THIS NOTE AND THE COMMON STOCK  REFERENCED  HEREIN HAVE NOT BEEN REGISTERED
WITH OR APPROVED OR  DISAPPROVED  BY THE UNITED STATES  SECURITIES  AND EXCHANGE
COMMISSION OR ANY STATE  SECURITIES  COMMISSION OR REGULATORY  AUTHORITY AND ARE
BEING OFFERED PURSUANT TO AN EXEMPTION FROM REGISTRATION UNDER THE UNITED STATES
SECURITIES ACT OF 1933, AS AMENDED (THE, "SECURITIES ACT").

     THE SALE, ASSIGNMENT,  CONVEYANCE, PLEDGE, HYPOTHECATION OR TRANSFER OF THE
SECURITIES  REPRESENTED  BY THIS  NOTE OR THE  UNDERLYING  COMMON  STOCK TO U.S.
PERSONS,  AS  DEFINED  IN RULE  902(k) OF  REGULATION  S  PROMULGATED  UNDER THE
SECURITIES  ACT, IS PROHIBITED  EXCEPT (1) IN ACCORDANCE  WITH THE PROVISIONS OF
REGULATION  S  AS  PROMULGATED   UNDER  THE  SECURITIES  ACT;  (2)  PURSUANT  TO
REGISTRATION UNDER THE SECURITIES ACT; OR (3) PURSUANT TO AN AVAILABLE EXEMPTION
FROM REGISTRATION UNDER THE SECURITIES ACT.

 This note is one of a series of notes (the "Serial Notes") issued in the
aggregate principal amount of $1,500,000.00.

                           APPLIED DNA SCIENCES, INC.


March 8, 2006                                                        $__________


                     10% SECURED CONVERTIBLE PROMISSORY NOTE

Applied DNA Sciences,  Inc., a Nevada  corporation  (the  "Company"),  for value
received, hereby promises to pay to _________________ or registered assigns (the
"Holder") on September 7, 2007,  the  "Maturity  Date"),  , the principal sum of
_____ THOUSAND  DOLLARS  ($______) in such coin or currency of the United States
of America as at the time of payment  shall be legal  tender for the  payment of
public and private debts,  and to pay interest on the outstanding  principal sum
hereof at the rate of ten  percent  (10%) per annum.  Any  principal  payment or
interest  payment on the unpaid principal amount of this Note not paid when due,
whether at the Maturity Date, by acceleration or otherwise,  shall bear interest
at twelve  percent (12%) or the maximum rate  permissible  by law,  whichever is
less. Payment of Principal and accrued interest, if any, shall be payable on the
Maturity  Date in like coin or currency  to the Holder  hereof at the address of
the Holder on file with the Company or at such other  place as the Holder  shall
have  notified the Company in writing at least five (5) days before the Maturity
Date,  provided that any payment  otherwise  due on a Saturday,  Sunday or legal
Bank holiday may be paid on the following business day.


                                       1


     This Note is  secured by all the assets of the  Company  including  but not
limited to  patents,  licenses,  equipment,  fixtures,  inventory  and  accounts
receivable,  for the benefit of the Holder pursuant to a Security  Agreement set
forth in Section 4(f) hereof  ("Security  Agreement").  Reference  herein to the
Security  Agreement  shall  in no way  impair  the  absolute  and  unconditional
obligation of the Company to pay both principal and interest  hereon as provided
herein.

     The rights and  remedies of the Holder  hereunder  are subject to the terms
and  conditions  of the Security  Agreement  and the  provisions  of the Uniform
Commercial Code of the State of Nevada  including,  without  limitation,  powers
with  respect  to the  enforceability  and  collectibility  of all  amounts  due
hereunder.  Reference to the Uniform  Commercial  Code of the State of Nevada is
made for a complete  description  of the rights,  powers and  obligations of the
Holder.

