As filed with the Securities and Exchange Commission on November 17, 2000
Registration No. 333-
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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
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FORM S-3
REGISTRATION STATEMENT
Under
THE SECURITIES ACT OF 1933
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XOMA LTD.
(Exact name of registrant as specified in its charter)
Bermuda 52-2154066
(State or other jurisdiction of (I.R.S. Employer
incorporation or organization) Identification No.)
2910 Seventh Street
Berkeley, California 94710
(510) 644-1170
(Address, including ZIP code, and telephone number, including
area code, of registrant's principal executive offices)
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CHRISTOPHER J. MARGOLIN, ESQ.
XOMA LTD.
2910 Seventh Street
Berkeley, California 94710
(510) 644-1170
(Name, address, including ZIP code, and telephone number,
including area code, of agent for service)
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Copy to:
GEOFFREY E. LIEBMANN, ESQ.
CAHILL GORDON & REINDEL
80 Pine Street
New York, New York 10005
(212) 701-3000
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Approximate date of commencement of proposed sale to the public: From time to
time after the effective date of this Registration Statement. If the only
securities being registered on this Form are being offered pursuant to dividend
or interest reinvestment plans, please check the following box. / /
If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. |X|
If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering. / /
If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. / /
If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. / /
CALCULATION OF REGISTRATION FEE
Title of Each Class Proposed Proposed
of Securities Amount Maximum Maximum Amount of
To Be To Be Offering Price Aggregate Registration
Registered Registered per Unit(1) Offering Price(1) Fee
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Common Shares,
par value U.S. $.0005
per share................... 10,000,000(2)(3) $11.25 $112,500,000 $29,700
(1) Estimated solely for the purpose of computing the registration fee pursuant
to Rule 457(c).
(2) Includes a like number of Preference Share Purchase Rights (the "Rights").
Since no separate consideration is paid for the Rights, the registration
fee is included in the fee for the Common Shares.
(3) Pursuant to Rule 416 under the Securities Act of 1933, any additional
Common Shares issued as a result of stock splits, stock dividends or
similar transactions are deemed to be registered herewith.
The Registrant hereby amends this Registration Statement on such date or dates
as may be necessary to delay its effective date until the Registrant shall file
a further amendment which specifically states that this Registration Statement
shall thereafter become effective in accordance with Section 8(a) of the
Securities Act of 1933 or until the Registration Statement shall become
effective on such date as the Commission, acting pursuant to said Section 8(a),
may determine.
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The information contained in this prospectus is not complete and may be changed.
This prospectus is not an offer to sell these securities and it is not
soliciting an offer to buy these securities in any state where the offer or sale
is not permitted.
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Prospectus Subject to Completion,
dated November 17, 2000
XOMA Ltd.
Common Shares
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o We may from time to time issue up to 10,000,000 o We may sell these common shares to or through
common shares. We will specify in the underwriters and also to other purchasers or
accompanying prospectus supplement the terms of through agents. We will set forth the names
any such offering. of any underwriters or agents in the
accompanying prospectus supplement.
This investment involves a high degree of risk. Consider carefully the risk
factors beginning on page 4 of this prospectus before you invest.
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Neither the SEC nor any state securities commission has approved these
securities or determined that this prospectus is accurate or complete. Any
representation to the contrary is a criminal offense.
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The date of this prospectus is ________,2000.
TABLE OF CONTENTS
About This Prospectus............................ 2 Use of Proceeds.................................. 14
Risk Factors..................................... 3 Description of Share Capital..................... 15
Incorporation of Information We File Plan of Distribution............................. 18
with the SEC.................................. 10 Legal Opinion.................................... 19
Special Note Regarding Forward-Looking Experts.......................................... 19
Statements.................................... 11 Where You Can Get More Information............... 19
XOMA............................................. 12
Price Range of Common Shares and Dividend
Information................................... 13
2
ABOUT THIS PROSPECTUS
This prospectus is part of a registration statement that we filed with the
Securities and Exchange Commission, or SEC, utilizing a "shelf" registration
process. Under this shelf process, we may sell up to 10,000,000 common shares.
Each time we sell common shares, we will provide a prospectus supplement that
will contain specific information about the terms of that offering.
3
RISK FACTORS
You should carefully consider the following factors and other information
in this prospectus before deciding to invest in common shares.
None Of Our Pharmaceutical Products Have Received Regulatory Approval; If Our
Products Do Not Receive Regulatory Approval, Neither We Nor Our Third Party
Collaborators Will Be Able To Manufacture And Market Them
Even our most developed pharmaceutical product has yet to complete final
clinical testing. We will be unable to manufacture and market our products
without required regulatory approvals in the United States and other countries.
The United States government and governments of other countries extensively
regulate many aspects of our products, including:
o testing
o manufacturing
o promotion and marketing and
o exporting.
In the United States, the Food and Drug Administration regulates
pharmaceutical products under the Federal Food, Drug, and Cosmetic Act and other
laws, including, in the case of biologics, the Public Health Service Act. At the
present time, we believe that our products will be regulated by the FDA as
biologics. State regulations may also affect our proposed products.
In December 1992, we submitted an investigational new drug application to
the FDA to begin human testing of our NEUPREX(R) product, a
genetically-engineered fragment of a human protein (BPI). In April 2000, members
of the FDA and representatives of XOMA and Baxter Healthcare Corporation, to
whom we have licensed worldwide rights to all pharmaceutical compositions
containing BPI (including NEUPREX(R)) for treatment of meningococcemia and in
substantially all future anti-bacterial and anti-endotoxin human clinical
indications, discussed results from the Phase III trial that tested NEUPREX(R)
in pediatric patients with severe meningococcemia (a potentially deadly
bacterial infection principally of children), and senior representatives of the
FDA indicated that the data presented were not sufficient to support the filing
of an application for marketing approval at that time. We and Baxter are
therefore examining ways to supply additional data necessary to proceed with the
filing. We cannot confirm that we will be able to supply such additional data.
If we conduct an additional trial, we cannot assure you that the results will be
adequate for approval. In September 1999, we discontinued patient enrollment in
our Phase III clinical trial testing NEUPREX(R) in trauma patients with severe
blood loss because an independent data safety monitoring board told us that
interim results from the trial did not support continuing the trial. We have
conducted earlier stage clinical trials testing NEUPREX(R) as a treatment in
three additional indications:
o prevention of complications following partial hepatectomy (a type of
major liver surgery)
o treatment of severe infections within the abdomen in combination with
antibiotics and
o treatment of cystic fibrosis patients (whose genetic disorder
predisposes them to recurring bacterial lung infections).
