Exhibit 99.1


            SETTLEMENT AGREEMENT, INDEMNIFICATION AND MUTUAL RELEASE

         This   Settlement   Agreement,   Indemnification   and  Mutual  Release
("Agreement"),  effective April 24, 2009, is by and among Malcolm  Skolnick,  an
individual residing at 8993 Briar Forest Drive, Houston, Texas 77024 ("Skolnick"
or "Employee"),  and CytoGenix,  Inc., a Nevada corporation having its principle
place  of  business  located  at  3100  Wilcrest  Drive,  Houston,  Texas  77042
("CytoGenix" or "Company").

         WHEREAS,  on August 18, 2008,  Employee resigned as the Chief Executive
Officer,  President,  and  Chairman  and  member of the Board of  Directors,  an
officer and an employee of CytoGenix; and

         WHEREAS,  following his resignations as Officer and Director,  Skolnick
has asserted certain claims relating to his employment with CytoGenix, including
past due wages, Skolnick's rights and obligations under his employment agreement
with CytoGenix and  CytoGenix's  obligations  under a Secured Loan Agreement For
Services  Rendered between  CytoGenix and Skolnick  executed prior to Skolnick's
resignations; and

         WHEREAS, the parties hereto, in an effort to prevent disputes and avoid
controversy,  expense  and  delay,  desire to settle and  compromise  the claims
asserted, or that could have been asserted.

NOW, THEREFORE,  for and in consideration of the mutual obligations and promises
herein  contained,  and other good and valuable  consideration,  the receipt and
sufficiency of which is hereby acknowledged, the parties agree as follows:

1.       CONSIDERATION.

     (a)  CytoGenix  shall pay  Skolnick  the sum of $10.00,  due at the time of
          execution of this Agreement.

     (b)  CytoGenix  intends to negotiate a consulting  agreement  with Skolnick
          according to the non-binding terms  incorporated  herein in Attachment
          A.

     (c)  Upon  execution of this  Agreement by all parties,  any and all actual
          and  potential  claims  that have been raised or which could have been
          raised at the time of execution of this Agreement existing between the
          parties shall be dismissed.

     (d)  For  all  matters  and  controversies  arising  from  this  Agreement,
          CytoGenix  and  Skolnick  shall  each be  responsible  for  their  own
          attorneys' fees and costs.

2.       RELEASE - Skolnick.

Skolnick,  his  heirs,  executors,  administrators,  attorneys,  successors  and
assigns,  as well as any person or entity  claiming by,  through or under any of
the foregoing,  hereby  RELEASE,  ACQUIT AND FOREVER  DISCHARGE  CytoGenix,  its
current and former officers, directors, employees,  shareholders,  agents, legal
representatives,  attorneys,  successors  and assigns,  from any and all claims,
causes of action, suits, damages (actual, compensatory,  exemplary or punitive),
debts, secured loans, obligations,  benefits, wages, bonuses, compensation, back
pay, front pay, vacation pay, sick pay, medical bills and expenses, and demands,
of any kind, nature or description whatsoever, whether known or unknown, whether
at law or in equity, whether:

     (a)  in  contract  or in tort  (including  but not  limited  to claims  for
          wrongful   discharge,   constructive   termination,    discrimination,
          retaliation,  interference  with protected  rights,  interference with
          present or  prospective  contractual  relations,  breach of  contract,
          defamation,  invasion of privacy,  intentional or negligent infliction
          of emotional  distress,  fraud,  misrepresentation,  personal  injury,
          negligence,  intentional  conduct,  misconduct  or  interference  with
          present or prospective business relations or contracts),

     (b)  arising under federal or state statutory or common law (including, but
          not limited to: Title VII of the Civil Rights Act of 1964, as amended,
          42 U.S.C.  ss. 2000e et seq.,  the Civil Rights Act of 1866, 42 U.S.C.
          ss. 1981 et seq.,  the Equal Pay Act, 29 U.S.C.  ss. 206; the Employee
          Retirement  Income  Security  Act of 1974,  as amended  ("ERISA"),  29
          U.S.C.  ss.  1001 et seq.  (non-vested  rights);  the  Americans  with
          Disabilities Act, 42 U.S.C. ss. 12101 et seq.; the Age  Discrimination



