United States Securities And Exchange Commission
                              Washington, DC 20549
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                                  SCHEDULE 14A
                                 (Rule 14a-101)


                            Schedule 14A Information

                  Proxy Statement Pursuant to Section 14(a) of
                       the Securities Exchange Act of 1934

Filed by the Registrant                              [X]
Filed by a Party other than the Registrant           [ ]

Check the appropriate box:
[ ] Preliminary Proxy Statement
[X]  Definitive Proxy Statement
[ ]  Confidential,  for  Use  of  the  Commission  Only  (as  permitted  by Rule
     14a-5(d) (1))

                         PROVECTUS PHARMACEUTICALS, INC.
                (Name of Registrant as Specified in Its Charter)

Payment of Filing Fee (Check the appropriate box):

[X]  No fee required
[ ]  Fee computed on table below per Exchange Act Rules 14c-5(g) and 0-11.
     (1)  Title of each class of securities to which transaction applies:
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     (2)  Aggregate number of securities to which transaction applies:
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     (3)  Per unit  price  or other  underlying  value of  transaction  computed
          pursuant to Exchange  Act Rule 0-11 (set forth the amount on which the
          filing fee is calculated and state how it was determined):
- --------------------------------------------------------------------------------
     (4)  Proposed maximum aggregate value of transaction:
- --------------------------------------------------------------------------------
     (5)  Total fee paid:

          [ ]  Fee previously paid with preliminary materials.

          [ ]  Check  box  if  any  part of the fee is  offset  as  provided  by
               Exchange  Act Rule  0-11(a)(2)  and identify the filing for which
               the  offsetting  fee was paid  previously.  Identify the previous
               filing by registration  statement number, or the form or schedule
               and the date of its filing.

              (1) Amount Previously Paid:
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              (2) Form, Schedule or Registration Statement No.:
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              (3) Filing Party:
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              (4) Date Filed:
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PROVECTUS                                        7327 Oak Ridge Highway, Suite A
PHARMACEUTICALS, INC.                                        Knoxville, TN 37931
                                                              phone 865/769-4011
                                                                fax 865/769-4013


                  Notice of 2004 Annual Meeting of Stockholders
                           To Be Held on May 27, 2004

To Our Stockholders:

     We will hold the 2004  annual  meeting  of the  stockholders  of  Provectus
Pharmaceuticals,  Inc. on Thursday, May 27, 2004, beginning at 3:00 p.m. Eastern
time, at the offices of Baker, Donelson,  Bearman,  Caldwell & Berkowitz located
at  Riverview  Tower,  Suite 2200,  900 South Gay Street,  Knoxville,  Tennessee
37902. The annual meeting is being held for the following purposes:

     1.   To elect  four  directors  to serve on our  Board of  Directors  for a
          one-year term; and

     2.   To approve an amendment to our Amended and Restated 2002 Stock Plan to
          increase the number of shares  reserved for issuance from 2,000,000 to
          3,000,000

     3.   To transact any other  business that properly  comes before the annual
          meeting.

     Only  stockholders  of record as of the close of business on April 20, 2004
will be entitled to notice of and to vote at the annual meeting.

     You are  cordially  invited  to attend the annual  meeting.  Regardless  of
whether you plan to attend the annual meeting in person,  please complete,  sign
and date the  enclosed  proxy card and return it  promptly  in the  accompanying
postage-paid envelope.

                                    By order of the Board of Directors,



                                    Peter R. Culpepper
                                    Secretary

April 29, 2004


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                             YOUR VOTE IS IMPORTANT

TO ENSURE THAT YOU ARE REPRESENTED AT THE ANNUAL MEETING, PLEASE COMPLETE, SIGN,
DATE AND  PROMPTLY  RETURN  THE  ENCLOSED  PROXY IN THE  ACCOMPANYING  ENVELOPE,
REGARDLESS  OF  WHETHER  YOU PLAN TO ATTEND THE  ANNUAL  MEETING  IN PERSON.  NO
ADDITIONAL POSTAGE IS NECESSARY IF THE PROXY IS MAILED IN THE UNITED STATES. YOU
MAY REVOKE YOUR PROXY AT ANY TIME BEFORE IT IS VOTED AT THE MEETING.

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PROVECTUS                                        7327 Oak Ridge Highway, Suite A
PHARMACEUTICALS, INC.                                        Knoxville, TN 37931
                                                              phone 865/769-4011
                                                                fax 865/769-4013


                               PROXY Statement for
                       2004 Annual Meeting of Stockholders
                           to be held on May 27, 2004


     We are delivering these proxy materials to solicit proxies on behalf of the
Board of Directors of Provectus Pharmaceuticals, Inc., for the annual meeting of
stockholders  to be held on  Thursday,  May 27,  2004,  beginning  at 3:00  p.m.
Eastern time, at Riverview Tower,  Suite 2200, 900 South Gay Street,  Knoxville,
Tennessee.

     We are mailing this proxy statement,  together with a form of proxy and our
annual report on Form 10-KSB for the year ended December 31, 2003,  beginning on
April 29, 2004.

ABOUT THE ANNUAL MEETING

     What is the purpose of the Annual Meeting?

     At the annual meeting, stockholders will act upon the following matters:

          o    The election of four directors to serve on our Board of Directors
               for a one-year term.

          o    The approval of an increase in the number of shares  reserved for
               issuance under our 2002 Stock Plan from 2,000,000 to 3,000,000.

     Who is entitled to vote?

     Only stockholders of record at the close of business on April 20, 2004, the
record date for the annual meeting, are entitled to receive notice of the annual
meeting  and to vote the  shares of common  stock that they held on that date at
the annual meeting.  Each outstanding  share of common stock entitles its holder
to cast one vote on each matter to be voted on at the annual meeting.

     What constitutes a quorum?

     The presence at the annual  meeting,  in person or by proxy, of the holders
of a majority of the shares of the common stock  outstanding  on the record date
will  constitute  a  quorum.  As of  the  record  date,  there  were  13,507,030
outstanding shares of common stock.  Shares held by stockholders  present at the
annual meeting who elect to abstain from voting  nonetheless will be included in
the  calculation  of the  number  of shares  considered  present  at the  annual
meeting.