4
We are currently evaluating with Baxter alternatives regarding future
indications. Should we decide to conduct trials in such future indications, we
cannot predict that the results will support product approval or justify further
development.
In September 1996, XOMA and Genentech, Inc. announced that an
investigational new drug application had been filed with the FDA for clinical
testing of anti-CD11a in patients with moderate to severe psoriasis. We
completed a Phase II efficacy study in Canada in psoriasis patients in late
1998, subsequently received a $2 million milestone payment from Genentech, and
agreed with Genentech to continue collaborative development of the product in
psoriasis through Phase III and to expand the program to include all indications
for the product. Genentech has subsequently completed enrollment in two Phase
III trials of anti-CD11a in psoriasis and XOMA has initiated and completed
enrollment in a Phase I/II study of anti-CD11a in kidney transplant recipients.
In November 2000, we initiated a Phase I study in cancer patients of ING-1,
a high-affinity antibody to an antigen expressed on epithelial cell cancers
(breast, colorectal, prostate and others) that destroys cancer cells by
recruiting the patient's own immune system.
Our other potential products will also require significant additional
development, including extensive preclinical and clinical testing.
The FDA has substantial discretion in both the product approval process and
manufacturing facility approval process and we cannot predict at what point, or
whether, the FDA will be satisfied with our submissions or whether the FDA will
raise questions which may be material and delay or preclude product approval or
manufacturing facility approval. As we accumulate additional clinical data, we
will submit it to the FDA, which may have a material impact on the FDA product
approval process.
Given that regulatory review is an interactive and continuous process, we
maintain a policy of limiting announcements and comments upon the specific
details of the ongoing regulatory review of our products, subject to our
obligations under the securities laws, until definitive action is taken.
Because All Of Our Products Are Still In Development, We Will Require
Substantial Funds To Continue; We Cannot Be Certain That Funds Will Be Available
And, If Not Available, We May Have To Take Actions Which Could Adversely Affect
Your Rights
If adequate funds are not available, we may have to dilute or otherwise
adversely affect the rights of existing shareholders, curtail or cease
operations or, in extreme circumstances, file for bankruptcy protection. We have
spent, and we expect to continue to spend, substantial funds in connection with:
o research and development relating to our products and production
technologies
o scale-up of our production capabilities
o extensive human clinical trials and
o protection of our intellectual property.
We believe we have enough cash (including interest income) to meet our currently
anticipated needs for operating expenses, working capital, equipment
acquisitions and current research projects through at least the second quarter
of 2002. We continue to evaluate strategic alliances, potential partnerships and
financing ar-
5
rangements which would further strengthen our competitive position and provide
additional funding. Accordingly, we cannot assure you that:
o operations will generate meaningful funds
o additional agreements for product development funding can be reached
o strategic alliances can be negotiated or
o adequate additional financing will be available for us to finance our
own development on acceptable terms, if at all.
Cash balances and operating cash flow are influenced primarily by the timing and
level of payments by the Company's licensees and development partners, as well
as by the Company's operating costs.
Because All Of Our Products Are Still In Development, We Have Sustained Losses
In The Past And We Expect To Sustain Losses In The Future
We have experienced significant losses and, as of September 30, 2000, we
had an accumulated deficit of approximately U.S.$470.2 million.
For the year ended December 31, 1999 and the nine months ended September
30, 2000, we had net losses of approximately U.S.$45.8 million, or U.S.$.87 per
common share (basic and diluted), and U.S.$20.0 million, or U.S.$0.31 per common
share (basic and diluted), respectively. We expect to incur additional losses in
the future. Our ability to make profits is dependent in large part on obtaining
regulatory approval for our products and entering into agreements for product
development and commercialization. Our ability to fund our ongoing operations is
dependent on the foregoing factors and on our ability to secure additional
funds. We cannot assure you that we will ever make a profit or that cash flow
from future operations will be sufficient to meet our needs.
If Third Party Collaborators Do Not Successfully Develop and Market Our
Products, We May Not Be Able To Do So On Our Own
Our financial resources and our marketing experience and expertise are
limited. Consequently, we depend to a large extent upon securing the financial
resources and marketing capabilities of third parties with whom we collaborate.
In April 1996, XOMA and Genentech entered into an agreement whereby XOMA agreed
to co-develop Genentech's humanized monoclonal antibody product anti-CD11a. In
April 1999, the companies extended and expanded the agreement. In January 2000,
we licensed the worldwide rights to all pharmaceutical compositions containing
BPI (including NEUPREX(R)) for treatment of meningococcemia and substantially
all future anti-bacterial and anti-endotoxin human clinical indications to
Baxter Healthcare Corporation. We cannot assure you that Genentech or Baxter
will successfully develop or market any products.
Even when we have a collaboration relationship, we cannot assure you that
it will result in successful development of marketable products. For example, in
June 1999, we licensed certain genetically-engineered fragments of BPI to
Allergan Inc. to use in combination with other anti-infectives in products to
treat bacterial ophthalmic infections. In May 2000, following successful product
testing at Allergan, we expanded the collaboration to include "stand-alone"
formulations of BPI and to cover eye infections caused by any microbes. In
November 2000, Allergan advised us that for internal economic reasons they
planned to discontinue development of BPI-derived ophthalmic anti-infective
products. We cannot assure you that we will succeed in finding another licensee
for these products or that any such licensee will be successful in developing
and marketing the products.
6
As of the date of this prospectus, we have not entered into any other
license agreements regarding our other products currently in development.
Although we continue to evaluate additional strategic alliances and potential
partnerships, we cannot predict whether or when any such alliances or
partnerships will be entered into.
If Any Of Our Products Receives Regulatory Approval, We May Not Be Able To
Increase Existing Or Acquire New Manufacturing Capacity Sufficient To Meet
Market Demand
We have never commercially introduced any pharmaceutical products. We
cannot assure you that the capacity of our existing manufacturing facilities can
be increased to produce sufficient quantities of our products to meet market
demand. Also, if we need additional manufacturing facilities to meet market
demand, we cannot assure you that we will successfully obtain those facilities.
If Our Patent Protection For Our Principal Products Is Not Enforceable, We Will
Not Realize Our Profit Potential
Because of the length of time and the expense associated with bringing new
products to the marketplace, we hold and are in the process of applying for a
number of patents in the United States and abroad to protect our products and
important processes and also have obtained or have the right to obtain exclusive
licenses to certain patents and applications filed by others. However, the
patent position of biotechnology companies generally is highly uncertain, and no
consistent policy regarding the breadth of allowed claims has emerged from the
actions of the U.S. Patent and Trademark Office with respect to biotechnology
patents. Legal considerations surrounding the validity of biotechnology patents
continue to be in transition, and we cannot assure you that historical legal
standards surrounding questions of validity will continue to be applied or that
current defenses as to issued biotechnology patents will in fact be considered
substantial in the future. Accordingly, we cannot assure you as to:
o the degree and range of protection any patents will afford against
competitors with similar technologies
o if and when patents will issue
o whether or not others will obtain patents claiming aspects similar to
those covered by our patent applications or
o the extent to which we will be successful in avoiding any patents
granted to others.