     1. Transfers of Note to Comply with the Securities Act

     The Holder  agrees  that this Note may not be sold,  transferred,  pledged,
hypothecated  or  otherwise  disposed  of  except  (1) IN  ACCORDANCE  WITH  THE
PROVISIONS OF REGULATION S AS PROMULGATED UNDER THE SECURITIES ACT; (2) PURSUANT
TO  REGISTRATION  UNDER THE  SECURITIES  ACT; OR (3)  PURSUANT  TO AN  AVAILABLE
EXEMPTION


     2. Prepayment;  Holders' Premaking Rights;  Repayment Upon Consolidation or
Merger

     (a) The  principal  amount of this Note may be prepaid by the  Company,  in
whole or in part, on three days prior written notice without premium or penalty,
at any time.  Upon any prepayment of the entire  principal  amount of this Note,
all  accrued,  but unpaid,  interest  shall be paid to the Holder on the date of
prepayment.  The date upon which the  Company  prepays  the  principal  plus all
accrued and unpaid interest due on this Note shall be hereinafter referred to as
the "Prepayment  Date."  Notwithstanding  the foregoing  right of payment,  upon
receipt of the three day notice, the Holder shall have the conversion rights set
forth under  Section  3(b) hereof,  regardless  of when said three day notice is
given.

     (b) The  Holder  shall  have the  right,  but not the  obligation  from the
commencement  of the  fifteenth  (15th)  month  from the date  hereof  until the
Maturity Date to request payment of accrued interest and principal  hereunder in
full payment of this Note prior to the automatic  conversion provided in Section
3(a) hereof.

     (c) This  Note  shall be paid in full,  without  premium,  in the event the
Company consolidates or merges with another corporation,  unless (i) the Company
shall be the surviving  corporation in such  consolidation or merger or (ii) the
other corporation controls, is under common control with or is controlled by the
Company  immediately  prior to the  consolidation  or merger  whether or not the
Company shall be the surviving  corporation in such  consolidation or merger, in
which  event  this  Note  shall  remain  outstanding  as an  obligation  of  the
consolidated or surviving corporation.

                                       2


     3. Conversion of Note

     (a) This Note shall  automatically  convert  into shares of Common Stock of
the Company at the Maturity Date..  The conversion rate shall be calculated at a
twenty (20%)  percent  discount  from the average  closing bid price for the ten
(10) trading days prior to conversion,  and the entirety of the debt (consisting
of principal and accrued  interest) shall be applied to purchase of Common Stock
at such price.

     (b) The Holder  shall have the right from time to time,  and at any time on
or prior to the first anniversary of the date hereof, to convert all or any part
of the entirety of the debt then outstanding under this Note into fully paid and
non-assessable  shares of Common Stock, as such Common Stock exists on the issue
date,  or any shares of capital  stock or other  securities  of the Company into
which  such  Common  Stock  shall  hereafter  be changed  or  reclassified  at a
conversion price equal to $.50 per share;


     4. Covenants of Company

     The Company  covenants  and agrees that,  so long as any  principal  of, or
interest on, this Note shall remain  unpaid,  unless the Holder shall  otherwise
consent in writing, it will comply with the following terms:

     (a) Reporting Requirements. The Company will furnish to the Holder:

        (i) as soon as  possible,  and in any event  within  ten (10) days after
obtaining knowledge of the occurrence of (A) an Event of Default, as hereinafter
defined,  (B) an event which,  with the giving of notice or the lapse of time or
both, would constitute an Event of Default,  or (C) a material adverse change in
the condition or operations,  financial or otherwise,  of the Company,  taken as
whole,  the  written  statement  of the  Chief  Executive  Officer  or the Chief
Financial  Officer of the  Company,  setting  forth the details of such Event of
Default,  event or  material  adverse  change and the action  which the  Company
proposes to take with respect thereto;

        (ii)  promptly  after  the  sending  or  filing  thereof,  copies of all
financial  statements,  reports,  certificates of its Chief  Executive  Officer,
Chief Financial  Officer or accountants and other  information which the Company
or any subsidiary sends to any holders (other than the Notes) of its securities;

        (iii) promptly after the  commencement  thereof,  notice of each action,
suit or  proceeding  before any court or other  governmental  authority or other
regulatory body or any arbitrator as to which there is a reasonable  possibility
of a determination  that would (A) materially  impact the ability of the Company
or any subsidiary to conduct its business,  (B) materially and adversely  affect
the business, operations or financial condition of the Company taken as a whole,
or (C) impair the validity or  enforceability of the Notes or the ability of the
Company to perform its obligations under the Notes;

                                       3


        (iv)  promptly  upon  request,  such other  information  concerning  the
condition or  operations,  financial or otherwise,  of the Company as the Holder
from time to time may reasonably request.

