Exhibit
10.51


                   OFFSHORE SECURITIES SUBSCRIPTION AGREEMENT

         This Offshore Securities Subscription Agreement
("Agreement") is
executed in reliance upon the transaction exemption afforded by
Regulation S
("Regulation S") as promulgated by the Securities and Exchange
Commission
("SEC"), under the Securities Act of 1933, as amended ("1933 Act").

         This Agreement has been executed by the undersigned in
connection with
the private placement of up to U.S. $9,000,000 in principal amount
of 4%
Convertible Subordinated Debentures due November ___, 1998
(hereinafter referred
to as the "Debentures") of Xoma Corporation, a corporation
organized and
existing under the laws of the State of Delaware, U.S.A., NASDAQ
National Market
Symbol "XOMA" (hereinafter referred to as the "COMPANY"). The
Debentures being
purchased pursuant to this Agreement ("Purchaser's Debentures")
have not been
registered under the 1933 Act and may not be offered or sold in the
United
States or to U.S. persons, other than distributors (as such terms
are defined in
Regulation S), unless the Debentures are registered under the 1933
Act, or an
exemption from the registration provisions of the 1933 Act is
available. The
terms on which the Debentures may be converted into common stock
(the "Shares")
and the other terms of the Debentures are set forth in the form of
Debenture
annexed hereto as ANNEX I. This subscription and, if accepted by
the COMPANY,
the offer and sale of Debentures and the Shares issuable upon
conversion thereof
(collectively the "Securities"), are being made in reliance upon
the provisions
of Regulation S ("Regulation S") under the 1933 Act.

         The undersigned

NAME:     ----------------------------------------------------

ADDRESS:  ----------------------------------------------------

- - --------------------------------------------------------------

- - --------------------------------------------------------------

if applicable, a [Corporation][Partnership][Trust] organized under
the laws
of __________, a non USA jurisdiction (hereinafter referred to as
the
"PURCHASER")

hereby represents and warrants to, and agrees with, the COMPANY as
follows:

     1. AGREEMENT TO SUBSCRIBE.
     a. SUBSCRIPTION  AMOUNT. The undersigned hereby
        subscribes for U.S. $______________ in principal amount of
Debentures.

     b. FORM OF PAYMENT. The PURCHASER shall pay the purchase price
        for the Purchaser's Debentures by delivering good funds in
        United States Dollars to the escrow agent identified in the
        Joint Escrow Instructions attached hereto as ANNEX II (the
        "Escrow Agent"). Promptly following notice by the Escrow
Agent
        of receipt of payment from the PURCHASER of the
subscription
        price for the Purchaser's Debentures, the COMPANY shall
        determine whether to accept such subscription and, if so
        accepted, shall deliver one or more certificates for the
        Purchaser's Debentures to the Escrow Agent. Delivery of
such
        funds to the COMPANY by the Escrow Agent shall be made
against
        delivery by the COMPANY of one or more Debentures in
        accordance with this Agreement. By signing this Agreement,
the
        PURCHASER and the COMPANY each agrees to all of the terms
and
        conditions of, and becomes a party to, the Joint Escrow
        Instructions attached hereto as ANNEX II, all of the
        provisions of which are incorporated herein by this
reference
        as if set forth in full.

     c. METHOD OF PAYMENT.  Payment of the purchase price for the
Purchaser's
        Debentures shall be made by wire transfer of funds to:

                Bank of New York
                350 Fifth Avenue
                New York, New York 10001

                ABA# 021000018
                For Further Credit to A/C# 105-0036843
                for credit to the account of Krieger & Prager,
Attorneys
                Escrow Account: Master Escrow Account

        Not later than five (5) business days after acceptance and
        execution of this Agreement by the COMPANY, the PURCHASER
        shall deposit with the Escrow Agent the aggregate
subscription
        price for the Purchaser's Debentures.

     2. SUBSCRIBER REPRESENTATIONS; ACCESS TO INFORMATION;
INDEPENDENT
        INVESTIGATION.

        a. OFFSHORE TRANSACTION.  PURCHASER represents and warrants
to COMPANY 
           as follows:

           (i)    PURCHASER is not a U.S. person as that term is
defined under 
                  Regulation S.

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           (ii)   PURCHASER is outside the United States
                  as of the date of the execution and delivery
                  of this Agreement.

