As filed with the Securities and Exchange Commission on January 11, 2002 Registration No. 333___________ ================================================================================ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ________________ FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ________________ DURECT CORPORATION (Exact name of Registrant as specified in its charter) Delaware 94-3297098 (State or other jurisdiction of (I.R.S. Employer incorporation on or organization) Identification No.) 10240 Bubb Road Cupertino, CA 95014 (Address of Principal Executive Offices) _______________________ Southern BioSystems, Inc. 1993 Stock Option Plan Southern Research Technologies, Inc. 1995 Nonqualified Stock Option Plan (Full title of the plans) _______________________ James E. Brown Chief Executive Officer DURECT Corporation 10240 Bubb Road Cupertino, CA 95014 (Name and address of agent for service) (408) 777-1417 (Telephone number, including area code, of agent for service) _______________________ Copy to: Mark B. Weeks Stephen B. Thau Venture Law Group A Professional Corporation 2800 Sand Hill Road Menlo Park, California 94025 (650) 854-4488 (Calculation of Registration Fee on following page) - -------------------------------------------------------------------------------------------------------------------- CALCULATION OF REGISTRATION FEE - -------------------------------------------------------------------------------------------------------------------- Proposed Proposed maximum maximum Amount of Title of each class of securities Amount to be offering price aggregate registration to be registered registered(1) per share offering price fee - -------------------------------------------------------------------------------------------------------------------- Southern BioSystems, Inc. 1993 Stock Option Plan Common Stock, $0.0001 par value ............... 118,396 Shares $10.99(2) $1,301,172.04 $310.98 Southern Research Technologies, Inc. 1995 Nonqualified Stock Option Plan Common Stock, $0.0001 par value ............................. 73,402 Shares $10.99(2) $ 806,687.98 $192.80 TOTAL 191,798 Shares $2,107,860.02 $503.78 - -------------------------------------------------------------------------------------------------------------------- _______________________ (1) This registration statement shall also cover any additional shares of common stock which become issuable under any of the plans being registered pursuant to this registration statement by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of the registrant's outstanding shares of common stock. (2) Computed in accordance with Rule 457(h) under the Securities Act (the "Securities Act") solely for the purpose of calculating the registration fee. The computation with respect to unissued options is based on the average of the high and low sale price of the common stock as reported on The Nasdaq National Market on January 7, 2002. The contents of the Registration Statement on Form S-8 filed by the issuer on May 18, 2001, file number 333-61244, are incorporated by reference. This Registration Statement relates solely to the registration of additional securities of the same class as other securities for which a registration statement on this form relating to an employee benefit plan is effective. ================================================================================ [Signature Pages Follow] SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cupertino, State of California on January 11, 2002. DURECT Corporation By: /s/ James E. Brown --------------------------------------- James E. Brown President and Chief Executive Officer -3- POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints James E. Brown and Thomas A. Schreck, jointly and severally, his or her attorneys-in-fact and agents, each with the power of substitution and resubstitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any amendments to this Registration Statement on Form S-8, and to file such amendments, together with exhibits and other documents in connection therewith, with the Securities and Exchange Commission, granting to each attorney-in-fact and agent, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully as he or she might or could do in person, and ratifying and confirming all that the attorneys-in-fact and agents, or his or her substitute or substitutes, may do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated. Signature Title Date --------- ----- ---- /s/ James E. Brown President, Chief Executive Officer and January 11, 2002 ------------------------- Director (Principal Executive Officer) James E. Brown /s/ Felix Theeuwes Chairman and Chief Scientific Officer January 11, 2002 ------------------------- Felix Theeuwes /s/ Thomas A. Schreck Chief Financial Officer and Director January 11, 2002 --------------------- (Principal Financial and Thomas A. Schreck Accounting Officer) /s/ James R. Butler Director January 11, 2002 ------------------- James R. Butler /s/ John L. Doyle Director January 11, 2002 ----------------- John L. Doyle /s/ Matthew V. McPherron Director January 11, 2002 ------------------------ Matthew V. McPherron /s/ Armand P. Neukermans Director January 11, 2002 ------------------------ Armand P. Neukermans /s/ Albert L. Zesiger Director January 11, 2002 --------------------- Albert L. Zesiger INDEX TO EXHIBITS Exhibit Number ------ 5.1 Opinion of Venture Law Group, A Professional Corporation 23.1 Consent of Venture Law Group, A Professional Corporation (included in Exhibit 5.1). 23.2 Consent of Ernst & Young LLP, Independent Auditors. 24.1 Powers of Attorney (see signature page).