SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549




                                    FORM 8-K


                 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(D)
                     OF THE SECURITIES EXCHANGE ACT OF 1934




         Date of Report (Date of earliest event reported) April 3, 2000
                         Commission File Number 0-23155


                                 TRIMERIS, INC.
                           (Exact name of registrant)


       Delaware                                         56-1808663
(State of organization)                  (I.R.S. Employer Identification Number)


         4727 University Drive, Suite 100, Durham, North Carolina 27707
             (Address of principal executive offices and zip code)

                                 (919) 419-6050
                         (Registrant's telephone Number)





ITEM 5.  OTHER EVENTS

                  Trimeris, Inc. incorporates herein by reference the
information contained in the press release filed as Exhibit 99 to this Current
Report.


ITEM 7.  EXHIBITS

                EXHIBIT NO.

                  99       Press Release by Trimeris, Inc., dated April 3, 2000




                                    SIGNATURE


                  Pursuant to the requirements of the Securities Exchange Act of
1934, the registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.


                        TRIMERIS, INC.



                        By: /s/ Dani P. Bolgnesi
                            Dani P. Bolognesi
                            Chief Executive Officer and Chief Scientific Officer



Dated:  April 3, 2000