                  maintain on a consolidated basis Tangible Net Worth in the
                  following amounts as of the following dates:


          ===========================================================
           FISCAL QUARTER END                    TANGIBLE NET WORTH
          -----------------------------------------------------------
                                                  
            June 30, 1996                               $5,700,000
          -----------------------------------------------------------
            September 30, 1996                          $7,000,000
          -----------------------------------------------------------
            December 31, 1996                           $8,800,000
          -----------------------------------------------------------
            March 31, 1997                             $10,500,000
          -----------------------------------------------------------
            June 30, 1997 and thereafter               $12,500,000
            during the term of this
            Agreement
          ===========================================================


         24. NET WORTH INCREASE. Section 6.13 of the Credit Agreement is hereby
deleted in its entirety and the following inserted therefor:

                                      -16-
   17
                           Section 6.13     INTENTIONALLY DELETED

         25. BEECHAM LOAN. Section 6.16 of the Credit Agreement is hereby
deleted in its entirety and the following inserted therefor:

                           Section 6.16 Total Liabilities to Tangible Net Worth.
                  Borrower shall maintain on a consolidated basis, measured
                  quarterly as of the last day of March, June, September and
                  December, a ratio of total liabilities under GAAP to Tangible
                  Net Worth of no more than 1.50:1 as of June 30, 1996,
                  September 30, 1996 and December 31, 1996; a ratio of total
                  liabilities under GAAP to Tangible Net Worth of no more than
                  1.25:1 as of March 31, 1997; and a ratio of total liabilities
                  under GAAP to Tangible Net Worth of no more than 1:1 from and
                  including June 30, 1997 through the remaining term of this
                  Agreement.

         26. CURRENT RATIO. Article 6 of the Credit Agreement is hereby amended
to add the following:

                           Section 6.18 Current Ratio. During the term of this
                  Agreement, Borrower shall maintain on a consolidated basis,
                  measured monthly as of the last day of each month commencing
                  June 30, 1996, a Current Ratio of no less than 1.7:1.

         27. INVESTMENTS AND SUBSIDIARIES. Section 7.4(a) of the Credit
Agreement is hereby deleted in its entirety and the following inserted therefor:

                           (a) The Borrower will not purchase or hold
                  beneficially any stock or other securities or evidences of
                  indebtedness of, make or permit to exist any loans or advances
                  to, or make any investment or acquire any interest whatsoever
                  in, any other Person, including specifically, but without
                  limitation, any partnership or joint venture, except for the
                  following:

                                  (i) Permitted Investments;

                                  (ii) advances in the form of progress
                             payments, prepaid rent or security deposits;

                                  (iii) loans to employees in an aggregate
                             amount outstanding at any time not to exceed
                             $25,000; and

                                      -17-
   18
                                  (iv) other uses mutually agreed upon in
                             writing by Borrower and Lender in their sole and
                             absolute discretion.

         28. CAPITAL EXPENDITURES. Section 7.10 of the Credit Agreement is
hereby deleted in its entirety and the following inserted therefor:

                           Section 7.10 Capital Expenditures. The Borrower will
                  not expend, or contract to expend, to purchase Capital Assets
                  more than $100,000 in Fiscal Year 1996 (excluding Borrower's
                  purchase of modular furniture having an approximate value of
                  $60,000); more than $500,000 in Fiscal Year 1997; and,
                  thereafter, during the term this Agreement, more than $200,000
                  in any Fiscal Year.

