As filed with the Securities and Exchange Commission on April 21, 2000

                                                 Registration No. 333-__________

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549


                                   FORM S-8
                            REGISTRATION STATEMENT
                                     UNDER
                          THE SECURITIES ACT OF 1933
                      ___________________________________

                            APPLIED MATERIALS, INC.
               (Exact name of issuer as specified in its charter)

              Delaware                                       94-1655526
     (State or other jurisdiction                        (I.R.S. employer
     of incorporation or organization)                   identification number)

              3050 Bowers Avenue, Santa Clara, California  95054
             (Address of principal executive offices) (Zip Code)

                            APPLIED MATERIALS, INC.
                          1995 EQUITY INCENTIVE PLAN

                               Joseph J. Sweeney
                            Applied Materials, Inc.
              3050 Bowers Avenue, Santa Clara, California  95054
                    (Name and address of agent for service)

 Telephone number, including area code, of agent for service:  (408) 727-5555

                                   Copy to:
                                John E. Aguirre
                     Wilson Sonsini Goodrich & Rosati, PC
                              650 Page Mill Road
                         Palo Alto, California  94304


                                                CALCULATION OF REGISTRATION FEE
======================================================================================================================
                                                       Proposed            Proposed Maximum
 Title of Securities to be      Amount to be       Maximum Offering       Aggregate Offering          Amount of
        Registered               Registered*        Price Per Share**           Price**           Registration Fee**
- ----------------------------------------------------------------------------------------------------------------------
                                                                                      
1995 Equity Incentive Plan      38,200,000 shares        $83.16             $3,176,712,000            $838,651.97
   Common Stock*** and
   Options to Purchase
   Common Stock



================================================================================
 *   This Registration Statement shall also cover any additional shares of
     Registrant's Common Stock that become issuable under the Applied Materials,
     Inc. 1995 Equity Incentive Plan by reason of any stock dividend, stock
     split, recapitalization or other similar transaction effected without the
     Registrant's receipt of consideration that results in an increase in the
     number of the Registrant's outstanding shares of Common Stock.

 **  Estimated solely for the purpose of calculating the registration fee on the
     basis of $83.16 per share, the average of the high and low prices for the
     Common Stock on April 14, 2000, as reported by Nasdaq.

 *** Includes associated rights (the "Rights") to purchase preferred or common
     stock. Until the occurrence of certain prescribed events, none of which has
     occurred, the Rights are not exercisable.
================================================================================

                                       2


              INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

The following documents are incorporated by reference in this registration
statement:  (i) the latest annual report of Applied Materials, Inc. (the
"Registrant") filed pursuant to Section 13(a) or 15(d) of the Securities
Exchange Act of 1934, as amended (the "Exchange Act"); (ii) all other reports
filed by the Registrant pursuant to Sections 13(a) or 15(d) of the Exchange Act
since the end of the fiscal year covered by the annual report referred to in
clause (i) above; and (iii) the description of the Registrant's common stock set
forth in the Registrant's Registration Statement on Form 8-A relating thereto,
including any amendment or report filed for the purpose of updating such
description.  All documents filed by the Registrant after the date of this
registration statement pursuant to Sections 13(a), 13(c), 14, and 15(d) of the
Exchange Act, prior to the filing of a post-effective amendment (that indicates
all securities offered have been sold or deregisters all securities then
remaining unsold), shall be deemed to be incorporated by reference in this
registration statement and to be a part hereof from the date of filing of such
documents.

ITEM 4.  DESCRIPTION OF SECURITIES

Inapplicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

Inapplicable.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

Section 145 of the Delaware General Corporation Law (the "Delaware Law")
authorizes a court to award, or a corporation's board of directors to grant,
indemnity to directors and officers in terms sufficiently broad to permit such
indemnification under certain circumstances for liabilities (including
reimbursement for expenses incurred) arising under the Securities Act of 1933,
as amended.  The Registrant's Certificate of Incorporation provides for
indemnification of the Registrant's directors, officers, employees and other
agents to the maximum extent permitted by Delaware Law.  In addition, the
Registrant has entered into indemnification agreements with its directors and
certain of its officers.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED

Inapplicable.

ITEM 8.  EXHIBITS

4.1   Applied Materials, Inc. 1995 Equity Incentive Plan, as amended
      (incorporated by reference from the Registrant's Preliminary Proxy
      Statement, Commission file No. 0-06920, filed on February 4, 2000).

                                       3


4.2  Form of Nonqualified Stock Option Agreement for Employees (incorporated by
     reference from Exhibit 10.5 of the Registrant's report on Form 10-Q,
     Commission File No. 0-06920, filed on June 15, 1999).

4.3  Form of Nonqualified Stock Option Agreement for Consultants (incorporated
     by reference from Exhibit 4.3 of the Registrant's Registration Statement on
     Form S-8, Commission file No. 333-71245, filed on January 27, 1999).

