As filed with the Securities and Exchange Commission on November 1, 2001 Registration No. 333-_____ ================================================================================ SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 -------------------------------------- FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 -------------------------------------- Essential Therapeutics, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 94-3186021 (State or Other Jurisdiction of (IRS Employer Incorporation or Organization) Identification Number) ----------------------------------- 1365 Main Street Waltham, Massachusetts 02451 (Address of Principal Executive Offices including Zip Code) --------------------------------------- Essential Therapeutics, Inc. 1996 Employee Stock Purchase Plan (Full Title of the Plan) -------------------------------------- Mark B. Skaletsky Copy to: President Alan C. Mendelson, Esq. and Chief Executive Officer Latham & Watkins Essential Therapeutics, Inc. 135 Commonwealth Drive 1365 Main Street Menlo Park, California 94025 Waltham, Massachusetts 02451 (650) 328-4600 (781) 647-5554 ----------------------------- (Name and Address, Including Zip Code, and Telephone Number, Including Area Code, of Agent for Service) -------------------------------------- ------------------------------------------------------------------------------------------------------------------- CALCULATION OF REGISTRATION FEE ------------------------------------------------------------------------------------------------------------------- Proposed Proposed Title Of Amount Maximum Maximum Amount Of Securities To Be To Be Offering Aggregate Registration Registered Registered (1) Price Per Offering Fee Share (2) Price (3) --------------------------------------------- ----------------- ----------------- ---------------- ---------------- Common Stock, par value $0.001 per share 250,000 $3.345 $836,250 $209.06 --------------------------------------------- ----------------- ----------------- ---------------- ---------------- (1) This registration statement shall also cover any additional shares of Common Stock that become issuable under the Essential Therapeutics, Inc. (the "Company") 1996 Employee Stock Purchase Plan (the "Plan") by reason of any stock split, reverse stock split, stock dividend, combination or reclassification or other similar transaction effected without the receipt of consideration that results in an increase in the number of outstanding shares of the Company's Common Stock. (2) Estimated for the purpose of calculating the registration fee pursuant to Rule 457(c) of the Securities Act of 1933, as amended (the "Securities Act"), for 250,000 shares based on the average ($3.345) of the high ($3.47) and low ($3.22) prices for the Company's Common Stock as reported on the Nasdaq National Market on October 31, 2001. (3) Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457 of the Securities Act. Proposed sale to take place as soon after the effective date of the Registration Statement as options granted under the 1996 Employee Stock Purchase Plan, as amended, are exercised. ================================================================================ Total Pages 5 Exhibit Index on Page 5 REGISTRATION OF ADDITIONAL SECURITIES Essential Therapeutics, Inc. (the "Company") filed with the Securities and Exchange Commission ("SEC") the following Registration Statements on Form S-8 relating to shares of the Company's common stock, par value $0.001 per share (the "Common Stock"), to be offered and sold under the Company's 1996 Employee Stock Purchase Plan, as amended (the "Plan"), and the contents of such prior Registration Statements are incorporated by reference in this Registration Statement: (1) Registration Statement on Form S-8 filed September 11, 1996 (File No. 333-11759), and (2) Registration Statement on Form S-8 filed September 1, 1999 (File No. 333-86383). The Company is hereby registering an additional 250,000 shares of Common Stock issuable under the Plan, none of which has been issued as of the date of this Registration Statement. Item 8. Exhibits -------- See Index to Exhibits on page 5. 2 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended (the "Securities Act"), the Company certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Waltham, State of Massachusetts, on October 31, 2001. Essential Therapeutics, Inc. By: /s/ Mark B. Skaletsky ------------------------------- Mark B. Skaletsky President and Chief Executive Officer 3 POWER OF ATTORNEY KNOW ALL MEN BY THESE PRESENT, that each person whose signature appears below constitutes and appoints Mark B. Skaletsky and Paul J. Mellett, and each or any of them, his true and lawful attorneys-in-fact and agents, and each with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto and other documents in connection therewith, with the SEC, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in order to effectuate the same as fully, to all intents and purposes, as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities indicated on the dates indicated. Signatures Title Date ------------------------------------------- ------------------------------------------ ------------------------- /s/ Mark B. Skaletsky Chief Executive Officer, President, and October 31, 2001 ------------------------------------------- Chairman of the Board of Directors Mark B. Skaletsky (Principal Executive Officer) /s/ Donald D. Huffman Chief Financial Officer October 31, 2001 ------------------------------------------- (Principal Financial and Accounting Donald D. Huffman Officer) Director ------------------------------------------- Richard Aldrich Director ------------------------------------------- Kate Bingham Director ------------------------------------------- Charles Newhall /s/ James E. Rurka Director October 31, 2001 ------------------------------------------- James E. Rurka /s/ David Schnell Director October 31, 2001 ------------------------------------------- David Schnell /s/ John P. Walker Director October 31, 2001 ------------------------------------------- John P. Walker 4 INDEX TO EXHIBITS EXHIBIT ------- 4.1 1996 Employee Stock Purchase Plan (1) 4.2 Amendment to 1996 Employee Stock Purchase Plan dated October 18, 2001 5.1 Opinion of Latham & Watkins 23.1 Consent of Ernst & Young LLP 23.2 Consent of Latham & Watkins (included in Exhibit 5.1) 24.1 Power of Attorney (included in the signature page to this Registration Statement) --------- (1) Incorporated by reference to the Company's Registration Statement on Form S-1, as amended (File No. 333-02400), filed with the SEC on May 14, 1996. 5.