FIFTH AMENDMENT TO
                                  AGREEMENT FOR
                        DEVELOPMENT AND IMPLEMENTATION OF
                           EPO UTILIZATION DATA AUDIT

         This Fifth  Amendment  ("Amendment"),  effective  June 12, 1996, by and
between HCIA Inc. ("HCIA"), a Maryland  corporation,  and successor by merger to
Healthcare Knowledge Resources,  Inc., a Michigan corporation ("HKR"), and Amgen
Inc., a Delaware corporation ("Client") with reference to the following:

         A. Effective  January 1, 1992, HKR and Client entered into that certain
Agreement for Development and  Implementation of EPO Utilization Data Audit (the
"Agreement"),  as amended on August 1, 1992,  April 6, 1993,  July 1, 1994,  and
June 30, 1995.

         B. Effective  October 4, 1993,  HCIA became the corporate  successor to
HKR by merger and,  pursuant to Section 12.14 of the  Agreement,  HCIA expressly
assumed all of HKR's rights and obligations under the Agreement.  All references
in the Agreement to HKR shall be deemed references to HCIA.

         NOW,  THEREFORE,  for good and valuable  consideration,  the receipt of
which is hereby  acknowledged,  the parties hereto hereby amend the Agreement as
follows:

         1.       Section 10.1.  Term is amended in its entirety as follows:

                  The term of this  Agreement  shall be for a period  of six (6)
         years from the effective date of this  Agreement.  This Agreement shall
         be automatically  extended for additional terms of one (1) year, unless
         Client  delivers to HCIA  written  notice of Client's  intent not to so
         renew not less than one hundred and eighty  (180) days prior to the end
         of the initial or any extended term.

         2. Sections 10.2.2.  Termination by Client and 10.2.3.  Termination Due
to  Arbitrator's  Decision as added by the Second  Amendment to Agreement  dated
April 16, 1993,  and as amended by the Third  Amendment to Agreement  dated July
1994,  and the Fourth  Amendment  to Agreement  dated June 30, 1995,  are hereby
amended in their entirety as follows:

         10.2.2.  Termination by Client.  Client reserves the right to terminate
         this  Agreement,  for any  reason  other  than as set forth in  Section
         10.2.3, upon ninety (90) days' prior written notice to HCIA;  provided,
         however, that in the event Client so elects to terminate this Agreement
         prior to December  31,  1997,  Client  agrees to pay to HCIA,  upon the
         effective date of such termination and in addition to all other amounts
         then owing,  (a)  $180,000  per month  through  December  31, 1997 (the
         "Severance  Amount"),  which Severance Amount shall constitute a credit
         against the payment by Client of any fees for any  products or services


         offered by HCIA (including,  without limitation, receipt of audit data)
         and ordered by Client or its  affiliates  by December  31, 1997 or such
         later date as agreed upon by the  parties;  plus (b) an amount equal to
         the out-of-pocket  expenses incurred by HCIA under this Agreement as of
         the effective date of such termination. In connection with any products
         or  services  ordered by Client or its  affiliates  under this  Section
         10.2.2.,  Client agrees to execute HCIA's  standard  agreement for such
         products or services.

         10.2.3.  Termination Due to Arbitrator's Decision.  Client reserves the
         right to terminate  this Agreement upon thirty (30) days' prior written
         notice  to  HCIA  in  the  event  the  arbitrator  of  the  arbitration
         proceedings  between  Client  and  Ortho   Pharmaceutical   Corporation
         determines  that  the  Audit  Program  shall  not  be  utilized  in the
         arbitrator's  audit of EPO  administration  to hospital  inpatients and
         outpatients;  provided,  however, that in the event Client so elects to
         terminate this Agreement prior to December 31, 1997, Client agrees that
         it shall pay to HCIA,  upon the effective date of such  termination and
         in  addition  to all other  amounts  then  owing,  either,  at Client's
         election (a) the Severance  Amount,  which such Severance  Amount shall
         constitute  a credit  against the payment by Client of any fees for any
         products or services  offered by HCIA (including,  without  limitation,
         receipt  of audit  data) and  ordered  by Client or its  affiliates  by
         December  31,  1997 or such later date as agreed  upon by the  parties;
         plus the  out-of-pocket  expenses incurred under this Agreement by HCIA
         as of the effective date of such termination, or (b) an amount equal to
         one-half  (1/2) of the  Severance  Amount,  which such amount shall not
         constitute  a credit  against the payment by Client of any fees for any
         products or services offered by HCIA, plus the  out-of-pocket  expenses
         incurred  by HCIA as of the  effective  date  of such  termination.  In
         connection  with any  products  or  services  ordered  by Client or its
         affiliates  under this Section 10.2.3,  Client agrees to execute HCIA's
         standard agreement for such products or services.

         3. Except as amended  hereby,  the  Agreement,  as amended on August 1,
1992,  April 6, 1993,  July 1, 1994,  and June 30, 1995,  shall continue in full
force and effect in accordance with its terms.

                                      -2-





         IN  WITNESS  WHEREOF,  each  of the  parties  has  duly  executed  this
Amendment effective as of the date first written above.

WITNESS:                           HCIA INC.


_____________________              By:  /s/ Barry C. Offutt
                                        Barry C. Offutt
                                         Senior Vice President

                                   AMGEN INC.


_____________________              By:  /s/ Thomas A. Hardy
                                        Name:  Thomas A. Hardy
                                        Title: Director, Finance Admin.

                                      -3-