        (b) Taxes.  The  Company has filed or will file all  federal,  state and
local  tax  returns  required  to be  filed or sent or has  obtained  extensions
thereof.  Except as  otherwise  disclosed,  the  Company has timely paid or made
provision for all taxes shown as due and payable on its tax returns  required to
be filed  prior to the date hereof and all  assessments  received by the Company
and will  timely pay all taxes that will be shown as due and  payable on its tax
returns  required to be filed after the date  hereof,  except to the extent that
the Company  shall be  contesting  such taxes and  assessments  in good faith by
appropriate proceedings.

        (c)  Compliance  with Laws.  The Company  will  comply,  in all material
respects with all applicable laws, rules,  regulations and orders, except to the
extent  that  noncompliance  would not have a material  adverse  effect upon the
business, operations or financial condition of the Company taken as a whole.

        (d)  Keeping of Records  and Books of  Account.  The  Company  will keep
adequate records and books of account,  with complete entries made in accordance
with generally accepted accounting  principles,  reflecting all of its financial
and other business transactions.

        (e) Negative Covenants. The Company covenants and agrees that while this
Note is outstanding it will not directly or indirectly:

          (i) Sell,  transfer or dispose of, any of its assets other than in the
ordinary course of its business and for fair value; or

          (ii)  Repay  out of the  proceeds  of this Note any  indebtedness  for
borrowed  funds or any related  party  obligations  except for Notes  heretofore
issued to persons to  investors  through  offerings  in which  Vertical  Capital
Partners, Inc acted as placement agent.

     (f) Security  Agreement.  The Company  hereby  grants to the holders of the
Serial Notes a security interest in all of the assets of the Company  including,
but not limited to,  patents,  trademarks,  equipment,  fixtures,  inventory and
accounts  receivable  with all of the rights and powers of a secured party under
the Uniform Commercial Code of the State of Nevada. Except with respect to prior
Notes of the Company sold through  offerings in which Vertical Capital Partners,
Inc.  acted as placement  agent and which the Company  intends to repay with the
proceeds of these Notes,  the Company  represents  and warrants  that it has not
granted any other party a security  interest in any of its (or its subsidiaries)
patents,  licenses,  equipment,  fixtures,  inventory  or  accounts  receivable.
Subject to the rights of the Company set forth at the end of this paragraph, the
Company  certifies  under  penalty of perjury that the security  interest in the
collateral is not pledged and the Holder will assume a senior security  position
on such collateral. The Company reserves the right to issue up to $11,500,000 of
additional  debt  secured by a security  interest  in the assets of the  Company
which is pari  passu  with the  security  interest  of the  holder  of this Note
granted herein.


                                       4

     (g) Registration Under the Securities Act of 1933. The Company will prepare
and file a registration  statement  with the Securities and Exchange  Commission
covering  the Common  Stock of the Company  underlying  the Serial  Notes within
thirty (30) days of the  effective  date of the Company's  pending  registration
statement on Form SB-2 (SEC File  333-122848)  being  declared  effective by the
SEC, and it agrees to use its reasonable  best efforts to have the  registration
statement  declared effective by the SEC by no later than one hundred and eighty
(180) days after filing.  If the Company fails to file a registration  statement
with the SEC on or before the time frame described,  the Holder will be entitled
to  liquidated  damages in the amount of 2% per month for each month the Company
is delinquent in filing the registration statement.

     5. Events of Default and Remedies


     (a) Any one or more of the  following  events which shall have occurred and
be continuing shall constitute an event of default (Event of Default):

        (i) Default in the payment of the principal or accrued  interest on this
Note or upon any other indebtedness of the Company after the date hereof that is
greater than $100,000, as and when the same shall become due, whether by default
or  otherwise,  which  Default  shall  have  continued  for a period of five (5)
business days; or

        (ii) Any  representation  or warranty made by the Company or any officer
of the Company in the Notes, or in any agreement,  report,  certificate or other
document delivered to the Holder pursuant to the Notes shall have been incorrect
in any material  respect  when made which shall not have been  remedied ten (10)
days after written notice thereof shall have been given by the Holder; or

