EXHIBIT 21 SUBSIDIARIES OF THE REGISTRANT REGISTRANT: Name: ProxyMed, Inc. State of Incorporation: Florida SUBSIDIARIES: Name: Hayes Telecommunication Services, Inc. State of Incorporation: Florida Name: Key Communications Service, Inc. State of Incorporation: Indiana Name: ProxyCare, Inc. State of Incorporation: Florida Name: WPJ, Inc. d/b/a Integrated Medical Systems State of Incorporation: California