           (iii)  PURCHASER is purchasing the
                  Purchaser's Debentures for its own account
                  and not on behalf of any U.S. person, and
                  PURCHASER is the sole beneficial owner of
                  the Purchaser's Debentures, and has not
                  pre-arranged any sale with purchasers in the
                  United States.

           (iv)   PURCHASER represents and warrants and
                  hereby agrees that all offers and sales of
                  the Debentures prior to the expiration of a
                  period commencing on the date of the receipt
                  of funds by the COMPANY and ending 40 days
                  thereafter shall only be made in compliance
                  with the safe harbor contained in Regulation
                  S, pursuant to the registration provisions
                  under the 1933 Act or pursuant to an
                  exemption from registration, and all offers
                  and sales after the expiration of the 40-day
                  period shall be made only pursuant to such
                  registration or to such exemption from
                  registration.

           (v)    PURCHASER acknowledges that the purchase
                  of the Debentures involves a high degree of
                  risk, is aware of the risks and further
                  acknowledges that it can bear the economic
                  risk of the purchase of the Purchaser's
                  Debentures, including the total loss of its
                  investment.

           (vi)   PURCHASER understands that the
                  Debentures are being offered and sold to it
                  in reliance on specific exemptions from the
                  registration requirements of U.S. securities
                  laws and that the COMPANY is relying upon
                  the truth and accuracy of the
                  representations, warranties, agreements,
                  acknowledgements and understandings of
                  PURCHASER set forth herein in order to
                  determine the applicability of such
                  exemptions and the suitability of PURCHASER
                  to acquire the Purchaser's Debentures.

           (vii)  PURCHASER is sufficiently experienced
                  in financial and business matters to be
                  capable of evaluating the merits and risks
                  of its investments, and to make an informed
                  decision relating thereto.

           (viii) In evaluating its investment,
                  PURCHASER has consulted its own investment
                  and/or legal and/or tax advisors.

           (ix)   PURCHASER understands that in the view
                  of the SEC the statutory basis for the
                  exemption claimed for this transaction would
                  not be present if the offering of
                  Debentures, although in technical compliance
                  with Regulation S, is part of a plan or
                  scheme to evade the registration provisions
                  of the 1933 Act. PURCHASER is


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                  acquiring the Purchaser's Debentures for
                  investment purposes and has no present
                  intention to sell the Debentures in the
                  United States or to a U.S. Person or for the
                  account or benefit of a U.S. Person either
                  now or after the expiration of the
                  Restricted Period.

           (x)    PURCHASER is not an underwriter of, or dealer in,
the
                  Securities, and PURCHASER is not participating,
pursuant to a
                  contractual agreement, in the distribution of the
Securities.

           (xi)   During the Restricted Period (as
                  hereinafter defined), neither PURCHASER nor
                  any of its affiliates will, directly or
                  indirectly, maintain any short position in
                  the securities of the COMPANY.

     b.    CURRENT PUBLIC  INFORMATION.  PURCHASER acknowledges
that PURCHASER 
           has been furnished with or has acquired copies of the
COMPANY'S
           most recent Annual Report on the Form 10-K filed  with
the SEC and 
           the Forms 10-Q and 8-K filed thereafter (collectively
the "SEC
           Filings").

     c.    INDEPENDENT INVESTIGATION; ACCESS. PURCHASER
           acknowledges that PURCHASER, in making the decision
           to purchase the Debentures subscribed for, has relied
           upon independent investigations made by it and its
           representatives, if any, and PURCHASER and such
           representatives, if any, have, prior to any sale to
           it, been given access and the opportunity to examine
           all material publicly available, books and records of
           the COMPANY, all material contracts and documents
           relating to this offering and an opportunity to ask
           questions of, and to receive answers from the COMPANY
           or any person acting on its behalf concerning the
           terms and conditions of this offering. PURCHASER and
           its advisors, if any, have been furnished with access
           to all publicly available materials relating to the
           business, finances and operation of the COMPANY and
           materials relating to the offer and sale of the
           Debentures which have been requested. PURCHASER and
           its advisors, if any, have received complete and
           satisfactory answers to any such inquiries.

     d.    NO GOVERNMENT RECOMMENDATION OR APPROVAL.  PURCHASER
understands
           that no federal or state agency has passed on or made
any 
           recommendation or endorsement of the Securities.

     e.    ENTITY PURCHASERS. If PURCHASER is a partnership,
corporation or
           trust, the person executing this Agreement on its behalf
represents 
           and warrants that:


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           (i)    He or she has made due inquiry to determine the
truthfulness
                  of the representations and warranties made
pursuant to this 
                  Agreement.

