As filed with the Securities and Exchange Commission on December 22, 1997 Registration No. 333-31281 ================================================================================ SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ____________________ POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ___________________ CRESCENDO PHARMACEUTICALS CORPORATION (Exact name of registrant on Form S-1 as specified in its charter) DELAWARE 8521214 77-0460388 (State or other (Primary Standard Industrial (I.R.S. Employer jurisdiction of Classification Code Number) Identification No.) Incorporation or organization) 1454 PAGE MILL ROAD PALO ALTO, CALIFORNIA 94304 (650) 494-5600 (Address, including zip code, and telephone number, including area code, of registrant's principal executive offices) ___________________ GARY L. NEIL, PH.D. President and Chief Executive Officer CRESCENDO PHARMACEUTICALS CORPORATION 1454 PAGE MILL ROAD PALO ALTO, CALIFORNIA 94304 (650) 494-5600 (Name, address, including zip code, and telephone number, including area code, of agent for service) ___________________ COPY TO: SARAH A. O'DOWD, ESQ. HELLER EHRMAN WHITE & MCAULIFFE 525 UNIVERSITY AVENUE PALO ALTO, CALIFORNIA 94301 TELEPHONE: (650) 324-7000 FACSIMILE: (650) 324-0638 ================================================================================ On September 30, 1997, the Registrant issued to ALZA Corporation ("ALZA"), and ALZA distributed to its stockholders and debenture holders, 4,965,470 shares of common stock of the Registrant pursuant to this Registration Statement. The Registrant hereby withdraws from registration 834,530 shares of its common stock that were covered by this Registration Statement, but not issued in the distribution. The Registration Statement is hereby amended, as appropriate, to reflect the distribution of 4,965,470 shares. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, Crescendo Pharmaceuticals Corporation has duly caused this Post-Effective Amendment No. 1 to the Registration Statement on Form S-1 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Palo Alto, State of California on December 22, 1997. Crescendo Pharmaceuticals Corporation By: /s/ Gary L. Neil ------------------------------------- GARY L. NEIL, PH.D., DIRECTOR, PRESIDENT AND CHIEF EXECUTIVE OFFICER Pursuant to the requirements of the Securities Act of 1933, this Post- Effective Amendment No. 1 to the Registration Statement on Form S-1 has been signed by the following persons in the capacities and on the dates indicated SIGNATURE CAPACITY DATE --------- -------- ----- /s/ Gary L. Neil Director, President and Chief Executive December 22, 1997 - ----------------------------------------- Officer (Principal Executive Officer) GARY L. NEIL, PH.D. /s/ Terrence F. Blaschke Director December 22, 1997 - ----------------------------------------- TERRENCE F. BLASCHKE, M.D. Director - ----------------------------------------- JERRY T. JACKSON /s/ M. David MacFarlane Director December 22, 1997 - ----------------------------------------- M. DAVID MACFARLANE, PH.D. /s/ Gerald J. Papariello Director December 22, 1997 - ----------------------------------------- GERALD J. PAPARIELLO, PH.D. /s/ Ley S. Smith Director December 22, 1997 - ----------------------------------------- LEY S. SMITH /s/ David R. Hoffmann Vice President, Finance (Principal December 22, 1997 - ----------------------------------------- Financial and Accounting Officer) DAVID R. HOFFMANN