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Exhibit 4.1




                             SUBSCRIPTION AGREEMENT


                        Investor Financial Questionnaire
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     Before you make an investment, you must complete this questionnaire. Please
     check  the  appropriate  box below  and sign  this  questionnaire  before a
     notary. We require that this be returned with your  Subscription  Agreement
     for your  purchase of Common  Shares of Applied  DNA  Sciences,  Inc.  (the
     "Company").  Information will be held in strict  confidence and used solely
     to ensure that all  prospective  investors are qualified under the relevant
     sections of the Securities Act of 1933.

     [ ] I am a natural  person who has had  individual  income of more than Two
     Hundred Thousand US Dollars (US $200,000.00) in each of the most recent two
     years,  or joint income with my spouse in excess of Three Hundred  Thousand
     US  Dollars  (US  $300,000.00)  in each of the most  recent  two  years and
     reasonably  expect to reach that same  income  level for the  current  year
     ("income"  for purposes  hereof  should be computed as follows:  individual
     adjusted gross income as reported,  or to be reported,  on a federal income
     tax return, increased by (i) any deduction of long-term capital gains under
     section 1202 of the Internal Code of 1936 (the "Code"),  (ii) any deduction
     or depletion  under  Section 611 et. seq. of the Code,  (iii) any exclusion
     for  interest  under  Section  103 of the Code and  (iv)  any  losses  of a
     partnership as reported in Schedule E of Form 1040;

     [ ] The  Subscriber is a natural  person whose  individual  net worth (i.e.
     total  assets in excess of total  liabilities),  or joint net worth with my
     spouse,  will at the time of purchase of the Common  Shares be in excess of
     One Million US Dollars (US $1,000,000.00);

     [ ] The Subscriber is an investor  satisfying the  requirements  of Section
     501(a)(1)(2) or (3) of Regulation D promulgated under the Securities Act of
     1933,  which  includes,  but is not  limited to, a  self-directed  employee
     benefit plan where investment  decisions are made solely by persons who are
     "accredited investors" as otherwise defined in Regulation D;

     [ ] The  Subscriber  is a trust,  which trust has total assets in excess of
     Five  Million US Dollars  (US  $5,000,000.00)  which was not formed for the
     specific  purpose of acquiring the Common Shares  offered  hereby and whose
     purchase  is  directed  by a  sophisticated  person  as  described  in Rule
     506(b)(ii)  of Regulation D and who has such  knowledge  and  experience in
     financial and business  matters that he is capable of evaluating  the risks
     and merits of an investment in the Common Shares;

     [ ] The Subscriber is a director or executive officer of the Company;

     [ ] The  Subscriber  is an entity  (other than a trust) in which all of the
     equity  owners  meet  the  requirements  of  at  least  one  of  the  above
     paragraphs; or

     [ ] The  Subscriber  is not a resident of the United State of America,  but
     acknowledges  he/she meets or exceeds at least one of the minimum financial
     requirements set forth above.

     I represent  that I have reviewed the Company's  information  as filed with
     the US Securities and Exchange Commission, and that I understand the merits
     and the risks involved in this offering,  that I have sufficient  knowledge
     and  experience in similar  programs or  investments to evaluate the merits
     and risks of an  investment  in the  Company  (or that I have  retained  an
     attorney,  accountant,  financial  advisor or  consultant  as my  purchaser
     representative);  that  because of my  background,  employment  experience,
     family or financial situation or economic bargaining power,

                                        1

     I have  received and have had access to material  and relevant  information
     enabling  me  to  make  an  informed  investment  decision,  and  that  all
     information I have  requested has been  furnished to me; and that I am able
     to bear the economic risk of loss of the entire investment which I may make
     in the Company.