           (ii)   He or she is duly authorized (if the
                  undersigned is a trust, by the trust
                  agreement) to make this investment and to
                  enter into and execute this Agreement on
                  behalf of such entity.

    3. COMPANY REPRESENTATIONS.

       a.  REPORTING COMPANY STATUS. The COMPANY is a
           reporting issuer as defined by Rule 902 of Regulation
           S. The COMPANY is in full compliance, to the extent
           applicable, with all reporting obligations under
           either Section 12(b), 12(g) or 15(d) of the
           Securities Exchange Act of 1934, as amended (the
           "Exchange Act"). The COMPANY has registered its
           common stock pursuant to Section 12 of the Exchange
           Act and the common stock trades on NASDAQ.

       b.  OFFSHORE TRANSACTION.  The COMPANY has not offered these
securities 
           to any person in the United States or to any U.S. person
as that
           term is defined in Regulation S.

       c.  NO DIRECTED SELLING EFFORTS. In regard to this
           transaction, the COMPANY has not conducted any
           "direct selling efforts" as that term is defined in
           Rule 902 of Regulation S nor has the COMPANY
           conducted any general solicitation relating to the
           offer and sale of the within securities to persons
           resident within the United States or elsewhere.

        d. TERMS OF DEBENTURES. The COMPANY will issue the
Debentures in
           accordance with the terms of the form of Debenture
contained in
           ANNEX I attached hereto.

        e. LEGALITY. The COMPANY has the requisite corporate power
and
           authority to enter into this Agreement and to sell and
deliver the
           Debentures; this Agreement and the issuance of the
Debentures have
           been duly and validly authorized by all necessary
corporate action
           by the COMPANY; this Agreement has been duly and validly
executed
           and delivered by and on behalf of the COMPANY, and is a
valid
           and binding agreement of the COMPANY, enforceable
against it in
           accordance with its terms, except as enforceability may
be limited  
           by general equitable principles, bankruptcy, insolvency,
fraudulent 
           conveyance, reorganization, moratorium or other laws
affecting
           creditors rights generally.


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        f. NON-CONTRAVENTION. The execution and delivery of
           this Agreement and the issuance of the Debentures,
           and the consummation of the transactions contemplated
           by this Agreement by the COMPANY do not and will not
           conflict with or result in a breach by the COMPANY of
           any of the terms or provisions of, or constitute a
           default under, the Certificate of Incorporation or
           by-laws of the COMPANY, or any material indenture,
           mortgage, deed of trust, or other material agreement
           or instrument to which the COMPANY is a party or by
           which it or any of its properties or assets are bound
           or (assuming that the representations and warranties
           of the PURCHASER in Section 2 hereof, and the
           representations and warranties of the distributor to
           the COMPANY, are true and correct) any existing
           applicable U.S. law, rule, or regulation or any
           applicable decrees, judgment or order of any U.S.
           court, federal or state regulatory body,
           administrative agency or other U.S. governmental body
           having jurisdiction over the COMPANY or any of its
           properties or assets, the conflict, breach, violation
           or default of or under which would have a material
           adverse effect on the COMPANY'S business or financial
           condition.

        g. FILINGS. The COMPANY undertakes and agrees to make all
necessary
           filings in connection with the sale of the Debentures as
required
           by United States laws and regulations or by the rules of
any
           domestic securities exchange or trading market.

        h. ABSENCE OF CERTAIN CHANGES.  Since June 30, 1995, there
has been no
           material adverse development in the assets, liabilities,
business, 
           properties, operations, financial condition or results
of operations
           of the COMPANY, except as disclosed in the SEC filings.

    4.  EXPIRATION OF RESTRICTED PERIOD.

        a. Promptly following the delivery by PURCHASER of the
subscription price in accordance with Section 1(c) hereof, the
COMPANY will
determine whether to accept such subscription and, if so accepted,
will prepare
and issue one or more Debentures registered in such name or names
as specified
by PURCHASER and cause the same to be delivered to the Escrow
Agent. The
COMPANY'S transfer agent will be instructed to issue one or more
certificates
for the Shares without restrictive legend upon conversion of the
Purchaser's
Debentures in accordance with this Agreement, registered in the
name of the
holder of Purchaser's Debentures who converts any Purchaser's
Debentures or its
nominee and in such denominations to be specified by the such
holder in
connection with such conversion. The COMPANY warrants that no
restriction or
instruction (other than these instructions and a "stop transfer"
restriction on
the COMPANY'S Debenture Register relating to the Debentures until
the end of the
forty (40) day Restricted Period applicable under Regulation S)
will be imposed
by the COMPANY or given by the COMPANY to its transfer agent for
the Shares and
that the Purchaser's Debentures and the Shares issuable upon
conversion thereof
shall otherwise be freely