     How do I vote?

     If you complete and properly sign the accompanying proxy card and return it
to us, the proxy  holders  named on the proxy card will vote your  shares as you
direct. If you are a registered  stockholder and attend the annual meeting,  you
may deliver your completed  proxy card or vote in person at the meeting.  If you
hold your shares in a brokerage account or in "street name" and you wish to vote
at the annual meeting,  you will need to obtain a proxy from the broker or other
nominee who holds your shares.

     Can I change my vote after I return my proxy card?

     Yes. Even after you have submitted your proxy card, you may change your
vote at any time before the proxy is exercised by filing with the Secretary
either a notice of revocation or a duly executed proxy card bearing a

                                       1


later date. "Street name" stockholders must contact your broker or other nominee
and follow its  instructions  if they wish to change their votes.  The powers of
the proxy  holders will be suspended if you attend the annual  meeting in person
and so request,  although  your  attendance  at the annual  meeting  will not by
itself revoke a previously granted proxy.

     What are the Board's recommendations?

     Unless you give other instructions on your proxy card, the persons named as
proxies  on the  proxy  card  will  vote  your  shares  in  accordance  with the
recommendations  of the  Board of  Directors.  The Board  recommends  a vote FOR
election  of each of the four  candidates  nominated  to  serve on our  Board of
Directors for a one-year term and FOR approval of the proposed  amendment to our
2002 Stock Plan to increase  the number of shares  reserved  for  issuance  from
2,000,000 to 3,000,000.

     If any other business is properly  brought before the annual  meeting,  the
proxies will vote your shares as the Board of Directors recommends. If the Board
does not give a  recommendation,  the proxies  will vote your shares as they may
determine in their own discretion.

     What vote is required to approve each item?

               Election of Directors

     The affirmative vote of a plurality of the votes cast at the annual meeting
is required for the election of directors. If you are present at the meeting and
you  abstain  from  voting for one or more  directors,  your  shares will not be
counted  in the vote for any  nominee,  although  they will be  counted  for the
purpose of determining  whether there is a quorum present.  A properly  executed
proxy card marked  "WITHHOLD  AUTHORITY"  with respect to the election of one or
more  directors  will not be voted with  respect to the  director  or  directors
indicated  and will be treated as an  abstention  with  respect to voting on the
director or directors.

               Approval of the  Amendment to the Amended and Restated 2002 Stock
               Plan and Other Items

     For approval of the amendment to the 2002 Stock Plan and for any other item
of business that properly comes before the annual meeting,  the affirmative vote
of the holders of a majority of the common stock present at the annual  meeting,
in person or by proxy,  and entitled to vote will be required for approval.  The
shares of any stockholder present at the meeting who abstains from voting on the
proposed  ratification  or on any other  item will not be  counted  in the vote,
although they will be counted for the purpose of determining  whether there is a
quorum at the annual meeting. An abstention,  therefore, will have the effect of
a negative vote. A properly executed proxy card marked "ABSTAIN" with respect to
any such  matter  will not be voted and will be  treated as an  abstention  with
respect to that matter.

     In general,  if you hold shares of common stock in "street  name" through a
broker or other  nominee,  and if your broker or other nominee is not instructed
or  otherwise  empowered  to vote your  shares at a meeting  with  respect  to a
particular matter, then your shares will constitute "broker non-votes" as to the
matter. In the election of directors,  brokers generally have discretion to vote
your  shares  even in the  absence of express  instructions  from you. As to all
matters, a broker non-vote will have the same effect as an abstention.




                                       2





                                 STOCK OWNERSHIP

     The table below shows the amount of our common stock beneficially owned
as of April 20, 2004 by each of our directors and officers, each person whom we
believe beneficially owns more than 5% of our outstanding voting stock, and all
executive officers and directors as a group.




                                                                   Amount and Nature of           Percentage
                     Name and Address (1)                        Beneficial Ownership (2)        of Class (3)
                     --------------------                        ------------------------        ------------
                                                                                             
H. Craig Dees.................................................         1,516,609       (4)            11.1%

Timothy C. Scott..............................................         1,516,269       (5)            11.1

Eric A. Wachter...............................................         1,528,849       (6)            11.2

Peter R. Culpepper............................................                 0                       0

Stuart Fuchs..................................................           826,418       (7)             6.1

Gryffindor Capital Partners I, L.L.C..........................           452,919       (8)             3.4
   150 North Wacker Drive, Suite 800
   Chicago, IL 60606

Walter G. Fisher..............................................           802,315       (9)             5.9
   2009 Still Water Lane
    Knoxville, TN 37922

John Smolik...................................................           897,339      (10)             6.6
   119 Tanasi Court
    Loudon, TN 37774

All directors and executive officers as a group
   (5 persons)................................................         5,388,145      (11)            38.8

- ---------------------------------------

(1)  If no address is given,  the named  individual  is an executive  officer or
     director of Provectus Pharmaceuticals, Inc., whose business address is 7327
     Oak Ridge Highway, Suite A, Knoxville, TN 37931.

(2)  Shares of common  stock that a person  has the right to  acquire  within 60
     days of April 20, 2004 are deemed  outstanding for computing the percentage
     ownership of the person  having the right to acquire  such shares,  but are
     not deemed outstanding for computing the percentage  ownership of any other
     person. Except as indicated by a note, each stockholder listed in the table
     has sole voting and investment power as to the shares owned by that person.

(3)  As of April 20, 2004,  there were 13,507,030  shares of common stock issued
     and outstanding.

(4)  Dr.  Dees'  beneficial  ownership  includes  536 shares held by Dees Family
     Foundation,  an entity established for the benefit of Dr. Dees' family, and
     118,750 shares subject to options which are exercisable within 60 days.

(5)  Dr.  Scott's  beneficial  ownership  includes  55,996  shares held by Scott
     Family Investment Limited  Partnership,  a limited partnership  established
     for the  benefit of Dr.  Scott's  family,  and  118,750  shares  subject to
     options which are exercisable within 60 days.

(6)  Dr. Wachter's  beneficial  ownership includes 4,867 shares held by the Eric
     A. Wachter 1998 Charitable Remainder Unitrust and 118,750 shares subject to
     options which are exercisable within 60 days.