5.1  Opinion of Wilson Sonsini Goodrich & Rosati, PC.

23.1 Consent of Independent Accountants.

23.2 Consent of Wilson Sonsini Goodrich & Rosati, PC is included in Exhibit 5.1
     to this Registration Statement.

24.1 Power of Attorney of Directors.

ITEM 9.   UNDERTAKINGS

     (a)  The undersigned registrant hereby undertakes:

          (1)  To file, during any period in which offers or sales are being
made, a post-effective amendment to this registration statement:

               (i)   To include any prospectus required by section 10(a)(3) of
the Securities Act of 1933;

               (ii)  To reflect in the prospectus any facts or events arising
after the effective date of the registration statement (or the most recent post-
effective amendment thereof) which, individually or in the aggregate, represent
a fundamental change in the information set forth in the registration statement;

               (iii) To include any material information with respect to the
plan of distribution not previously disclosed in the registration statement or
any material change to such information in the registration statement;

          Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do not
apply if the registration statement is on Form S-3 or Form S-8 and the
information required to be included in a post-effective amendment by those
paragraphs is contained in periodic reports filed by the registrant pursuant to
section 13 or section 15(d) of the Securities Exchange Act of 1934 that are
incorporated by reference in the registration statement.

          (2)  That, for the purpose of determining any liability under the
Securities Act of 1933, each such post-effective amendment shall be deemed to be
a new registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

                                       4


          (3)  To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the
termination of the offering.

     (b)  The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to section 13(a) or section 15(d) of the
Securities Exchange Act of 1934 (and, where applicable, each filing of an
employee benefit plan's annual report pursuant to section 15(d) of the
Securities Exchange Act of 1934) that is incorporated by reference in the
registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

     (c)  Insofar as indemnification for liabilities arising under the
Securities Act of 1933 may be permitted to directors, officers and controlling
persons of the registrant pursuant to the foregoing provisions, or otherwise,
the registrant has been advised that in the opinion of the Securities and
Exchange Commission such indemnification is against public policy as expressed
in the Act and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Act and will
be governed by the final adjudication of such issue.

                                       5


                                  Signatures

THE REGISTRANT

Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Santa Clara, State of California on the 21st day of
April, 2000.

APPLIED MATERIALS, INC.
     (Registrant)

   /s/ James C. Morgan
__________________________________
       James C. Morgan
   Chairman of the Board and
    Chief Executive Officer

Pursuant to the requirements of the Securities Act of 1933, this registration
statement has been signed by the following persons in the capacities and on the
dates indicated.

                  Signature             Title                        Date

Principal Executive Officer:

   /s/ James C. Morgan
______________________________      Chairman of the Board and    April 21, 2000
       James C. Morgan              Chief Executive Officer

Principal Financial Officer:

   /s/ Joseph R. Bronson
______________________________      Senior Vice President,       April 21, 2000
       Joseph R. Bronson            Office of the President,
                                    Chief Financial Officer and
                                    Chief Administrative
                                    Officer

Principal Accounting Officer:

   /s/ Patrick Crom
______________________________      Vice President, Global       April 21, 2000
       Patrick Crom                 Controller, Chief
                                    Accounting Officer and
                                    Assistant Secretary

                                       6


Directors:
            *                       Director                     March 22, 2000
_____________________________
     James C. Morgan

            *                       Director                     March 22, 2000
_____________________________

   Michael H. Armacost

            *                       Director                     March 22, 2000
_____________________________
   Deborah A. Coleman

            *                       Director                     March 22, 2000

_____________________________
   Herbert M. Dwight, Jr.

            *                       Director                     March 22, 2000
_____________________________
      Philip V. Gerdine

            *                       Director                     March 22, 2000
_____________________________
     Tsuyoshi Kawanishi

            *                       Director                     March 22, 2000
_____________________________
          Paul R. Low

            *                       Director                     March 22, 2000
_____________________________
       Steven L. Miller

            *                       Director                     March 22, 2000
_____________________________
           Stan Shih

*By  /s/ James C. Morgan
   --------------------------
         James C. Morgan
         Attorney-in-Fact

A majority of the members of the Board of Directors.

                                       7


                                 EXHIBIT INDEX

4.1  Applied Materials, Inc. 1995 Equity Incentive Plan, as amended
     (incorporated by reference from the Registrant's Preliminary Proxy
     Statement, Commission file No. 0-06920, filed on February 4, 2000).

4.2  Form of Nonqualified Stock Option Agreement for Employees (incorporated by
     reference from Exhibit 10.5 of the Registrant's report on Form 10-Q,
     Commission File No. 0-06920, filed on June 15, 1999).

4.3  Form of Nonqualified Stock Option Agreement for Consultants (incorporated
     by reference from Exhibit 4.3 of the Registrant's Registration Statement on
     Form S-8, Commission file No. 333-71245, filed on January 27, 1999).

5.1  Opinion of Wilson Sonsini Goodrich & Rosati, PC.

23.1 Consent of Independent Accountants.

23.2 Consent of Wilson Sonsini Goodrich & Rosati, PC is included in Exhibit 5.1
     to this Registration Statement.

24.1 Power of Attorney of Directors.

                                       8