EXHIBIT 10.13
                          PATENT DEVELOPMENT AGREEMENT


THIS AGREEMENT executed as of January 14, 2002.

AMONG:

     DRAGON  PHARMACEUTICALS  INC., a company  organized and existing  under the
     Laws of the  State of  Florida,  the  United  States of  America,  having a
     principal  place of business  at 1200 - 543  Granville  Street,  Vancouver,
     B.C., V6C 1X8

     ("Dragon")

AND:

     LONGBIN LIU, of 1528 Errigal Place, West Vancouver, B.C., V7S 3H1

     ("Liu")

AND:

     NOVAGEN HOLDING INC., of 350-655 West Kent Avenue North,  Vancouver,  B.C.,
     V6P 6T7

     ("Novagen")

WHEREAS:

     (A)  Dragon carries on the  business  of the  development,  production  and
marketing of recombinant protein medicines;

     (B)  Novagen  is  a  private   corporation  that  researches  and  develops
biotechnology-based  pharmaceutical  projects  with  the aim of  patenting  such
projects in the United States or the rest of the world;

     (C) Liu is the controlling shareholder and sole director of Novagen and has
substantial and valuable  expertise  relating to the research and development of
recombinant protein medicines;  and (D) Liu and Novagen agree to grant to Dragon
the  right  to  acquire  a patent  (related  to the  discovery  of a new gene or
protein)  for  one of  their  projects  when  Liu  and  Novagen  file  a  patent
application for such project.

NOW THEREFORE THIS AGREEMENT WITNESSES THAT in consideration for the sum of
$10.00 and the mutual covenants and agreements herein contained, and other good
and valuable consideration the sufficiency and receipt of which are hereby
acknowledged, the parties mutually agree as follows:

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                                     PART 1

                                 INTERPRETATION

Definitions

     1.1  In  this  Agreement,  including  the  recitals,  except  as  otherwise
expressly provided or unless the context otherwise requires,

     Additional Project Patent has the meaning ascribed to it inss.2.2;

     Affiliate  means a company that is related to another  company by virtue of
     the fact that the first company is, directly or indirectly, a subsidiary of
     the  second  company  or  both  companies  are,   directly  or  indirectly,
     subsidiaries   of  the  same  company  or  each  company  is,  directly  or
     indirectly, controlled by the same person or company;

     Business  means the  business  of  researching,  developing  and  patenting
     biotechnology based pharmaceutical projects.

     Business  Day means a day that is not a  Saturday  or a Sunday or a British
     Columbia provincial, Canadian federal, Florida state, United States federal
     holiday or Hong Kong holiday;

     Confidential   Information  means  all  information   (including,   without
     limitation,  trade secrets, know-how,  specifications,  analyses, formulae,
     drawings,   data,  reports,   patterns,   devices,   plans,  processes,  or
     compilations)  and any other  documentation,  whether  written,  graphic or
     stored electronically or magnetically,  belonging to either Party or any of
     its Affiliates, including:

          (a) all  proprietary  information  licensed  to or  acquired,  used or
     developed by the party  including  information  in respect of laboratory or
     research procedures and techniques,  research data,  chemical  compositions
     and processes and other scientific strategies and concepts; and

          (b) all  information  relating  to the  party's  business,  structure,
     personnel,  operations,  financial  condition,  marketing,  advertising and
     commercial  strategies,   customer  and  supplier  lists,   agreements  and
     contractual records and correspondence that may not be generally known;

     Development  means the  research and  development  of  biotechnology  based
     pharmaceutical products;

     Discloser has the meaning ascribed to it in ss.5.1;

     Dragon Warrant has the meaning ascribed to it in ss.2.5;

     Governmental Authority means, as applicable,  the government of Canada, the
     government  of the United States of America,  the  government of a Canadian
     province or  territory,  the  government of a state in the United States of
     America,  and a ministry,  department,  commission,  board, bureau or other
     agency of, or municipality, regional district or other local governing body
     established by, any such government, or other political subdivision thereof
     and  includes  any  Person  exercising  executive,  legislative,  judicial,
     regulatory  or  administrative  functions  of, or  pertaining  to, any such
     government;

     Indemnified Party has the meaning ascribed to it in ss.7.1;

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     Indemnifying Parties has the meaning ascribed to it in ss.7.1;

     Intellectual  Property  means  a  patent,  patent  application,  industrial
     design,   invention,   design,  trade  secret,  idea,  work,   methodology,
     technology,   innovation,   creation,  concept,  moral  right,  development
     drawing,  research,  analysis,  know-how,   experiment,   copyright,  data,
     formula,  method,  procedure,  process,  system  or  technique,   including
     trademarks or tradenames;

     Person means an individual,  corporation,  body  corporate,  firm,  limited
     liability  company,   partnership,   syndicate,   joint  venture,  society,
     association,  trust,  unincorporated organization or Governmental Authority
     or any trustee, executor, administrator or other legal representative;

     Project Patent has the meaning ascribed to it in ss.2.1;

     Recipient has the meaning ascribed to it in ss.5.1;

     Recipient's Agent has the meaning ascribed to it in ss.5.5;

     Selected Project Patent has the meaning ascribed to it in ss.2.11;

     SDA means the State Drug Administration of China.