The Patent Office has issued and/or allowed 53 patents to us related to our
BPI-based products, including novel compositions, their manufacture,
formulation, assay and use. In addition, we are the exclusive licensee of
BPI-related patents and applications owned by New York University and Incyte
Pharmaceuticals Inc. The Patent Office has also issued and/or allowed nine
patents to us related to our bacterial expression technology.
If certain patents issued to others are upheld or if certain patent
applications filed by others issue and are upheld, we may require licenses from
others in order to develop and commercialize certain potential products
incorporating our technology. We cannot assure you that these licenses, if
required, will be available on acceptable terms.
Due to the uncertainties regarding biotechnology patents, we also have
relied and will continue to rely upon trade secrets, know-how and continuing
technological advancement to develop and maintain our com-
7
petitive position. All of our employees have signed confidentiality agreements
under which they have agreed not to use or disclose any of our proprietary
information. Research and development contracts and relationships between us and
our scientific consultants and potential customers provide access to aspects of
our know-how that are protected generally under confidentiality agreements. We
cannot assure you that all confidentiality agreements will be honored or are
enforceable.
Other Companies May Render Some Or All Of Our Products Noncompetitive Or
Obsolete
We cannot assure you that developments by others will not render our
products or technologies obsolete or uncompetitive. Technologies developed and
utilized by the biotechnology and pharmaceutical industries are continuously and
substantially changing. Competition in the areas of genetically-engineered
DNA-based and antibody-based technologies is intense and expected to increase in
the future as a number of established biotechnology firms and large chemical and
pharmaceutical companies advance in these fields. Many of these competitors may
be able to develop products and processes competitive with or superior to our
own for many reasons, including that they may have:
o significantly greater financial resources
o larger research and development and marketing staffs
o larger production facilities
o entered into arrangements with, or acquired, biotechnology companies
to enhance their capabilities or
o extensive experience in preclinical testing and human clinical trials.
Without limiting the foregoing, XOMA is aware that Biogen Inc. is in Phase
III testing of its Amevive(TM) product in chronic plaque psoriasis, Immunex
Corp. may be testing its rheumatoid arthritis drug in psoriasis and other
companies are developing monoclonal antibody or other products for treatment of
inflammatory skin disorders.
These factors may enable others to develop products and processes
competitive with or superior to our own. In addition, a significant amount of
research in biotechnology is being carried out in universities and other
non-profit research organizations. These entities are becoming increasingly
interested in the commercial value of their work and may become more aggressive
in seeking patent protection and licensing arrangements.
It is possible that one or more other companies may be developing one or
more products based on BPI, and we cannot assure you that these product(s) will
not prove to be more effective than NEUPREX(R).
If We Do Business Internationally, We Will Be Subject To Additional Political,
Economic and Regulatory Uncertainties
We cannot assure you that we will be able to successfully operate in any
foreign market. We believe that, because the pharmaceutical industry is global
in nature, international activities will be a significant part of our future
business activities and that, when and if we are able to generate income, a
substantial portion of that income will be derived from product sales and other
activities outside the United States. Foreign regulatory agencies often
establish standards different from those in the United States, and an inability
to obtain foreign regulatory approvals on a timely basis could have an adverse
effect on our business. International operations may be limited or disrupted by:
8
o imposition of government controls
o export license requirements
o political or economic instability
o trade restrictions
o changes in tariffs
o restrictions on repatriating profits
o taxation and
o difficulties in staffing and managing international operations.
Also, our business may be adversely affected by fluctuations in currency
exchange rates.
Because We Are A Relatively Small Biopharmaceutical Company With Limited
Resources, We May Not Be Able To Attract And Retain Qualified Personnel, And The
Loss Of Key Personnel Could Delay Or Prevent Achieving Our Objectives
Our success in developing marketable products and achieving a competitive
position will depend, in part, on our ability to attract and retain qualified
scientific and management personnel, particularly in areas requiring specific
technical, scientific or medical expertise. There is intense competition for
such personnel, and we cannot assure you that we will be able to attract or
retain them. Our research, product development and business efforts would be
adversely affected by the loss of a significant group of key members of our
scientific or management staff.
Because We Engage In Human Testing, We Are Exposed To An Increased Risk Of
Product Liability Claims, Which Would Have An Adverse Effect On Our Business
The testing and marketing of medical products entails an inherent risk of
allegations of product liability. We believe that we currently have adequate
levels of insurance for our clinical trials. We will seek to obtain additional
insurance, if needed, if and when our products are commercialized; however, we
cannot assure you that adequate insurance coverage will be available or be
available at acceptable costs or that a product liability claim would not
materially adversely affect our business.
Our Shareholder Rights Agreement Or Bye-laws May Prevent Transactions That Could
Be Beneficial To Our Shareholders
Our shareholder rights agreement could make it considerably more difficult
or costly for a person or group to acquire control of XOMA in a transaction that
our board of directors opposes.
Our bye-laws:
o require certain procedures to be followed and time periods to be met
for any shareholder to propose matters to be considered at annual
meetings of shareholders, including nominating directors for election
at those meetings;
9
o authorize our board of directors to issue up to 1,000,000 preference
shares without shareholder approval and to set the rights, preferences
and other designations, including voting rights, of those shares as
the board of directors may determine; and
o contain provisions, similar to those contained in the Delaware General
Corporation Law, that may make business combinations with interested
shareholders more difficult.
These provisions, alone or in combination with each other, may discourage
transactions involving actual or potential changes of control, including
transactions that otherwise could involve payment of a premium over prevailing
market prices to holders of common shares, or could limit the ability of
shareholders to approve transactions that they may deem to be in their best
interests.
Because We Have No History Of Profitability And Because The Biotechnology Sector
Has Been Characterized By Highly Volatile Stock Prices, Announcements We Make
And General Market Conditions For Biotechnology Stocks Could Result In A Sudden
Change In The Value Of Our Stock
As a biopharmaceutical company, we have experienced significant volatility
in our common shares. Fluctuations in our operating results and general market
conditions for biotechnology stocks could have a significant impact on the
volatility of our common share price. From November 1, 1999 through October 31,
2000, our share price has ranged from a low of U.S.$2 1/2 to a high of U.S.$16.
