SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, DC 20549
                                 _____________

                                 SCHEDULE 13E-3
                                        

                        RULE 13E-3 TRANSACTION STATEMENT
       (PURSUANT TO SECTION 13(E) OF THE SECURITIES EXCHANGE ACT OF 1934)


                       ALZA TTS RESEARCH PARTNERS, LTD.
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                             (Name of the Issuer)


               ALZA DEVELOPMENT CORPORATION and ALZA CORPORATION
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                     (Name of Person(s) Filing Statement)


                     Class A Limited Partnership Interests
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                        (Title of Class of Securities)


                                Not Applicable
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                     (CUSIP Number of Class of Securities)


David R. Hoffmann                                      Bruce C. Cozadd
President                                              Senior Vice President and
ALZA Development Corporation                           Chief Financial Officer
950 Page Mill Road                                     ALZA Corporation
P.O. Box 10950                                         950 Page Mill Road
Palo Alto, CA  94303-0802                              P.O. Box 10950
(650) 494-5300                                         Palo Alto, CA  94303-0802
                                                       (650) 494-5000
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  (Name, Address and Telephone Number of Person Authorized to Receive Notices
          and Communications on Behalf of Person(s) Filing Statement)


This statement is filed in connection with (check the appropriate box):
        (a)  [_]  The filing of solicitation materials or an information
                  statement subject to Regulation 14A, Regulation 14C, or Rule
                  13e-3(c) under the Securities Exchange Act of 1934.

        (b)  [_]  The filing of a registration statement under the Securities
                  Act of 1933.

        (c)  [_]  A tender offer.

        (d)  [X]  None of the above.

Check the following box if the soliciting materials or information statement
referred to in checking box (a) are preliminary copies. [_]

                           Calculation of Filing Fee
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Transaction Valuation/1/:  $91,176,592.48      Amount of Filing Fee/2/:  $18,236
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- ------------------

       /1/ For purposes of calculating the filing fee only. This calculation is
based upon the purchase price of $91,176,592.48 million for all issued and
outstanding limited partnership interests to be acquired pursuant to this
transaction.

       /2/ The amount of the filing fee, calculated in accordance with Rule 
0-11 of the Securities Exchange Act of 1934, as amended, equals 1/50th of one
percent of the aggregate value of cash to be paid by the general partner of ALZA
TTS Research Partners, Ltd. for such limited partnership interests.


[_]    Check box if any part of the fee is offset as provided by Rule 0-11(a)(2)
and identify the filing with which the offsetting fee was previously paid.
Identify the previous filing by registration statement number, or the form or
schedule and the date of its filing.


Amount previously paid:                       Filing party:
                       -------------------                 -------------------

Form or registration no.:                     Date filed:
                         -----------------                --------------------


       Instruction.  Eight copies of this statement, including all exhibits,
should be filed with the Commission.

 
INTRODUCTION.
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     This Schedule 13E-3 Transaction Statement (the "Statement") relates to the
exercise by ALZA Development Corporation, a California corporation ("ADC"), of
its option to purchase all issued and outstanding limited partnership interests
of ALZA TTS Research Partners, Ltd., a California limited partnership (the
"Issuer").  ADC is the general partner of the Issuer (referred to herein, in
such capacity, as the "General Partner") and a wholly owned subsidiary of ALZA
Corporation, a Delaware corporation ("ALZA").  This Statement is being filed by
ALZA and ADC.  Notwithstanding this Statement, ALZA and ADC disclaim application
of Rule 13e-3 under the Securities Exchange Act of 1934, as amended, to the
transaction described herein.

Item 1.  Issuer and Class of Security Subject to the Transaction.
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     (a)  The issuer of the class of equity security which is the subject of
          this filing and the address of its principal executive offices is:

                    ALZA TTS Research Partners, Ltd.
                    c/o ALZA Development Corporation
                    950 Page Mill Road
                    P.O. Box 10950
                    Palo Alto, California 94303-0802

     (b)  The exact title of the class of security which is the subject of this
          filing is the Class A Limited Partnership Interests of ALZA TTS
          Research Partners, Ltd.  As of March 31, 1998 (the most recent
          practicable date), there were (i) 3,200 Class A Limited Partnership
          Interests (the "Class A Limited Partnership Interests") and (ii) one
          Class B Limited Partnership Interest (the "Class B Limited Partnership
          Interest" and collectively with the Class A Limited Partnership
          Interests, the "Limited Partnership Interests") issued and
          outstanding.  As of March 31, 1998 (the most recent practicable date),
          there were approximately 1,972 holders of record of Class A Limited
          Partnership Interests and one holder of record of the Class B Limited
          Partnership Interest.  The rights of the Class A Limited Partnership
          Interests and the Class B Limited Partnership Interest are the same
          except that the holder of the Class B Limited Partnership Interest has
          a right to consult with ADC with respect to certain matters.