          Employment  Act of  1967,  as  amended  by the  Older  Worker  Benefit
          Protection  Act ("ADEA"),  29 U.S.C.  ss. 621 et seq.;  the Fair Labor
          Standards  Act, as amended,  29 U.S.C.  ss. 201 et seq.;  the National
          Labor  Relations  Act, 29 U.S.C.  ss.ss.  151 et seq.;  the Family and
          Medical  Leave Act of 1993,  29 U.S.A.  ss.  2601 et seq.;  the Worker
          Adjustment and Retraining Notification Act (WARN), 29 U.S.C., ss. 2101
          et seq.; the Occupational  Safety and Health Act, as amended,  Chapter
          21 of the Texas Labor Code (the Texas Commission on Human Rights Act),
          Texas Labor Code ss. 21.001 et seq.; the Texas Payday Act, Texas Labor
          Code,  ss. 61.01 et seq.;  the Texas  Workers'  Compensation  Statute,
          Texas Labor Code ss. 451.0001 et seq.; the Sarbanes-Oxley Act; and any
          other employment or civil rights act),

     (c)  any and all claims for past or future employment benefits,  including,
          but not limited to, wages,  severance pay,  bonuses,  stock options or
          grants of rights to  acquire  shares of common  stock,  vacation  pay,
          medical or dental  insurance  coverage,  short or long term disability
          benefits,  and/or other benefits  which may hereafter  accrue or which
          have accrued as a result of Skolnick's  employment and/or  affiliation
          with, and/or termination and/or separation from the Company;

     (d)  any and all claims  arising out of any previous  Employment  Agreement
          with Skolnick which Skolnick asserted, or could have asserted, against
          the Company; and

     (e)  any and all claims arising out of or relating in any way to Skolnick's
          employment  and/or  affiliation with and/or  resignation or separation
          from the Company, which Skolnick asserted, or could have asserted,

relating to or arising out of the employment  relationship  between the parties,
as well as the matters that were asserted,  in any current,  actual or potential
claim or complaint. This release applies to all claims and causes of action that
exist or could  have been  asserted  on or  before  the  effective  date of this
Agreement.

3.       RELEASE - CytoGenix.

CytoGenix, its current and former officers, directors,  employees, agents, legal
representatives,  attorneys,  successors  and assigns,  as well as any person or
entity  claiming  by,  through or under any of the  foregoing,  hereby  RELEASE,
ACQUIT  AND  FOREVER  DISCHARGE  Skolnick,  his  respective  heirs,   executors,
administrators,  attorneys,  successors and assigns, from any and all claims and
causes of action as legally  allowed by law, in equity,  statutory or otherwise,
including,  without  limitation,  all claims and causes of action relating to or
arising out of the employment  relationship  between the parties, as well as the
matters that were asserted, or could have been asserted, in any current,  actual
or potential  claim or complaint.  This release applies to all claims and causes
of action that exist or could have been asserted on or before the effective date
of this Agreement.

     (a) Recognizing that Skolnick was an employee and officer of CytoGenix, the
       Company  agrees to indemnify  and hold harmless  Skolnick,  his heirs and
       assigns (the "Indemnified  Parties"),  from and against any and all loss,
       charge, claim, damage, expense and liability related to or arising in any
       manner out of, based upon, or in connection  with  Skolnick's  employment
       with  CytoGenix,  hereunder  (hereinafter  referred  to as a "Matter"  or
       "Matters") to the limits provided by the Company's  current Directors and
       Officers'  insurance  policy and will reimburse  Skolnick for all covered
       expenses  (including  reasonable  fees and expenses of legal  counsel) as
       incurred in connection  with the  investigation  of,  preparation  for or
       defense of any pending or  threatened  Claim related to or arising in any
       manner out of any Matter hereunder,  or any action or proceeding  arising
       therefrom (collectively,  "Proceedings") up to the limits provided by the
       insurance  policy,  whether or not Skolnick is a formal party to any such
       Proceeding.

     (b)  Notwithstanding  the  foregoing,  the  Company  shall not be liable in
       respect  of any  Claims  resulting  from the  gross  negligence,  willful
       misconduct or criminal  conduct of Skolnick  during his employment by the
       Company.