         29. ADDRESS FOR NOTICES, ETC. (a) For purposes of Section 9.3 of the
Credit Agreement, the address for notices, requests, demands or other
communications provided for under the Loan Documents to Lender shall be as
follows:

                        Norwest Bank Arizona, National Association
                        64 East Broadway
                        Tempe, Arizona   85282
                        Attn:   Mr. Jeffrey R. Wentzel, Vice President
                        Telecopier: (602) 644-8392

(b) Copies of all notices, requests, demands or other communications provided
for under Section 9.3 of the Credit Agreement or other communications provided
for under the Loan Documents to Borrower shall be delivered as follows:

                        Brown & Bain, P.A.
                        2901 North Central Avenue
                        P.O. Box 400
                        Phoenix, Arizona 85001-0400
                        Attn:   Frank M. Placenti, Esq.
                        Telecopier: (602) 351-8516

         30. FINANCING STATEMENT. For purposes of Section 9.4 of the Credit
Agreement, the name and address of the Secured Party shall be as follows:

                        Norwest Bank Arizona, National Association
                        64 East Broadway
                        Tempe, Arizona   85282
                        Attn:   Mr. Jeffrey R. Wentzel, Vice President

                                      -18-
   19
         31. COSTS AND EXPENSES. Section 9.7 of the Credit Agreement is hereby
deleted in its entirety and the following inserted therefor:

                           Section 9.7 Costs and Expenses. Borrower agrees to
                  pay to Lender on demand any and all costs, expenses and fees
                  (including reasonable attorneys' fees) incurred in enforcing
                  or attempting to recover payment of the amount due under this
                  Agreement, including, without limitation, negotiating,
                  documenting and otherwise pursuing or consummating any
                  modifications, extensions, compositions, renewals or other
                  similar transactions pertaining to this Agreement,
                  irrespective of the existence of a default, and including
                  costs, expenses and fees incurred before, after or
                  irrespective of whether suit is commenced and including costs,
                  expenses and fees incurred by Lender in any bankruptcy
                  proceedings (including, without limitation, efforts to modify
                  or vacate any automatic stay or injunction) or appellate
                  proceeding, and in the event suit or arbitration is brought to
                  enforce payment hereof, such costs, expenses and fees and all
                  other issues in such suit shall be determined by a court
                  sitting without a jury or by the arbitrator(s), as applicable.

         32. GOVERNING LAW; JURISDICTION, VENUE; WAIVER OF JURY TRIAL. Section
9.12 of the Credit Agreement is hereby deleted in its entirety and the following
inserted therefor:

                           Section 9.12 Arbitration; Waiver of Jury Trial.
                  EXCEPT FOR "CORE PROCEEDINGS" UNDER THE UNITED STATES
                  BANKRUPTCY CODE, THE PARTIES AGREE TO SUBMIT TO BINDING
                  ARBITRATION ALL CLAIMS, DISPUTES AND CONTROVERSIES BETWEEN
                  THEM, WHETHER IN TORT, CONTRACT OR OTHERWISE (AND THEIR
                  RESPECTIVE EMPLOYEES, OFFICERS, DIRECTORS, ATTORNEYS, AND
                  OTHER AGENTS) ARISING OUT OF OR RELATING TO IN ANY WAY THIS
                  CREDIT AGREEMENT. ANY ARBITRATION PROCEEDING WILL (A) PROCEED
                  IN PHOENIX, ARIZONA; (B) BE GOVERNED BY THE FEDERAL
                  ARBITRATION ACT (TITLE 9 OF THE UNITED STATES CODE); AND (C)
                  BE CONDUCTED IN ACCORDANCE WITH THE COMMERCIAL ARBITRATION
                  RULES OF THE AMERICAN ARBITRATION ASSOCIATION ("AAA"). THIS
                  ARBITRATION REQUIREMENT DOES NOT LIMIT THE RIGHT OF ANY PARTY
                  TO (I) FORECLOSE 