Factors contributing to such volatility include:
o results of preclinical studies and clinical trials,
o evidence of the safety or efficacy of our products,
o announcements of new collaborations,
o failure to enter into collaborations,
o developments in existing collaborations,
o our funding requirements and the terms of our financing arrangements,
o announcements of technological innovations or new indications for our
therapeutic products,
o government regulations,
o developments in patent or other proprietary rights,
o announcements regarding other participants in the biotechnology and
pharmaceutical industries, and
o market speculation regarding any of the foregoing.
10
If You Were To Obtain A Judgment Against Us, It May Be Difficult To Enforce
Against Us Because We Are A Foreign Entity
We are a Bermuda company. All or a substantial portion of our assets may be
located outside the United States. As a result, it may be difficult for
investors to enforce in United States courts judgments obtained against us. We
have irrevocably agreed that we may be served with process with respect to
actions based on offers and sales of securities made hereby in the United States
by serving Christopher J. Margolin, c/o XOMA Ltd., 2910 Seventh Street,
Berkeley, California 94710, our United States agent appointed for that purpose.
XOMA has been advised by its Bermuda counsel, Conyers Dill & Pearman, that there
is doubt as to whether Bermuda courts would enforce judgments of United States
courts obtained in (a) actions against such persons or XOMA that are predicated
upon the civil liability provisions of the Securities Act or (b) original
actions brought in Bermuda against XOMA or such persons predicated upon the
Securities Act. There is no treaty in effect between the United States and
Bermuda providing for such enforcement, and there are grounds upon which Bermuda
courts may not enforce judgments of United States courts. Certain remedies
available under the United States federal securities laws may not be allowed in
Bermuda courts as contrary to that nation's policy.
11
INCORPORATION OF INFORMATION WE FILE WITH THE SEC
The following documents filed by XOMA with the SEC pursuant to the
Securities Exchange Act are "incorporated by reference" in this prospectus,
which means we can disclose important information to you by referring you to
these documents and they are considered to be a part of this prospectus:
(1) annual report on Form 10-K for the fiscal year ended December 31, 1999 as
amended by an amendment on Form 10-K/A dated and filed on April 25, 2000
(file no. 0-14710);
(2) quarterly reports on Form 10-Q for the quarterly periods ended March 31,
2000, June 30, 2000 and September 30, 2000 (file no. 0-14710);
(3) current report on Form 8-K dated January 24, 2000 filed on January 25,
2000, as amended by amendments on Form 8-K/A dated and filed on February 3,
2000 and March 9, 2000 (file no. 0-14710);
(4) current report on Form 8-K dated February 11, 2000 filed on February 14,
2000 (file no. 0-14710);
(5) current report on Form 8-K dated and filed on April 25, 2000 (file no.
0-14710);
(6) amendment to current report on Form 8-K/A dated and filed on November 17,
2000 (file no. 0-14710); and
(7) the description of the common shares in the registration statement on Form
8-A dated and filed on May 21, 1999 under Section 12 of the Securities
Exchange Act, including any amendment or report for the purpose of updating
such description (registration no. 333-68045).
All documents filed by XOMA with the SEC pursuant to Section 13(a), 13(c),
14 or 15(d) of the Securities Exchange Act after the date of this prospectus and
before all of the common shares offered by this prospectus have been sold are
deemed to be incorporated by reference in, and to be part of, this prospectus
from the date any such document is filed.
Any statements contained in a document incorporated by reference in this
prospectus are deemed to be modified or superseded for purposes of this
prospectus to the extent that a statement contained in this prospectus (or in
any other subsequently filed document which also is incorporated by reference in
this prospectus) modifies or supersedes such statement. Any statement so
modified or superseded is not deemed to constitute a part of this prospectus
except as so modified or superseded.
12
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS
Some of the statements made in this prospectus are forward-looking in
nature, including those relating to the sufficiency of our cash position, the
FDA regulatory process, timing and results of clinical trials and other aspects
of product development, strategic collaborative relationships and other
statements that are not historical facts. The occurrence of the events
described, and the achievement of the intended results, depend on many events,
some or all of which are not predictable or not within our control. Actual
results may differ materially from those anticipated in any forward-looking
statements. Many risks and uncertainties are inherent in the biopharmaceutical
industry. Others are more specific to our business. Many of the significant
risks related to our business are described in this prospectus. These include,
among others, risks associated with technology and product development,
sufficiency and availability of funds, marketing risks, patent and intellectual
property matters, regulatory and manufacturing issues and risks associated with
competition from other companies. Many of these risks are discussed further in
"Risk Factors."
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We have not authorized any dealer, salesperson or other person to give you
written information other than this prospectus or to make representations as to
matters not stated in this prospectus. You must not rely on unauthorized
information. This prospectus is not an offer to sell these common shares or our
solicitation of your offer to buy the common shares in any jurisdiction where
that would not be permitted or legal. Neither the delivery of this prospectus
nor any sales made hereunder after the date of this prospectus should imply that
the information contained in this prospectus or the affairs of XOMA have not
changed since the date of this prospectus.
13
XOMA
We are a biopharmaceutical company developing products to treat bacterial
and fungal infections, infectious complications (such as those that may follow
surgery), and immunologic and inflammatory disorders. Our current product
development programs include:
o Anti-CD11a, a humanized monoclonal antibody product being developed in
collaboration with Genentech, Inc. Genentech has completed enrollment
in two Phase III trials of anti-CD11a in psoriasis and we have
initiated and completed enrollment in a Phase I/II study of anti-CD11a
in kidney transplant recipients.
o ING-1, a high-affinity antibody to an antigen expressed on epithelial
cell cancers (breast, colorectal, prostate and others) that destroys
cancer cells by recruiting the patient's own immune system. We have
initiated a Phase I study of ING-1 in cancer patients.
o Genimune(TM), a product developed using our proprietary targeted
gelonin fusion technology. The product delivers a proprietary,
genetically-engineered cytotoxin called rGelonin specifically to
CD5-positive cells. The CD5 antigen is expressed on mature T cells and
some B cells, but not stem cells or other tissues. The product may
treat cancers such as T and B-cell lymphomas and chronic lymphocytic
leukemia, as well as autoimmune diseases such as rheumatoid arthritis.
We are seeking one or more partners for commercialization of the
product and plan to outlicense the technology.
o NEUPREX(R) (rBPI21), a genetically-engineered modified fragment of a
human protein known as BPI and our lead BPI-derived product. The
product completed a Phase III efficacy clinical trial in 1999 in one
indication, with the resulting clinical data published in a
peer-reviewed medical journal in September 2000, and has been in
various earlier phase clinical trials in four additional indications.
