NOTICE OF TERMINATION


          WHEREAS, on February 15, 2002, Sanguine Corporation (the "Company"
and the "Licensor") entered into an Exclusive License Agreement with
Ascendiant-Asia, LLC, a Nevada limited liability corporation (the "Licensee"),
pursuant to which the Licensee agreed to certain minimum levels of annual
production of the Licensed Products (the "Minimum Production"); and in the
event the Licensee failed to achieve the Minimum Production, to pay a royalty
to the Licensor; and

          WHEREAS, the Licensee has failed to meet the Minimum Production (as
defined therein) and has failed to pay the Make-Up Royalty (as defined
therein) payments to the Licensor as set forth in Section 2.2 of the Exclusive
License Agreement and in the amounts per commercial Unit Produced (as defined
therein) as provided in Section 5.1 thereof;

          NOW, THEREFORE, pursuant to Section 13.2 of the Exclusive License
Agreement, the Company hereby elects to terminate the above referenced
Exclusive License Agreement.

          DATED this 24th day of September, 2004.

                              SANGUINE CORPORATION

                               By     /s/ Thomas C. Drees
                                   Thomas C. Drees, Ph.D., MBA