Exhibit 16.1 April 7, 2005 U.S. Securities and Exchange Commission Office of the Chief Accountant 450 Fifth Street, NW Washington, DC 20549 Re: Republic First Bancorp, Inc. File No. 0-17007 Dear Sir or Madam: We have read Item 4.01 of Form 8-K of Republic First Bancorp, Inc. dated April 4, 2005 and agree with the statements concerning our Firm contained therein. Very truly yours, /signature/ Grant Thornton LLP April 7, 2005