     (c)  There is no established trading market for the Limited Partnership
          Interests.

     (d)  The Issuer has not paid any dividends on the Limited Partnership
          Interests in the past two years, except for distributions made to the
          holders of 

 
          Limited Partnership Interests pursuant to the terms of the Agreement
          of Limited Partnership, as amended (the "Limited Partnership
          Agreement"), by and among the General Partner and the limited partners
          of the Issuer (the "Limited Partners"). For information with respect
          to distributions made by the Issuer in the past two fiscal years, see
          Item 3 below.

     (e)  Not applicable.

     (f)  Not applicable.

Item 2.  Identity and Background.
- --------------------------------

     The Statement is being filed by ADC and ALZA.  ADC is the general partner
of the Issuer and a wholly owned subsidiary of ALZA.


     ALZA's principal business is the development and commercialization of
pharmaceutical products.  ALZA is incorporated in the State of Delaware and the
address of its principal executive offices is 950 Page Mill Road, P.O. Box
10950, Palo Alto, CA  94303-0802.

     ADC's principal business is acting as general partner of the Issuer.  ADC
is incorporated in the State of California and the address of its principal
executive offices is 950 Page Mill Road, P.O. Box 10950, Palo Alto, CA  94303-
0802.

     During the last five years, neither ALZA nor ADC has been convicted in a
criminal proceeding (excluding traffic violations or similar misdemeanors).
During the last five years, neither ALZA nor ADC has been a party to a civil
proceeding of a judicial or administrative body of competent jurisdiction and as
a result of such proceeding was or is subject to a judgment, decree or final
order enjoining further violations of, or prohibiting activities subject to,
federal or state securities laws or finding any violation of such laws.


Information with Respect to Executive Officers and Directors of ALZA.
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Name:  Dr. Ernest Mario (Chairman and Chief Executive Officer)
Business Address:  950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Chief Executive Officer of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America

                                       2

 
Name:  William G. Davis (Director)
Business Address:  3532 Bay Road, South Drive, Indianapolis, IN  49240
Principal Occupation:  Independent Business Consultant
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Dr. William R. Brody (Director)
Business Address:  3400 North Charles Street, 242 Garland Hall, Baltimore, MD
21218
Principal Occupation:  President of The John Hopkins University (from 1996 to
present); Provost of The University of Minnesota Academic Health Center (from
1994 to 1996); and Martin Donner Professor and Director of the Department of
Radiology at The John Hopkins University (from 1987 to 1994)
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Robert J. Glaser, M.D. (Director)
Business Address:  1 Elm Place, Atherton, CA  94027
Principal Occupation:  Director (retired) for Medical Science and Trustee of the
        Lucille P. Markey Charitable Trust
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America

                                       3

 
Name:  Dean O. Morton (Director)
Business Address:  3200 Hillview Avenue, Palo Alto, CA  94304
Principal Occupation:  Executive Vice President and Chief Operating Officer
        (Retired in 1992) of Hewlett-Packard Corporation
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Denise M. O'Leary (Director)
Business Address:  c/o Vivra, Inc., 1850 Gateway Drive, Suite 5000, San Mateo,
        CA  94404
Principal Occupation:  Special Limited Partner with Menlo Ventures
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Isaac Stein (Director)
Business Address:  525 University Avenue, Suite 700, Palo Alto, CA  94301
Principal Occupation:  President of Waverley Associates, Inc.
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Julian N. Stern (Director and Secretary)
Business Address:  525 University Avenue, Suite 1100, Palo Alto, CA  94301
Principal Occupation:  Partner of Heller Ehrman White & McAuliffe
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America

                                       4

 
Name:  James Butler (Senior Vice President of Sales and Marketing)
Business Address:  950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Senior Vice President of Sales and Marketing of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Bruce C. Cozadd (Senior Vice President and Chief Financial Officer)
Business Address:  950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Senior Vice President and Chief Financial Officer of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Harold Fethe (Vice President of Human Resources)
Business Address:  950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Vice President of Human Resources of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Dr. Gary V. Fulscher (Senior Vice President of Commercial Services)
Business Address:  950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Senior Vice President of Commercial Services of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America