                                      -19-
   20
                  AGAINST REAL OR PERSONAL PROPERTY COLLATERAL OR SUE FOR AND
                  OBTAIN A DEFICIENCY JUDGMENT AFTER FORECLOSURE; (II) EXERCISE
                  SELF-HELP REMEDIES RELATING TO COLLATERAL OR PROCEEDS OF
                  COLLATERAL SUCH AS SETOFF OR REPOSSESSION; OR (III) OBTAIN
                  PROVISIONAL ANCILLARY REMEDIES SUCH AS REPLEVIN, INJUNCTIVE
                  RELIEF, ATTACHMENT OR THE APPOINTMENT OF A RECEIVER, BEFORE,
                  DURING OR AFTER THE PENDENCY OR ANY ARBITRATION PROCEEDING.
                  THIS EXCLUSION DOES NOT CONSTITUTE A WAIVER OF THE RIGHT OR
                  OBLIGATION OF ANY PARTY TO SUBMIT ANY DISPUTE TO ARBITRATION,
                  INCLUDING THOSE DISPUTES ARISING FROM THE EXERCISE OF THE
                  ACTIONS DETAILED IN CLAUSES (I), (II) AND (III) ABOVE. ANY
                  ARBITRATION PROCEEDING WILL BE BEFORE A SINGLE ARBITRATOR. THE
                  PARTIES SHALL USE REASONABLE EFFORTS TO AGREE UPON A SINGLE
                  ARBITRATOR WITHIN TEN (10) DAYS AFTER WRITTEN NOTICE FROM ONE
                  PARTY TO THE OTHER REQUESTING ARBITRATION. IF THE PARTIES ARE
                  UNABLE TO AGREE UPON AN ARBITRATOR WITHIN SUCH TEN (10) DAY
                  PERIOD, AT ANY TIME THEREAFTER EITHER PARTY MAY REQUIRE THAT
                  THE ARBITRATOR BE SELECTED ACCORDING TO THE COMMERCIAL
                  ARBITRATION RULES OF THE AAA. THE ARBITRATOR WILL BE A NEUTRAL
                  ATTORNEY WHO PRACTICES IN THE AREA OF COMMERCIAL OR BUSINESS
                  LAW. THE ARBITRATOR WILL DETERMINE WHETHER OR NOT AN ISSUE IS
                  ARBITRABLE AND WILL GIVE EFFECT TO THE STATUTES OF LIMITATION
                  IN DETERMINING ANY CLAIM. JUDGMENT UPON THE AWARD RENDERED BY
                  THE ARBITRATOR MAY BE ENTERED IN ANY COURT HAVING
                  JURISDICTION. IN ANY ARBITRATION PROCEEDING, THE ARBITRATOR
                  WILL DECIDE (BY DOCUMENTS ONLY OR WITH A HEARING AT THE
                  ARBITRATOR'S DISCRETION) ANY PRE-HEARING MOTIONS WHICH ARE
                  SIMILAR TO MOTIONS TO DISMISS FOR FAILURE TO STATE A CLAIM OR
                  MOTIONS FOR SUMMARY ADJUDICATION. IN ANY ARBITRATION
                  PROCEEDING, DISCOVERY WILL BE PERMITTED AND WILL BE GOVERNED
                  BY THE ARIZONA RULES OF CIVIL PROCEDURE. ALL 

                                      -20-
   21
                  DISCOVERY MUST BE COMPLETED NO LATER THAN 20 DAYS BEFORE THE
                  HEARING DATE AND WITHIN 180 DAYS OF THE COMMENCEMENT OF
                  ARBITRATION PROCEEDINGS. ANY REQUESTS FOR AN EXTENSION OF THE
                  DISCOVERY PERIODS, OR ANY DISCOVERY DISPUTES, WILL BE SUBJECT
                  TO FINAL DETERMINATION BY THE ARBITRATOR UPON A SHOWING THAT
                  THE REQUEST FOR DISCOVERY IS ESSENTIAL FOR THE PARTY'S
                  PRESENTATION AND THAT NO ALTERNATIVE MEANS FOR OBTAINING
                  INFORMATION IS AVAILABLE. THE ARBITRATOR SHALL AWARD COSTS AND
                  EXPENSES OF THE ARBITRATION PROCEEDING IN ACCORDANCE WITH THE
                  PROVISIONS OF THE CREDIT AGREEMENT. EXCEPT AS OTHERWISE
                  PROVIDED HEREIN, THIS AGREEMENT SHALL BE GOVERNED BY AND
                  CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF ARIZONA,
                  WITHOUT REGARD TO ITS CONFLICT OF LAWS RULES. IN THE EVENT
                  THAT LENDER EXERCISES ITS RIGHTS TO FORECLOSE AGAINST REAL OR
                  PERSONAL PROPERTY COLLATERAL OR OBTAIN PROVISIONAL ANCILLARY
                  REMEDIES SUCH AS REPLEVIN, INJUNCTIVE RELIEF, ATTACHMENT OR
                  THE APPOINTMENT OF A RECEIVER, THE PARTIES AGREE THAT ANY
                  LAWSUIT ARISING OUT OF ANY SUCH CONTROVERSY SHALL BE TRIED IN
                  A COURT OF COMPETENT JURISDICTION BY A JUDGE SITTING WITHOUT A
                  JURY.