        (iii) The  Company  shall fail to perform  or  observe  any  affirmative
covenant  contained  in  Section  4 of this  Note or any of the  Notes  and such
Default,  if capable of being  remedied,  shall not have been  remedied ten (10)
days after written notice thereof shall have been given by the Holder; or

        (iv) The Company or any subsidiary (A) shall institute any proceeding or
voluntary  case  seeking to  adjudicate  it  bankrupt or  insolvent,  or seeking
dissolution,  liquidation, winding up, reorganization,  arrangement, adjustment,
protection,  relief or  composition of it or its debts under any law relating to
bankruptcy,  insolvency or reorganization  or relief of debtors,  or seeking the
entry of any  order  for  relief  or the  appointment  of a  receiver,  trustee,
custodian or other  similar  official for such the Company or any  subsidiary or
for any substantial  part of its property,  or shall consent to the commencement
against  it of such a  proceeding  or case,  or shall file an answer in any such
case or proceeding  commenced  against it consenting  to or  acquiescing  in the
commencement of such case or proceeding, or shall consent to or acquiesce in the
appointment  of such a receiver,  trustee,  custodian or similar  official;  (B)
shall be unable to pay its debts as such debts  become  due,  or shall  admit in
writing its  inability  to apply its debts  generally;  (C) shall make a general
assignment  for the  benefit  of  creditors;  or (D)  shall  take any  action to
authorize  or  effect  any of the  actions  set forth  above in this  subsection
5(a)(iv); or

                                       5


        (v) Any proceeding  shall be instituted  against the Company  seeking to
adjudicate  it a bankrupt or  insolvent,  or seeking  dissolution,  liquidation,
winding  up,  reorganization,  arrangement,  adjustment,  protection,  relief of
debtors,  or seeking  the entry of an order for relief or the  appointment  of a
receiver,  trustee,  custodian or other similar  official for the Company or for
any substantial part of its property,  and either such proceeding shall not have
been  dismissed or shall not have been stayed for a period of sixty (60) days or
any of the actions sought in such proceeding (including, without limitation, the
entry of any order for  relief  against  it or the  appointment  of a  receiver,
trustee,  custodian or other similar official for it or for any substantial part
of its property) shall occur; or

        (vi) One or more final judgments,  arbitration  awards or orders for the
payment  of money in excess  of  $250,000  in the  aggregate  shall be  rendered
against the Company,  which judgment  remains  unsatisfied  for thirty (30) days
after the date of such entry.

        (vii)  Delisting  of the  Common  Stock  from the  principal  market  or
exchange on which the Common Stock is listed for trading;  Company's  failure to
comply with the conditions for listing;  or notification that the Company is not
in compliance with the conditions for such continued listing.

        (viii) The  issuance of an SEC stop trade  order or an order  suspending
trading of the Common Stock from the  principal  market or exchange on which the
Common Stock is listed for trading for longer than five (5) trading days.

        (ix) The failure by the Company to issue  shares of Common  Stock to the
Holder  upon  exercise by the Holder of the  conversion  rights of the Holder in
accordance  with the terms of this Note, or the failure to transfer or cause its
transfer  agent  to  transfer  (electronically  or  in  certificated  form)  any
certificate  for shares of Common Stock issued to the Holder upon  conversion of
or  otherwise  pursuant to this Note as and when  required by this Note,  or the
failure  to remove any  restrictive  legend (or to  withdraw  any stop  transfer
instructions  in respect  thereof) on any  certificate  for any shares of Common
Stock issued to the Holder upon conversion of or otherwise pursuant to this Note
as and when required by this Note, and any such failure shall  continue  uncured
for ten (10) days after the Company shall have been notified  thereof in writing
by the Holder;

        (x) The  failure  by the  Company  to  prepare  and file a  registration
statement with the Securities and Exchange  Commission covering the Common Stock
within  thirty  (30)  days  of  the  effective  date  of the  Company's  pending
registration  statement  on Form  SB-2  (SEC  File  333-122848)  being  declared
effective  by the  SEC,  or to use its  reasonable  best  efforts  to  have  the
registration  statement  declared  effective  by the SEC by no  later  than  one
hundred and eighty (180) days after filing.