Further development of this product will continue under a licensing
agreement with Baxter Healthcare Corporation.
o Mycoprex(TM), a fungicidal compound that is currently in preclinical
product development. It is initially targeted at systemic fungal
infections. We are seeking one or more partners for commercialization
of this product.
o Antiangiogenic compounds, which are in preclinical development with an
initial focus on retinal disorders. We are seeking one or more
partners for clinical development and commercialization of this
product.
We believe our cash position and resulting interest income are sufficient
to finance our currently anticipated needs for operating expenses, working
capital, equipment acquisitions and current research projects through at least
the second quarter of 2002. We continue to evaluate strategic alliances,
potential partnerships and financing arrangements which would further strengthen
our competitive position and provide additional funding. We cannot predict
whether or when any such alliances, partnerships or arrangements will be
consummated or whether additional funding will be available when required and on
terms acceptable to us.
14
PRICE RANGE OF COMMON SHARES AND DIVIDEND INFORMATION
XOMA's common shares (such common shares and the common stock of our
predecessor Delaware corporation are referred to in this prospectus as the
common shares) trade on the Nasdaq National Market under the symbol "XOMA." The
following table sets forth the quarterly range of high and low reported sale
prices of the common shares on the Nasdaq National Market for the periods
indicated (in United States dollars):
High Low
---- ---
1998:
First Quarter $6 1/2 $4 5/16
Second Quarter 6 4 1/4
Third Quarter 5 1 27/32
Fourth Quarter 5 1 13/16
1999:
First Quarter $4 3/16 $2 13/16
Second Quarter 6 3/4 2 1/2
Third Quarter 8 2 1/32
Fourth Quarter 3 3/4 2
2000:
First Quarter $16 $2 3/4
Second Quarter 10 1/8 3 1/8
Third Quarter 14 3/4 4
Fourth Quarter (through 15 1/4 7 3/4
November 15)
On October 31, 2000 the last reported sale price of the common shares as
reported on the Nasdaq National Market was U.S.$12 3/16 per share. As of October
31, 2000, there were approximately 3,565 record holders of XOMA's common shares.
XOMA has not paid dividends on its common equity. XOMA currently does not
intend to pay dividends and intends to retain any earnings for use in its
business and the financing of its capital requirements for the foreseeable
future. The payment of any future cash dividends on XOMA's common shares will
necessarily be dependent upon the earnings and financial needs of XOMA, along
with applicable legal and contractual restrictions.
15
USE OF PROCEEDS
We intend to use the net proceeds from this offering for general corporate
purposes, including current research and development projects, the development
of new products or technologies, equipment acquisitions, general working capital
and operating expenses.
We have not determined the amounts we plan to spend on any of the areas
listed above or the timing of these expenditures. As a result, our management
will have broad discretion to allocate the net proceeds from this offering.
Pending application of the net proceeds as described above, we intend to invest
the net proceeds of the offering in short-term, investment-grade,
interest-bearing securities.
16
DESCRIPTION OF SHARE CAPITAL
The following statements with respect to our share capital are subject to
the detailed provisions of XOMA's memorandum of continuance and bye-laws. These
statements do not purport to be complete and, while we believe the descriptions
of the material provisions of the memorandum of continuance and the bye-laws
incorporated by reference are accurate statements with respect to such material
provisions, such statements are subject to the detailed provisions in the
memorandum of continuance and the bye-laws, to which reference is hereby made
for a full description of such provisions.
COMMON SHARES
General
The memorandum of continuance and the bye-laws provide that our authorized
common share capital is limited to 135,000,000 common shares, par value U.S.
$.0005 per share. As of October 31, 2000, there were 66,017,172 common shares
outstanding.
Voting
The holders of common shares are entitled to one vote per share. All
actions submitted to a vote of shareholders shall be voted on by the holders of
common shares, voting together as a single class (together with the Series A
preference shares (as described below), if any), except as provided by law.
Dividends
Holders of common shares are entitled to participate, on a share for share
basis, with the holders of any other common shares outstanding, with respect to
any dividends declared by our board of directors, subject to the rights of
holders of preference shares. Dividends will generally be payable in U.S.
dollars. We have not paid cash dividends on the common shares. We currently do
not intend to pay dividends and intend to retain any of our earnings for use in
our business and the financing of our capital requirements for the foreseeable
future. The payment of any future cash dividends on the common shares is
necessarily dependent upon our earnings and financial needs, along with
applicable legal and contractual restrictions.
Liquidation
On a liquidation of XOMA, holders of common shares will be entitled to
receive any assets remaining after the payment of our debts and the expenses of
the liquidation, subject to such special rights as may be attached to any other
class of shares.
Redemption
The common shares are not subject to redemption either by us or the holder
thereof.
Variation Of Rights
Under our bye-laws, if at any time our share capital is divided into
different classes of shares, the rights attached to any class (unless otherwise
provided by the terms of the issue of the shares of that class) may be varied
with the consent in writing of the holders of a majority of the issued shares of
that class either in writing or with the sanction of a resolution passed at a
separate general meeting.
17
PREFERENCE SHARES
General
Under our memorandum of continuance and bye-laws, we have the authority to
issue 1,000,000 preference shares, par value U.S. $.05 per share. Of these,
650,000 preference shares have been designated Series A Cumulative Preference
Shares and 7,500 preference shares have been designated Convertible Preference
Shares, Series B. Under our bye-laws, subject to the special rights attaching to
any class of our shares not being varied and to any resolution approved by the
holders of 75% of the issued shares entitled to vote in respect thereof, our
board of directors may establish one or more classes or series of preference
shares having the number of shares, designations, relative voting rights,
dividend rates, liquidation and other rights, preferences and limitations that
the board of directors fixes without any shareholder approval.
The Series A Preference Shares
There are no Series A preference shares outstanding. Pursuant to the rights
of the Series A preference shares, subject to the rights of holders of any
shares of any series of preference shares ranking prior and superior, the
holders of Series A preference shares are entitled to receive, when, as and if
declared by our board of directors out of funds legally available for the
purpose, quarterly dividends payable in cash on the first day of March, June,
September and December in each year, commencing on the first dividend payment
date after the first issuance of a share or fraction of a share of Series A
preference shares, in an amount per share equal to the greater of (a) $1.00 or
(b) 100 times the aggregate per share amount of all cash dividends, plus 100
times the aggregate per share amount of all non-cash dividends or other
distributions, other than a dividend payable in common shares, declared on the
common shares since the immediately preceding dividend payment date, or, with
respect to the first dividend payment date, since the first issuance of Series A
preference shares.
In addition to any other voting rights required by law, holders of Series A
preference shares shall have the right to vote on all matters submitted to a
vote of our shareholders with each share of Series A preference shares entitled
to 100 votes. Except as otherwise provided by law, holders of Series A
preference shares and holders of common shares shall vote together as one class
on all matters submitted to a vote of our shareholders.
