EXHIBIT 11.1 MEGABIOS CORP. STATEMENT OF COMPUTATION OF NET LOSS PER SHARE (IN THOUSANDS, EXCEPT PER SHARE AMOUNTS) NINE MONTHS YEAR ENDED JUNE 30, ENDED MARCH 31, ------------------------- ---------------- 1994 1995 1996 1996 1997 ------- ------- ------- ------- ------- HISTORICAL NET LOSS PER SHARE Net loss applicable to common stock........................... $(2,153) $(5,429) $(6,901) $(5,496) $(2,861) ======= ======= ======= ======= ======= Weighted average shares of common stock outstanding............... 601 635 809 714 1,409 Shares related to Staff Accounting...................... Bulletin topic 4D: Stock options and warrants... 336 336 336 336 336 Convertible preferred stock.. 1,333 1,333 1,333 1,333 1,333 ------- ------- ------- ------- ------- 1,669 1,669 1,669 1,669 1,669 ------- ------- ------- ------- ------- Shares used in computing net loss per share....................... 2,270 2,304 2,478 2,383 3,078 ======= ======= ======= ======= ======= Net loss per share............... $ (0.95) $ (2.36) $ (2.78) $ (2.31) $ (0.93) ======= ======= ======= ======= ======= PRO FORMA NET LOSS PER SHARE Net loss applicable to common stock........................... $(2,153) $(5,429) $(6,901) $(5,496) $(2,861) ======= ======= ======= ======= ======= CALCULATION OF SHARES OUTSTANDING FOR COMPUTING PRO FORMA NET LOSS PER SHARE: Shares used in computing net loss per share................ 2,478 3,078 Adjustment to reflect the effect of the assumed conversion of preferred stock. 4,861 5,488 ------- ------- Shares used in computing pro forma net loss per share........ 7,339 8,566 ======= ======= Pro forma net loss per share..... $ (0.94) $ (0.33) ======= =======