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transferable on the books and records of the COMPANY as and to the
extent
provided in this Agreement. Nothing in this Section shall affect in
any way
PURCHASER'S obligations and agreement to comply with all applicable
securities
laws and PURCHASER'S representations and warranties set forth
herein.

        b. In connection with the exercise of conversion rights
relating to the Debentures, if the Debentures and the Shares have
not been
registered under the 1933 Act prior to such conversion, PURCHASER
or any
subsequent holder of the Debentures shall, in addition to any other
requirement
imposed by the terms of the Debentures, be required to complete,
sign and
furnish to the COMPANY a conversion certificate in the form
attached as Exhibit
1 to ANNEX I hereto. PURCHASER acknowledges that the COMPANY is
under no
obligation to register the Debentures or the Shares issuable upon
conversion
thereof under the 1933 Act.

        c. If, solely as a result of the COMPANY'S wrongful refusal
to
honor PURCHASER'S instruction, or wrongful refusal or failure to
transfer or
issue the Shares, PURCHASER incurs any loss (other than any
consequential,
indirect, incidental or special damages), the COMPANY shall
reimburse PURCHASER
for such loss unless PURCHASER shall have breached any of its
representations,
warranties or covenants set forth in this Agreement, or otherwise
taken or
omitted to take actions, which actions or omissions constitute
gross negligence,
bad faith or willful misconduct.

    5. EXEMPTION; RELIANCE ON REPRESENTATION. PURCHASER understands
that
the offer and sale of the Debentures is not being registered under
the 1933 Act.
The COMPANY is relying on the rules governing offers and sales made
outside the
United States pursuant to Regulation S. Rules 901 through 904 of
Regulation S
govern this transaction.

    6. CLOSING DATE AND ESCROW AGENT. The date of the issuance of
the
Purchaser's Debentures and the sale of the Purchaser's Debentures
as evidenced
by receipt by the COMPANY of PURCHASER'S purchase funds (the
"Closing Date")
shall be no later than ten (10) business days after execution
hereof by all
parties or such other mutually agreed to time. PURCHASER shall,
within five (5)
business days after acceptance and execution of this Agreement by
the COMPANY,
deliver the necessary funds as indicated in Paragraph 1 to the
Escrow Agent.
Purchaser's Debentures will be delivered to the Escrow Agent at the
instructions
of the COMPANY. PURCHASER agrees that the Escrow Agent has no
liability as a
result of any fraudulent or unlawful conduct of any other party,
and agrees to
hold the Escrow Agent harmless.

     7. CONDITIONS TO THE COMPANY'S OBLIGATION TO SELL.  PURCHASER
understands
that  COMPANY'S obligation to sell the Purchaser's Debentures is
conditioned
upon:

        a. The receipt and acceptance by the COMPANY of this
Agreement as
           evidenced by execution of this Agreement by the
President or any
           Vice President of the COMPANY. The acceptance of funds
by the


                                  7

           COMPANY shall be deemed to be constructive acceptance of
this
           Agreement;

       b.  Delivery to the Escrow  Agent by PURCHASER of good funds
as payment 
           in full for the purchase of the Purchaser's Debentures;
and

       c. The accuracy on the Closing Date of the
          representations and warranties of PURCHASER contained
          in this Agreement and the performance by PURCHASER on
          or before the Closing Date of all covenants and
          agreements of PURCHASER required to be performed on
          or before the Closing Date.

    8. CONDITIONS TO PURCHASER'S OBLIGATION TO PURCHASE.  The
COMPANY
understands that PURCHASER'S  obligation to purchase the
Purchaser's
Debentures is conditioned upon:

       a. Acceptance by PURCHASER of an Agreement for the sale of
Purchaser's
          Debentures;

       b. Delivery of Purchaser's Debentures to Escrow Agent as
herein set
          forth;

       c. The accuracy on the Closing Date of the representations
and
          warranties of the COMPANY contained in this Agreement and
the
          performance by the COMPANY on or before the Closing Date
of all 
          covenants and agreements of the COMPANY required to be
performed on
          or before the Closing Date; and

       d. Delivery to the Escrow  Agent of an opinion of counsel
for the
          COMPANY, dated the Closing Date and addressed to
PURCHASER, in the
          form attached hereto as ANNEX III.