                                       5

 
Name:  Dr. Samuel R. Saks (Senior Vice President of Medical Affairs)
Business Address:  950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Senior Vice President of Medical Affairs of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Peter D. Staple (Senior Vice President and General Counsel)
Business Address:  950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Senior Vice President and General Counsel of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Dr. Felix Theeuwes (President of New Ventures)
Business Address:  950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  President of New Ventures of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  Belgium


Name:  Janne Wissel (Senior Vice President of Operations)
Business Address: 950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Senior Vice President of Operations of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America

                                       6

 
Name:  Dr. James W. Young (Senior Vice President of Research and Development)
Business Address:  950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Senior Vice President of Research and Development of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Information with Respect to Executive Officers and Directors of ADC.
- ------------------------------------------------------------------- 


Name:  David R. Hoffmann (President, Chief Financial Officer, Secretary and
        Director)
Business Address:  950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Vice President and Treasurer of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Robert M. Myers (Vice President and Director)
Business Address: 950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Vice President, Commercial Development of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America


Name:  Dr. James W. Young (Vice President and Director)
Business Address: 950 Page Mill Road, Palo Alto, CA  94304
Principal Occupation:  Senior Vice President, Research and Development of ALZA
Criminal Convictions During Proceeding Five Years:  None
Judgments, Decrees or Orders Under Federal or State Securities Laws
During Preceding Five Years:  None
Citizenship:  United States of America

                                       7

 
Item 3.  Past Contacts, Transactions or Negotiations.
- ---------------------------------------------------- 

     (a)  (1)  The nature and approximate amount in dollars of any transaction
          which has occurred since the commencement of the Issuer's second full
          fiscal year preceding the date of this Statement between ALZA and ADC
          on one hand and the Issuer on the other hand are as follows:

               As part of its initial organization and funding, the Issuer
          granted ALZA an option (the "License Option") to acquire a license
          for any or all of the products (the "Issuer Products") for which
          development was funded by the Issuer under its Research and
          Development Agreement with ALZA. In 1990, ALZA exercised its License
          Option for two Issuer Products: (i) a transdermal fentanyl product
          sold in the United States under the name Duragesic(R) and (ii) a
          transdermal testosterone product sold under the name Testoderm(R).
          Under each license, ALZA makes payments to the Issuer based on
          ALZA's and its affiliates' and sublicensees' sales of the licensed
          product. ALZA paid the Issuer $2,644,646, $8,776,814 and $6,265,401
          for the three months ended March 31, 1998 and the years ended
          December 31, 1997 and December 31, 1996, respectively, of which
          approximately 97.5%, 95% and 96% were attributed to Duragesic(R) for
          the three months ended March 31, 1998 and fiscal 1997 and 1996,
          respectively.

               The administrative, accounting, contract management and record
          keeping services required by the Issuer have been provided in the past
          and are currently being provided by ALZA and are billed to the Issuer
          at ALZA's standard administrative services rate. The Issuer paid ALZA
          $18,835, $105,512 and $86,548 for the three months ended March 31,
          1998 and the years ended December 31, 1997 and December 31, 1996,
          respectively.

          (2)  On November 20, 1997, PharmaInvest, L.L.C. ("PharmaInvest") on
          behalf of Pharmaceutical Royalties L.L.C., Pharmaceutical Royalty
          Investments Ltd. and Pharmaceutical Partners L.L.C. ("Pharmaceutical
          Partners") made an unsolicited tender offer (the "Tender Offer") to
          purchase up to 1,400 Class A Limited Partnership Interests,
          representing approximately 44% of the total outstanding Class A
          Limited Partnership Interests, for cash consideration per Class A
          Limited Partnership Interest of $12,000.  In response to the Tender
          Offer, the General Partner filed a Schedule 14D-9 (the "Schedule 14D-
          9") with the Securities and Exchange Commission (the "Commission"), in
          which the General Partner expressed no opinion with respect to the
          Tender Offer to the holders of the Class A Limited Partnership
          Interests and stated that the General Partner would remain neutral as
          to whether the Limited Partners should tender or refrain from
          tendering their Class A Limited Partnership Interests.  In its letter
          to 