     By,_______________________________________

     PRINT NAME
     ________________________________________
     Investor Signature

     With a current address of__________________________________________________

     In the City of____________________________, State/Province of ____________,

     Country of_______________

     DATE:_____, December, 2004


     IN WITNESS WHEREOF, I have hereunto witnessed the signature of the
     above Investor;

     By,___________________________________________

     ______________________________________________
     Witness Signature

     Date:___________________

                                       2


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                APPLIED DNA SCIENCES, INC. SUBSCRIPTION AGREEMENT
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          1.   Subscription.   Subject  to  the  terms  and  conditions  hereof,
     __________________  __________________________,  the  undersigned  Investor
     ("Investor")  hereby  subscribes  to  purchase  _____  units of the Private
     Placement  offering by Applied DNA Sciences Inc.,  dated December 30, 2004.
     to which the terms and conditions of the offer are:

     Applied DNA  Sciences,  Inc.,  a Nevada  corporation  (the  "Company"),  is
     offering up to One Hundred and twenty (120 units (the  "Units") for sale to
     accredited   investors  at  a  price  of  US  Dollars  Fifty   Thousand  US
     ($50,000.00) per Unit (the "Offering") on a "best efforts" no minimum, with
     a maximum offering basis of Six Million US Dollars (US $6,000,000.00). Each
     Unit consists of (i) a US Dollars Fifty Thousand US ($50,000.00)  Principal
     Amount Ten Percent (10.0%) Secured  Convertible  Promissory Note ("Note" or
     "Notes")  and (ii)  warrants to purchase  One  Hundred  Thousand  (100,000)
     shares of the Company's common stock,  exercisable for a period of five (5)
     years  at  a  price  of  US  Seventy   Five  Cents  (US  $0.75)  per  share
     ("Warrants"). The warrants are callable anytime after the underlying shares
     are  registered  if the stock  trades above $1.25 per share for twenty (20)
     trading days. The Notes are convertible  into shares of common stock of the
     Company  at a price of US Fifty  Cents  (US  $0.50)  per  share,  and shall
     automatically convert on the filing of the registration statement indicated
     below.

          2. Private Placement.  The parties  acknowledge that this offering has
     been  made and this  Subscription  Agreement  has  been  entered  into as a
     private placement negotiated between the parties dated December 30, 2004.

          3.  Registration  Rights. By accepting this  subscription,  and as set
     forth in greater detail in the Registration  Rights Agreement,  the Company
     hereby  agrees to include  any shares  purchased  in its next  registration
     statement  filed with the  Securities  and  Exchange  Commission  under the
     Securities  Act of 1933,  as amended and which  registration  statement the
     Company  commits  to file on Form  S-1,  SB2 or other  required  form on or
     before February 15th, 2005. The Company will pay liquidated  damages in the
     amount of Three and a Half Percent  (3.5%) per month for each month or part
     thereof that the  registration  statement is delayed beyond  February 15th,
     2005 and said  penalty  will also take effect if the company  does not have
     the Registration  statement  declared effective within 120 days of February
     15, 2005.

          4.  Knowledge of Financial  and Business  Status of Company.  Investor
     acknowledges  that he has been  involved  with the  Company for a period of
     time, has met in person or telephonically with management immediately prior
     to this investment, and has reviewed the current financial condition of the
     Company and its business  plan.  Investor is aware that the Company and the
     Company's  subsidiary  requires  net capital and the  Company,  as a whole,
     needs operating capital without which it may become insolvent.

          5.  Representations  and Warranties.  In  consideration of the sale of
     such common shares, intending to be legally bound and intending the Company
     to rely thereupon, Investor hereby represents,  warrants, and covenants, to
     the Company as follows:

     Neither  the  Company  nor any person  acting on behalf of the  Company has
     offered to sell,  offered  for sale or sold the Units,  Notes,  Warrants or
     Underlying  Common  Stock  (collectively,  the  "Securities")  by  means of
     general  solicitation  or general  advertising.  Investor has not received,
     paid or given,  directly or indirectly,  any commission or remuneration for
     or because of any sale or the solicitation of any sale of the Securities.