Interpretation

     1.2 In this Agreement,  except as expressly  provided or unless the context
otherwise requires,

          (a)  "this  Agreement"  means  this  Patent   Development   Agreement,
     including  the  Schedules  hereto,  as from  time to time  supplemented  or
     amended by one or more  agreements  entered into pursuant to the applicable
     provisions hereof,

          (b) the headings in this Agreement are inserted for  convenience  only
     and do not form a part of this Agreement and are not intended to interpret,
     define or limit the  scope,  extent  or  intent  of this  Agreement  or any
     provision hereof,

          (c) the word  "including",  when  following  any general  statement or
     term,  is not to be construed as limiting the general  statement or term to
     the specific items or matters set forth or to similar items or matters, but
     rather as  permitting  the general  statement or term to refer to all other
     items or matters that could  reasonably  fall within its broadest  possible
     scope,

          (d) all  accounting  terms  not  otherwise  defined  herein  have  the
     meanings assigned to them, and all calculations to be made hereunder are to
     be made, in accordance  with United States  generally  accepted  accounting
     principles applied on a consistent basis,

          (e) all  references  to currency mean currency of the United States of
     America,

          (f) a reference to a statute includes all regulations made thereunder,
     all  amendments to the statute or  regulations  in force from time to time,
     and any statute or regulation  that  supplements or supersedes such statute
     or regulations,

          (g) a reference to an entity includes any successor to that entity,

          (h) words  importing  the  masculine  gender  include the  feminine or
     neuter,  words in the  singular  include  the  plural,  words  importing  a
     corporate entity include individuals, and vice versa,

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          (i) a reference to  "approval",  "authorization"  or  "consent"  means
     written approval, authorization or consent, and

          (j) a  reference  to a Part  is to a Part of  this  Agreement  and the
     symbol ss. followed by a number or some  combination of numbers and letters
     refers to the section, paragraph, subparagraph, clause or subclause of this
     Agreement so designated.

     1.3 The Schedules  attached  hereto are  incorporated  in this Agreement by
reference and deemed to form a part hereof.

                                     PART 2

                                 GRANT OF PATENT

Selected Project Patent

     2.1 Liu and Novagen hereby grant to Dragon for a period of three years from
the date of this Agreement (the "Option Period"),  the first right to select and
acquire, for no additional cost other than as set out in section 2.5, one patent
(a "Selected Project Patent") owned by Liu and Novagen with respect to a project
that relates to the discovery of a new gene or protein (a "Project Patent").

     2.2  Liu  and  Novagen  will  provide  to  Dragon  a copy  of  each  patent
application  (a "Notice")  filed in the United  States  during the Option Period
relating  to a Project  Patent,  along  with such  other  information  as may be
reasonably requested by Dragon.

     2.3 Dragon will have 90 days from the date of receipt of a Notice to advise
Liu and Novagen  whether  Dragon  selects the Project  Patent  described  in the
Notice to be the Selected Project Patent. If Dragon does not select that Project
Patent as the Selected  Project  Patent,  such Project  Patent will no longer be
subject to this Agreement.

     2.4 On Dragon  selecting a Selected  Project  Patent,  Liu and Novagen will
transfer to Dragon all right,  title and interest in the Select Project  Patent,
free of any  encumbrances,  including  all rights to any  Intellectual  Property
related to the Selected Project Patent.

     2.5 Upon Dragon selecting a Selected  Project Patent,  Liu and Novagen will
have no right,  title or interest in or to the Intellectual  Property related to
the Selected Project Patent, or any part thereof,  and nothing in this Agreement
will be  construed  as an  assignment  or grant to Liu or  Novagen of any right,
title or interest in or to the  Intellectual  Property  related to the  Selected
Project Patent.

     2.6 Liu and  Novagen  agree that upon Dragon  selecting a Selected  Project
Patent, all Confidential Information related to the Selected Project Patent will
belong to Dragon and will be subject  to the  provisions  set forth in Part 5 of
this Agreement.

     2.7 During the Option  Period,  Liu and Novagen  will bear all  development
costs for the Project  Patents,  including the Selected  Project Patent,  except
that upon  choosing a Selected  Project  Patent,  Dragon will  reimburse Liu and
Novagen for all reasonable  legal costs incurred by Liu and Novagen in obtaining
the patent and Dragon will bear all costs related to the Selected Project Patent
thereafter.

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Additional Project Patent

     2.8 If

          (a) during the Option Period Dragon does not determine  that a Project
     Patent is suitable for selection as a Selected Project Patent, or

          (b) the patent application for the Selected Project Patent is denied,

Dragon may select an additional Project Patent (an "Additional  Project Patent")
of Liu and Novagen to be acquired by Dragon and the provisions of section 2.1 to
2.6 will apply to the Additional Project Patent, with the necessary changes. For
clarity,  Liu and Novagen will  continue to bear all  development  costs for the
Project  Patents,  including the Additional  Project Patent,  except that on the
filing of a United States patent for an  Additional  Project  Patent Dragon will
reimburse  Liu and Novagen for all  reasonable  legal costs  incurred by Liu and
Novagen in obtaining the patent.