                  ------------                                ------------
                  Initial                                     Initial

         33. COMPLIANCE CERTIFICATE. Exhibit E to the Credit Agreement is hereby
deleted in its entirety and replaced by Exhibit E attached to the First
Amendment, which is incorporated in the Agreement by this reference.

         34. PATENT APPLICATIONS. Exhibit F to the Credit Agreement is hereby
deleted in its entirety and replaced by Exhibit F attached to the First
Amendment, which is incorporated in the Agreement by this reference.

         35. MISCELLANEOUS.

                  (a) Arbitration Agreement; Waiver of Right to Jury Trial. The
Agreement contains an arbitration provision and waiver of right to jury trial.
In the 

                                      -21-
   22
event of any dispute arising out of or related to this Amendment, the provisions
of Section 9.12 of the Agreement shall apply.

                  (b) Voluntary Agreement. Borrower represents and warrants to
Lender that (i) it is, or has had the opportunity to be, represented by legal
counsel of its choice in regard to the transaction provided for by this
Amendment and that such counsel (if engaged) has explained the significance of
the terms, and the meaning and effect of this Amendment; (ii) it is fully aware
and clearly understands all of the terms and provisions contained in this
Amendment; (iii) it has voluntarily, with full knowledge and without coercion or
duress of any kind, entered into this Amendment and the documents executed in
connection with this Amendment; (iv) it is not relying on any representations,
either written or oral, express or implied, made to it by Lender other than as
set forth in this Amendment; and (v) the consideration received by Borrower to
enter into this Amendment and the arrangement contemplated by this Amendment has
been actual and adequate.

                  (c) Entire Agreement. This Amendment and the Loan Documents
constitute the entire agreement among the parties as to the agreements and
understandings contemplated by this Amendment. All parties to this Amendment
acknowledge that there are no agreements, understandings, warranties or
representations among the parties except as set forth in the Loan Documents and
this Amendment.

                  (d) Counterpart Execution. This Amendment may be executed in
counterparts, each of which shall be deemed an original document, and all of
which combined shall constitute a single document.

                  (e) Waiver. Neither this Amendment nor any of the provisions
hereof may be changed, waived, discharged or terminated, except by an instrument
in writing signed by the party against whom enforcement of the change, waiver,
discharge or termination is sought.

                  (f) Headings. Paragraph or other headings contained in this
Amendment are for reference purposes only and are not intended to affect in any
way the meaning or interpretation of this Amendment.

                  (g) Severability. If any clause or provision of this Amendment
is determined to be illegal, invalid, or unenforceable under any present or
future law by the final judgement of a court of competent jurisdiction, such
clause or provision shall be ineffective, but the remainder of this Amendment
will not be affected thereby.

                  (h) Binding Effect. All of the provisions of this Amendment
shall be binding upon and shall inure to the benefit of Borrower and Lender and
their permitted successors and assigns, including, without limitation, any
successor holder of any Note and any successor mortgagee/beneficiary under any
security document.

                                      -22-
   23
                  (i) Time of the Essence. Time is of the essence of each and
every provision under this Amendment.

                  (j) Amendment. Except as specifically set forth herein, the
Agreement and the other Loan Documents shall remain in full force and effect. In
the event of a conflict between the terms and provisions of this Amendment and
the terms and provisions of the Agreement, the terms and provisions of this
Amendment shall govern and control. This Amendment replaces and supersedes in
its entirety those certain letter agreements dated March 6, 1996 and April 11,
1996 between NBCI and Borrower. Nothing contained in this Amendment is intended
to or shall be construed as relieving any person or entity, whether a party to
this Amendment or not, of any of such person's or entity's obligations to
Lender.

