Exhibit 32.1


                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002


I, Christopher A. Marlett,, Chief Executive Officer of Integrated Surgical
Systems, Inc. (the "Company"), hereby certify, pursuant to 18 U.S.C. Section
1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002,
that:

1.         The Annual Report on Form 10-K of the Company for the year ended
           December 31, 2008, which this certification accompanies (the
           "Periodic Report"), fully complies with the requirements of Section
           13(a) or 15(d) of the Securities Exchange Act of 1934; and

2.         The information contained in the Periodic Report fairly presents, in
           all material respects, the financial condition and results of
           operations of the Company.




 Dated: March 30, 2009                         /s/ CHRISTOPHER A. MARLETT
                                               --------------------------
                                                  Christopher A. Marlett
                                                  Chief Executive Officer