    9. GOVERNING LAW. This Agreement shall be governed by and
construed under
the laws of the State of New York without giving effect to
principles governing
the conflicts of laws. A facsimile transmission of this signed
Agreement shall
be legal and binding on all parties hereto.

    10. NOTICES. Any notice required or permitted hereunder shall
be given
in writing (unless otherwise specified herein) and shall be deemed
effectively
given upon personal delivery or three business days after deposit
in the United
States Postal Service, by registered or certified mail with postage
and fees
prepaid, addressed to each of the other parties thereunto entitled
at the
following addresses, or at such other addresses as a party may
designate by ten
days advance written notice to each of the other parties hereto.


                                   8

COMPANY:          Xoma Corporation
                  2910 Seventh Street
                  Berkeley, California 94710
                  ATT:  General Counsel

PURCHASER:        At the address set forth on the first page of
this Agreement.

ESCROW AGENT:     Krieger & Prager, Esqs.
                  319 Fifth Avenue
                  New York, New York 10016


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                    SIGNATURE(S) FOR INDIVIDUAL SUBSCRIBER(S)

         IN WITNESS WHEREOF, the undersigned represents that the
foregoing
statements are true and correct and that he, she or they have
executed this
Offshore Securities Subscription Agreement this ------ day of
- - --------------,
1995.


- - -----------------------------------          
- - --------------------------------
Printed Name                                  Signature


- - -----------------------------------          
- - --------------------------------
Printed Name                                  Signature



                         SIGNATURES FOR ENTITIES

         IN WITNESS WHEREOF, the undersigned represents that the
following
statements are true and correct and that it has caused this
Offshore Securities
Subscription Agreement to be duly executed on its behalf this
- - -------- day of
- - -------------------, 1995.



                          -------------------------------------
                          Printed Name of Subscriber


                          By: ---------------------------------
                          (Signature of Authorized Person)

                          -------------------------------------
                          Printed Name and Title

Accepted this ---------- day of the month of -------------------,
199---.

XOMA CORPORATION


By: ------------------------------------------
    Title: -----------------------------------


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         All correspondence and delivery of certificates and
confirmations
should be addressed to the above named person and sent by the
COMPANY to his
- - ----- business ----- home address (check one).

Capacity of Subscriber (check one):

         Individual                                  ----------
         Corporation                                 ----------
         Partnership                                 ----------
         Other                                       ----------
(please specify)

Ownership of Debentures (check one):

         Individual                                  ----------
         Joint Tenants, with right of survivorship   ----------*
         Tenants in Common                           ----------*
         Tenants in Entirety                         ----------*
         Community Property                          ----------*

Country of Citizenship:   ----------------------------------------

Country of incorporation or formation:
- - ------------------------------

*    If you are purchasing Debentures with only your spouse as
co-owner,
     both you and your spouse must sign the signature page. If any
co-owner
     is not your spouse, all co-owners must sign the signature
page.

Name of PURCHASER Representative, if any:  
- - ------------------------------

                  Address:                 
- - ------------------------------

                                           
- - ------------------------------

                  Telephone:               
- - ------------------------------


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FULL NAME AND ADDRESS OF PURCHASER FOR REGISTRATION PURPOSES:


NAME:                     
- - ----------------------------------------------

ADDRESS:                  
- - ----------------------------------------------

                          
- - ----------------------------------------------

                          
- - ----------------------------------------------

TEL. NO.                  
- - ----------------------------------------------

FAX. NO.                  
- - ----------------------------------------------

CONTACT NAME:             
- - ----------------------------------------------


DELIVERY INSTRUCTIONS (IF DIFFERENT FROM REGISTRATION NAME):


NAME:                     
- - ----------------------------------------------

ADDRESS:                  
- - ----------------------------------------------

                          
- - ----------------------------------------------

                          
- - ----------------------------------------------

TEL. NO.                  
- - ----------------------------------------------

FAX. NO.                  
- - ----------------------------------------------

CONTACT NAME:             
- - ----------------------------------------------

SPECIAL
INSTRUCTIONS:             
- - ----------------------------------------------

                          
- - ----------------------------------------------

                          
- - ----------------------------------------------


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