                                       3




(7)  Mr.  Fuchs's  beneficial  ownership  includes  226,459  shares  held by SFF
     Limited  Partnership,  a  limited  partnership  of which  Mr.  Fuchs is the
     general partner;  348,499 shares an IRA of Mr. Fuch;  25,000 shares subject
     to options which are exercisable  within 60 days and 226,460 shares held by
     Gryffindor Capital Partners I, L.L.C., a Delaware limited liability company
     of  which  Mr.  Fuchs  is  the  managing  principal   ("Gryffindor").   Our
     relationship  with  Gryffindor  is discussed in more detail below under the
     heading  "Certain  Relationships  and  Related  Transactions-Investment  by
     Gryffindor."

(8)  Dr.  Fisher's  beneficial  ownership  includes 55,577 shares held by Fisher
     Family  Investment  Limited  Partnership  and 9,734 shares held by the Walt
     Fisher 1998 Charitable Remainder Unitrust.

(9)  Mr.  Smolik's  beneficial  ownership  includes 48,666 shares held by Smolik
     Family LLP.

(10) Gryffindor's  beneficial  ownership  includes  226,459  shares  held by SFF
     Limited  Partnership,  a limited  partnership of which Stuart Fuchs, one of
     our directors,  is the general  partner.  Gryffindor  disclaims  beneficial
     ownership of these shares.

(11) Includes 381,250 shares subject to options which are exercisable  within 60
     days.

             SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

The federal  securities  laws require our directors  and executive  officers and
persons who  beneficially  own more than 10% of a registered class of our equity
securities  to file with the SEC  initial  reports of  ownership  and reports of
changes in ownership of our securities. Based solely on our review of the copies
of these forms received by us or representations from certain reporting persons,
we believe that SEC beneficial  ownership  reporting  requirements for 2003 were
met.

                                   PROPOSAL 1:
                                   -----------
                              ELECTION OF DIRECTORS

     The persons  listed below have been  nominated by the Board of Directors to
serve as  directors  for a  one-year  term  expiring  at the  annual  meeting of
stockholders occurring in 2005. Each nominee has consented to serve on the Board
of Directors.  If any nominee were to become unavailable to serve as a director,
the Board of Directors may  designate a substitute  nominee.  In that case,  the
persons  named as  proxies  on the  accompanying  proxy  card  will vote for the
substitute nominee designated by the Board of Directors.

     H. Craig Dees,  Ph.D., 52, has served as our Chief Executive Officer and as
a member of our Board of  Directors  since we  acquired  PPI on April 23,  2002.
Before  joining  us,  from  1997 to 2002  he  served  as  senior  member  of the
management team of Photogen Technologies, Inc., including serving as a member of
the Board of Directors of Photogen from 1997 to 2000. Prior to joining Photogen,
Dr. Dees served as a Group Leader at the Oak Ridge National Laboratory, and as a
senior  member of the  management  teams of LipoGen  Inc., a medical  diagnostic
company  which  used  genetic   engineering   technologies  to  manufacture  and
distribute diagnostic assay kits for auto-immune diseases, and TechAmerica Group
Inc., now a part of Boehringer Ingelheim Vetmedica, Inc., the U.S. animal health
subsidiary  of  Boehringer   Ingelhem  GmbH,  an   international   chemical  and
pharmaceutical  company headquartered in Germany. He earned a Ph.D. in Molecular
Virology from the University of Wisconsin - Madison in 1984.

     Timothy C. Scott, Ph.D., 46, has served as our President and as a member of
our Board of Directors since we acquired PPI on April 23, 2002. Prior to joining
us, Dr. Scott was as a senior member of the Photogen  management  team from 1997
to 2002,  including  serving as Photogen's Chief Operating  Officer from 1999 to
2002,  as a director  of  Photogen  from 1997 to 2000,  and as interim CEO for a
period in 2000.  Before  joining  Photogen,  he served as senior  management  of
Genase  LLC, a  developer  of  enzymes  for fabric  treatment,  and held  senior
research and management  positions at Oak Ridge National  Laboratory.  Dr. Scott
earned a Ph.D.  in  Chemical  Engineering  from the  University  of  Wisconsin -
Madison in 1985.

     Eric  A.  Wachter,   Ph.D.,   41,  has  served  as  our  Vice  President  -
Pharmaceuticals  and as a member of our Board of Directors since we acquired PPI
on April 23, 2002. Prior to joining us, from 1997 to 2002 he was a senior member
of the  management  team of  Photogen,  including  serving  as  Secretary  and a
director of Photogen since 1997

                                       4


and as Vice President and Secretary and a director of Photogen since 1999. Prior
to joining  Photogen,  Dr. Wachter served as a senior research staff member with
Oak  Ridge  National  Laboratory.  He  earned  a Ph.D.  in  Chemistry  from  the
University of Wisconsin - Madison in 1988.

     Stuart  Fuchs,  57, has served as a member of our Board of Directors  since
January 23, 2003.  He is the  co-founder  and managing  principal of  Gryffindor
since  January  2000, a  Chicago-based  venture  capital  firm.  Before  joining
Gryffindor,  he  was  a  founding  stockholder  of  several  biotech  companies,
including  Angiogen LLC (since 1998),  which develops  combinations  of drugs to
stimulate in vivo production of factors that inhibit the growth of blood vessels
in tumors,  and Nace Pharma LLC (since 1996),  which  develops drugs that employ
novel drug  delivery  technologies.  Through  Nace  Resources  Inc.,  a Delaware
corporation  providing  strategic  and  financial  advice  to  companies  in the
technology  sector,  Mr. Fuchs has formed or participated in groups of investors
on behalf of  several  companies,  including  Miicro  Inc.,  Celsion  Corp.  and
Photogen.  Before  founding  Nace  Resources  Inc., he served for 19 years as an
investment  banker with Goldman,  Sachs & Co.,  where he  co-managed  the firm's
public finance activities for the Midwest region. Before joining Goldman,  Sachs
& Co., Mr. Fuchs was a lawyer in private  practice with Barrett Smith Schapiro &
Simon in New York.  Mr. Fuchs holds an A.B.  degree from  Harvard  College and a
J.D.  from Harvard Law School and is a member of the  Association  of the Bar of
the City of New York.

