Exhibit 31.1


                            CERTIFICATION PURSUANT TO
                  SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Christopher A. Marlett certify that:

1.   I have reviewed this Annual Report on Form 10-K of Integrated Surgical
     Systems, Inc.(the "Registrant");

2.   Based on my knowledge, this report does not contain any untrue statement of
     a material fact or omit to state a material fact necessary to make the
     statements made, in light of the circumstances under which such statements
     were made, not misleading with respect to the period covered by this Annual
     Report;

3.   Based on my knowledge, the financial statements, and other financial
     information included in this report, fairly present in all material
     respects the financial condition, results of operations and cash flows of
     the Registrant as of, and for, the periods presented in this Annual Report;

4.   The small Registrant's other certifying officers and I are responsible for
     establishing and maintaining disclosure controls and procedures (as defined
     in Exchange Act Rules 13a-15(e) and 15d-15(e) and internal control over
     financial reporting (as defined in Exchange Act Rules 13a-15(f) and
     15d-15(f)) for the Registrant and have:

                     a) designed such disclosure controls and procedures, or
                caused such disclosure controls and procedures to be designed
                under our supervision, to ensure that material information
                relating to the Registrant, including its consolidated
                subsidiaries, is made known to me by others within those
                entities, particularly during the period in which this Annual
                Report is being prepared;

                    b) designed such internal control over financial reporting,
                or caused such internal control over financial reporting to be
                designed under our supervision, to provide reasonable assurance
                regarding the reliability of financial reporting and the
                preparation of financial statements for external purposes in
                accordance with generally accepted accounting principles;

                     c) evaluated the effectiveness of the Registrant's
                disclosure controls and procedures and presented in this Annual
                Report my conclusions about the effectiveness of the disclosure
                controls and procedures, as of the end of the period covered by
                this Annual Report based on such evaluation; and

                     d) disclosed in this Annual Report any change in the
                Registrant's's internal control over financial reporting that
                occurred during the Registrant'smost recent fiscal quarter (the
                Registrant'sfourth fiscal quarter in the case of an annual
                report) that has materially affected, or is reasonably likely to
                materially affect, the Registrant'sinternal control over
                financial reporting; and

5.   The Registrant'sother certifying officer(s) and I have disclosed, based on
     our most recent evaluation of internal control over financial reporting, to
     the Registrant'sauditors and the audit committee of the small
     Registrant'sboard of directors (or persons performing the equivalent
     functions);

              a)  all significant deficiencies and material weaknesses in the
                  design or operation of internal control over financial
                  reporting which are reasonably likely to adversely affect the
                  Registrant's ability to record, process, summarize and report
                  financial information; and

              b)  any fraud, whether or not material, that involves management
                  or other employees who have a significant role in the
                  Registrant'sinternal control over financial reporting.


Date: March 30, 2009                      By: /s/   CHRISTOPHER A. MARLETT
                                              ----------------------------------
                                                    Christopher A. Marlett
                                                    Chief Executive Officer