Registration No. 333-114384
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                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549
                                    --------

                        POST-EFFECTIVE AMENDMENT NO. 1 TO
                                    FORM S-4
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                                    --------

                         NATIONAL PENN BANCSHARES, INC.
             (Exact name of registrant as specified in its charter)

                                    --------


 Pennsylvania                        6021                       23-2215075
- -------------                  ------------------               ----------
(State or other               (Primary Standard              (I.R.S. Employer
jurisdiction of           Industrial Classification No.)     Identification No.)
incorporation or
                                 organization)

                        Reading and Philadelphia Avenues
                               Boyertown, PA 19512
                                 (610) 367-6001
       (Address, including zip code, and telephone number, including area
               code, of registrant's principal executive offices)

                                    --------


                                Wayne R. Weidner
                      Chairman and Chief Executive Officer
                         National Penn Bancshares, Inc.
                        Reading and Philadelphia Avenues
                               Boyertown, PA 19512
                                 (610) 367-6001
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                                    --------

                        Copies of all communications to:

       Jay W. Waldman                                  David W. Swartz
       Mary Alice Busby                                Stevens & Lee, P.C.
       Ellsworth, Carlton,                             111 North Sixth Street
       Mixell & Waldman, P.C.                          P.O. Box 679
       1105 Berkshire Blvd., Suite 320                 Reading, PA 19603-0679
       Wyomissing, PA  19610                           (610) 478-2184
       (610) 374-1135


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         Pursuant to Registration Statement No. 333-114384 on Form S-4, National
Penn Bancshares,  Inc., a Pennsylvania corporation,  registered 3,204,470 shares
of its common stock,  without par value,  and associated  stock purchase rights,
issuable pursuant to an Agreement between the Registrant and Peoples First, Inc.
dated as of  December  17,  2003,  which  Agreement  provided  for the merger of
Peoples First, Inc. with and into National Penn Bancshares,  Inc., with National
Penn Bancshares,  Inc.  surviving the merger. The Registrant hereby removes from
registration  90,021 shares of its common stock,  and associated  stock purchase
rights, that remain unissued after completion of the merger.




                                       2


                                   SIGNATURES


         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
Registrant has duly caused this  Post-effective  Amendment No. 1 to Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the Borough of Boyertown,  Commonwealth of Pennsylvania,  on this
19th day of August, 2004.


                                                 NATIONAL PENN BANCSHARES, INC.
                                                 (Registrant)


August 19, 2004
                                                 /s/ Wayne R. Weidner
                                                 -----------------------
                                                 Wayne R. Weidner
                                                 Chairman and
                                                 Chief Executive Officer


         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
Post-effective  Amendment No. 1 to Registration  Statement has been signed below
by the following persons in the capacities and on the dates indicated:





                                                                              

Signature                                            Title                            Date
- ---------                                            -----                            -----


/s/ Gary L. Rhoads                                   Treasurer and              August 19, 2004
- -------------------                                  Principal Accounting
Gary L. Rhoads                                       and Financial Officer


/s/ John H. Body *                                   Director                   August 19, 2004
- ------------------
John H. Body


/s/ J. Ralph Borneman, Jr. *                         Director                   August 19, 2004
- ---------------------------
J. Ralph Borneman, Jr.


- ----------------------------                         Director
Fred D. Hafer


/s/ Frederick P. Krott *                             Director                   August 19, 2004
- ------------------------
Frederick P. Krott


/s/ Patricia L. Langiotti *                          Director                   August 19, 2004
- ---------------------------
Patricia L. Langiotti



                                       3




/s/ Kenneth A. Longacre *                            Director                   August 19, 2004
- -------------------------
Kenneth A. Longacre


- ----------------------------                         Director
George C. Mason


/s/ Glenn E. Moyer *                                 Director                   August 19, 2004
- --------------------
Glenn E. Moyer


/s/ Alexander Rankin *                               Director                   August 19, 2004
- --------------------
Alexander Rankin


/s/ Robert E. Rigg *                                 Director                   August 19, 2004
- --------------------
Robert E. Rigg


/s/ C. Robert Roth *                                 Director                   August 19, 2004
- --------------------
C. Robert Roth


/s/ Donald P. Worthington *                          Director                   August 19, 2004
- ---------------------------
Donald P. Worthington


/s/ Wayne R. Weidner                                 Director, Chairman and     August 19, 2004
- --------------------                                 Chief Executive Officer
Wayne R. Weidner                                     (Principal Executive Officer)





* By /s/ Wayne R. Weidner
     --------------------
      Wayne R. Weidner
      Attorney-in-Fact





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