     (c) The  indemnity,  reimbursement  and  contribution  obligations  of  the
       Company set forth herein shall be in addition to any liability  which the
       Company  may  otherwise  have and shall be binding  upon and inure to the
       benefit of any successors, assigns, heirs and personal representatives of
       the Company or an Indemnified Party.

     (d) The  indemnity,  reimbursement  and  contribution  provisions set forth
       herein shall remain operative and in full force and effect  regardless of
       any other provision of this Agreement and shall survive this Agreement.

4.       Non-Admission
This Agreement  shall not in any way be construed as an admission by the Company
of any act of discrimination  or other unlawful act whatsoever  against Skolnick
or any other person, and the Company specifically  disclaims any liability to or
discrimination  against Skolnick or any other person on the part of itself,  its
employees or its agents.




5.       Non-disparagement
Skolnick agrees that he will act at all times hereafter,  in a manner consistent
with the best  interests of Company and with respect to the  Company's  Board of
Directors,  employees,  agents and third parties, and that he will not engage in
any act or make any comments (written or oral),  which are intended or which may
reasonably be expected to harm the missions,  reputations or other  interests of
the Company,  its Board members or its  employees.  Similarly,  the officers and
directors of the Company and its Board of  Directors  agree not to engage in any
act or make any comments  (written or oral),  which are intended to or which may
reasonably be expected to harm  Skolnick's  reputation or employment  prospects.
Nothing in this  section of the  Agreement  prevents  Skolnick  or Company  from
engaging in any act (written or oral) that is necessary  for Skolnick or Company
to respond to any  request  made or  statutorily  required  by any  governmental
agency, or appear in any proceedings before a court of law.

6.       Confidential and Proprietary Information
Skolnick  acknowledges that, during his employment with CytoGenix,  Skolnick had
access  to  confidential   and  proprietary   business,   technical,   financial
information and materials that constitute  valuable and unique properties of the
Company.  For purposes of this Agreement,  "Confidential  Information" means and
includes  CytoGenix'  confidential,  financial  and/or  proprietary  information
including  but not  limited  to trade  secrets  that  have been  and/or  will be
developed or used which cannot be obtained readily by third parties from outside
sources.

Confidential   Information  includes  but  is  not  limited  to  the  following:
information  regarding  past,  current,  and prospective  customers,  investors,
business  affiliates,  employees,  contractors  and the  industry  which  is not
generally known to the public; financial information critical to the workings of
the Company;  technical information such as strategies,  methods, books, records
and documents;  technical information concerning products,  equipment,  services
and processes; procurement procedures; pricing schedules and pricing techniques;
contacts  including  names,  services  provided,  pricing,  type and  amount  of
services used,  financial data;  pricing  strategies and price curves;  business
position  and  competitive  analysis;  plans  or  strategies  for  expansion  or
acquisitions; budgets; research; financial and sales data; trading methodologies
and terms; communications information; evaluations, opinions and interpretations
of information  and data;  marketing and  merchandising  techniques;  electronic
databases;  models;  specifications;   computer  programs;  contracts;  bids  or
proposals;  technologies  and  methods;  information  regarding  synDNA and gene
targets,  ssDNA  expression   technology,   anti-herpes  technology  and/or  the
Company's anti-microbial and biotin technology; personnel information;  payments
or rates  paid to  consultants  or  other  service  providers;  and  other  such
confidential or proprietary  information.  Skolnick acknowledges that CytoGenix'
business is highly competitive, that this Confidential Information constitutes a
valuable,  special and unique asset of the Company,  and that protection of such
Confidential  Information against unauthorized disclosure and use is of critical
importance to CytoGenix.

Skolnick   acknowledges   that  disclosure  of  this  information   would  cause
substantial and irreparable  harm, loss of goodwill,  and injury to the Company.
Skolnick agrees that he has not and will not,  directly or indirectly;  disclose
any  confidential  or  proprietary  information  or  documents  relating  to the
Company,   unless  with  written  authorization  by  the  Company.  The  Company
acknowledges  that Skolnick has returned to the Company all of Company  property
formerly in his possession.