                                       8

 
          the Limited Partners advising them of its neutrality with respect to
          the Tender Offer, the General Partner drew the attention of the
          Limited Partners to certain facts, including, (i) the dates on which
          ALZA's exclusive rights with respect to Duragesic(R) and Testoderm(R)
          were scheduled to expire, (ii) the General Partner's expectation of
          the growth of sales of Duragesic(R) and (iii) the report of Securities
          Pricing and Research, Inc., an independent appraisal firm ("SPAR"),
          estimating that the rounded net asset value and fair market value of a
          Class A Limited Partnership Interest as of December 31, 1996 were
          $21,200 and $15,900, respectively. None of ADC, ALZA or the Issuer has
          any affiliation with SPAR, nor does any of them endorse the report
          prepared by SPAR (the "SPAR Report"). In addition, neither the General
          Partner nor the Issuer engaged SPAR to prepare the SPAR Report or
          participated in the preparation of the SPAR Report. The SPAR Report
          was not related to the Tender Offer and is not related to the Purchase
          Option.

               Also on November 20, 1997, Pharmaceutical Partners, an
          affiliate of PharmaInvest,  in a letter addressed to ALZA, set forth
          its views about the Purchase Option and its effects on the Limited
          Partners, the Issuer, the General Partner and ALZA.  In connection
          with the Issuer's consideration and evaluation of the Tender Offer,
          ALZA, on December 2, 1997, advised the Issuer of the matters raised in
          Pharmaceutical Partners' letter to ALZA and informed the Issuer of
          ALZA's position regarding such matters.  A copy of such letter was,
          with ALZA's permission, included as an exhibit to the Schedule 14D-9
          and sent to the holders of the Limited Partnership Interests.  On
          January 16, 1998, PharmaInvest amended its offer by increasing the
          purchase price of each Class A Limited Partnership Interest from
          $12,000 to $13,200.  In connection with the increase in the purchase
          price, the General Partner filed an amendment to its Schedule 14D-9
          stating that the General Partner continued to express no opinion to
          the holders of the Class A Limited Partnership Interests and that the
          General Partner would continue to remain neutral as to whether the
          Limited Partners should tender or refrain from tendering their Class A
          Limited Partnership Interests. In addition, the General Partner
          informed the Limited Partners that in reaching its conclusion with
          respect to the Tender Offer, the General Partner had taken into
          account (i) that SPAR had reduced its estimates of the rounded net
          asset value and fair market value of the Class A Limited Partnership
          Interests as of December 31, 1996, and (ii) the General Partner's
          expectation of the growth of sales of Duragesic.  On February 2, 1998,
          PharmaInvest announced that the Tender Offer had expired and that 72
          Class A Limited Partnership Interests were tendered in connection with
          the Tender Offer.

                                       9

 
     (b)  As described in Section (a)(2) above, in November 1997, PharmaInvest
          made the Tender Offer. In the last fiscal year, PharmaInvest contacted
          the General Partner to make it aware of its possible interest in the
          Issuer as an investment opportunity. PharmaInvest sent letters on July
          11 and 17, 1997 continuing to express its interest in the Issuer. In
          October 1997, PharmaInvest had a conversation with the General Partner
          reiterating its interest in the Issuer. Following the conversation,
          PharmaInvest acquired two Class A Limited Partnership Interests, and
          on October 22, 1997 made a written request to receive a list of names
          and addresses of Limited Partners (the "List"). PharmaInvest received
          the List on November 2, 1997 and commenced the Tender Offer on
          November 20, 1997.

Item 4.  Terms of Transaction.
- ----------------------------- 

     (a)  Pursuant to the terms of the Limited Partnership Agreement, ADC has an
          option to purchase all (but not less than all) of the Limited
          Partnership Interests (the "Purchase Option"). The exercise price for
          exercise of the Purchase Option is $120 million less an amount equal
          to all cash distributed to the Limited Partners by the Issuer (the
          "Exercise Price").  As of the date hereof, the Exercise Price is
          $91,176,592.48.  The Exercise Price will be allocated among the
          Limited Partners based on their pro rata contributions.  At the
                                          ---------                      
          closing (the "Closing"), the holders of record of Class A Limited
          Partnership Interests as of the Closing date will receive $27,216.21
          per Class A Limited Partnership Interest (purchased in the original
          offering for $5,000 each) and the holder of the Class B Limited
          Partnership Interest will receive $4,084,720.48 for its Class B
          Limited Partnership Interest.  The Exercise Price will be paid by
          check to each holder of the Limited Partnership Interests.