     The Board of Directors  recommends that the  stockholders  vote FOR each of
the nominees for election to the Board of Directors named above.

                                   PROPOSAL 2:
                                   -----------
              AMENDMENT TO THE AMENDED AND RESTATED 2002 STOCK PLAN

     The Board of  Directors  has  approved  an  amendment  to our  Amended  and
Restated 2002 Stock Plan, subject to stockholder approval to increase the number
of  shares  reserved  for  issuance  under  the Plan  from  2,000,000  shares to
3,000,000.  The Plan was last approved by the stockholders at the annual meeting
in 2003. Our Board has  determined  that an increase in the reserve of shares is
necessary,  especially  in light of the fact  that as of April  20,  2004,  only
500,000  shares remain in the reserve.  The Board  believes that we must offer a
competitive  equity  compensation  program if we are to continue to successfully
attract and retain the most  qualified  candidates as  employees,  directors and
consultants.  The Board expects that the Plan, as amended,  will be an important
factor in attracting and retaining the personnel essential to our success and in
motivating these individuals to strive to enhance our growth and  profitability.
The opportunity to acquire an equity  interest will align the economic  interest
of these individuals with those of other stockholders, thereby benefiting all of
our stockholders. The Plan remains unchanged in all other respects.

     The  Plan  provides  for the  grant of stock  options,  stock  appreciation
rights,  rights to purchase  restricted stock and long-term  performance awards.
Our employees, consultants and directors who are not employees whose present and
potential  contributions  are important to our continued success are eligible to
receive awards. The Plan is administered by the Board of Directors which has the
power to authorize  awards and determine  their terms and  conditions.  The Plan
will remain in effect until all awards under the Plan have been issued,  expired
or otherwise  terminated  or the Plan is  terminated  by the Board of Directors.
However,  no award may be  granted  more  than ten  years  after the date of the
Plan's approval (2013).  Generally, a participant's awards issued under the Plan
are not transferable except by will or by the laws of descent and distribution.

     The  Board  of  Directors  recommends  that the  stockholders  vote FOR the
adoption of this proposal.


                    INFORMATION ABOUT THE BOARD OF DIRECTORS

     How often did the Board of Directors meet in 2003?

     The  Board of  Directors  met once and took  action  by  unanimous  written
consent 11 times during 2003.  Each Board member  attended  more than 75% of the
total  number of  meetings of the Board and its  committees  on which he served.
Members of the Board of Directors are  encouraged to attend the annual  meeting.
All members of our Board attended the 2003 annual meeting of stockholders.

                                       5


     How does the Board of Directors operate?

     Because  the  Board of  Directors  consists  of only four  members  and our
operations  remain  amenable to oversight by a limited number of directors,  the
Board has not delegated any of its functions to committees.  None of the members
of our Board of Directors is considered  independent.  The Board has not adopted
either a nominating or audit committee charter.

     The entire  Board of  Directors  acts as our audit  committee  as permitted
under  Section  3(a)(58)(B)  of the  Securities  Exchange Act of 1934 and as our
nominating  committee.  The Board  views its  duties  as an audit  committee  as
follows:

          o    Review  recommendations  of independent  auditors  concerning our
               accounting   principles,   internal   controls   and   accounting
               procedures and practices;

          o    Review the scope of the annual audit;

          o    Approve  or  disapprove  each  professional  service  or  type of
               service other than standard  auditing  services to be provided by
               the auditors; and

          o    Review and  discuss  with the  independent  auditors  the audited
               financial statements.

     The entire Board of Directors acts as our nominating  committee.  The Board
has no set  procedures  or policy on the  selection of nominees or evaluation of
shareholder  recommendations  and will consider  these issues on a  case-by-case
basis. The Board will consider shareholder recommendations for director nominees
that are  properly  received in  accordance  with our bylaws and the  applicable
rules and  regulations  of the  Securities  and  Exchange  Commission.  For more
information,  please see the section  entitled  "Stockholder  Proposals for 2005
Annual  Meeting of  Stockholders"  below.  Stockholders  who wish to contact the
members of the Board of  Directors  may do so by sending an e-mail  addressed to
them at info@pvct.com.

     How are directors compensated?

     Three of our  four  directors,  Drs.  Dees,  Scott  and  Wachter,  are also
full-time  employees.  As discussed below under the heading  "EXECUTIVE  OFFICER
COMPENSATION,"  they are compensated for their service in those roles.  They are
not separately compensated for their service as directors.

     We reimburse Mr. Fuchs for expenses he incurs in fulfilling his duties as a
director,  including  attending  meetings of the Board of  Directors.  We do not
otherwise compensate Mr. Fuchs for his services as a director.

     On the date of each  annual  meeting of  shareholders,  each  member of the
Board receives options exercisable for 25,000 shares of our common stock.

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

          Acquisition of Provectus Pharmaceuticals, Inc.

     On  April  23,  2002,  we  acquired  Provectus  Pharmaceuticals,  Inc.,  (a
privately held company which we refer to as "PPI") by issuing  6,680,000  shares
of our common  stock to its  stockholders  in exchange for all of the issued and
outstanding stock of PPI. As a result of this transaction, PPI became our wholly
owned  subsidiary.  H. Craig Dees,  our Chief  Executive  Officer and one of our
directors, was the Chief Executive Officer, a director and a stockholder of PPI.
Timothy C. Scott, our President and one of our directors,  was the President,  a
director  and a  stockholder  of PPI.  Eric A.  Wachter,  our Vice  President  -
Pharmaceuticals   and  one  of  our   directors,   was  the  Vice   President  -
Pharmaceuticals,  a director and a  stockholder  of PPI.  Drs.  Dees,  Scott and
Wachter had no relationship  with us Company prior to the acquisition of PPI. We
believe that the terms of the  acquisition  of PPI were obtained by  arms-length
bargaining.