     2.9 If

          (a) during the Option Period Dragon does not determine  that a Project
     Patent is suitable for selection as an Additional Project Patent, or

          (b) the  patent  application  for the  Additional  Project  Patent  is
     denied,

the  provisions  of  section  2.6 will  continue  to apply as if the  Additional
Project Patent had not been selected.

Right of First Offer

     2.10 If during the  Option  Period,  Liu or  Novagen  decides to sell their
patent or patent  applications  to a third  party,  whether  on a  solicited  or
un-solicited  basis,  Liu or  Novagen  will  first  offer to Dragon the right to
acquire  such  patent.  Dragon will have 60 days to  consider  such offer and if
Dragon  declines to acquire such patent,  Liu or Novagen may sell such patent on
terms no more favourable than those offered to Dragon.

Consideration

     2.11 In  consideration  for the right to select and  acquire  the  Selected
Project Patent or Additional Project Patent,  Dragon agrees to within 7 business
days from the date of this Agreement,

          (a) pay to Liu and Novagen a total of US$500,000  divided  between Liu
     and Novagen; and;

          (b)  subject  to any  required  regulatory  approvals,  issue  to Liu,
     Novagen or their nominees warrants  exercisable for 1,000,000 common shares
     of Dragon at a price of  US$2.50  per share for a term of five  years  (the
     "Dragon Warrant").

     2.12 If Dragon does not choose a Selected  Project  Patent or the  Selected
Project Patent is not granted by the patent  authority within three years of the
date of this Agreement, Dragon may cancel the Dragon Warrant by giving notice to
Liu or Novagen at any time after the  expiration of three years from the date of
this Agreement. For clarity, the US$500,000 paid pursuant to ss.2.11(a) will not
be refunded if Dragon does not choose a Selected  Project  Patent  within  three

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years from the date of this Agreement. If no patent applications have been filed
within  three years from the date of this  agreement  Liu and  Novagen  agree to
refund the  US$500,000  within 7 business  days and the Dragon  Warrants will be
cancelled.


                                     PART 3

                         REPRESENTATIONS AND WARRANTIES

Representations and Warranties of Novagen and Liu

     3.1 In order to induce Dragon to enter into and consummate the transactions
contemplated by this Agreement,  Liu and Novagen jointly and severally represent
and warrant to Dragon the statements  contained in Schedule A as representations
and  warranties  that are true,  accurate  and  complete  as at the date of this
Agreement (except insofar as such  representations  and warranties are stated to
be given as of a particular date or for a particular period and relate solely to
such date or period, in which case such representations and warranties are true,
accurate and complete in all material respects as at that date).

Representations and Warranties of Dragon

     3.2 In order to induce Liu and  Novagen to enter  into and  consummate  the
transactions  contemplated by this Agreement,  Dragon represents and warrants to
Liu and Novagen the statements  contained in Schedule B as  representations  and
warranties that are true, accurate and complete as at the date of this Agreement
(except insofar as such representations and warranties are stated to be given as
of a particular  date or for a particular  period and relate solely to such date
or period, in which case such  representations and warranties are true, accurate
and complete in all material respects as at that date).

                                     PART 4

                                   DELIVERIES

Deliveries of Novagen

     4.1 As soon as reasonably practicable following the date of this Agreement,
Novagen will deliver or cause to be delivered to Dragon

          (a) a  certified  copy of a  resolution  of the  directors  of Novagen
     authorizing the execution,  delivery and  implementation of this Agreement,
     and of all  transactions  contemplated  hereby and of all  documents  to be
     delivered by Novagen pursuant hereto,

          (b) a certificate of a senior officer of Novagen  certifying as to the
     accuracy of the  representations and warranties of Novagen herein as at the
     date of this  Agreement and the  fulfilment by Novagen of the covenants and
     agreements required to be fulfilled by it pursuant to this Agreement, and

          (c) all such other documents and instruments as counsel for Dragon may
     reasonably require.

     4.2  Novagen  will  immediately  notify  Dragon in writing of any  actions,
suits, proceedings, investigations, complaints, orders, directives or notices of
defect  or  non-compliance  by or before  any  court,  administrative  tribunal,
arbitrator or  Governmental  Authority  issued,  pending or, to the knowledge of

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Novagen,  threatened against or affecting  Novagen,  the Business or the Project
Patents  which,  if  successful,  could have a materially  adverse effect on the
Business.

Deliveries of Liu

     4.3 Liu will  immediately  notify Dragon in writing of any actions,  suits,
proceedings, investigations, complaints, orders, directives or notices of defect
or non-compliance by or before any court, administrative tribunal, arbitrator or
Governmental  Authority issued,  pending or, to the knowledge of Liu, threatened
against or  affecting  Liu,  the  Business  or the  Project  Patents  which,  if
successful, could have a materially adverse effect on the Business.