Unless otherwise provided in the rights attaching to a subsequently
designated series of our preference shares, the Series A preference shares shall
rank junior to any other series of preference shares as to the payment of
dividends and distribution of assets on liquidation, dissolution or winding-up
and shall rank senior to the common shares. Upon any liquidation, dissolution or
winding-up of XOMA, no distributions shall be made to holders of shares ranking
junior to the Series A preference shares unless, prior thereto, the holders of
Series A preference shares shall have received an amount equal to accrued and
unpaid dividends and distributions, whether or not declared, to the date of such
payment, plus an amount equal to the greater of (1) $100.00 per share or (2) an
aggregate amount per share equal to 100 times the aggregate amount to be
distributed per share to holders of common shares or to the holders of shares
ranking on parity with the Series A preference shares, except distributions made
ratably on the Series A preference shares and all other such parity shares in
proportion to the total amount to which the holders of all such shares are
entitled upon such liquidation, dissolution or winding-up.
If we shall enter into any consolidation, amalgamation, merger, combination
or other transaction in which common shares are exchanged for or changed into
cash, other securities and/or any other property, then any Series A preference
shares outstanding shall at the same time be similarly exchanged or changed in
an amount per share equal to 100 times the aggregate amount of cash, securities
and/or other property, as the case may be, into which or for which each common
share is changed or exchanged.
18
The Series A preference shares shall not be redeemable.
The Series B Preference Shares
There are no Series B preference shares outstanding. The 7,500 Series B
preference shares have been designated for issuance upon conversion of the
convertible subordinated loans to us made and to be made by Genentech in
connection with the funding of the our development costs for hull24. Such loans
are and will be convertible into Series B preference shares upon the occurrence
of certain events relating to certain regulatory approvals, payment defaults,
prepayments and other circumstances. Pursuant to the rights of the Series B
preference shares, the holders of Series B preference shares will not be
entitled to receive any dividends on the Series B preference shares.
The Series B preference shares will rank senior with respect to rights on
liquidation, winding-up and dissolution of XOMA to all classes of common shares.
Upon any voluntary or involuntary liquidation, dissolution or winding-up of
XOMA, holders of Series B preference shares will be entitled to receive $10,000
per share of Series B preference shares before any distribution is made on the
common shares. The holders of Series B preference shares will have no voting
rights, except as required under Bermuda law.
The holders of Series B preference shares will have the right to convert
Series B preference shares into common shares at a conversion price equal to the
current market price of the common shares (determined as provided below). The
current market price will be determined (a) for Series B preference shares
issued in connection with a conversion of one or more of the convertible
subordinated loans upon certain regulatory approvals, payment defaults or in
certain other circumstances, as of the first date on which such a conversion
occurs, and (b) for Series B preference shares issued in connection with certain
prepayments of one or more of the convertible subordinated loans or a conversion
thereof in certain other circumstances, as of the date of the issuance of such
Series B preference shares.
The Series B preference shares will be automatically converted into common
shares at its then effective conversion rate immediately upon the transfer by
the initial holder to any third party which is not an affiliate of such holder.
We will have the right, at any time and from time to time, to redeem any or
all Series B preference shares for cash in an amount equal to the conversion
price multiplied by the number of common shares into which each such share of
Series B preference shares would then be convertible.
OUTSTANDING WARRANTS
XOMA issued 618,681 common stock purchase warrants in June 1998. Each June
1998 warrant outstanding entitles the holder thereof to purchase one common
share, subject to anti-dilution adjustments. A holder may exercise the 1998
warrants at an exercise price of U.S.$7.00 per share on or before June 26, 2001.
XOMA issued 250,000 common stock purchase warrants to Incyte in July 1998.
Each Incyte warrant outstanding entitles the holder thereof to purchase one
common share, subject to anti-dilution adjustments. A holder may exercise the
Incyte warrants at an exercise price of U.S.$6.00 per share on or before July 9,
2008 or earlier upon the related license becoming fully paid up.
XOMA issued 379,000 warrants to purchase common shares in January 1999 and
March 1999, of which 175,000 remain outstanding. Each January and March 1999
warrant entitles the holder thereof to purchase one common share, subject to
anti-dilution adjustments. A holder may exercise the January and March 1999
warrants at an exercise price of U.S.$5.85008 per share on or before January 29,
2004.
19
XOMA issued 150,000 warrants to purchase common shares in July 1999. Each
July 1999 warrant entitles the holder thereof to purchase one common share,
subject to anti-dilution adjustments. A holder may exercise the July 1999
warrants at an exercise price of U.S.$5.75 per share on or before July 21, 2004.
XOMA issued 250,000 warrants to purchase common shares in February 2000.
Each February 2000 warrant entitles the holder thereof to purchase one common
share, subject to anti-dilution adjustments. A holder may exercise the 2000
warrants at an exercise price of U.S.$5.00 per share on or before February 11,
2005.
None of the warrants described above have been registered under the
Securities Act and none may be transferred except pursuant to an effective
registration statement under the Securities Act or pursuant to an exception from
registration thereunder. Additionally, all of the warrants contain certain
restrictions on their transfer. XOMA is not obligated and does not intend to
register the warrants under the Securities Act.
20
PLAN OF DISTRIBUTION
We may sell the common shares being offered hereby in one or more of the
following ways from time to time:
o through dealers or agents to the public or to investors;
o to underwriters for resale to the public or to investors;
o directly to investors (including upon conversion, exchange or exercise
of outstanding securities of XOMA); or
o through a combination of such methods.
We will set forth in a prospectus supplement the terms of the offering of
securities, including:
o the name or names of any agents, dealers or underwriters;
o the purchase price of the securities being offered and the proceeds we
will receive from the sale;
o any over-allotment options under which underwriters may purchase
additional securities from us;
o any agency fees or underwriting discounts and other items constituting
agents' or underwriters' compensation;
o any discounts or concessions allowed or reallowed or paid to dealers;
and
o any securities exchanges on which such securities may be listed.
LEGAL OPINION
The validity of the common shares to which this prospectus relates has been
passed upon for XOMA by Conyers Dill & Pearman, located in Hamilton, Bermuda.
EXPERTS
The consolidated financial statements of XOMA Ltd. at December 31, 1998 and
1999 and for the years then ended, appearing in XOMA Ltd.'s annual report (Form
10-K), as amended, for the year ended December 31, 1999 have been audited by
Ernst & Young LLP, independent auditors, as set forth in their report thereon
included therein and incorporated herein by reference. Such consolidated
financial statements are incorporated herein by reference in reliance upon such
report given on the authority of such firm as experts in accounting and
auditing.