          In accordance with the terms of the Limited Partnership Agreement, the
          Limited Partners are not required to take any steps to approve the
          exercise of the Purchase Option or the consummation of the
          transactions pursuant to the Purchase Option. Title to the Limited
          Partnership Interests automatically vests in ADC no later than 30 days
          after notice of the exercise of the Purchase Option is given to the
          Limited Partners, upon payment of the Purchase Price for the Limited
          Partnership Interests.  The exact date of Closing will be set forth in
          the Notice to Limited Partners of the Issuer to be distributed to the
          Limited Partners. 

     (b)  Not applicable.

                                       10

 
Item 5.  Plans or Proposals of the Issuer or Affiliate.
- ------------------------------------------------------ 

     Exercise of the Purchase Option will result in ADC owning all of the
Limited Partnership Interests. Upon purchase of all of the Limited Partnership
Interests by ADC, the Issuer will terminate as a limited partnership and the
General Partner will take all appropriate and necessary actions to suspend the
Issuer's public reporting obligations by filing a Form 15 with the Commission
and to wind up the affairs of the Issuer in accordance with California law. ADC
will continue as a wholly owned subsidiary of ALZA. Although ALZA and ADC have
no specific intentions with respect to the operations of the business of the
Issuer following the exercise of the Purchase Option, ALZA and ADC intend to
operate the business of the Issuer in a manner best designed, in the judgment of
ALZA, to realize the benefit of that business to ALZA and its stockholders.

Item 6.  Source and Amount of Funds or Other Consideration.
- ---------------------------------------------------------- 

     (a)  In accordance with the terms of the Limited Partnership Agreement, the
          Exercise Price is $91,176,592.48.  ALZA intends to contribute to ADC
          the amount of cash necessary to exercise the Purchase Option, which
          contribution ALZA intends to finance with its cash and marketable
          securities.

     (b)  The following tables set forth an estimate (except for the filing fee)
          of expenses for the transaction:

          Filing fees............................................    $ 18,236
          Accounting fees and expenses...........................       5,000
          Legal fees and expenses................................      25,000
          Printing expenses......................................       3,500
              Total..............................................    $ 51,736

          All of the expenses and fees will be paid by ALZA.

     (c)  Not applicable.

     (d)  Not applicable.

Item 7.  Purposes, Alternatives, Reasons and Effects.
- ---------------------------------------------------- 

     (a)  The purpose of this transaction is for ALZA, through ADC, to acquire
          all rights, on an exclusive basis, to the Issuer Products. ALZA
          believes that it is in the best interests of ALZA and ALZA's
          stockholders to exercise the Purchase Option at this time. ALZA has
          worldwide licenses, including the

                                       11

 
          right to sublicense, to make, use and sell Testoderm(R) and
          Duragesic(R) products. Such licenses are currently exclusive; however,
          ALZA's exclusive rights with respect to Testoderm(R) and Duragesic(R)
          would end on July 26, 1998 and December 4, 1998, respectively. Because
          ALZA's exclusive rights are limited in duration, ALZA believes that
          exercising the Purchase Option is the most effective and comprehensive
          method of acquiring continued exclusive rights to Testoderm(R),
          Duragesic(R) and other Issuer Products. In addition, because ALZA's
          obligations to pay royalties to the Issuer under the licenses for
          Testoderm(R) and Duragesic(R) will terminate upon exercise of the
          Purchase Option, ALZA will benefit by retaining the full royalty 
          received on sales of Duragesic(R) and the full sales margin on 
          Testoderm(R).

     (b)  ADC and ALZA did not consider alternative means to accomplish the
          transaction because of the previously granted Purchase Option.

     (c)  The structure of the transaction is in accordance with the terms of
          the previously granted Purchase Option as set forth in the Limited
          Partnership Agreement. The transaction is being undertaken at this
          time because of the timing of the expiration of ALZA's exclusive
          rights discussed in Item 7(a) above.

     (d)  As a result of the transaction described herein, the Issuer will
          terminate as a limited partnership and the General Partner will take
          all appropriate and necessary actions to suspend the Issuer's public
          reporting obligations and to wind up the affairs of the Issuer in
          accordance with California law. The General Partner will continue as a
          wholly owned subsidiary of ALZA. For federal income tax purposes the
          Issuer will be treated as terminating on the date of the transaction
          and as distributing all of its assets, subject to all of its
          liabilities, to the General Partner on that date. The Issuer will not
          have taxable gain or loss as a result of the transaction described
          herein.