          Agreement with Nace Pharma

     On June 7, 2002, we entered into a letter  agreement with Nace Pharma under
which Nace Pharma has agreed to act as our  representative  to  introduce us and
our products to certain designated major pharmaceutical

                                       6



companies such as Pfizer Inc. and Bayer A.G. In the letter agreement, we granted
Nace Pharma  warrants for the purchase of 100,000  shares of our common stock at
an exercise price of approximately  $2.29 per share.  These warrants will become
exercisable  only when and if Nace Pharma  successfully  introduces us to one of
the designated major pharmaceutical companies and that introduction results in a
transaction  with an  estimated  value to us of at least $10  million,  and will
expire on June 7, 2005 if not  exercised  before  that date.  In addition to the
warrants,  the letter agreement  provides that we will pay Nace a portion of any
revenues we receive from any of the designated major  pharmaceutical  companies:
2.5% of the first $50 million in cumulative  revenues,  and 5.0% of any revenues
beyond  $50  million.  Since we signed the letter  agreement  with Nace  Pharma,
Stuart  Fuchs,  one of the  principals  of Nace  Pharma,  has  become one of our
directors.  We believe  that the terms of our  agreement  with Nace  Pharma were
obtained  by  arms-length  bargaining  prior  to the  time  Mr.  Fuchs  became a
director.

          Agreement with Nace Resources

     On August 29, 2002, we entered into a letter  agreement with Nace Resources
under  which Nace  Resources  has agreed to provide us with  certain  investment
banking  services  focusing on obtaining  investment  in our business  through a
private placement of our securities. If Nace Resources assists us in obtaining a
successful  investment,  the letter agreement provides that we will be obligated
to pay Nace Resources 5% of any cash  consideration we receive in the investment
transaction,  as well as warrants  for the  purchase  of our common  stock at an
exercise  price equal to the price per share paid by investors in the investment
transaction.  The number of shares of our common  stock that would be subject to
these  warrants  would be equal to 5% of the number of shares issued or issuable
to investors in the investment transaction. Since we signed the letter agreement
with Nace Resources,  Stuart Fuchs, one of its principals, has become one of our
directors.  We believe that the terms of our agreement  with Nace Resources were
obtained by arms-length bargaining prior to the time Mr. Fuchs became one of our
directors.

          Acquisition of Valley Pharmaceuticals, Inc.

     On November 19, 2002, we acquired Valley  Pharmaceuticals,  Inc. by merging
PPI with and into Valley.  As a result of this  transaction,  Valley  became our
wholly owned subsidiary and changed its name to "Xantech Pharmaceuticals,  Inc."
As  consideration  for the  acquisition  of Valley,  we issued an  aggregate  of
500,007  shares of common  stock to the Valley  stockholders,  who were the five
scientists who initially  founded Valley (under the name Photogen,  Inc.).  Drs.
Dees,  Scott and Wachter were officers and directors and stockholders of Valley.
We believe that the terms of the  transaction  are no less  favorable to us than
terms that could have been determined through arms-length bargaining.

          Investment by Gryffindor

     On November  26,  2002,  Gryffindor  purchased  our $1 million  Convertible
Secured  Promissory Note dated November 26, 2002. This Note bears interest at 8%
per annum,  payable  quarterly  in  arrears,  and is due and  payable in full on
November 26, 2004. Subject to certain  exceptions,  the Note is convertible into
shares of our common  stock on or after  November  26,  2003,  at which time the
principal amount of the Note is convertible into common stock at the rate of one
share for each  $0.737 of  principal  so  converted  and any  accrued but unpaid
interest on the Note is  convertible  at the rate of one share for each $0.55 of
accrued but unpaid  interest so converted.  Our  obligations  under the Note are
secured by a first priority  security  interest in all of our assets,  including
the capital  stock of our wholly owned  subsidiary  Xantech.  In  addition,  our
obligations to Gryffindor are guaranteed by Xantech,  and Xantech's guarantee is
secured  by a first  priority  security  interest  in all of  Xantech's  assets.
Pursuant to our agreement with  Gryffindor,  we also issued to Gryffindor and to
Stuart  Fuchs,  the managing  principal  of  Gryffindor,  Common Stock  Purchase
Warrants  dated  November  26,  2002,  entitling  Gryffindor  and Mr.  Fuchs  to
purchase,  in the aggregate,  up to 452,919 shares of common stock at a price of
$0.001 per share.  Simultaneously with the completion of the these transactions,
Gryffindor and Mr. Fuchs exercised the warrants in their entirety, and we issued
226,460  shares of our common  stock to  Gryffindor  and  226,459  shares to Mr.
Fuchs.  On January 23, 2003, as required by our agreement with  Gryffindor,  Mr.
Fuchs  became  one  of our  directors.  We  believe  that  the  terms  of  these
transactions were obtained by arms-length bargaining prior to the time Mr. Fuchs
became one of our directors.

                                       7


                         EXECUTIVE OFFICER COMPENSATION

     The table below shows the  compensation  for services in all  capacities we
paid during the year ended December 31, 2003 to our Chief Executive  Officer and
the other  executive  officers  during  the year  ended  December  31,  2003 who
received more than $100,000:

                           Summary Compensation Table


                                                                     Long Term
                                    Annual Compensation            Compensation
                                                             Securities Underlying           All Other
   Name and Position      Year    Salary ($)        Bonus($)     Options/SARs(#)            Compensation(1)
   -----------------      ----    ----------        --------     ---------------            ---------------
                                                                                  
H. Craig Dees...........  2003     131,250            --             100,000                        --
Chief Executive Officer   2002      18,750            --                                         $18,750
Timothy C. Scott........  2003     131,250            --             100,000                        --
President                 2002      18,750            --                                         $18,750
Eric A. Wachter.........  2003     131,250            --             100,000                        --
Vice                      2002      18,750            --                                         $18,750
President--Pharmaceuticals


(1)  Drs.  Dees,  Scott and Wachter  served  without  salary from April 23, 2002
     until November 16, 2002.  Beginning November 16, 2002, we began paying them
     their respective  regular salaries.  From November 16, 2002 to December 31,
     2002,  we also paid them an amount equal to their salary for that period as
     compensation for their earlier service without salary.