                                       3


     Company  represents and warrants that the Common Shares being issued herein
     are restricted under SEC Rule 144, and Investor is aware of restricted sale
     provisions that make up Rule 144.

     Investor  has been  offered  full  access to all  underlying  documents  in
     connection  with this  transaction  as well as such  other  information  as
     Investor   has  deemed   necessary  or   appropriate   for  a  prudent  and
     knowledgeable  investor to  evaluate  the  purchase  of the Common  Shares.
     Investor  acknowledges  that the Company has made available to Investor the
     opportunity to obtain additional information from, to ask questions of, and
     receive  satisfactory  answers from the officers of the Company  concerning
     the  terms and  conditions  of the  private  placement  and to  verify  the
     information  given.  Investor  is  satisfied  that  there  is  no  material
     information concerning the condition, properties,  operations and prospects
     of  the  Company  of  which  Investor  is  unaware.  In  making  his or her
     investment decision, Investor has relied solely upon his or her independent
     investigation of the investment.

     Investor  is  aware  that  an  investment  in the  Securities  is a  highly
     speculative investment that involves a substantial degree of risk. Investor
     warrants that he/she has such sufficient requisite knowledge and experience
     in business and  financial  matters that  Investor is capable of evaluating
     the merits and risks of an  investment  in the  Company,  which is an early
     stage  business.  Investor  understands  that the  Company  is  relying  on
     Investor's  representations  for  the  purposes  of  confirming  Investor's
     suitability as an investor in the Company.

     Investor is aware that the Securities  have not been  registered  under the
     Securities  Act of 1933 (the "Act"),  and that Investor must therefore bear
     the economic risk of the  investment  indefinitely  because the  Securities
     cannot be sold  unless  subsequently  registered  under the Act or under an
     available  exemption  from  registration.  Investor  agrees not to sell his
     Common  Shares  without  registration  under the Act and  applicable  state
     securities laws unless in a transaction exempt therefrom.

     The Units for which  Investor  hereby  subscribes  are being  acquired  for
     investment purposes, solely for Investor's own account and not on behalf of
     other  persons,  and not  with a view to or for the  resale,  distribution,
     subdivision, or fractionalization thereof; Investor has no present plans to
     enter into any contract,  undertaking,  agreement,  or arrangement  for any
     such  resale,  distribution,  subdivision,  or  fractionalization  thereof.
     Investor  agrees  that he or she  will  not  sell,  assign,  pledge,  give,
     transfer  or  otherwise  dispose of any or all of the Common  Shares or any
     interest therein unless and until Investor has complied with all applicable
     provisions of federal and state securities laws.

     Investor has reviewed his or her financial condition and commitments. Based
     upon such review,  Investor is satisfied  that he or she has adequate means
     of providing for his or her financial needs and possible  contingencies  as
     well as  those  of any  dependents,  and  that he or she  does not have any
     current  or  foreseeable  future  need for  liquidity  of the  funds  being
     utilized  in the  purchase  of the Common  Shares.  Investor  is capable of
     bearing the economic  risk of the  investment  in the Common Shares for the
     indefinite  future. At this time,  Investor has assets or sources of income
     that, if taken  together,  are more than  sufficient so that Investor could
     bear the risk of loss of its,  his or her entire  investment  in the Common
     Shares.


                                    4


     Investor is aware that this  transaction  is a "private  placement" and has
     not been reviewed by the United States  Securities and Exchange  Commission
     or by any state securities  authorities.  No agency,  federal or state, has
     passed upon the fairness or merits of this investment.