Deliveries of Dragon

     4.4 As soon as  reasonably  practicable  after the date of this  Agreement,
Dragon will deliver or cause to be delivered to Liu and Novagen.

          (a) a  certified  copy of  resolutions  of the  directors  of  Dragon,
     authorizing the execution,  delivery and  implementation of this Agreement,
     and of all  transactions  contemplated  hereby and of all  documents  to be
     delivered by Dragon pursuant hereto, and

          (b) a certificate of a senior  officer of Dragon  certifying as to the
     accuracy of the  representations  and warranties of Dragon herein as at the
     date of this  Agreement  and the  fulfilment by Dragon of the covenants and
     agreements required to be fulfilled by it pursuant to this Agreement.

                                     PART 5

                                 CONFIDENTIALITY

Confidential Information

     5.1 As a  result  of  completing  the  transactions  contemplated  by  this
Agreement, each party (the "Recipient") acknowledges that it may acquire or hold
Confidential Information belonging to the other party (the "Discloser") (whether
acquired  by  Discloser  before the date of, or as a result of the  transactions
contemplated by, this Agreement).

Property

     5.2 Except as provided for in this Agreement,  all Confidential Information
belonging to Discloser  (whether acquired by Discloser before the date of, or as
a result of the  transactions  contemplated  by, this Agreement) will remain the
exclusive  property of the  Discloser.

     5.3 Except as expressly set out herein,  nothing in this Agreement  confers
on Recipient  any  interest,  licence or other right in respect of  Confidential
Information of the Discloser.

Fiduciary Relationship

     5.4 Recipient  acknowledges  that certain of the  Confidential  Information
consists of  information  vital to the  business  and  commercial  prospects  of

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Discloser and that such information is of a special,  valuable and unique nature
and would not normally be disclosed to  Recipient  and,  accordingly,  Recipient
will act as a fiduciary  of  Discloser  in holding  and using such  Confidential
Information.

Obligation of Confidentiality

     5.5 Except as provided for in this Agreement,  all Confidential Information
belonging to Discloser and known to or held by Recipient  will be held in strict
confidence  and the  Recipient

          (a) agrees to use such Confidential  Information only for the purposes
     of completing the transactions contemplated by this Agreement,

          (b)  will,  and will  ensure  that  each of its  directors,  officers,
     employees and agents (collectively, the "Recipient's Agents") will, hold in
     confidence and keep confidential the Confidential  Information disclosed to
     them by the Discloser,

          (c) will not,  and will  ensure  that none of the  Recipient's  Agents
     will,  directly  or  indirectly,  use or  disclose  any  such  Confidential
     Information  except to the extent that it is strictly  necessary  to enable
     the Recipient to exercise its rights and perform its obligations under this
     Agreement,

          (d) will not,  and will  ensure  that none of the  Recipient's  Agents
     will,  except to the extent  necessary to enable the  Recipient to exercise
     its rights or perform its obligations under this Agreement,  make copies of
     such Confidential Information,

          (e) will,  upon the request of the  Discloser,  return,  and cause the
     Recipient's  Agents to  return,  all  Confidential  Information  and copies
     thereof to the Discloser, and

          (f) will,  and will ensure that each of the  Recipient's  Agents will,
     maintain all such Confidential Information in a manner so as to protect the
     same against wrongful disclosure, misuse, espionage and theft.

Exceptions

     5.6 Nothing in this Agreement will prevent the Recipient or the Recipient's
Agents from making use of or disclosing any Confidential Information

          (a) which has already become generally available to the public through
     no breach of this Agreement or any other obligation of the Recipient or the
     Recipient's Agents to the Disclosing Party,

          (b) which the Recipient can show,  through written evidence,  has been
     independently  developed,  without  use  of  any  Confidential  Information
     belonging to the Discloser, by employees of the Recipient who had no access
     to such Confidential Information,

          (c) which  the  Recipient  can show,  through  written  evidence,  was
     received  by it on a  non-confidential  basis from a source  other than the
     Discloser  and  which  source,  to the  knowledge  of  Recipient,  lawfully
     obtained such  information and had the right to disclose such  information,
     or

          (d) which is  required  to be  disclosed  pursuant to a final order or
     judgment of a court of competent  jurisdiction and in such case the parties
     will cooperate with one another to seek to obtain an appropriate protective
     order or other  reliable  assurance  that  confidential  treatment  will be
     afforded to such Confidential Information.

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Recipient  will  immediately  notify  Discloser  if  Recipient  becomes  legally
compelled to disclose any  Confidential  Information  sufficiently in advance of
the date of disclosure so as to provide Discloser with a reasonable  opportunity
to seek an appropriate remedy to enjoin such disclosure from occurring.