        (xi)  Except  as  permitted  herein,   the  Company  shall  encumber  or
hypothecate the collateral subject to the Security Agreement to any party;

     (b) In the  event of and  immediately  upon the  occurrence  of an Event of
Default, the Note shall become immediately due and payable without any action by
the Holder and the Note  shall bear  interest  until paid at the rate of 12% per
annum or such amount as shall be allowed by law (the "Default  Interest  Rate").
If an Event of Default occurs and is continuing, Holder may pursue any available
remedy to collect  the  payment of all  amounts due under the Note or to enforce
the performance of any provision of the Note. No waiver of any default under the
Note shall be construed as a waiver of any subsequent  default,  and the failure
to exercise any right or remedy thereunder shall not waive the right to exercise
such right or remedy thereafter.

                                       6


     (c) The  Company  covenants  that in case the  principal  of,  and  accrued
interest on, the Note becomes due and payable by declaration or otherwise,  then
the Company  will pay in cash to the Holder of this Note,  the whole amount that
then shall have become due and payable on this Note for  principal  or interest,
as the case may be, and in addition  thereto,  such  further  amount as shall be
sufficient to cover the costs and expenses of collection,  including  reasonable
fees and disbursements of the Holder's legal counsel.  In case the Company shall
fail  forthwith  to pay such  amount,  the  Holder  may  commence  an  action or
proceeding at law or in equity for the collection of the sums so due and unpaid,
and may  prosecute  any such action or  proceeding  to judgment or final  decree
against Company or other obligor upon this Note,  wherever situated,  the monies
adjudicated or decreed to be payable.

         (d) The Company agrees that it shall give notice to the Holder at its
registered address by facsimile, confirmed by certified mail, of the occurrence
of any Event of Default within ten (10) days after such Event of Default shall
have occurred.

     6. Unconditional Obligation; Fees, Waivers, Other

     (a) The  obligations  to make the  payments  provided  for in this Note are
absolute  and   unconditional   and  not  subject  to  any   defense,   set-off,
counterclaim, rescission, recoupment or adjustment whatsoever.

     (b) If, following the occurrence of an Event of Default,  Holder shall seek
to enforce the collection of any amount of principal of and/or  interest on this
Note,  there shall be immediately due and payable from the Company,  in addition
to the then unpaid  principal of, and accrued unpaid interest on, this Note, all
costs  and  expenses  incurred  by Holder in  connection  therewith,  including,
without limitation, reasonable attorneys' fees and disbursements.

     (c) No forbearance,  indulgence,  delay or failure to exercise any right or
remedy with respect to this Note shall operate as a waiver or as an acquiescence
in any default,  nor shall any single or partial exercise of any right or remedy
preclude  any other or further  exercise  thereof or the  exercise  of any other
right or remedy.

     (d) This Note may not be modified or  discharged  (other than by payment or
conversion) except by a writing duly executed by the Company and Holder.

     (e) Holder  hereby  expressly  waives demand and  presentment  for payment,
notice of nonpayment,  notice of dishonor,  protest, notice of protest, bringing
of suit,  and  diligence  in taking  any action to  collect  amounts  called for
hereunder,  and shall be directly  and  primarily  liable for the payment of all
sums  owing  and to be owing  hereon,  regardless  of and  without  any  notice,
diligence,  act or omission with respect to the  collection of any amount called
for hereunder or in connection with any right, lien, interest or property at any
and all times which the  Company  had or is existing as security  for any amount
called for hereunder.

                                       7



     7. Miscellaneous

     (a) The headings of the various paragraphs of this Note are for convenience
of reference  only and shall in no way modify any of the terms or  provisions of
this Note.

     (b) This Note has been issued by the Company  pursuant to  authorization of
the Board of Directors of the Company.

     All notices required or permitted to be given hereunder shall be in writing
and shall be deemed to have been duly given when personally delivered or sent by
registered  or  certified  mail (return  receipt  requested,  postage  prepaid),
facsimile  transmission or overnight courier to the Holder at the address in the
records of the Company,  to the Company at 25 Health Sciences Dr., Stoney Brook,
N.Y.  11790 or at such  other  address  as the  intended  recipient  shall  have
hereafter  given to the other party hereto  pursuant to the  provisions  of this
Note.

