Shire Pharmaceuticals Group plc
Hampshire International Business Park,
Chineham, Basingstoke RG24 8EP  UK
Tel +44 1256 894000 Fax +44 1256 894708
http://www.shire.com

                                                        Shire

26 June 2003

Shire Pharmaceuticals Group plc (the 'Company')

Share Repurchase

The Company announces that on 25 June 2003 it purchased for cancellation
1,000,000 of its ordinary shares of (pound)0.05 each at a price of 398.85p per
share and 60,000 of its ordinary shares of (pound)0.05 each at a price of
US$6.766 per share.


T May

Company Secretary


For further information please contact:

Gordon Ngan - Investor Relations                    +44 1256 894 160


Notes to editors

Shire Pharmaceuticals Group plc
Shire Pharmaceuticals Group plc (Shire) is a rapidly growing international
emerging pharmaceutical company with a strategic focus on four therapeutic areas
- - central nervous system disorders (CNS), gastrointestinal (GI), oncology, and
anti-infectives. Shire also has three platform technologies: advanced drug
delivery, lead optimization for small molecules and Biologics. Shire's core
strategy is based on research and development combined with in-licensing and a
focus on eight key pharmaceutical markets.

For further information on Shire, please visit the Company's website:
www.shire.com