Reasonable Restriction

     5.7 Each party  agrees  that the  restrictions  contained  in this Part are
reasonable in order to protect the respective  legitimate  business interests of
the parties and all defences to the strict  enforcement of such restrictions are
hereby waived by the parties.

Injunctive Relief

     5.8 Each party acknowledges that a breach by it of any covenants  contained
in this Part could result in damages to the other party to this Agreement  which
damages could not adequately be compensated for by monetary award.  Accordingly,
each  party  agrees  that in the  event of any such  breach  by such  party,  in
addition to all other remedies available to any other party at law or in equity,
such other  party will be  entitled  as a matter of right to apply to a court of
competent jurisdiction for such relief by way of restraining order,  injunction,
decree  or  otherwise,  as may be  appropriate,  to ensure  compliance  with the
provisions of this Agreement.

Survival of Covenants

     5.9 The covenants and agreements  contained in this Part will survive for a
period of three years after the date of this  Agreement and will be separate and
distinct  covenants and  agreements  enforceable  after the  termination  of the
remainder  of this  Agreement  in  accordance  with the terms  thereof,  and any
reference in this Agreement to termination will not influence the termination of
this Part unless specifically agreed to by the parties.

                                     PART 6

                               DISPUTE RESOLUTION

Disputes

     6.1 If at any time there is a dispute among the parties with respect to any
matter  relating  to this  Agreement,  any  party  that  wishes  the issue to be
considered  further  will give notice to the others that it requires the dispute
to be decided under the terms of this Agreement.

Referral to Senior Officers

     6.2 If a notice is given under ss.6.1,  each party will  designate a person
(a  "Representative")  to undertake  discussions for the purpose of settling the
dispute. A decision reached by these Representatives and communicated in writing
to the parties will be  determinative of the dispute and will be binding on each
party.

Arbitration

     6.3 If no decision is reached  under  ss.6.2  within 30 days of the dispute
being  sent for  consideration,  any party may,  by notice to the other  parties
given at any time before a decision is rendered under ss.6.2, submit the dispute

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for  determination by a single  arbitrator acting under the Rules of the British
Columbia Commercial Arbitration Centre.

     6.4 If the parties  can not agree on a single  arbitrator,  the  arbitrator
will be appointed by the British Columbia  International  Commercial Arbitration
Centre.

     6.5 The arbitration will take place in Vancouver, British Columbia and will
be administered by the British  Columbia  International  Arbitration  Centre and
conducted in accordance with the procedures of the Centre.

Legal Proceedings

     6.6 A legal proceeding commenced by a party to this Agreement in respect of
an issue or dispute that may be arbitrated  under this  Agreement will be stayed
until the time during which an  arbitration  may be initiated has expired or, if
an arbitration is initiated,  a decision on the  arbitration is delivered or the
arbitration process has otherwise ended.

Exclusions

     6.7 This  Part  will  not  apply to any  action  pursuant  to Part 5 or any
actions  seeking  any  grant of  provisional  remedies,  including  injunctions,
restraining orders and specific  performance,  and each party reserves its right
to  commence  such  action  or seek  such  remedies  from a court  of  competent
jurisdiction.

                                     PART 7

                                   INDEMNITIES

Indemnity

     7.1 Subject to ss.7.2 and without  prejudice to any other remedy  available
to a party (the "Indemnified Party") at law or in equity, the other parties (the
"Indemnifying  Parties") hereby agree,  forthwith upon demand,  to indemnify and
save harmless the Indemnified Party from and against any and all costs,  losses,
damages,  taxes or expenses suffered or incurred by the Indemnified Party in any
manner  arising out of, in connection  with,  with respect to or relating to any
representation or warranty the Indemnifying Parties set forth in this Agreement,
being untrue or incorrect or the failure of the Indemnifying  Parties to observe
or perform any of its  obligations  pursuant  hereto,  and any and all goods and
services taxes, actions, suits, proceedings,  demands,  assessments,  judgments,
reasonable costs and reasonable legal and other expenses incidental thereto.

Claim Limits

     7.2 Any claim(s) underss.7.1,

          (a) must exceed $100,000 in the aggregate before any claim is made, in
     which  event all  damages or  deficiencies  may be claimed and not just the
     amount in excess of the aforementioned amount, and

          (b) must be claimed  within a period of four  years  after the date of
     this Agreement.

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Notification Regarding Claim

     7.3 Each party will promptly  notify the others when it has determined that
it has actual  (and not  attributed  or assumed)  knowledge  of a state of facts
which gives rise to a claim under this Part.

                                     PART 8

                               GENERAL PROVISIONS

Modifications, Approvals and Consents

     8.1 No amendment,  modification,  supplement,  termination or waiver of any
provision of this  Agreement  will be effective  unless in writing signed by the
appropriate  party and then only in the  specific  instance and for the specific
purpose given.

Survival of Covenants

     8.2 The  covenants  and  agreements  contained  in Part 5 will  survive the
termination of the remainder of this Agreement and will be separate and distinct
covenants and agreements  enforceable  after the termination of the remainder of
this Agreement in accordance  with the terms thereof,  and any reference in this
Agreement to termination  will not influence the  termination of such provisions
unless specifically agreed to by the parties.