Skolnick understands and acknowledges that the consideration set forth herein is
provided solely in  consideration  of this release,  except as may be explicitly
stated herein. Skolnick understands, agrees and intends that upon payment of the
consideration   set  forth,  that  he  will  have  received  full  and  complete
satisfaction of any and all claims,  whether known, suspected or unknown that he
may have or have  had  against  the  Company  as of the date of this  Agreement.
Skolnick hereby waives any and all relief not explicitly provided for herein.




7.       No Right to Reinstatement
Skolnick waives any right to  reinstatement  or any future  employment,  but may
assume an independent contractor  relationship with the Company.  Skolnick shall
at no time following the Separation Date,  represent himself as being affiliated
with the Company in any capacity other than what is provided herein.

8.       Miscellaneous

     (a)  None of the  releases  set forth herein are intended to release any of
          the rights and obligations  established by this Agreement.  The rights
          duties and  obligations  set forth herein shall survive the release of
          claims set forth herein.

     (b)  The parties  hereto  acknowledge  that this Agreement is being made by
          each party of its own free choice.  The parties  further state that in
          entering  into  this  Agreement,  each  party has been  advised  by an
          attorney  of  that  party's  choice  and  selection,  and  has had the
          opportunity  to consult with such attorney  regarding the benefits and
          detriments of entering into this Agreement.  Skolnick,  who is himself
          an attorney, has chosen to act as an attorney on his own behalf.

     (c)  This Agreement contains the full and complete agreement of the parties
          hereto,  and all prior  negotiations and agreements  pertaining to the
          subject   matter  hereof  are  merged  into  and  superseded  by  this
          Agreement. No change, amendment,  waiver or discharge of any provision
          of all or any  part of this  Agreement  shall  be  valid  unless  such
          change, amendment, waiver or discharge is in writing and duly executed
          by all parties to this Agreement, or their authorized agents.

     (d)  This Agreement may be executed in more than one  counterpart,  each of
          which shall be an original, but all of which, taken together, shall be
          and remain one instrument.

     (e)  The parties  hereto  warrant and represent that none of them has sold,
          assigned,  granted,  or  otherwise  transferred  to anyone not a party
          hereto any  right,  privilege,  claim or cause of action,  or any part
          thereof, arising out of or otherwise connected with the subject matter
          of this Agreement.

     (f)  This  Agreement is entered into and is  performable  in Harris County,
          Texas, and shall be governed by, construed,  interpreted, and enforced
          in accordance with the laws of the State of Texas.

     (g)  The persons  signing  this  Agreement  on behalf of any of the parties
          hereto hereby  warrant and represent  that they are authorized to sign
          this  Agreement on behalf of themselves or their  respective  entities
          and that such persons have the power to bind  themselves  and/or their
          respective entities.

     (h)  This  Agreement is a result of  substantial  negotiations  between the
          parties and their counsel.  Accordingly, the fact that counsel for one
          party or another  drafted this Agreement  shall not be material to the
          interpretation  of this Agreement.  As an attorney,  Skolnick acted as
          his own counsel during these negotiations.

     (i)  All  parties  to this  Agreement  have  read the  Agreement  and fully
          understand and comprehend its meaning and binding effect.

     (j)  If any  portion  of  this  Agreement  is  found  to be  null,  void or
          unenforceable,  the remainder of this  Agreement  shall remain in full
          force and effect.

     (k)  The headings of the several  sections of this  Agreement  are inserted
          for  convenience  only and shall not  control or affect the meaning or
          construction of any of the provisions hereof.

     (l)  This Agreement  shall be effective upon full execution and delivery of
          the  Agreement by each of the parties  hereto.  This  Agreement may be
          executed by fax, and in multiple counterparts or copies, each of which
          shall be deemed to be an original for all purposes.

     (m)  The execution of this Agreement will warrant  public  announcement  by
          CYGX. A draft of the proposed Press Release is incorporated  herein as
          Attachment B.

     IN  WITNESS  WHEREOF,  the  parties  hereto  have  caused  this  Separation
Agreement to be executed as of the day and year set forth above.

           CytoGenix                                        Employee

/s/ Lex M> Cowsert, PhD                           /s/ Malcolm Skolnick, PhD, JD
- --------------------------                        -----------------------------
Lex M. Cowsert, PhD                               Malcolm Skolnick, PhD, JD
President & CEO

/s/ Randy Moseley                                 April 24, 2009
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Randy Moseley                                             Date
Chairman of the Board