          The transaction described herein will cause each Limited Partner to
          dispose of its Limited Partnership Interests for consideration equal
          to such holder's pro rata share of the Exercise Price.  The following
                           --------                                            
          discussion sets forth general federal income tax considerations under
          the Internal Revenue Code (the "Code") for the Limited Partners with
          respect to cash received by the Limited Partners for the Limited
          Partnership Interests.  This discussion is intended only to provide
          general information to the Limited Partners that are subject to United
          States federal income tax; it may not address all relevant federal
          income tax consequences to such persons or to other categories of the
          Limited Partners (e.g., foreign persons, dealers in 
                            ----                                             

                                       12

 
          securities, and persons that are exempt from federal income tax). This
          discussion is based upon present federal income tax laws and does not
          attempt to anticipate changes, including changes in tax rates, that
          may be made under currently pending legislative proposals. This
          discussion assumes that the Limited Partnership Interests were at all
          relevant times capital assets of the Limited Partners. This discussion
          does not address state, local or foreign tax considerations. ALL
          LIMITED PARTNERS ARE URGED TO CONSULT THEIR OWN TAX ADVISORS.

          Except as described below, the holder of a Limited Partnership
          Interest should generally have a capital gain or loss due to ADC's
          exercise of the Purchase Option equal to the difference between (i)
          the amount of cash received and (ii) the holder's basis in the Limited
          Partnership Interest.  A Limited Partner's basis in a Limited
          Partnership Interest is the Limited Partner's initial purchase price
          decreased by any partnership deductions taken by the Limited Partner
          and any cash distributed by the Issuer to the Limited Partner and
          increased by the Limited Partner's share of the Issuer's income. Under
          current law, capital gain or loss will be: (a) long-term if the
          Limited Partnership Interest has been held at least 18 months at the
          time the Purchase Option is exercised, (b) mid-term if the holding
          period is more than one year but less than (or equal to) 18 months,
          and (c) short term if the holding period is a year or less. Under
          Section 751 of the Code, the difference between the portion of the
          cash received by the holder that is attributable to "unrealized
          receivables" and "inventory" of the Issuer (together, "Section 751
          Property") over the portion of the holder's adjusted tax basis in the
          Limited Partnership Interest allocable to Section 751 Property will be
          treated as ordinary income or loss, rather than capital gain or loss.
          Although this conclusion is not entirely free from doubt, ADC believes
          that the only "unrealized receivables" of the Issuer should be the
          amount, if any, of accrued, but unpaid royalties under ALZA's licenses
          to Duragesic(R) and Testoderm(R). Treasury regulations require each
          person who transfers an interest in a partnership possessing Section
          751 Property to file a statement with such person's tax return
          reporting the transfer and certain other information relating thereto.
          Limitations may apply to deduction of capital loss.

          To the extent that any holder of a Limited Partnership Interest has
          not provided an appropriate taxpayer identification number on IRS Form
          W-9 or a substitute therefor, the holder may be subject to backup
          withholding by ALZA or ADC.

                                       13

 
     (e)  The Purchase Price will be amortized by ALZA over a number of
          years.

Item 8.  Fairness of the Transaction.
- ------------------------------------ 

     (a)  Each of ADC and ALZA reasonably believes that the transaction reported
          herein is fair to the Limited Partners.  None of ALZA's or the General
          Partner's directors dissented to or abstained from voting on such
          transaction.