Further Assurances

     8.3 The parties will execute such further  assurances  and other  documents
and  instruments  and do such  further and other  things as may be  necessary to
implement and carry out the intent of this Agreement.

Entire Agreement

     8.4 The provisions in this Agreement and the other agreements  contemplated
herein  constitute  the entire  agreement  among the parties and  supersede  all
previous  expectations,  understandings,   communications,  representations  and
agreements,  whether verbal or written,  among the parties,  including,  without
limitation,  all previous confidentiality agreements between the parties, and if
there is any conflict  between the terms of this  Agreement and the terms of any
other  agreements  with respect to the subject matter hereof,  the provisions of
this Agreement will prevail.

Notice

     8.5 Every notice, request,  demand, direction or other communication (each,
for the purposes of ss.8.5, ss.8.6 and ss.8.7, a "Notice") required or permitted
to  be  given  pursuant  to  this  Agreement  will  be  deemed  to be  well  and
sufficiently  given if in writing and  delivered by hand  (including  recognized
overnight  courier service) or transmitted by facsimile,  in each case addressed
as follows:

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        (a) if to Novagen at:

                  350-655 West Kent Avenue North
                  Vancouver, B.C.
                  V6P 6T7
                  Attention:  Longbin Liu
                  Fax:  (604) 323-8187

        (b)      if to Longbin Liu at:

                  1528 Errigal Place
                  West Vancouver, B.C.
                  V7S 3H1
                  Fax:  (604) 921-4124

                  with a copy to:

                  Koffman Kalef
                  19th Floor
                  885 West Georgia Street
                  Vancouver, B.C.
                  V6C 3H4
                  Attention:  Bernard G. Poznanski
                  Fax:  (604) 891-3788

        (c)      if to Dragon at:

                  12th Floor
                  543 Granville Street
                  Vancouver, B.C.
                  V6C 2X8
                  Attention:  Chairman of the Board of Directors and CFO
                  Fax:  (604) 669-4243

                  with a copy to

                  Lang Michener
                  1500 - 1055 West Georgia Street
                  P.O. Box 11117
                  Vancouver, British Columbia
                  V6E 4N7
                  Attention:  Leo Raffin
                  Fax:  (604) 689-9111

or to such other address or  transmission  receiving  station as is specified by
the particular party by Notice to the other.

13

Deemed Receipt

     8.6 Any Notice  delivered or sent as aforesaid will be deemed  conclusively
to have been  effectively  given and received on the day Notice was delivered or
sent as aforesaid  if it was  delivered or sent on a day that was a Business Day
or on the next day that is a Business  Day if it was  delivered or sent on a day
that was not a Business Day.

Change of Address

     8.7 A party may at any time, by Notice to the other,  change its address to
some no less  convenient  address  and will so change its address  whenever  its
address ceases to be suitable for delivery by hand.

Enurement

     8.8  This  Agreement  will  enure to the  benefit  of and be  binding  upon
Novagen, Liu and Dragon and their respective permitted assigns.

Assignment

     8.9 Neither Liu or Novagen may assign their rights, title or interests,  or
any part thereof,  under this Agreement,  other than to an Affiliate of Novagen,
except  with  the  prior  written  consent  of  Dragon,  which  consent  may  be
arbitrarily withheld.  Dragon may not assign its rights, title or interests,  or
any part thereof, under this Agreement to any person, other than to an Affiliate
of Dragon,  except  with the prior  written  consent of Liu and  Novagen,  which
consent may be arbitrarily withheld.

Applicable Law

     8.10 This  Agreement  will be deemed to have been made in the  Province  of
British  Columbia  and  the  construction,  validity  and  performance  of  this
Agreement  will be  governed  in all  respects  by the  laws  prevailing  in the
Province of British Columbia.

Attornment

     8.11 Each party irrevocably  attorns to the  non-exclusive  jurisdiction of
the courts of British  Columbia  and all courts  having  appellate  jurisdiction
thereover  in respect  of any  proceeding  arising  out of or  relating  to this
Agreement.

Convenient Forum

     8.12 Notwithstanding ss.8.10 and ss.8.11, at its absolute discretion Dragon
may proceed against Liu or Novagen in any court of any other jurisdiction in the
world and, if required by law,  may elect for this  Agreement  to be governed by
the laws of the jurisdiction most applicable to Liu and/or Novagen in respect of
the action undertaken.

Severability

     8.13 If any one or more of the  provisions  contained in this  Agreement is
invalid,  illegal  or  unenforceable  in any  respect in any  jurisdiction,  the
validity,  legality and  enforceability of such provision or provisions will not
in any way be  affected or impaired  thereby in any other  jurisdiction  and the
validity,  legality and  enforceability  of the remaining  provisions  contained

14

herein will not in any way be affected  or  impaired  thereby,  unless in either
case  as a  result  of  such  determination  this  Agreement  would  fail in its
essential purpose.