     (c) The Company may  consider  and treat the entity in whose name this Note
shall be  registered as the absolute  owner thereof for all purposes  whatsoever
(whether  or not this  Note  shall be  overdue)  and the  Company  shall  not be
affected  by any  notice to the  contrary.  Subject  to the  limitations  herein
stated,  the registered owner of this Note shall have the right to transfer this
Note by assignment,  and the transferee  thereof shall, upon his registration as
owner  of this  Note,  become  vested  with all the  powers  and  rights  of the
transferor. Registration of any new owners shall take place upon presentation of
this  Note  to  the  Company  at its  principal  offices,  together  with a duly
authenticated  assignment.  In  case  of  transfer  by  operation  of  law,  the
transferee agrees to notify the Company of such transfer and of his address, and
to submit  appropriate  evidence regarding the transfer so that this Note may be
registered in the name of the transferee.  This Note is transferable only on the
books of the  Company by the holder  hereof,  in person or by  attorney,  on the
surrender  hereof,  duly endorsed.  Communications  sent to any registered owner
shall be  effective  as  against  all  holders  or  transferees  of the Note not
registered at the time of sending the communication.

     (d) Payments of principal and interest shall be made as specified  above to
the  registered  owner of this Note.  No interest  shall be due on this Note for
such period of time that may elapse  between  the  maturity of this Note and its
presentation for payment.

     (e) The Holder shall not, by virtue, hereof, be entitled to any rights of a
shareholder in the Company,  whether at law or in equity,  and the rights of the
Holder are limited to those expressed in this Note.

     (f) Upon receipt by the Company of evidence  reasonably  satisfactory to it
of the loss, theft,  destruction or mutilation of this Note, and (in the case of
loss, theft or destruction) of reasonably satisfactory indemnification, and upon
surrender and cancellation of this Note, if mutilated, the Company shall execute
and deliver a new Note of like tenor and date.

                                       8


     (g) This Note shall be construed and enforced in  accordance  with the laws
of the  State  of New  York,  without  giving  effect  to the  conflicts  of law
principles  thereof or the actual domiciles of the parties.  The Company and the
Holder hereby consent to the jurisdiction of the Courts of the State of New York
and the United States District  Courts  situated  therein in connection with any
action  concerning the provisions of this Note  instituted by the Holder against
the Company.

     (h) The Company  and the  Holder(i)  agree that any legal  suit,  action or
proceeding  arising  out  of or  relating  to  this  Note  shall  be  instituted
exclusively  in the New York State Supreme  Court,  County of New York or in the
United States  District Court for the Southern  District of New York, (ii) waive
any  objection  which the Holder or the Company may have now or hereafter  based
upon  forum  non  conveniens  or to  the  venue  of any  such  suit,  action  or
proceeding,  and (iii) irrevocably  consents to the jurisdiction of the New York
State Supreme Court, County of New York and the United States District Court for
the Southern  District of New York in any such suit,  action or proceeding.  The
Holder and the Company  further agree to accept and  acknowledge  service of any
and all process  which may be served in any such suit,  action or  proceeding in
the New York State  Supreme  Court,  County of New York or in the United  States
District  Court for the Southern  District of New York and agree that service of
process upon the Company,  mailed by certified  mail to the  Company's  address,
will be deemed in every respect  effective service of process upon Payor, in any
suit,  action or proceeding.  FURTHER,  THE HOLDER AND  THECOMPANY  HEREBY WAIVE
TRIAL BY JURY IN ANY  ACTION TO  ENFORCE  THIS NOTE AND IN  CONNECTION  WITH ANY
DEFENSE, COUNTERCLAIM OR CROSSCLAIM ASSERTED IN ANY SUCH ACTION.

        (i) No  recourse  shall  be had  for the  payment  of the  principal  or
interest of this Note against any  incorporator  or any past,  present or future
stockholder  officer,  director,  agent or  attorney of the  Company,  or of any
successor  corporation,  either directly or through the Company or any successor
corporation,  otherwise, all such liability of the incorporators,  stockholders,
officers, directors, attorneys and agents being waived, released and surrendered
by the Holder hereof by the acceptance of this Note.

        (j) This Note shall bind the Company and its successors and assigns.


IN WITNESS WHEREOF, the undersigned has duly executed and delivered this Note as
of the day and year first above written.




                      [THIS SPACE INTENTIONALLY LEFT BLANK]


                                       9






                                         APPLIED DNA SCIENCES, INC


                                         By /s/James Hayward
                                         --------------------------
                                         Name: James Hayward
                                         Title:CEO