          Other Executive Officer

     Serving as an executive  officer in addition to those listed above is Peter
R.  Culpepper  who was  appointed  to serve as our Chief  Financial  Officer  in
February 2004.  Previously,  Mr. Culpepper served as Chief Financial Officer for
Felix  Culpepper  International,  Inc.  from  2001  to  2004;  was a  Registered
Representative  with AXA  Advisors,  LLC from 2002 to 2003;  has served as Chief
Accounting Officer and Corporate  Controller for Neptec, Inc. from 2000 to 2001;
has served in various  Senior  Director  positions  with  Metromedia  Affiliated
Companies  from 1998 to 2000;  has served in various  Senior  Director and other
financial positions with Paging Network,  Inc. from 1993 to 1998; and has served
in a variety of financial  roles in public  accounting and industry from 1982 to
1993.  He  earned a Masters  in  Business  Administration  in  Finance  from the
University of Maryland - College Park in 1992 and an  undergraduate  degree from
the  College of  William  and Mary -  Williamsburg,  Virginia  in 1982.  He is a
licensed  Certified  Public  Accountant in both  Tennessee and Maryland and is a
faculty member with the University of Phoenix.

                        Option Grants in Last Fiscal Year



                                                          % of total options
                                     Number of shares     granted to employees     Exercise     Expiration
               Name                 underlying options       in fiscal year       price ($/sh)      Date
               ----                 ------------------       --------------       -----------       ----
                                                                                        
H. Craig Dees..................           75,000              17.6                    0.32          2013
                                          25,000               5.9                    0.60          2013
Timothy C. Scott...............           75,000              17.6                    0.32          2013
                                          25,000               5.9                    0.60          2013
Eric A. Wachter................           75,000              17.6                    0.32          2013
                                          25,000               5.9                    0.60          2013


     Aggregated  Option/SAR  Exercises  in Last Fiscal Year And Fiscal  Year-End
     Option/SAR Values

                                       8



     The following table discloses  information  regarding stock options held at
the end of or  exercised  in the year  2003 for each of the  executive  officers
listed in the Summary Compensation Table above.


                             Shares                       Securities underlying           Value of unexercised
                          acquired on       Value          unexercised options            in-the-money options
         Name             exercise(1)    realized (1)      at December 31, 2003         at December 31, 2003 (2)
         ----             -----------    ------------      --------------------         ------------------------
                                                       Exercisable   Unexercisable    Exercisable    Unexercisable
                                                       -----------   -------------    -----------    -------------
                                                                                      
H. Craig Dees........         ---            ---          43,750         56,250         $35,875         $55,125
Timothy C. Scott ....         ---            ---          43,750         56,250         $35,875         $55,125
Eric A. Wachter......         ---            ---          43,750         56,250         $35,875         $55,125

- -----------------
(1)  As of December 31, 2003,  no options have been  exercised by the  executive
     officers under the Amended and Restated 2002 Stock Option Plan.

(2)  Based on the closing price of the OTCC Bulletin Board of $1.30 per share as
     of April 20, 2004.

     Employment Agreements

     As a condition to the loan we obtained from  Gryffindor  which we described
above   under  the  section   entitled   "Certain   Relationships   and  Related
Transactions," we entered into  Confidentiality,  Inventions and Non-Competition
Agreements with Drs. Dees,  Scott, and Wachter.  These agreements  prohibit Drs.
Dees,  Scott, and Wachter each from disclosing our  confidential  information at
any time while he is employed  by us or during the  five-year  period  after his
employment ends for any reason. These agreements also provide that any invention
or development  that Dr. Dees, Dr. Scott,  or Dr. Wachter may invent as a result
of the work he does for us during his  employment or during the one-year  period
after  his  employment  ends  for  any  reason  belongs  to us.  Finally,  these
agreements prevent each of Drs. Dees, Scott, or Wachter from engaging in certain
kinds of competition with us for a period of 18 months after his employment ends
for any  reason.  We believe  that these  provisions  are prudent  practice  for
technology-intensive  businesses  such  as  ours,  and  similar  provisions  are
included  in  the   employment   agreements   of  executive   officers  of  most
biopharmaceutical companies.

     Equity Compensation Plan Information

     The table below sets forth certain  information  regarding shares available
as of December 31, 2003 for issuance under our equity compensation plans:



                                                      (a)                  (b)                        (c)
                                                                                                   Number of
                                                                                                  securities
                                                                                                  remaining
                                                                                             available for future
                                                   Number of                                    issuance under
                                                securities to be                                    equity
                                                  issued upon        Weighted-average            compensation
                                                  exercise of       exercise price of               plans
                                                  outstanding          outstanding               (excluding
                                                options, warrants   options, warrants       securities reflected
Category                                          and rights            and rights               in column (a))
                                                                                        
Equity compensation plans approved by
     stockholders...............................   356,250             $   0.40                    1,643,750

Equity compensation plans not approved by
     stockholders (1)(2)........................   180,000             $   1.49                            -
                                                   -------                                         ---------

         Total..................................   536,250                                         1,643,750
                                                   =======                                         =========

- ------------
(1)  In connection with our acquisition of Pure-ific, L.L.C.  ("Pure-ific"),  we
     agreed to issue  warrants to the former owners of Pure-ific  entitling them
     to  purchase  an  aggregate  of  80,000  shares of our  common  stock at an
     exercise price of $0.50 per share (the closing price of our common stock on
     December 5, 2002). We will issue these warrants upon (i) the achievement of
     certain targets for sales of Pure-ific personal sanitizing sprays; and (ii)
     December 5, 2003,  2004 and 2005.  These warrants have not been approved by
     the stockholders.

                                       9


(2)  We have  granted  Nace Pharma  warrants for the purchase of an aggregate of
     100,000  shares of our common stock at an exercise  price of  approximately
     $2.29 per share.  These warrants will become  exercisable  only when and if
     Nace  Pharma  successfully  introduces  us to one of the  designated  major
     pharmaceutical  companies  and that  introduction  results in a transaction
     with an estimated  value to us of at least $10 million,  and will expire on
     June 7, 2005 if not exercised  before that date.  Our  agreement  with Nace
     Pharma  is  discussed  in more  detail  above  under the  heading  "CERTAIN
     RELATIONSHIPS AND RELATED  TRANSACTIONS-Agreement  with Nace Pharma." These
     warrants have not been approved by the stockholders.

