EXHIBIT 5









                                  HART & TRINEN
                               1624 Washington St.
                                Denver, CO 80203
                                 (303) 839-0061



                                 August 29, 2006
CEL-SCI Corporation
8229 Boone Blvd. #802
Vienna, VA 22182

      This letter will constitute an opinion upon the legality of the sale by
CEL-SCI Corporation, a Colorado corporation, and by certain shareholders
CEL-SCI, of up to 26,213,952 shares of common stock, all as referred to in the
Registration Statement on Form S-1 filed by CEL-SCI with the Securities and
Exchange Commission.

      We have examined the Articles of Incorporation, the Bylaws and the minutes
of the Board of Directors of CEL-SCI and the applicable laws of the State of
Colorado, and a copy of the Registration Statement. In our opinion, CEL-SCI has
duly authorized the issuance of the shares of stock mentioned above and, when
sold in accordance with the terms and conditions set out in the Registration
Statement, such shares of common stock, will be legally issued, fully paid and
non-assessable.

                                  Very truly yours,

                                  HART & TRINEN, L.L.P.



                                  /s/ William T. Hart
                                  -------------------------------------
                                 William T. Hart