     Investor is aware that the assets of the Company are  presently  encumbered
     by the Bridge  Note  investors  and that up to US Dollars  One  Million Six
     Hundred Thousand (US  $1,600,000.00) of this investment may be allocated to
     pay back the Bridge Note holders.  On December 10th 2004 the Company signed
     a letter agreement with Vertical Capital Partners to act on a non-exclusive
     basis as a Placement Agent for all or part of this Placement.  Further, the
     Investor acknowledges as does the Company that a pre-existing  relationship
     exists  between  the  parties  that dates back prior to the  engagement  of
     Vertical. As part of the Agreement,  Vertical has committed to use its best
     efforts  to raise Two  Million  US Dollars  (US  $2,000,000.00)  of the Six
     Million US Dollars (US  $6,000,000.00)  contemplated  in this  Subscription
     Agreement. Vertical has also committed to use its best efforts to cause its
     Bridge Note Holders to convert on or about  December  31st,  2004,  thereby
     removing the need to repay the Bridge Note holders referred to herein.

     Neither this Subscription Agreement nor Investor's rights hereunder, may be
     assigned, sold or transferred in any manner and this Subscription Agreement
     may not be altered, amended or revoked without the prior written consent of
     the President of the Company.

     Investor is a bona fide resident as set forth next to Investor's signature,
     such location is Investor's principal  residence,  and Investor is at least
     18 years of age.

     Investor  understands  and  agrees  that  if  Investor's   subscription  is
     accepted, Investor will be required to execute such additional documents as
     may be  necessary  to effect the issuance of the  Company's  Common  Shares
     which Investor has purchased.

     The  foregoing  representations,  warranties  and  covenants  are  true and
     accurate  as of the date  hereof and shall be true and  accurate  as of the
     date of completion of the Private Placement.  If such  representations  and
     warranties  shall  not be  true  and  accurate  in  any  respect  prior  to
     completion of the Private Placement,  Investor shall give written notice of
     such fact to the Company,  specifying which  representations and warranties
     are not true and accurate and the reasons therefore.


          6.  Escrow  Account.  Funds  should  be sent by wire  transfer  to the
     following  escrow  account:  Bank: Bank of New York, Mt. Freedom New Jersey
     Name:  Escrow Account Applied DNA Sciences Inc. Account # 2 Routing number:
     021000018 Account Number: 6175822540

          7. Miscellaneous.

     This  Subscription  Agreement  constitutes the entire agreement between the
     parties with respect to the subject  matter hereof and supersedes all prior
     negotiations  and  understandings  which are  deemed  to have  been  merged
     herein. No representations  were made or relied upon by either party, other
     than those expressly set forth herein.  The investor has been provided with
     a copy of the Private  Placement  Memorandum  outlining the business of the
     Company along with the terms of the offering.

                                       5

     This  writing  shall  be  amended  only by a  further  writing.  No  agent,
     employee, or other representative of any party is empowered to alter any of
     the terms hereof,  including  specifically  this Paragraph,  unless done in
     writing and signed by both parties.

     Whenever  required by the context  hereof:  the  masculine  gender shall be
     deemed to include the feminine and neuter; and the singular member shall be
     deemed to include  the  plural.  Time is  expressly  declared  to be of the
     essence  of this  Agreement.  This  Agreement  shall be deemed to have been
     mutually  prepared by all parties  and shall not be  construed  against any
     particular party as the draftsman. The invalidity of any one or more of the
     words, phrases,  sentences,  clauses,  sections or subsections contained in
     this  Agreement  shall  not  affect  the  enforceability  of the  remaining
     portions of this  Agreement or any part  hereof,  all of which are inserted
     conditionally  on their being valid in law,  and, in the event that any one
     or more of the words, phrases, sentences,  clauses, sections or subsections
     contained  in this  Agreement  shall  be  declared  invalid  by a court  of
     competent  jurisdiction,  this  Agreement  shall  be  construed  as if such
     invalid word or words, phrase or phrases, sentence or sentences,  clause or
     clauses,  section or sections,  or subsection or  subsections  had not been
     inserted.