         REPORT OF THE BOARD OF DIRECTORS ACTING AS THE AUDIT COMMITTEE

     The Board of Directors serves as our audit  committee.  None of the members
of the Board are  independent.  The Board acting as audit committee  reviews our
financial reporting process. In this context, the Board

o    has reviewed and discussed with management the audited financial statements
     for the year ended December 31, 2003.

o    has discussed with BDO Seidman, LLP, our independent auditors,  the matters
     required to be  discussed by  Statement  on auditing  Standards  No. 61, as
     modified or supplemented.

o    has received the written disclosures and the letter from BDO Seidman,  LLP,
     required by  Independence  Standards  Board  Standard No. 1  ("Independence
     Discussions with Audit Committees"),  as modified or supplemented,  and has
     discussed with BDO Seidman, LLP, the independent accountant's independence.

     Based on this  review  and the  discussions  referred  to above,  the Board
determined  that the  audited  financial  statements  be  included in our Annual
Report on Form 10-KSB for the year ended  December 31, 2003, for filing with the
Securities and Exchange Commission.  The Board also appointed BDO Seidman,  LLP,
as our independent auditor for 2004.

     This report is submitted on behalf of the members of the Board of Directors
acting as the Audit Committee:

                   H. Craig Dees             Timothy C. Scott
                   Eric A. Wachter           Stuart Fuchs

     The Report of the Board acting as the Audit  Committee  set out above shall
not be deemed  "soliciting  material" or to be "filed" with the  Securities  and
Exchange  Commission,  nor shall it be  incorporated  by any  general  statement
incorporating  by  reference  this proxy  statement  into any  filing  under the
Securities Act of 1933, as amended,  or the Securities  Exchange Act of 1934, as
amended, except to the extent that we specifically  incorporate this information
by reference and shall not otherwise be deemed filed under these Acts.

                                   AUDIT FEES

     The firm of BDO  Seidman,  LLP,  served  as our  independent  auditors  and
audited our financial statements for 2003. We expect that representatives of BDO
Seidman,  LLP,  will be  present at the  annual  meeting.  They will be given an
opportunity  to make a  statement  if they so desire  and will be  available  to
respond to appropriate  questions.  The table below sets out the fees we paid to
BDO Seidman, LLP, our independent auditors for 2002 and 2003.



                                                                2002      2003
                                                              -------   -------
       Audit fees.....................................        $28,000   $53,400
       Audit-related fees.............................             --        --
       Tax fees.......................................             --        --
       All other fees.................................             --        --
                                                             --------   -------
          Total.......................................        $28,000   $53,400
                                                             ========   =======

                                       10


     It is the policy of the Board of  Directors  to  pre-approve  all audit and
non-audit services provided by the Company's  independent  auditor. The Board of
Directors has considered whether the provision by BDO Seidman,  LLP, of services
of the varieties described above is compatible with maintaining the independence
of BDO  Seidman,  LLP. In view of the fact that BDO  Seidman,  LLP,  provides no
services to us other than audit services,  the Board of Directors  believes that
such services do not jeopardize the independence of BDO Seidman, LLP.

Change in Certifying Accountant

     As reported  previously,  during the fourth quarter of 2002, we engaged BDO
Seidman,  LLP, to prepare the annual audit of our financial  statements  for the
year ended December 31, 2002 and we notified our former  accountants,  Bierwolf,
Nilson & Associates, of this engagement on January 3, 2003.

     During our engagement of Bierwolf, which began October 30, 2000, there were
no  disagreements  with  Bierwolf  on any  matter of  accounting  principles  or
practices, financial statement disclosure, or auditing scope or procedure, which
disagreements,  if not  resolved to the  satisfaction  of  Bierwolf,  would have
caused that firm to make reference to the subject matter of the  disagreement in
connection with its reports.  No report of Bierwolf on our financial  statements
has contained an adverse  opinion or a disclaimer  of opinion,  nor was any such
report  qualified  or modified  as to  uncertainty,  audit  scope or  accounting
principles, except as follows:

     o    The report of Bierwolf  with respect to our  financial  statements  at
          December 31, 2001 and for the 12-month period then ended stated,  "The
          Company  has an  accumulated  deficit  and a  negative  net  worth  at
          December 31, 2001.  These  factors raise  substantial  doubt about the
          Company's ability to continue as a going concern." Further, the report
          of Bierwolf with respect to those financial  statements noted that our
          audited  financial  statements  did not include any  adjustments  that
          might result from the outcome of the  uncertainty as to our ability to
          continue as a going concern.

     o    The report of Bierwolf  with respect to our  financial  statements  at
          December 31, 2000 and for the 12-month period then ended stated,  "The
          Company  has an  accumulated  deficit  and a  negative  net  worth  at
          December 31, 2000.  These  factors raise  substantial  doubt about the
          Company's ability to continue as a going concern." Further, the report
          of Bierwolf with respect to those financial  statements noted that our
          audited  financial  statements  did not include any  adjustments  that
          might result from the outcome of the  uncertainty as to our ability to
          continue as a going concern.

     During our fiscal years ended  December  31, 2000 and 2001,  and during the
period from January 1, 2002 to our  engagement  of BDO  Seidman,  neither we nor
anyone acting on our behalf consulted with BDO Seidman  regarding either (1) the
application of accounting  principles to a specified  transaction or the type of
audit  opinion that might be rendered on our  financial  statements  or (ii) any
matter that was the subject of a disagreement with Bierwolf.

     We previously provided Bierwolf with a copy of this disclosure.  Bierwolf's
response was previously filed with the Securities and Exchange  Commission as an
exhibit  to our  Current  Report  on Form 8-K  dated  December  20,  2002 and is
incorporated herein by reference.

                                  OTHER MATTERS

     As of the date of this proxy  statement,  we know of no other business that
will be presented for  consideration  at the annual meeting other than the items
referred to above.  If any other  matter  properly is brought  before the annual
meeting for action by the  stockholders,  the persons  named in the proxies will
vote the shares of common stock  represented  by proxies as  recommended  by the
Board  of  Directors  or,  if the  Board  gives no  recommendation,  as they may
determine in their own discretion.