     (b)  Each of ADC and ALZA has based its respective belief that the
          transaction is fair to the holders of the Limited Partnership
          Interests on the fact that the Limited Partners were fully aware of
          the Purchase Option, which was an essential economic term of the
          Limited Partnership Interests, when they purchased their Limited
          Partnership Interests. The prospectus, pursuant to which the Limited
          Partnership Interests were offered and sold, fully described the
          Purchase Option. The Purchase Option, which is contained in the
          Limited Partnership Agreement, was also publicly filed with the
          Commission. The Limited Partners were also advised of the Purchase
          Option in each Form 10-K and each recent Form 10-Q public filing made
          by the Issuer with the Commission. In addition, the Limited Partners
          were reminded of the Purchase Option in connection with the Tender
          Offer and in evaluating whether or not to tender their Limited
          Partnership Interests in the Tender Offer. Accordingly, the Purchase
          Option was present in the initial public sale, was disseminated in the
          Issuer's charter documents and was discussed in the Issuer's periodic
          filings. As a result, every Limited Partner received substantial
          notice as to the terms of the Purchase Option prior to making any
          investment decision with respect to the Limited Partnership Interests.
          In addition, in its most recent filings the Issuer has indicated that
          ALZA's exclusive rights with respect to Duragesic(R) and Testoderm(R)
          would expire soon and that such expiration could lead to the exercise
          of the Purchase Option. In connection with its decision whether to
          exercise the Purchase Option, ALZA commissioned Frost & Sullivan, an
          independent market research firm ("Frost & Sullivan"), to prepare a
          market research report (the "Report") of revenue forecasts for
          Duragesic(R) (see Item 9 below). ALZA took into account the
          information contained in the Report in deciding whether the exercise
          of the Purchase Option was in the best interests of ALZA and ALZA's
          stockholders; however, because the Report did not assess the fairness
          of the exercise price of the Purchase Option, neither ALZA nor ADC
          considers that the Report is relevant with respect to the fairness of
          the transaction to the Limited Partners.

                                       14

 
     (c)  The exercise of the Purchase Option and the consummation of the
          transactions thereunder do not require approval of the Limited
          Partners.

     (d)  No director of ALZA or the General Partner has retained an
          unaffiliated representative to act solely on behalf of the Limited
          Partners. As a limited partnership, the Issuer does not have any
          directors. Each director of the General Partner is an officer of the
          General Partner and an employee and officer or vice-president of ALZA.

     (e)  See Item 8(d) above.

     (f)  On November 20, 1997, PharmaInvest made the Tender Offer.  For further
          information with respect to the Tender Offer see Item 3(a)(2) above.

Item 9.  Reports, Opinions, Appraisals and Certain Negotiations.
- --------------------------------------------------------------- 

     (a)  In February of 1998, ALZA engaged Frost & Sullivan to prepare the 
          Report.

     (b)  ALZA engaged Frost & Sullivan to prepare the Report because of Frost &
          Sullivan's expertise with respect to analyzing sales and marketing
          information and trends of product sales in the pharmaceutical
          industry. Prior to engaging Frost & Sullivan, ALZA contacted several
          other market research firms, but chose Frost & Sullivan because of its
          availability and experience. ALZA has engaged Frost & Sullivan for
          other market research engagements from time to time and has paid
          normal service fees in connection with such engagements. The
          objectives of the Report were to (i) assess the revenue potential for
          Duragesic(R) during the period from 1997 to 2006, (ii) analyze the
          market opportunity for the same period, (iii) identify key competitive
          factors in the current and future market environment and (iv) identify
          key drivers of and restraints to market growth. After research using
          both primary and secondary sources, the key findings provided by the
          Report were (a) if a second transdermal product does not emerge on the
          market, Duragesic(R) is expected to continue to experience substantial
          growth throughout the forecast period due to an increased penetration
          into an expanding market, increased pricing and increased acceptance
          in key foreign markets, and (b) if a second transdermal product
          emerges on the market, in order to be competitive, a competitor would
          need to undercut the price of Duragesic(R).

     (c)  A copy of the Report is available for inspection and copying at the
          principal executive offices of ALZA during its regular business hours
          by any interested Limited Partner or his or her representative who has
          been so designated in writing.  A copy of the Report will be
          transmitted by ALZA 

                                       15

 
          to any interested Limited Partner or his or her
          representative who has been so designated in writing upon written
          request and at the expense of the requesting Limited Partner.  A copy
          of the Report is also attached hereto as Exhibit (b).

Item 10.  Interest in Securities of the Issuer.
- ---------------------------------------------- 

     (a)  None of ADC, ALZA or any of their respective directors or officers own
          any Limited Partnership Interests. ALZA is the sole shareholder of the
          General Partner and each officer and director of the General Partner
          is an employee and officer or vice-president of ALZA. As described in
          this Statement, the General Partner may at any time, pursuant to the
          Purchase Option, purchase all of the outstanding Limited Partnership
          Interests.

     (b)  None.

