Exhibit 10.43


                              SEPARATION AGREEMENT

     WHEREAS,  ROBERT C. VERFURTH and DIANON SYSTEMS,  INC.  ("COMPANY") wish to
end the  employment  relationship  between  them and wish to resolve any and all
claims, disputes or causes of action that do or may exist between them;

     NOW THEREFORE,  in consideration of the mutual covenants and other valuable
considerations  contained  herein,  the COMPANY and ROBERT C. VERFURTH  agree as
follows:

     1. ROBERT C.  VERFURTH  resigns his  full-time  employment  and his officer
position with the COMPANY effective as of September 15, 1997.

     2. The COMPANY  shall pay ROBERT C.  VERFURTH  separation  pay, at his last
rate of base salary, subject to applicable deductions, for the period six months
after his termination and for so much of the following three months as ROBERT C.
VERFURTH has not obtained  other  employment  (the  "Separation  Period").  This
separation pay shall be paid in equal  installments  on regular payroll dates of
the COMPANY throughout the Separation Period.




     3.  Throughout  the  Separation  Period,  the COMPANY  shall  contribute to
medical  coverage for ROBERT C. VERFURTH and his  dependents at the same rate it
contributes for active employees, provided ROBERT C. VERFURTH and his family are
eligible for and elect continuation coverage.

     4. The  COMPANY  shall pay  ROBERT  C.  VERFURTH  any  bonus he would  have
received  under  the  COMPANY's  1997  Management   Incentive  Program  had  his
employment  continued  through the date on which payments under said program are
made.  This payment will be made at the same time  payments to other  Management
Incentive Program participants are made.

     5. The COMPANY  shall pay for ROBERT C.  VERFURTH to  participate  in Drake
Beam Morin Inc.'s six month Senior Executive Program of outplacement services.

     6. ROBERT C. VERFURTH  agrees to comply with the provisions of the Employee
Proprietary  Information  Agreement  appended  to this  Agreement  as Exhibit A,
subject to Paragraph 11 of this Agreement.

     7.  ROBERT  C.  VERFURTH  agrees  to  cooperate  with the  COMPANY  and its
representatives  regarding  any claims or potential  claims or  litigation by or
against the COMPANY involving  matters about which ROBERT C. VERFURTH  possesses
knowledge.




     8. ROBERT C.  VERFURTH,  agrees to make  himself  reasonably  available  to
consult with the COMPANY on Sales matters during the Separation Period.

     9. ROBERT C. VERFURTH, on behalf of himself, his executors,  administrators
and assigns,  hereby releases the COMPANY, its affiliates,  and their respective
directors,   officers,   agents,  employees,   benefit  plans,  fiduciaries  and
administrators   of  such  benefit  plans  and  their   successors  and  assigns
(hereinafter  "Released  COMPANY  Parties") from any and all claims or causes of
action of any kind arising on or before the date he signs this Agreement,  other
than vested rights under benefit plans, which ROBERT C. VERFURTH has, had or may
have  against  any of them,  whether  or not now known  arising  from  ROBERT C.
VERFURTH's  recruitment  for  employment  with the COMPANY,  his  employment  or
officer  position with the COMPANY,  or the  termination  of his  employment and
officer position with the COMPANY,  including without  limitation any claims for
violation of employment  discrimination  statutes,  breach of contract,  tort or
other wrongdoing.

     10.  ROBERT C.  VERFURTH  on  behalf  of  himself,  his  heirs,  executors,
administrators  and assigns,  further  agrees never  directly or  indirectly  to




commence or prosecute, or to permit or advise to be commenced or prosecuted, any
action,  proceeding,  or charge against any Released COMPANY Party, in any state
or federal  court,  administrative  agency or arbitral forum with respect to any
matter whether or not now known, for any claim based upon any act,  transaction,
practice,  conduct,  or omission that  occurred  prior to the date he signs this
Agreement,  including but not limited to, rights under any other federal, state,
or local laws prohibiting age, race, sex,  national origin,  religion,  or other
forms of discrimination, claims for breach of contract or promissory estoppel or
tort, and claims growing out of any legal restrictions on the COMPANY's right to
terminate  its  employees  or officers  which he now has, or claims to have,  or
which at any time heretofore had, or which at any time hereafter he may have.

           11.  Notwithstanding  the  provisions of the  Employment  Proprietary
Information  Agreement  attached hereto,  ROBERT C. VERFURTH  undertakes and the
COMPANY shall enforce against him only the following obligation not to engage in
any competitive activity.  ROBERT C. VERFURTH agrees that, to the fullest extent
permitted  by law,  for the period of  eighteen  (18)  months  after the date of
termination of employment with the COMPANY,  he (a) will not solicit business on
behalf of any entity  which is  conducting  any  business  which  competes  with
DIANON's  business  ("Competing  Entity"),  (b) will not solicit  business  from
customers of DIANON,  (c) will not solicit the  employment or services of any of
the employees of DIANON,  (d) will not,  directly or indirectly,  participate in




the ownership,  management,  operation or control of any Competing Entity in the
geographic area in which Employee may have rendered service to DIANON during the
two (2) year period prior to the termination of employment.

     12. ROBERT C.  VERFURTH  agrees that he will not seek  employment  with the
COMPANY or its  affiliates or successors  and that any  application he makes for
such employment will be rejected without explanation or recourse.

     13. The parties  recognize and agree that this Agreement does not and shall
not  constitute an admission of liability or wrongdoing by any Released  COMPANY
Party.

     14. The parties  agree that,  except as  necessary  to comply and to obtain
compliance with this Agreement,  or to comply with any federal,  state, or local
law, they will not disclose the terms of this Agreement.

     15. In the event  ROBERT C.  VERFURTH  files a claim,  lawsuit or complaint
against any  Released  COMPANY  Party in any court or  governmental  agency with
respect to the claims he has released under this  Agreement,  ROBERT C. VERFURTH
shall be liable for all costs and expenses including legal fees, incurred by any
Released COMPANY Party in defense of that action.

     16. ROBERT C. VERFURTH represents that he has carefully read and completely
understands  this  Agreement  and  that  he  has  entered  into  this  Agreement




voluntarily  after having had a reasonable  amount of time to consider it and an
opportunity to consult with his legal advisors.

     17.  ROBERT C.  VERFURTH  acknowledges  that the  commitments,  waivers and
releases he gives in this  Agreement are in exchange for valuable  consideration
to which he is not otherwise  entitled,  and which constitutes a full accord and
satisfaction of any claims he may have against any Released COMPANY Party.

     18.  ROBERT C.  VERFURTH  acknowledges  that he has been given a reasonable
time to review the waivers and  releases  contained in this  Agreement  prior to
signing it.

     19. This Agreement  constitutes the entire  Agreement of the parties on the
subject   matter   hereof  and   supersedes   any  and  all  prior   agreements,
understandings or commitments, oral or written.







     20. This Agreement shall be governed by applicable Federal law and the laws
of the State of Connecticut.

                                           ROBERT C. VERFURTH



Dated:   15 SEP 97                         Signature:   /S/ ROBERT C. VERFURTH
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                                           DIANON SYSTEMS, INC.



Dated:   29 SEPTEMBER, 1997                By:    /S/ KEVIN C. JOHNSON
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