The financial statements of XOMA Ltd. for the periods through December 31,
1997 incorporated by reference in this prospectus and elsewhere in the
registration statement, to the extent and for the periods indicated in their
report, have been audited by Arthur Andersen LLP, independent public
accountants, as indicated in their report with respect thereto, and are
incorporated by reference herein in reliance upon the authority of said firm as
experts in giving said report.
21
WHERE YOU CAN GET MORE INFORMATION
This prospectus is part of a registration statement that we have filed with
the SEC. The registration statement contains exhibits and other information not
included in this prospectus. At your request, we will provide you, without
charge, a copy of any documents incorporated by reference in, or included as
exhibits to, our registration statement. If you would like more information,
write or call us at:
XOMA Ltd.
2910 Seventh Street
Berkeley, CA 94710
Telephone: (510) 644-1170
XOMA files annual, quarterly and current reports, proxy statements and
other information with the SEC. You may read and copy any reports, statements
and other information we file at the SEC's public reference room at 450 Fifth
Street, N.W., Washington D.C. 20549. You can request copies of these documents,
upon payment of a duplicating fee, by writing to the SEC. Please call the SEC at
1-800-SEC-0330 for further information on the operation of the public reference
rooms. XOMA's SEC filings are also available to the public on the SEC Internet
site at http://www.sec.gov.
22
PART II
INFORMATION NOT REQUIRED IN PROSPECTUS
Item 14. Other Expenses of Issuance and Distribution
The estimated expenses in connection with this offering are as follows:
Amount
to be Paid
----------
SEC registration fee ....................................... $ 29,700
Nasdaq fee ................................................. 17,500
Legal fees and expenses (including Blue Sky
fees and expenses)........................................ 75,000
Accounting fees and expenses ............................... 5,000
Miscellaneous .............................................. 7,800
---------
Total ............................................. $135,000
========
Item 15. Indemnification of Directors and Officers
Under Bermuda law, a company is permitted to indemnify any officer or
director, out of the funds of the company, against (i) any liability incurred by
him or her in defending any proceedings, whether civil or criminal, in which
judgment is given in his or her favor, or in which he or she is acquitted, or in
connection with any application under relevant Bermuda legislation in which
relief from liability is granted to him or her by the court and (ii) any loss or
liability resulting from negligence, default, breach of duty or breach of trust,
save for his or her fraud and dishonesty.
The bye-laws of XOMA provide for the indemnity by XOMA of the officers,
directors and employees of XOMA to the fullest extent permitted by law.
Expenses (including attorneys' fees) incurred by an officer or director of
XOMA in defending any civil, criminal, administrative or investigative action,
suit or proceeding shall be paid by XOMA in advance of the final disposition of
such action, suit or proceeding upon receipt of an undertaking by or on behalf
of such director or officer to repay such amount if it shall ultimately be
determined that he is not entitled to be indemnified by XOMA pursuant to the
Securities Act of 1933.
An officer or director of XOMA shall not be personally liable to XOMA or
its shareholders for monetary damages for any breach of fiduciary duty as a
director or officer, except to the extent that such limitation is prohibited by
the Securities Act of 1933 or Bermuda law.
The indemnification and advancement of expenses and the limitation of
liability provided by the bye-laws shall not be deemed exclusive of any other
rights which any officer, director or employee, as such, may have or hereafter
acquire under the Securities Act of 1933, any other provision of the bye-laws,
or any agreement or otherwise. Any repeal or modification of the aforementioned
provisions of the bye-laws shall not adversely affect any right or protection
existing at the time of such repeal or modification.
II-1
Item 16. Exhibits and Financial Statement Schedules
(a) Exhibits
Exhibit
Number
1.1 Form of equity underwriting agreement (1)
3.1 Memorandum of Continuance of XOMA Ltd. (Exhibit 3.4) (2)
3.2 Bye-Laws of XOMA Ltd. (Exhibit 3.5) (2)
4.1 Amended and Restated Shareholder Rights Agreement dated as of October
27, 1993 and amended and restated as of December 31, 1998 by and among
XOMA and ChaseMellon Shareholder Services, L.L.C. as Rights Agent
(Exhibit 4.1) (3)
4.2 Form of Resolution Regarding Preferences and Rights of Series A
Preference Shares (Exhibit 4.2) (2)
4.3 Form of Resolution Regarding Preferences and Rights of Series B
Preference Shares (Exhibit 4.3) (2)
4.4 Form of Common Stock Purchase Warrant (1998 Warrants) (Exhibit 3) (5)
4.5 Form of Common Stock Purchase Warrant (Incyte Warrants) (Exhibit 2)
(6)
4.6 Form of Common Share Purchase Warrant (January and March 1999
Warrants) (Exhibit 5) (7)
4.7 Form of Common Share Purchase Warrant (July 1999 Warrants) (Exhibit 4)
(8)
4.8 Form of Common Share Purchase Warrant (2000 Warrants) (Exhibit 4) (9)
5.1 Opinion of Conyers Dill & Pearman (1)
23.1 Consent of Ernst & Young LLP, Independent Auditors
23.2 Consent of Arthur Andersen LLP, Independent Public Accountants
23.3 Consent of Conyers Dill & Pearman (included in Exhibit 5.1)
24.1 Power of Attorney (included on the signature pages hereto)
- --------------------
(1) To be filed by amendment or as an exhibit to a report pursuant to Section
13(a), 13(c) or 15(d) of the Exchange Act.
(2) Incorporated by reference to the referenced exhibit to XOMA's Registration
Statement on Form S-4 filed November 27, 1998, as amended (File No.
333-68045).
II-2
(3) Incorporated by reference to the referenced exhibit to XOMA's Registration
Statement on Form 8-A filed May 21, 1999 (File No. 0-14710).
(4) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated August 13, 1997 filed August 18, 1997 (File No.
0-14710).
(5) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated June 28, 1998 filed June 29, 1998 (File No.
0-14710).
(6) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated July 9, 1998 filed July 16, 1998 (File No.
0-14710).
(7) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated January 28, 1999 filed January 29, 1999, as
amended (File No. 0-14710).
(8) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated July 23, 1999 filed July 26, 1999 (File No.
0-14710).
(9) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated February 11, 2000 filed February 14, 2000 (File
No. 0-14710).
