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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                               _________________

                                    FORM 8-K
                               _________________



                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(D) OF THE
                         SECURITIES EXCHANGE ACT OF 1934





        FEBRUARY 17, 2000                            0-16132
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          Date of Report                        Commission File Number
(Date of earliest event reported)



                               CELGENE CORPORATION
             (Exact name of registrant as specified in its charter)



         DELAWARE                                    22-2711928
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  (State or other jurisdiction                    (I.R.S. Employer
of incorporation or organization)               Identification Number)


                               7 Powder Horn Drive
                            Warren, New Jersey 07059
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               (Address of Principal Executive Offices) (Zip Code)


                                 (732) 271-1001
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              (Registrant's telephone number, including area code)


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ITEM 5.   OTHER EVENTS.

          On February 17, 2000, Celgene  Corporation (the "Company") amended the
Rights  Agreement,  dated as of  September  16,  1996  between  the  Company and
American  Stock  Transfer  &  Trust  Company,   as  Rights  Agent  (the  "Rights
Agreement"),  changing the initial  exercise price  thereunder  from $100.00 per
Right (as defined in the Rights  Agreement)  to $700.00 per Right and  extending
the Final  Expiration Date (as that term is defined in the Rights  Agreement) to
February 17, 2010.

          Amendment  Number One to the Rights  Agreement  is filed as an exhibit
hereto and is hereby incorporated by reference.

ITEM 7.   FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS.

     (a)  not applicable

     (b)  not applicable

     (c)  EXHIBITS

          99   Amendment  Number  One  to  the  Rights  Agreement  dated  as  of
               September 16, 1996 between Celgene Corporation and American Stock
               Transfer & Trust Company, as Rights Agent.








                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


Date: February 18, 2000                CELGENE CORPORATION



                                       By:   /S/ JOHN W. JACKSON
                                           -------------------------------
                                             Name:  John W. Jackson
                                             Title: Chairman of the Board and
                                                    Chief Executive Officer






                                  EXHIBIT INDEX



     Exhibit                       Description                            Page
     -------   ------------------------------------------------------     ----

        99     Amendment  Number  One  to  the  Rights  Agreement
               dated as of September 16, 1996 between Celgene
               Corporation and American Stock Transfer & Trust Company,
               as Rights Agent.