Counterparts

     8.14 This  Agreement  may be executed in any number of  counterparts  or by
facsimile, each of which will together, for all purposes, constitute one and the
same  instrument,  binding on the  parties,  and each of which will  together be
deemed  to be an  original,  notwithstanding  that  all of the  parties  are not
signatories to the same counterpart or facsimile.

IN WITNESS  WHEREOF the above noted parties have executed this  Agreement as and
of the date first above written.


The Common Seal of DRAGON PHARMACEUTICALS INC.             )
was affixed in the presence of:                            )
                                                           )
                                                           )
                                                           )  C/S
- -----------------------------------------------------      )
Authorized Signatory                                       )
                                                           )
- -----------------------------------------------------      )
Authorized Signatory                                       )


The Common Seal of NOVAGEN HOLDING INC.                    )
was affixed in the presence of:                            )
                                                           )
                                                           )
                                                           )  C/S
- -----------------------------------------------------      )
Authorized Signatory                                       )
                                                           )
- -----------------------------------------------------      )
Authorized Signatory                                       )


Signed, Sealed and Delivered by LONGBIN LIU                )
in the presence of:                                        )
                                                           )
                                                           )
- -----------------------------------------------------      )
Witness (Signature)                                        ) -------------------
                                                           ) LONGBIN LIU
                                                           )
- -----------------------------------------------------      )
Name (please print)                                        )
                                                           )
                                                           )
- -----------------------------------------------------      )
Address                                                    )
                                                           )
                                                           )
- -----------------------------------------------------      )
City, Province





                                   SCHEDULE A


                    REPRESENTATIONS AND WARRANTIES OF NOVAGEN


General

     1. Novagen

     (a) is a  corporation  duly  incorporated  under  the  laws  of the  Cayman
Islands,

     (b) is duly  organized,  validly  exists and is in good standing  under the
laws of its jurisdiction of incorporation,

     (c) is in good  standing  in each  jurisdiction  in which the nature of the
Business  conducted  by it,  except  where the failure to do so would not have a
material  adverse effect on the  organization,  operations,  affairs,  business,
properties,  prospects or financial  condition or position of the Business,  and

     (d) has the  corporate  capacity,  right  and  corporate  power  to own the
Project Patents and to carry on the Business as now being conducted.

     2. Novagen has good and sufficient corporate capacity,  power and authority
to execute and deliver this Agreement, to complete the transactions contemplated
hereby and to duly  observe  and perform all of its  covenants  and  obligations
pursuant to and in accordance with the terms and conditions of this Agreement.

     3. This  Agreement  has been duly  executed and  delivered by Novagen,  and
constitutes  a legal,  valid and  binding  obligation  of  Novagen,  enforceable
against  it in  accordance  with its terms  subject  to  applicable  bankruptcy,
insolvency  and other similar laws  affecting  creditors'  rights  generally and
except that the  remedies of specific  performance,  injunctive  relief or other
equitable  remedies  may not be  available in any  particular  instance.

     4. The  execution and delivery of this  Agreement and the other  agreements
and  instruments   contemplated  hereby,  the  completion  of  the  transactions
contemplated hereby and the performance and compliance with the terms hereof and
thereof do not and will not

          (a)  constitute or result in the breach of or default under any terms,
     provisions  or  conditions  of or  conflict  with,  violate  or  cause  any
     acceleration,  termination  or  cancellation  in or with respect to

               (i) any  constating  documents,  charter  documents or by-laws of
          Novagen or any  resolution  of directors or  shareholders  of Novagen,

               (ii) any indenture, mortgage, deed of trust, agreement, contract,
          lease,  franchise,  certificate,  consent  (whether  written or oral),
          permit,  license,  authority,  registration  or  other  instrument  or
          commitment which is required or desirable for the conduct in the usual
          and ordinary  course of the operation of the  Business,  and

               (iii) any law, judgment, decree, order, injunction, rule, statute
          or regulation of any court,  arbitrator or  Governmental  Authority to
          which the  Business or Novagen is subject,  or



          (b) result in any fees,  duties,  taxes,  assessments or other amounts
     relating to any of the Project Patents becoming due or payable,  other than
     sales,  use,  transfer and similar  taxes  payable by Novagen in connection
     with  the  transactions   contemplated   hereby.

     5. No written or oral authorization,  approval,  order, license,  permit or
certificate  with  any  Governmental  Authority,  court  or  arbitrator,  and no
registration,  declaration  or  filing  by  Novagen  with any such  Governmental
Authority, court or arbitrator, is required in order for Novagen to

          (a) incur the  obligations  expressed  to be incurred by Novagen in or
     pursuant to this Agreement,

          (b)  execute and deliver all other  documents  and  instruments  to be
     delivered by Novagen pursuant to this Agreement, and

          (c)  duly  perform  and  observe  the  terms  and  provisions  of this
     Agreement.

