CYTOGENIX, INC.
                         3100 Wilcrest Drive, Suite 140
                              Houston, Texas 77042
                         713-789-0070 * 713-789-0702 Fax




March 12, 2009


Ryan Milne
Division of Corporate Finance
Securities and Exchange Commission
Mail Stop 7010
100 F. Street, N.E.
Washington, D.C. 20549

          RE: CytoGenix, Inc.; Form 8K; Filed March 6, 2009; File No. 0-26807

Dear Mr. Milne:

This  letter  responds  to each of the  comments  regarding  Item 4.01 of our 8K
referenced  above  made in your  comments  letter  dated  March  10,  2009.  The
responses set forth and captioned below correspond to the respective captions of
the comments in your letter. With this by way of introduction, the following are
our responses to your comments:

Comment #1

1.       We note that your disclosure in the third paragraph.  Please amend your
         Form 8-K to  comply  with Item  304(a)(1)(ii)  of  Regulation  S-K that
         requires a statement whether the principal  accountant's  report on the
         financial statements for either the past two years contained an adverse
         opinion or a disclaimer  of opinion or was  qualified or modified as to
         uncertainty,  audit scope, or accounting principles;  and a description
         of the nature of each such  adverse  opinion,  disclaimer  of  opinion,
         modification,  or  qualification.  This  would  include  disclosure  of
         uncertainty regarding the ability to continue as a going concern in the
         accountant's report.

Response:  CytoGenix,  Inc.  filed an  amended  8-K on March 10,  2009  prior to
receiving your comment letter and the third paragraph was amended as follows;

                  LBB & Associates Ltd., LLP's report on the Company's financial
statements for years ended  December 31, 2007 and 2006, did not contain  adverse
opinions or  disclaimers  of opinion,  nor were they qualified or modified as to
uncertainty,  audit  scope  or  accounting  principles.  For both  years,  LBB &
Associates  Ltd.,  LLP's report  included an emphasis  paragraph  relating to an
uncertainty as to the Registrant's ability to continue as a going concern.

Comment #2

2.        Please  revise the fourth  paragraph to disclose the date you actually
          engaged Hall Group, CPA's your new principal independent accountants.

Response:  As  we  discussed  during  our  phone  conversation  yesterday,   the
engagement  of The Hall  Group,  CPA's  occurred  concurrently  with the  Boards
approval on March 2, 2009

Comment #3


3.       We note that you have  provided your former  auditor,  LBB & Associates
         Ltd., LLP with a copy of the Current Report on Form 8-K and requested a
         letter be furnished  to you stating  whether the audit firm agrees with
         the statements made in your report. To the extent that you make changes
         to the Form 8-K to comply


                                       1


                                 CYTOGENIX, INC.
                         3100 Wilcrest Drive, Suite 140
                              Houston, Texas 77042
                        713-789-0070 * 713-789-0702 Fax


         with our comments,  please obtain and file an updated Exhibit 16 letter
         from the former accountants  stating whether the accountant agrees with
         the statements made in your revised Form 8-K.


Response:  The Explanatory  Note to the 8-K/A filed yesterday  before  receiving
your  letter  had the  following  disclosure  indicating  that the  Company  had
received a letter from the former  accountants and the changes made to paragraph
#3 as discussed in Comment #1 above;

         "At the Company's request, LBB & Associates Ltd., LLP has furnished the
Company  with a letter  dated  March 9, 2009  addressed  to the  Securities  and
Exchange  Commission  stating  whether or not LBB & Associates  Ltd., LLP agrees
with the  Company's  statements  in this Form 8-K, and a copy of which letter is
filed as Exhibit 16.1 in this Form 8K/A. Except for the foregoing  changes,  and
changes to paragraph three that address comments in LBB & Associates Ltd., LLP's
response  in  Exhibit  16.1,  this  Amendment  does not  modify or update  those
disclosures in any way."

In submitting the filings  described in the first paragraph of this letter,  the
Company hereby acknowledges that:

o    It is  responsible  for the adequacy and accuracy of the  disclosure in the
     filings;
o    That staff  comments or changes to disclosure in response to staff comments
     in the filings  reviewed by the staff do not foreclose the Commission  from
     taking any action with respect to the filings; and
o    The Company may not assert  staff  comments as a defense in any  proceeding
     initiated by the Commission or any person under the federal securities laws
     of the United States.

We hope that we have  adequately  responded  to your  comments.  If you have any
questions on our  responses or further  comments,  please  contact us as soon as
possible.


Sincerely,


/s/ Randy Moseley
- -----------------
Randy Moseley
Principal Financial Officer


                                       2