Item 17. Undertakings
The undersigned registrant hereby undertakes:
(1) To file, during any period in which offers or sales are being
made, a post-effective amendment to this registration statement:
(i) To include any prospectus required by Section 10(a)(3) of the
Securities Act of 1933;
(ii) To reflect in the prospectus any facts or events arising
after the effective date of the registration statement (or the most
recent post-effective amendment thereof) which, individually or in the
aggregate, represent a fundamental change in the information set forth
in the registration statement;
(iii) To include any material information with respect to the
plan of distribution not previously disclosed in the registration
statement or any material change to such information in the
registration statement;
Provided, however, that paragraphs (1)(i) and (1)(ii) do not apply if
the registration statement is on Form S-3 or Form S-8, and the information
required to be included in the post-effective amendment by those paragraphs
is contained in periodic reports filed by the registrant pursuant to
Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are
incorporated by reference in the registration statement.
(2) That, for the purpose of determining any liability under the
Securities Act of 1933, each post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered herein, and
the offering of such securities at that time shall be deemed to be the
initial bona fide offering thereof.
II-3
(3) To remove from registration by means of a post-effective amendment
any of the securities being registered which remain unsold at the
termination of the offering.
The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities Exchange Act of 1934 that is incorporated by reference in the
registration statement shall be deemed to be a new registration statement
relating to the securities offered herein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.
Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Securities Act
of 1933 and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act of 1933 and will be governed by the final adjudication of such issue.
The undersigned registrant hereby undertakes to deliver or cause to be
delivered with the prospectus, to each person to whom the prospectus is sent or
given, the latest annual report to security holders that is incorporated by
reference in the prospectus and furnished pursuant to and meeting the
requirements of Rule 14a-3 or Rule 14c-3 under the Securities Exchange Act of
1934; and, where interim financial information required to be presented by
Article 3 of Regulation S-X is not set forth in the prospectus, to deliver, or
cause to be delivered to each person to whom the prospectus is sent or given,
the latest quarterly report that is specifically incorporated by reference in
the prospectus to provide such interim financial information.
II-4
SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-3 and has duly caused this Registration
Statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Berkeley, State of California, on November 16, 2000.
XOMA LTD.
By: /s/ John L. Castello
-----------------------------------------
Name: John L. Castello
Title: Chairman of the Board,
President and Chief
Executive Officer
II-5
POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints John L. Castello and Christopher J.
Margolin, and each of them, as his true and lawful attorneys-in-fact and agents,
with full power of substitution and resubstitution, for him and in his name,
place and stead, in any and all capacities, to sign any and all amendments
(including post-effective amendments) and supplements to this registration
statement, and to file the same, with the SEC and the Bermuda Registrar of
Companies, granting unto said attorneys-in-fact and agents, and each of them,
full power and authority to do and perform each and every act and thing
requisite and necessary to be done in connection therewith, as fully to all
intents and purposes as he might or could do in person, hereby ratifying and
confirming all that said attorneys-in-fact and agents, or any of them, or their
or his substitute or substitutes, may lawfully do or cause to be done by virtue
hereof.
Pursuant to the requirements of the Securities Act of 1933, this
Registration Statement has been signed below by the following persons in the
capacities and on the dates indicated.
Signature Title Date
--------- ----- ----
Chairman of the Board, President and Chief November 16, 2000
Executive Officer (Principal Executive
/s/ John L. Castello Officer)
- ------------------------------------
John L. Castello
Chief Scientific and Medical Officer and November 16, 2000
/s/ Patrick J. Scannon Director
- ------------------------------------
Patrick J. Scannon
Vice President, Finance and Chief Financial November 16, 2000
Officer (Principal Financial and Accounting
/s/ Peter B. Davis Officer)
- ------------------------------------
Peter B. Davis
/s/ James G. Andress Director November 16, 2000
- ------------------------------------
James G. Andress
- ------------------------------------ Director November 16, 2000
William K. Bowes, Jr.
/s/ Arthur Kornberg Director November 16, 2000
- ------------------------------------
Arthur Kornberg
/s/ Steven C. Mendell Director November 16, 2000
- ------------------------------------
Steven C. Mendell
/s/ W. Denman Van Ness Director November 16, 2000
- ------------------------------------
W. Denman Van Ness
II-6
EXHIBIT INDEX
Exhibit
Number Page
------ ----
1.1 Form of equity underwriting agreement (1)
3.1 Memorandum of Continuance of XOMA Ltd. (Exhibit 3.4) (2)
3.2 Bye-Laws of XOMA Ltd. (Exhibit 3.5) (2)
4.1 Amended and Restated Shareholder Rights Agreement dated as of October
27, 1993 and amended and restated as of December 31, 1998 by and among
XOMA and ChaseMellon Shareholder Services, L.L.C. as Rights Agent
(Exhibit 4.1) (3)
4.2 Form of Resolution Regarding Preferences and Rights of Series A
Preference Shares (Exhibit 4.2) (2)
4.3 Form of Resolution Regarding Preferences and Rights of Series B
Preference Shares (Exhibit 4.3) (2)
4.4 Form of Common Stock Purchase Warrant (1998 Warrants) (Exhibit 3) (5)
4.5 Form of Common Stock Purchase Warrant (Incyte Warrants) (Exhibit 2)
(6)
4.6 Form of Common Share Purchase Warrant (January and March 1999
Warrants) (Exhibit 5) (7)
4.7 Form of Common Share Purchase Warrant (July 1999 Warrants) (Exhibit 4)
(8)
4.8 Form of Common Share Purchase Warrant (2000 Warrants) (Exhibit 4) (9)
5.1 Opinion of Conyers Dill & Pearman (1)
23.1 Consent of Ernst & Young LLP, Independent Auditors
23.2 Consent of Arthur Andersen LLP, Independent Public Accountants
23.3 Consent of Conyers Dill & Pearman (included in Exhibit 5.1)
24.1 Power of Attorney (included on the signature pages hereto)
- --------------------
(1) To be filed by amendment or as an exhibit to a report pursuant to Section
13(a), 13(c) or 15(d) of the Exchange Act.
(2) Incorporated by reference to the referenced exhibit to XOMA's Registration
Statement on Form S-4 filed November 27, 1998, as amended (File No.
333-68045).
(3) Incorporated by reference to the referenced exhibit to XOMA's Registration
Statement on Form 8-A filed May 21, 1999 (File No. 0-14710).
(4) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated August 13, 1997 filed August 18, 1997 (File No.
0-14710).
(5) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated June 28, 1998 filed June 29, 1998 (File No.
0-14710).
(6) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated July 9, 1998 filed July 16, 1998 (File No.
0-14710).
(7) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated January 28, 1999 filed January 29, 1999, as
amended (File No. 0-14710).
(8) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated July 23, 1999 filed July 26, 1999 (File No.
0-14710).
(9) Incorporated by reference to the referenced exhibit to XOMA's Current
Report on Form 8-K dated February 11, 2000 filed February 14, 2000 (File
No. 0-14710).