Project Patents and Business

     6.  As of  the  date  of  this  Agreement,  there  are no  actions,  suits,
proceedings, investigations, complaints, orders, directives or notices of defect
or non-compliance by or before any court, administrative tribunal, arbitrator or
Governmental  Authority  issued,  pending  or,  to  the  knowledge  of  Novagen,
threatened  against or affecting  Novagen,  the Business or the Project  Patents
which, if successful, could have a materially adverse effect on the Business.


                      REPRESENTATIONS AND WARRANTIES OF LIU

General

     1. Liu

          (a) is a controlling shareholder and sole director of Novagen,

          (b) has the power and authority to execute and deliver this Agreement,
     to complete the  transactions  contemplated  hereby and to duly observe and
     perform all of his covenants and obligations  pursuant to and in accordance
     with the terms and conditions of this Agreement.

     2.  This  Agreement  has been  duly  executed  and  delivered  by Liu,  and
constitutes a legal, valid and binding obligation of Liu, enforceable against it
in accordance  with its terms subject to applicable  bankruptcy,  insolvency and
other similar laws  affecting  creditors'  rights  generally and except that the
remedies of specific performance,  injunctive relief or other equitable remedies
may not be available in any particular instance.

     3. No written or oral authorization,  approval,  order, license,  permit or
certificate  with  any  Governmental  Authority,  court  or  arbitrator,  and no
registration, declaration or filing by Liu with any such Governmental Authority,
court or arbitrator, is required in order for Liu to

          (a)  incur  the  obligations  expressed  to be  incurred  by Liu in or
     pursuant to this Agreement,

          (b)  execute and deliver all other  documents  and  instruments  to be
     delivered by Liu pursuant to this Agreement, and



          (c)  duly  perform  and  observe  the  terms  and  provisions  of this
     Agreement.

Project Patents and Business

     4.  As of  the  date  of  this  Agreement,  there  are no  actions,  suits,
proceedings, investigations, complaints, orders, directives or notices of defect
or non-compliance by or before any court, administrative tribunal, arbitrator or
Governmental  Authority issued,  pending or, to the knowledge of Liu, threatened
against or  affecting  Liu,  the  Business  or the  Project  Patents  which,  if
successful, could have a materially adverse effect on the Business.



                                   SCHEDULE B


                    REPRESENTATIONS AND WARRANTIES OF DRAGON


General

     1. Dragon

          (a) is a corporation duly incorporated  under the laws of the State of
     Florida,

          (b) is duly  organized,  validly  exists and is in good standing under
     the laws of its jurisdiction of incorporation,

          (c) is in good  standing in each  jurisdiction  in which the nature of
     the business  conducted by it,  except where the failure to do so would not
     have a material adverse effect on the  organization,  operations,  affairs,
     business,  properties,  prospects or financial condition or position of the
     Business, and

          (d) has the corporate capacity,  right and corporate power to carry on
     its business as now being conducted.

     2. Dragon has good and sufficient  corporate capacity,  power and authority
to execute and deliver this Agreement, to complete the transactions contemplated
hereby and to duly  observe  and perform all of its  covenants  and  obligations
pursuant to and in accordance with the terms and conditions of this Agreement.

     3. This  Agreement  has been duly  executed and  delivered  by Dragon,  and
constitutes a legal, valid and binding obligation of Dragon, enforceable against
it in accordance with its terms subject to applicable bankruptcy, insolvency and
other similar laws  affecting  creditors'  rights  generally and except that the
remedies of specific performance,  injunctive relief or other equitable remedies
may not be available in any particular instance.

     4. The  execution and delivery of this  Agreement and the other  agreements
and  instruments   contemplated  hereby,  the  completion  of  the  transactions
contemplated hereby and the performance and compliance with the terms hereof and
thereof do not and will not

          (a)  constitute or result in the breach of or default under any terms,
     provisions  or  conditions  of or  conflict  with,  violate  or  cause  any
     acceleration, termination or cancellation in or with respect to

               (i) any  constating  documents,  charter  documents or by-laws of
          Dragon or any resolution of directors or shareholders of Dragon,

               (ii) any indenture, mortgage, deed of trust, agreement, contract,
          lease,  certificate,  consent  (whether  written  or  oral),  license,
          authority,  registration  or other  instrument  or commitment to which
          Dragon is a party or under which it is bound, and

               (iii) any law, judgment, decree, order, injunction, rule, statute
          or regulation of any court,  arbitrator or  Governmental  Authority to
          which Dragon is subject.



     5. No written or oral authorization,  approval,  order, license,  permit or
certificate  with  any  Governmental  Authority,  court  or  arbitrator,  and no
registration,  declaration  or  filing  by  Dragon  with any  such  Governmental
Authority, court or arbitrator, is required in order for Dragon to

          (a) incur the  obligations  expressed  to be  incurred by Dragon in or
     pursuant to this Agreement,

          (b)  execute and deliver all other  documents  and  instruments  to be
     delivered by Dragon pursuant to this Agreement, and

          (c)  duly  perform  and  observe  the  terms  and  provisions  of this
     Agreement.