Item 11. Contracts, Arrangements or Understandings With Respect to the Issuer's
- -------------------------------------------------------------------------------
         Securities.
         ---------- 

     Article Seven of the Limited Partnership Agreement grants ADC the Purchase
Option. The Purchase Option states that ADC may purchase all (but not less than
all) of the issued and outstanding Limited Partnership Interests at any time
after January 1, 1987 and prior to dissolution of the Issuer.  ADC may exercise
the Purchase Option by mailing a notice of exercise to the Limited Partners.

Item 12.  Present Intention and Recommendation of Certain Persons With Regard 
- -----------------------------------------------------------------------------
          to the Transaction.
          ------------------ 

     (a)  Not applicable.

     (b)  Not applicable.

Item 13.  Other Provisions of the Transaction.
- --------------------------------------------- 

     (a)  Appraisal rights are not afforded under applicable law in respect of
          the exercise of the Purchase Option and none will be afforded. Neither
          ALZA nor the General Partner is aware of any rights available to
          objecting holders of the Limited Partnership Interests under
          applicable law.

                                       16

 
     (b)  None of ALZA, the General Partner or Issuer is aware of any grant of
          access to unaffiliated security holders to the corporate files of the
          Issuer or the appointment of counsel or appraisal services for
          unaffiliated security holders at the expense of the Issuer.

     (c)  Not applicable.

Item 14.  Financial Information.
- ------------------------------- 

     (a)  The Issuer's financial data is attached to this Statement as Exhibits
          (g)(1), (g)(2) and (g)(3).  The Issuer has no material fixed charges
          for the two most recent fiscal years and the appropriate interim
          period.  Book value per Class A Limited Partnership Interest at
          December 31, 1997 was $25.58 and at March 31, 1998 was $23.13.  Book
          value per Class B Limited Partnership Interest at December 31, 1997
          was $8,864 and at March 31, 1998 was $8,500.  Book value per General
          Partner interest at December 31, 1997 was $900 and at March 31, 1998
          was $849.

     (b)  The Issuer does not believe the pro forma disclosure required by this
          Item 14(b) is applicable because the Issuer would terminate upon
          giving effect to the transaction contemplated by this Schedule 13E-3.

Item 15.  Persons and Assets Employed, Retained or Utilized.
- ----------------------------------------------------------- 

     (a)  Not applicable.

     (b)  None.

Item 16.  Additional Information.
- -------------------------------- 

     Not applicable.

Item 17.  Material to be filed as Exhibits.
- ------------------------------------------ 

     (a)  Not applicable.

     (b)  Frost & Sullivan Report, "A Market Opportunity Assessment for the
          Duragesic Transdermal Patch", dated March 2, 1998.

     (c)  Agreement of Limited Partnership dated December 30, 1982./(1)/

                                       17

 
     (d)    Form of Notice to the Holders of Limited Partnership Interests of
            ALZA TTS Research Partners, Ltd., advising the Limited Partners of
            the exercise of the Purchase Option.

     (e)    Not applicable.

     (f)    Not applicable.

     (g)(1) Financial Statements extracted from the Issuer's Form 10-Q for the
            quarterly period ended March 31, 1998./(2)/

     (g)(2) Financial Statements and Additional Information extracted from the
            Issuer's Form 10-K for the year ended December 31, 1997./(3)/

     (g)(3) Financial Statements and Additional Information extracted from the
            Issuer's Form 10-K for the year ended December 31, 1996./(4)/

     _____________

     /(1)/  Incorporated herein by reference to Exhibit 4.1 of the Issuer's Form
     10-K for the year ended December 31, 1996.

     /(2)/  Incorporated herein by reference to the Issuer's Form 10-Q for the
     quarter ended March 31, 1998.

     /(3)/  Incorporated herein by reference to the Issuer's Form 10-K for the
     year ended December 31, 1997.

     /(4)/  Incorporated herein by reference to the Issuer's Form 10-K for the
     year ended December 31, 1996.

                                       18

 
                                   SIGNATURE

     After due inquiry and to the best of my knowledge and belief, the
undersigned certifies that the information set forth in this statement is true,
complete and correct.


                              ALZA CORPORATION



                              By: /s/ Bruce C. Cozadd
                                 ----------------------------------------
                                 Bruce C. Cozadd, Senior Vice President
                                 and Chief Financial Officer



                              ALZA DEVELOPMENT CORPORATION



                              By: /s/ David R. Hoffmann
                                 ----------------------------------------
                                 David R. Hoffmann, President
                                 and Chief Financial Officer

                                       19