                  (k) Power of Attorney. For purposes of compliance with Arizona
Revised Statutes Section 14-5503, Sections 3.2 and 6.11 of the Credit Agreement
and any other provisions in the Credit Agreement or Loan Documents granting a
power of attorney by Borrower to Lender are incorporated herein by this
reference.

                                      -23-
   24
         IN WITNESS WHEREOF, this Amendment is executed to be effective as of
the date first above written.

                                       BORROWER:

                                       MEDICIS PHARMACEUTICAL
                                       CORPORATION, a Delaware corporation
- ----------------------------------
Witness

                                       By:
                                          -------------------------------------
                                       Name:  Jonah Shacknai
                                            -----------------------------------
                                       Title:  Chairman of the Board
                                             ----------------------------------
                                       Execution Date:           May 29, 1996

                                       LENDER:

                                       NORWEST BANK ARIZONA, NATIONAL
                                       ASSOCIATION, a national banking
                                       association

                                       By:
                                          -------------------------------------
                                       Name:  Jeffrey R. Wentzel
                                            -----------------------------------
                                       Title:   Vice President
                                             ----------------------------------
                                       Execution Date:           May 29, 1996

                                      -24-
   25
STATE OF ARIZONA         )
                         ) ss.
County of Maricopa       )

                  The foregoing instrument was acknowledged before me, the
undersigned notary public, this 29th day of May, 1996, by Jonah Shacknai, the
Chairman of the Board of MEDICIS PHARMACEUTICAL CORPORATION, a Delaware
corporation, on behalf of the corporation.

                                       ---------------------------------
                                       Notary Public

My Commission Expires:

- ----------------------



STATE OF ARIZONA         )
                         ) ss.
County of Maricopa       )

                  The foregoing instrument was acknowledged before me, the
undersigned notary public, this 29th day of May, 1996, by Jeffrey R. Wentzel,
the Vice President of NORWEST BANK ARIZONA, NATIONAL ASSOCIATION, a national
banking association, on behalf of the banking association.

                                       ---------------------------------
                                       Notary Public

My Commission Expires:

- ----------------------

                                      -25-
   26
                                    EXHIBIT E

                             COMPLIANCE CERTIFICATE

         In accordance with our Credit and Security Agreement dated as of August
3, 1995, as amended (the "Credit Agreement"), attached are the financial
statements of Medicis Pharmaceutical Corporation (the "Borrower") as of and for
the month and year-to-date period ended ______________ __, 199_ (the "Current
Financials")

         I certify that the Current Financials have been prepared in accordance
with generally accepted accounting principles applied on a basis consistent with
the accounting practices reflected in the financial statements referred to in
Section 5.5 of the Credit Agreement, subject to year-end audit adjustments, if
applicable.

Defaults and Events of Default (check one)

    / /           I have no knowledge of the occurrence of any Default or Event
                  of Default under the Credit Agreement which has not previously
                  been reported to you and remedied.

    / /           Attached is a detailed description of all Defaults and Events
                  of Default of which I have knowledge and which have not
                  previously been reported to you and remedied.

         For the date and periods covered by the Current Financials, the
Borrower is in compliance with the covenants set forth in Sections 6.12, 6.16,
6.18 and 7.10 of the Credit Agreement, except as indicated below. The
calculations made to determine compliance are as follows:



Covenant                             Actual             Requirement
                                                        
6.12     Tangible Net Worth          $__________                $________

6.16     Total Liabilities to

         Tangible Net Worth          ___________                _________

6.18     Current Ratio               ___________                _________

7.10     Capital Expenditures        $__________        Maximum $________

   27
Date:____________________________, 199__

                                       MEDICIS PHARMACEUTICAL
                                       CORPORATION, a Delaware corporation

                                       By:_____________________________________
                                       Name:___________________________________
                                       Title:__________________________________