                             ADDITIONAL INFORMATION

     Solicitation of Proxies and Cost

     We will bear the cost of  soliciting  proxies  for the annual  meeting.  In
addition to solicitation of proxies by use of the mails, our employees,  without
extra remuneration, may solicit proxies personally or by telecommunications.  We
will reimburse brokerage firms,  nominees,  custodians and fiduciaries for their
out-of-pocket  expenses for forwarding proxy materials to beneficial  owners and
seeking instruction with respect thereto.

                                       11




     Stockholder Proposals for 2005 Annual Meeting of Stockholders

     Stockholders  interested in presenting a proposal for  consideration at our
annual  meeting of  stockholders  in 2005 may do so by following the  procedures
prescribed  in Rule  14a-8  under the  Securities  Exchange  Act of 1934 and our
bylaws. To be eligible for inclusion,  stockholder proposals must be received by
our Secretary no later than December 31, 2004.

                                  BY ORDER OF THE BOARD OF DIRECTORS



                                  PETER R. CULPEPPER
                                  Secretary




Knoxville, Tennessee
April 29, 2004




















                                       12


                       2004 Annual Meeting of Stockholders
                           to be held on May 27, 2004

           This Proxy Is Solicited On Behalf Of The Board Of Directors

     The 2004 Annual Meeting of Stockholders of Provectus Pharmaceuticals,  Inc.
a Nevada  corporation  (the  "Company")  will be held at the  offices  of Baker,
Donelson,  Bearman,  Caldwell & Berkowitz,  the  Company's  counsel,  located at
Riverview Tower, Suite 2200, 900 South Gay Street,  Knoxville,  Tennessee 37902,
on Thursday,  May 27, 2004, beginning at 3:00 p.m. Eastern time. The undersigned
hereby  acknowledges  receipt of the combined  Notice of 2004 Annual  Meeting of
Stockholders and Proxy Statement dated April 29, 2004,  accompanying this proxy,
to which reference is hereby made for further information  regarding the meeting
and the  matters  to be  considered  and  voted  on by the  stockholders  at the
meeting.

     The   undersigned   hereby   appoints  Peter  R.  Culpepper  and  Linda  M.
Crouch-McCreadie,  and each of them,  attorneys  and agents,  with full power of
substitution,  to vote as proxy all shares of common stock of the Company  owned
of record by the  undersigned  as of the  record  date and  otherwise  to act on
behalf of the  undersigned  at the meeting and any  postponement  or adjournment
thereof,  in  accordance  with  the  instructions  set  forth  herein  and  with
discretionary  authority  with  respect  to any  other  business,  not  known or
determined at the time of the  solicitation  of this proxy,  that properly comes
before such meeting or any postponement or adjournment thereof.

     The undersigned  hereby revokes any proxy heretofore given and directs said
attorneys and agents to vote or act as indicated on the reverse side hereof.  If
no instruction is given, this proxy will be voted FOR proposals 1, and 2.

                           (continued on reverse side)
- --------------------------------------------------------------------------------
                              FOLD AND DETACH HERE

PROVECTUS                                        7327 Oak Ridge Highway, Suite A
PHARMACEUTICALS, INC.                                        Knoxville, TN 37931
                                                              phone 865/769-4011
                                                                fax 865/769-4013

                                                                  April 29, 2004

Dear Stockholder:

     It is a great  pleasure  to have this  opportunity  to provide you with our
2003  Annual  Report  and the Proxy  Statement  for our 2004  Annual  Meeting of
Stockholders. The Annual Report discusses our performance in fiscal 2003 as well
as our business strategy for the future.  The Proxy Statement  provides you with
information  relating to the business to be  conducted at our annual  meeting on
May 27, 2004.

                             YOUR VOTE IS IMPORTANT!

     You can vote by completing,  signing, dating, and returning your proxy card
in the accompanying envelope.

     Thank you for your  continued  interest  in, and  ownership  of,  Provectus
Pharmaceuticals, Inc.

                                   Sincerely,

                                   /S/ Craig

                                   H. Craig Dees,
                                   Ph.D. Chief Executive Officer





     This proxy is  solicited on behalf of the Board of Directors of the Company
and will be voted in accordance with the  undersigned's  instructions  set forth
herein.  If no instructions  are provided,  this proxy will be voted FOR each of
the proposals  described below. THE BOARD OF DIRECTORS  RECOMMENDS THAT YOU VOTE
FOR THE PROPOSALS.

1.   As to the election to the Board of  Directors of the nominees  named in the
     proxy  statement  delivered  in  connection  with  the  Annual  Meeting  of
     Stockholders,  each for a one-year term expiring at the 2004 Annual Meeting
     of Stockholders:

     [ ] FOR all nominees listed below:
         H. Craig Dees, Ph.D.             Timothy C. Scott, Ph.D.
         Stuart Fuchs                     Eric A. Wachter, Ph.D.

     [ ] WITHHOLD AUTHORITY for all nominees
         Instruction:  To  withhold  authority to vote for any director nominee,
         mark  this  box  and draw a line through the name of the nominee in the
         list above.

2.   As to the approval of the  amendment to the Amended and Restated 2002 Stock
     Plan to  increase  the  number  of  shares  reserved  under  the Plan  from
     2,000,000 to 3,000,000:

         [ ]  FOR                [ ]  AGAINST                  [ ] ABSTAIN

     With respect to any other item of business that  properly  comes before the
meeting,  the proxy holders are authorized to vote the  undersigned's  shares in
accordance with their best judgment.

                               Date:                                      , 2003
                                    --------------------------------------


[X] PLEASE MARK YOUR VOTES          --------------------------------------------
AS INDICATED IN THIS EXAMPLE.             Signature of stockholder

                                    --------------------------------------------
                                     Signature of stockholder, if held jointly


                    Please  sign your name as it  appears on this  proxy.  Joint
                    owners  each   should   sign.   When   signing  as  trustee,
                    administrator,  executor,  attorney,  etc.,  please indicate
                    your full title as such.  Corporations  should  sign in full
                    corporate  name by  President or other  authorized  officer.
                    Partnerships   should  sign  in  full  partnership  name  by
                    authorized partner.

- --------------------------------------------------------------------------------
                              FOLD AND DETACH HERE

                                  Vote by Mail

Mark, sign, and date your proxy card and return it in the enclosed  postage-paid
envelope.




                              THANK YOU FOR VOTING