     The validity,  interpretation,  and  performance of this Agreement shall be
     controlled  by and construed  under the laws of the State of Nevada.  Venue
     and jurisdiction of any controversy or claim arising out of, or relating to
     this Subscription Agreement, or the breach thereof, that cannot be resolved
     by negotiation,  shall be in the County of Las Vegas,  State of Nevada.  In
     any legal action or other  proceeding  involving,  arising out of or in any
     way relating to this Agreement,  the prevailing  party shall be entitled to
     recover reasonable attorneys' fees, costs, and expenses of litigation.

     The failure of any party to object to, or to take  affirmative  action with
     respect to, any conduct of any other  party  which is in  violation  of the
     terms  of  this  Agreement  shall  not be  construed  as a  waiver  of such
     violation  or  breach,  or of any future  breach,  violation,  or  wrongful
     conduct.  No delay or failure by any party to exercise any right under this
     Agreement,  and  no  partial  or  single  exercise  of  that  right,  shall
     constitute  a waiver  or  exhaustion  of that or any  other  right,  unless
     otherwise expressly provided herein.

     Headings in this Subscription  Agreement are for convenience only and shall
     not be used to interpret or construe its provisions.

     This  Subscription  Agreement may be executed in two or more  counterparts,
     each of which shall be deemed an original but all of which  together  shall
     constitute one and the same instrument. The provisions of this Subscription
     Agreement  shall be  binding  upon and inure to the  benefit of each of the
     parties and their respective successors and assigns.

          8. Company Contact Details.

     Applied DNA Sciences, 9229 West Sunset Boulevard,  Suite #830, Los Angeles,
     CA 90069

     Facsimile: 818-860-1303
     Tel: 310-860-1362
     President: Peter Brocklesby, ext 123 or
     COO & Secretary: Ms. Karin Klemm, ext 124

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]
                                       6


     IN WITNESS  WHEREOF,  the  undersigned  has  executed  and  delivered  this
     Subscription Agreement dated this day of December, in the year 2004.

     By, _______________________________________
         PRINT NAME:

     __________________________
     (Signature of INVESTOR)

     With a current address of _________________________________________________

     In the City of_________________________, State/Province of _______________,
     Country of_______________

     ACCEPTED: APPLIED DNA SCIENCES, INC.

     By, __________________                 Title:____________________________
         Signature of Officer

     ________________________
     Name:

     DATE,__________ __, December, 200__


                                       7

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                        Securities Issuance Instructions
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     THE   UNDERSIGNED,   AS  A  CONDITION  TO  PURCHASE   ________  UNITS  (THE
     "SECURITIES")  OF APPLIED DNA  SCIENCES,  INC., A NEVADA  CORPORATION  (THE
     "COMPANY"), HEREBY CERTIFIES TO THE COMPANY AS FOLLOWS:

     1. I,  __________________________  (Purchaser Name) am purchasing the Units
     (the "Securities") on this ________day of ____________, in the year 20____,
     in my own name and for my own  account  (or for a trust  account  if I am a
     trustee),  and no other person has any interest in or right with respect to
     the  Securities,  nor have I agreed to give any person any such interest or
     right in the future.

     2. I am acquiring the  Securities  for investment and not with a view to or
     for sale in connection with any distribution of the Securities. I recognize
     that the Securities have not been registered  under the Federal  Securities
     Act  of  1933,  that  any  disposition  of the  Securities  is  subject  to
     restrictions  imposed  by federal  and state law and that the  certificates
     representing  the  Securities  will  bear  a  restrictive  legend.  I  also
     recognize that I cannot dispose of the Securities  absent  registration and
     qualification,   or  an   available   exemption   from   registration   and
     qualification.  I understand  that the  availability of an exemption in the
     future will depend in part on  circumstances  outside my control and that I
     may be  required  to  hold  the  Securities  for a  substantial  period.  I
     understand  that the United States  Securities and Exchange  Commission has
     made no finding or determination relating to the fairness for investment of
     the  Securities  offered by the Company and that the Commission has not and
     will not recommend or endorse the Securities.

     3. I have not seen or received any  advertisement  or general  solicitation
     with respect to the sale of the Securities.

     4. I believe,  by reason of my business or financial  experience  that I am
     capable  of  evaluating  the  merits  and risks of this  investment  and of
     protecting my own interests in connection with this investment.

     5. I acknowledge  that during the course of this  transaction  and prior to
     purchasing  the  Securities I have been provided  with  financial and other
     written information about the Company, I have been given the opportunity by
     the Company to obtain such  information  and ask such questions  concerning
     the Company, the Securities,  and my investment as I felt necessary, and to
     the extent I availed myself of such  opportunity,  I received  satisfactory
     information and answers. If I requested any additional  information,  which
     the Company  possessed  or could  acquire  without  unreasonable  effort or
     expense and which was necessary to verify the accuracy of the financial and
     other written information  furnished to me by the Company,  that additional
     information  was  provided to me. In reaching the decision to invest in the
     Securities,   I  have  carefully   evaluated  my  financial  resources  and
     investment  position and the risks associated with this  investment,  and I
     acknowledge that I am able to bear the economic risks of this investment. I
     further acknowledge that my financial condition is such that I am not under
     any present necessity or constraint to dispose of the Securities to satisfy
     any existent or contemplated debt or undertaking.

                                       8

     Please PRINT below the exact information regarding the Purchaser:

     INDIVIDUAL

     ___________________________________________________________________________
     Individual Name(s)

     ___________________________________________________________________________
     Citizenship

     ___________________________________________________________________________
     Street Address, City, State/Province/Country and Postal Code

     ___________________________________________________________________________
     Signature (All record holders should sign)

     Telephone Number: ______________      Fax Number:__________________________

     E-Mail Address: ___________________________________________________________

     I wish to receive news announcements and information about the company

     YES ____  NO ______ (check one)

     If yes to the above, Applied DNA, Inc. may contact me via:

     Fax: _____e-mail ____Telephone ___ (check one or more)


     CORPORATION, PARTNERSHIP, TRUST, OR OTHER ENTITY

     ___________________________________________________________________________
     Name of Entity

     Name,  Address(es),  and Country of  Citizenship  of each of the beneficial
     Owners of the Entity:
     ___________________________________________________________________________

     ___________________________________________________________________________
     ___________________________________________________________________________
      Address(es) to Which Correspondence should be Directed

     ___________________________________________________________________________

     ___________________________________________________________________________
     Type of Entity (i.e., corporation, partnership etc)

     ___________________________________________________________________________
     State/Province/ Country of Formation of Entity

     By:____________________________________ Printed Name:______________________

     Its:____________________________________

     Title: _________________________________

     Telephone Number: ____________________Fax Number:__________________________

     E-Mail Address: ___________________________________________________________

     I wish to receive news announcements and information about the company

     YES ____  NO ______ (check one)

     If yes to the above, Applied DNA, Inc. may contact me via:

     Fax: _____e-mail ____ Telephone ______(check one or more)

     If Securities  are being  subscribed for by an entity,  the  Certificate of
     Signatory below must be completed.

     CERTIFICATE OF SIGNATORY

     To be completed if Securities are being subscribed for by an entity.

     I,________________________________, am the ________________________________

     of_________________________________________________________(the "Entity ").

     I certify that I am empowered and duly  authorized by the Entity to execute
     and  carry  out the  terms of the  Subscription  Agreement  and  Securities
     Issuance Instructions to purchase and hold the Securities, and certify that
     the Subscription  Agreement and Securities Issuance  Instructions have been
     duly and validly  executed on behalf of the Entity and constitute legal and
     binding obligations of the Entity.

     IN WITNESS WHEREOF, I have hereto set my hand this ____day of______, 20___.

     __________________________________
     Signature